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EC / List no.: 200-238-7
CAS no.: 55-56-1
Mol. formula: C22H30Cl2N10
Chlorhexidine (CHX) (commonly known by the salt forms chlorhexidine gluconate and chlorhexidine digluconate (CHG) or chlorhexidine acetate) is a disinfectant and antiseptic that is used for skin disinfection before surgery and to sterilize surgical instruments.
Chlorhexidinemay be used both to disinfect the skin of the patient and the hands of the healthcare providers.
Chlorhexidineis also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking.
Chlorhexidineis used as a liquid or powder.
Side effects may include skin irritation, teeth discoloration, and allergic reactions, although the risk appears to be the same as other topical antiseptics.
Chlorhexidinemay cause eye problems if direct contact occurs.
Use in pregnancy appears to be safe.
Chlorhexidine may come mixed in alcohol, water, or surfactant solution.
Chlorhexidineis effective against a range of microorganisms, but does not inactivate spores.
Chlorhexidine came into medical use in the 1950s.
Chlorhexidine is available over the counter (OTC) in the United States.
Chlorhexidineis on the World Health Organization's List of Essential Medicines.
In 2017, Chlorhexidinewas the 286th most commonly prescribed medication in the United States, with more than one million prescriptions.
The name "chlorhexidine" breaks down as chlor(o) + hex(ane) + id(e) + (am)ine.
Uses:
Chlorhexidine is used in disinfectants (disinfection of the skin and hands), cosmetics (additive to creams, toothpaste, deodorants, and antiperspirants), and pharmaceutical products (preservative in eye drops, active substance in wound dressings and antiseptic mouthwashes).
A 2019 Cochrane review concluded that based on very low certainty evidence in those who are critically ill "Chlorhexidineis not clear whether bathing with chlorhexidine reduces hospital‐acquired infections, mortality, or length of stay in the ICU, or whether the use of chlorhexidine results in more skin reactions."
This medication is used along with regular tooth brushing/flossing to treat gingivitis, a gum disease that causes red, swollen, and easily bleeding gums.
Chlorhexidine belongs to a class of drugs known as antimicrobials.
Chlorhexidineworks by decreasing the amount of bacteria in the mouth, helping to reduce swelling and redness of the gums and bleeding when you brush.
Chlorhexidine is an antibacterial used for numerous applications.
Chlorhexidineis a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate.
Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system.
1. Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material.
2. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Chlorhexidineis used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry.
3. Hydrogenolysis of benzyl-nitrogen bonds.
4. Bacteriostatic;Detergent.
chlorhexidine is used as a topical antiseptic in liquid cosmetics.
Chlorhexidineis strongly alkaline and may cause irritation.
Chlorhexidine, the "gold standard" in oral antiseptics, has been used to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures.
Chlorhexidine, antibacterial agent, has been used in preparaing chlorhexidine-functionalized calcium phosphate nanoparticles, useful for oral hygiene and dental treatment.
Chlorhexidine is an important medical, dental and pharmaceutical antiseptic, disinfectant and preservative.
Chlorhexidineis bactericida and fungicidalsy but does not kill bacterial spores or mycobacteria, although it inhibits growth.
Chlorhexidinehas a low order of activity against viruses, but high concentrations are effective in killing cysts of Acanthamoeba spp., organisms of potential clinical significance to the wearers of contact lenses.
Properties Chlorhexidine is a bisbiguanide which is available as the acetate (diacetate), hydrochloride and gluconate salts. These are stable in solution and can be autoclaved although small amounts of chloroaniline are released.”
As a cationic agent, chlorhexidine is incompatible with anionic surfactants and its antimicrobial activity is reduced in the presence of non-ionic surface-active agents.
Activity is also reduced or abolished by phospholipids (a factor of significance in neutralizing chlorhexidine activity during the performance of biocidal tests) and by organic matter including serum.
Some of these aspects have been well documented in the recent comprehensive paper of Nicoletti et al.”
They also point out that the efficacy of chlorhexidine is influenced by formulation components and by the composition of the culture medium in which minimum inhibitory concentrations (MICs) are determined.
Production Methods
Chlorhexidine may be prepared either by condensation of polymethylene bisdicyandiamide with 4-chloroaniline hydrochloride or by condensation of 4-chlorophenyl dicyandiamine with hexamethylenediamine dihydrochloride.
Chlorhexidine may also be synthesized from a series of biguanides.
In endodontics, chlorhexidine is used for root canal irrigation and as an intracanal dressing, but has been replaced by the use of sodium hypochlorite bleach in much of the developed world.
Antiseptic
CHG is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts.
Chlorhexidineis particularly effective against Gram-positive bacteria (in concentrations ≥ 1 μg/l).
Significantly higher concentrations (10 to more than 73 μg/ml) are required for Gram-negative bacteria and fungi. Chlorhexidine is ineffective against polioviruses and adenoviruses.
The effectiveness against herpes viruses has not yet been established unequivocally.
There is strong evidence that chlorhexidine is more effective than povidone-iodine for clean surgery.
Evidence shows that it is the most effective antiseptic for upper limb surgery, and there is no data to suggest that alcoholic chlorhexidine increases the risk of tourniquet-related burns, ignition fires or allergic episodes during surgery.
Chlorhexidine, like other cation-active compounds, remains on the skin.
Chlorhexidineis frequently combined with alcohols (ethanol and isopropyl alcohol).
Dental use
Use of a CHG-based mouthwash in combination with normal tooth care can help reduce the build-up of plaque and improve mild gingivitis.
There is not enough evidence to determine the effect in moderate to severe gingivitis.
About 20 mL twice a day of concentrations of 0.1% to 0.2% is recommended for mouth-rinse solutions with a duration of at least 30 seconds.
Such mouthwash also has a number of adverse effects including damage to the mouth lining, tooth discoloration, tartar build-up, and impaired taste.
Extrinsic tooth staining occurs when chlorhexidine rinse has been used for 4 weeks or longer.
Mouthwashes containing chlorhexidine which stain teeth less than the classic solution have been developed, many of which contain chelated zinc.
Using chlorhexidine as a supplement to everyday mechanical oral hygiene procedures for 4 to 6 weeks and 6 months leads to a moderate reduction in gingivitis compared to placebo, control or mechanical oral hygiene alone.
Chlorhexidine is a cation which interacts with anionic components of toothpaste, such as sodium lauryl sulfate and sodium monofluorophosphate, and forms salts of low solubility and antibacterial activity.
Hence, to enhance the antiplaque effect of chlorhexidine, "it seems best that the interval between toothbrushing and rinsing with CHX [chlorhexidine] be more than 30 minutes, cautiously close to 2 hours after brushing".
Topical
Chlorhexidine gluconate is used as a skin cleanser for surgical scrubs, as a cleanser for skin wounds, for preoperative skin preparation, and for germicidal hand rinses.
Chlorhexidine eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Chlorhexidine is very effective for poor countries like Nepal and its use is growing in the world for treating the umbilical cord. A 2015 Cochrane review has yielded high-quality evidence that within the community setting, chlorhexidine skin or cord care can reduce the incidence of omphalitis (inflammation of the umbilical cord) by 50% and neonatal mortality by 12%.
Mechanism of action
At physiologic pH, chlorhexidine salts dissociate and release the positively charged chlorhexidine cation.
The bactericidal effect is a result of the binding of this cationic molecule to negatively charged bacterial cell walls.
At low concentrations of chlorhexidine, this results in a bacteriostatic effect; at high concentrations, membrane disruption results in cell death.
Chemistry
Chlorhexidineis a cationic polybiguanide (bisbiguanide).
Chlorhexidineis used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate).[citation needed]
Deactivation
Chlorhexidine is deactivated by forming insoluble salts with anionic compounds, including the anionic surfactants commonly used as detergents in toothpastes and mouthwashes, anionic thickeners such as carbomer, and anionic emulsifiers such as acrylates/C10-30 alkyl acrylate crosspolymer, among many others.
For this reason, chlorhexidine mouth rinses should be used at least 30 minutes after other dental products.
For best effectiveness, food, drink, smoking, and mouth rinses should be avoided for at least one hour after use.
Many topical skin products, cleansers, and hand sanitizers should also be avoided to prevent deactivation when chlorhexidine (as a topical by itself or as a residue from a cleanser) is meant to remain on the skin.
Chlorhexidine is an antiseptic and disinfectant.
Chlorhexidinehelps reduce the number of germs (bacteria) in your mouth or on your skin.
Chlorhexidine is usually combined with other ingredients. Some sore throat treatments have a local anaesthetic to help numb pain.
Mouth and throat treatments come as mouthwashes, lozenges, gels and sprays.
Skin treatments come as creams, ointments and lotions.
Many chlorhexidine treatments are available to buy in pharmacies, and some in shops and supermarkets.
For nose infections, there is a nasal cream that contains chlorhexidine and neomycin, an antibiotic. This medicine is available on prescription only and is known by the brand name Naseptin.
Chlorhexidine is also used in hospitals and clinics to clean skin or surgical equipment before surgery. Chlorhexidinecan be used in some bladder procedures, including cleaning catheters.
Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family.
Its mechanism of action involves destabilization of the outer bacterial membrane.
Chlorhexidineis effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. Chlorhexidinehas both bactericidal and bacteriostatic mechanisms of action.
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells.
After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable.
History
Chlorhexidine (CHX) was the first antimicrobial agent shown to inhibit dental plaque formation and the development of chronic gingivitis.
Chlorhexidine is a cationic chlorophenyl bisbiguanide antiseptic.
Bisbiguanides are the primary second generation antiplaque agents exhibiting considerable substantivity and broad spectrum antibacterial properties.
In dental medicine, CHX was initially used for disinfection of the oral cavity prior to oral surgical procedures and in endodontics.
Plaque inhibition by CHX was first investigated in 1969 but the first controlled clinical study was performed.
This study showed that rinsing for 60 sec, twice a day with 10 ml of a 0.2% (20 mg dose) CHX gluconate solution, in the absence of normal tooth cleaning, inhibited plaque regrowth and the development of gingivitis.
CHX is one of the most widely investigated and used antiplaque agents.
The advantage of CHX over other cationic agents is that it can bind strongly to many sites in the oral cavity and is released slowly over 7 to 12 hours after rinsing, thus providing considerable substantivity and a sustained antimicrobial effect restricting bacterial proliferation.
CHX binds strongly with anionic glycoproteins and phosphoproteins on the oral mucosa and tooth pellicle in addition to its property of binding to the surfaces of bacterial cell membranes affecting the cells ability to adhere.
CHX is considered the most potent chemotherapeutic agent currently available.
Indications
This topical antiseptic product acts rapidly but, like hexachlorophene, persists on the skin to give a cumulative, continuing antibacterial effect.
Like iodophors and alcohol, it is active against gram-positive and gram-negative bacteria, including P. aeruginosa, as well as common yeasts and fungi.
Chlorhexidinedoes not lose effectiveness in the presence of whole blood.
Many consider it the antiseptic of choice for skin cleansing and surgical scrubs. Contact allergy is not uncommon.
Chlorhexidine should not be used near the eyes or mucosal surfaces, because it may cause irritation or even anaphylaxis.
Manufacturing Process
25 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of beta-ethoxyethanol are stirred together at
130°C to 140°C for 2 hours under reflux.
The mixture is then cooled and filtered and the solid is washed with water and crystallized from 50% aqueous acetic acid. 1,6-di(N1,N1'-p-chlorophenyldiguanido-N5,N5')hexane dihydrochloride is obtained as colorless plates of MP 258°C to 260°C.
The following is an alternative route: 19.4 parts of pchlorophenyldicyandiamide, 9.4 parts of hexamethylene diaminedihydrochloride and 100 parts of nitrobenzene are stirred together and heated at 150 C to 160°C for 6 hours.
The mixture is cooled, diluted with 200 parts of benzene and filtered.
The solid residue is washed with benzene and crystallized from 50% acetic acid. 1,6-di(N1,N1'-p-chlorophenyldiguanidoN5,N5')hexane dihydrochloride is obtained.
Pharmaceutical Applications
Chlorhexidine salts are widely used in pharmaceutical formulations in Europe and Japan for their antimicrobial properties.
Although mainly used as disinfectants, chlorhexidine salts are also used as antimicrobial preservatives.
As excipients, chlorhexidine salts are mainly used for the preservation of eye-drops at a concentration of 0.01% w/v; generally the acetate or gluconate salt is used for this purpose.
Solutions containing 0.002–0.006% w/v chlorhexidine gluconate have also been used for the disinfection of hydrophilic contact lenses.
For skin disinfection, chlorhexidine has been formulated as a 0.5% w/v solution in 70% v/v ethanol and, in conjunction with detergents, as a 4% w/v surgical scrub.
Chlorhexidine salts may also be used in topical antiseptic creams, mouthwashes, dental gels, and in urology for catheter sterilization and bladder irrigation.
Chlorhexidine salts have additionally been used as constituents of medicated dressings, dusting powders, sprays, and creams.
Clinical Use
Chlorhexidine is a biguanide topical antiseptic and disinfectant with broad antimicrobial efficacy.
Chlorhexidineis increasingly being used as an aseptic but it is also gaining use as a biocidal ingredient in shampoos, conditioners, hair dyes, sunscreens, toothpastes, mouthwashes (Corsodyl), wet wipes (also for babies), eye creams, antiwrinkle creams, moisturizers, contact lens solutions, and instillation gels for urinary catheters.
Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity.
Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane.
Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death.
Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.
Chlorhexidinehas a role as an antiinfective agent and an antibacterial agent.
Chlorhexidineis a member of biguanides and a member of monochlorobenzenes.
Chlorhexidinederives from a biguanide.
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.
Chlorhexidineis one of the most common skin and mucous membrane antiseptic agents in use today.
The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain. Topical chlorhexidine for disinfection, as well as oral rinses for dental use, carries activity against a broad range of pathogens including bacteria, yeasts, and viruses.
Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s and was introduced to the US in the 1970s.
Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures.
Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodontal pockets and is indicated for the reduction of pocket depth in adult patients with periodontitis as an adjunct therapy to dental scaling and root planing procedures
Pharmacodynamics
Chlorhexidine is a broad-spectrum antimicrobial with demonstrated activity against both gram-positive and gram-negative bacteria, yeasts, and viruses.
Antimicrobial activity is dose-dependent - chlorhexidine is bacteriostatic at lower concentrations (0.02%-0.06%) and bactericidal at higher concentrations (>0.12%).
Pharmacokinetic studies of oral chlorhexidine rinses indicate that approximately 30% of the active ingredient is retained in the mouth following rinsing, which is subsequently slowly released into oral fluids.
This ability to adsorb to dentine, shared with tetracycline antibiotics such as doxycycline, is known as "substantivity" and is the result of chlorhexidine's positive charge - it is likely that this substantivity plays at least some role in chlorhexidine's antimicrobial activity, as its persistence on surfaces such as dentine prevent microbial colonization.
Dental chlorhexidine rinses may result in staining of oral surfaces, such as teeth.
This effect is not ubiquitous and appears to be more significant with extended therapy (i.e. up to 6 months) - nevertheless, patients for whom oral staining is unacceptable should use chlorhexidine rinse with caution and for the shortest effective interval.
Allergic reactions to chlorhexidine have been associated with the development of anaphylaxis.
Mechanism of action
Chlorhexidine’s broad-spectrum antimicrobial effects are due to its ability to disrupt microbial cell membranes.
The positively charged chlorhexidine molecule reacts with negatively charged phosphate groups on microbial cell surfaces - this reaction both destroys the integrity of the cell, allowing leakage of intracellular material, and allows chlorhexidine to enter the cell, causing precipitation of cytoplasmic components and ultimately cell death.
The specific means of cell death is dependent on the concentration of chlorhexidine - lower concentrations are bacteriostatic and result in leakage of intracellular substances such as potassium and phosphorous, whereas higher concentrations are bactericidal and cause cytoplasmic precipitation.
About Chlorhexidine
Helpful information
Chlorhexidine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.
Chlorhexidine is used at industrial sites and in manufacturing.
Consumer Uses
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which Chlorhexidine is most likely to be released to the environment.
Article service life
ECHA has no public registered data on the routes by which Chlorhexidine is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using Chlorhexidine. ECHA has no public registered data on the routes by which Chlorhexidine is most likely to be released to the environment.
Formulation or re-packing
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which Chlorhexidine is most likely to be released to the environment.
Uses at industrial sites
Chlorhexidine is used in the following products: pharmaceuticals.
Chlorhexidine has an industrial use resulting in manufacture of another substance (use of intermediates).
Chlorhexidine is used in the following areas: health services.
Release to the environment of Chlorhexidine can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates).
Manufacture
ECHA has no public registered data on the routes by which Chlorhexidine is most likely to be released to the environment.
IUPAC NAMES:
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
1,1'-Hexamethylenebis[5-(p-chlorophenyl)biguanide]
2,2'-hexane-1,6-diylbis(1-{amino[(4-chlorophenyl)amino]methylidene}guanidine)
CHLORHEXIDINE
Chlorhexidine
chlorhexidine
Chlorhexidine-base
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
N,N'"-BIS(4-CHLOROPHENYL)-3,12-DIIMINO-2,4,11,13-TETRAAZOTETRADECANEDIIMIDAMIDE
N-(4-chlorophenyl)-1-{N-[6-(N-{[N'-(4-chlorophenyl)carbamimidamido]methanimidoyl}amino)hexyl]carbamimidamido}methanimidamide
SYNONYMS:
1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguanid
1,6-bis(5-(p-chlorophenyl)biguandino)hexane
1,6-bis(p-chlorophenyldiguanido)hexane
1,6-di(4’-chlorophenyldiguanido)hexane
2,4,11,13-tetraazatetradecanediimidamide,n,n’’-bis(4-chlorophenyl)-3,12-diim
chlorhexidin
fimeil
hexadol
nolvasan
rotersept
soretol
sterilon
tubulicid
1,1'-HEXAMETHYLENEBIS[5-(4-CHLOROPHENYL)BIGUANIDE]
CHLORHEXIDINE BASE
CHLORHEXIDINE
LABOTEST-BB LT00440966
hexamethylenebis(5-(4-chlorophenyl)biguanide)
bis(5-(p-chlorophenyl)biguanidinio)hexane
n,n'-bis(4-chlorophenyl)-3,12-diimino-tetraazatetradecanediimidamide
5,5-bis(4-chlorophenyl)-1,1-hexamethylenedibiguanide
CHLORHEXIDINE, 99.5+%
CHLOROHEXIDINE
Chlorhexidine Factory in stock
2,4,11,13-Tetraazatetradecanediimidamide, N,N-bis(4-chlorophenyl)-3,12-diimino-
11HEXAMETHYLENEBIS5PARACHLOROPHENYLBIGUANIDE
chlorhexidine 55-56-1
Chlorhexidine (base and/or unspecified salts)
1,6-Bis[5-(p-chlorophenyl)biguanidino]hexane
1,6-Di(N-p-chlorophenylbiguanidino)hexane
Bis(p-chlorophenyldiguanido)hexane
MPB Chlorhexidine
Chlorhexidine (free base)
Chlorhexidine,1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]
Chlorhexidine (200 mg)
Chlorohexidine base
2,4,11,13-TetraazatetradecanediiMidaMide,N1,N14-bis(4-chlorophenyl)-3,12-diiMino-
1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Bis(5-(p-chlorophenyl)biguanidinio)hexane
Chlorohexidine for synthesis
1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO) HEXANE
Chlorhexidine Standard
Chlorhexidine CRS
Chlorhexidinum
orhexidine
chlorhexidine base fandachem
Chlorhexidine fandachem
Rotersept fandachem
Chlorhexidine Basic information
Chlorhexidine USP/EP/BP
API Chlorhexidine
chlorhexidine
55-56-1
Rotersept
Fimeil
Hexadol
Soretol
Chlorhexidin
Chlorhexidinum
Cloresidina [DCIT]
Chlorhexidin [Czech]
Chlorhexidinum [INN-Latin]
Clorhexidina [INN-Spanish]
56-95-1
Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-
CAS-55-56-1
Sterido
Savlon babycare
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
DSSTox_CID_13314
DSSTox_RID_79062
N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
DSSTox_GSID_33314
Chlorhexidine [INN:BAN]
Chlorhexidine dihydrochloride
Merfen-incolore
MLS001304094
1-(4-chlorophenyl)-3-[N-[6-[[N-[N-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]guanidine
N-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamide
CCRIS 9230
Chlorhexidine (INN)
C22H30Cl2N10
HSDB 7196
Merfen-incolore (TN)
SR-01000799135
Nolvasan (*Diacetate*)
1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
1,1'-hexamethylenebis[5-(p-chlorophenyl)biguanide]
SMR000718621
EINECS 200-238-7
Lisium (*Dihydrochloride*)
BRN 2826432
1,6-Di(N-p-chlorophenyldiguanido)hexane
Chlorhexadine
Dentisept
Dentisept [veterinary] (TN)
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
Prestwick_53
Chlorhexidine (1)
Hibidil (Salt/Mix)
Hibisol (Salt/Mix)
Chlorhexidine diacetate salt hydrate
Hibitane (Salt/Mix)
Hibiscrub (Salt/Mix)
Hibispray (Salt/Mix)
Hexamethylenebis(5-(4-chlorophenyl)biguanide)
EC 200-238-7
SCHEMBL3984
Chlorhexidine, >=99.5%
4-12-00-01201 (Beilstein Handbook Reference)
2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(4-chlorophenyl)-3,12-diimino-
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine
2,4,11,13-Tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-
N,N''''-hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)]
N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradeca- nediimidamide
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylene]amino]methylene]amino]hexyl]-1-[amino-(4-chloroanilino)methylene]guanidine
AS-12648
Chlorhexidine, purum, >=99.0% (HPLC)
1,1''-Hexamethylene bis(5-(p-chlorophenyl)biguanide)
BRD-K52256627-300-03-3
BRD-K52256627-300-05-8
SR-01000799135-10
SR-01000799135-11
Chlorhexidine, European Pharmacopoeia (EP) Reference Standard
1,1'-(Hexane-1,6-diyl)bis[5-(4-chlorophenyl)biguanide] diacetate
Chlorhexidine, United States Pharmacopeia (USP) Reference Standard
Chlorhexidine, Pharmaceutical Secondary Standard; Certified Reference Material
N'',N''''''''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylene]amino]methylene]amino]hexyl]-1-[amino-(4-chloroanilino)methylene]guanidine;hydrochloride
(1E)-2-[6-[[azanyl-[(E)-[azanyl-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]-1-[azanyl-[(4-chlorophenyl)amino]methylidene]guanidine
(1E)-2-[6-[[azanyl-[(E)-[azanyl-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]-1-[azanyl-[(4-chlorophenyl)amino]methylidene]guanidine;hydrochloride
2-[amino-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexylimino]methyl]-1-(4-chlorophenyl)guanidine
