CLIMBAZOLE

Climbazole is an imidazole-derived antifungal active widely used in anti-dandruff and scalp-care formulations to control Malassezia-related dandruff and reduce scalp flaking and irritation.
Climbazole is commonly used in shampoos, conditioners, leave-on tonics, and scalp treatments where targeted antifungal performance supports long-lasting dandruff control and improved scalp comfort.
Climbazole is valued for strong activity at low use levels, good compatibility with many surfactant systems, and effective performance in rinse-off and leave-on cosmetic formulations when properly solubilized.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol

Synonyms: Climbazole, 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, Climbazol (variant spelling), Climbazole Antifungal, Climbazole Anti-Dandruff Active, Imidazole Antimycotic Climbazole, Climbazole Cosmetic Active, Climbazole Scalp Care Ingredient, Climbazole Shampoo Active, Anti-Dandruff Agent Climbazole, Climbazole Fungicide (cosmetic use), Climbazole Dandruff Control Agent, Climbazole, CLIMBAZOLE, Climbazol, Climbazole Antifungal, Climbazole Anti-dandruff Agent, Climbazole Antidandruff, Climbazole Anti-seborrheic Agent, Climbazole Antimycotic, Climbazole Antifungal Active, Climbazole Dandruff Control Agent, Climbazole Scalp Treatment Active, Climbazole Shampoo Active, Climbazole Cosmetic Active, Climbazole Personal Care Active, 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, Imidazole Antifungal (Climbazole), Imidazole Derivative (Climbazole), Chlorophenoxy Imidazole (Climbazole), Climbazole (CAS 38083-17-9), CAS 38083-17-9, Climbazole (C15H17ClN2O2), C15H17ClN2O2, Climbazole 98%, Climbazole 99%, Climbazole High Purity, Climbazole Technical Grade, Climbazole Cosmetic Grade, Climbazole Pharmaceutical Grade, Climbazole Reagent Grade, Climbazole Raw Material, Climbazole Active Ingredient, Climbazole API (common wording), Climbazole Powder, Climbazole Crystalline Powder, Climbazole Micronized, Climbazole Fine Powder, Climbazole Solubilized (formulation), Climbazole in DPG (formulation), Climbazole in Alcohol (formulation), Climbazole Solution, Climbazole Concentrate, Climbazole Antidandruff Active Ingredient, Climbazole Anti-yeast Agent, Climbazole Anti-Malassezia Agent, Climbazole Seborrheic Dermatitis Active, Climbazole Scalp Antifungal, Climbazole Hair Care Active, Climbazole Leave-on Active, Climbazole Rinse-off Active, Climbazole Preservative Booster (common use claim), Climbazole Fungistatic Agent, Climbazole Antifungal Compound, Climbazole Hair & Scalp Antifungal, Climbazole INCI Name, Climbazole (EU cosmetic active), Climbazole (antifungal imidazole), Climbazole (chlorinated imidazole), 4-Chlorophenoxy Imidazole Ketone (descriptive), Climbazole Ketone (descriptive), Climbazole Standard, Climbazole Reference Standard, Climbazole Analytical Standard, Climbazole QC Standard, Climbazole Bulk, Climbazole Ingredient, Climbazole Dandruff Ingredient, Climbazole Scalp Care Ingredient, Climbazole Hair Shampoo Ingredient, Climbazole Anti-dandruff Powder, Climbazole Antifungal Powder

APPLICATIONS

Climbazole is used in anti-dandruff shampoos to reduce scalp flaking by controlling Malassezia growth.
Climbazole is incorporated into daily-use shampoos to provide ongoing dandruff prevention with gentle cleansing systems.
Climbazole is used in clarifying anti-dandruff shampoos to support rapid reduction of visible flakes.

Climbazole is used in anti-dandruff conditioners to provide scalp benefits while improving hair softness and manageability.
Climbazole is incorporated into conditioning shampoos to combine dandruff control with improved hair feel.
Climbazole is used in 2-in-1 shampoo and conditioner products where simplified routines are desired.

Climbazole is used in scalp tonics and leave-on treatments to extend antifungal activity between washes.
Climbazole is incorporated into scalp serums to support long-lasting dandruff control and reduce itching sensation.
Climbazole is used in scalp sprays to deliver targeted coverage to problem areas with minimal residue.

Climbazole is used in hair masks designed for scalp care to reduce flakes while providing deep conditioning.
Climbazole is incorporated into rinse-off scalp packs to provide intensive dandruff control during weekly routines.
Climbazole is used in anti-dandruff treatment kits that combine shampoo, conditioner, and leave-on scalp products.

Climbazole is used in sulfate-free anti-dandruff shampoos where solubilization systems are optimized for performance.
Climbazole is incorporated into mild surfactant blends to reduce irritation while maintaining antifungal efficacy.
Climbazole is used in sensitive scalp products designed to reduce redness and discomfort associated with dandruff.

Climbazole is used in men’s grooming shampoos to combine dandruff control with fresh sensory and fragrance profiles.
Climbazole is incorporated into salon and professional anti-dandruff products for enhanced performance.
Climbazole is used in travel-size anti-dandruff products to maintain scalp control during routine disruption.

Climbazole is used in anti-dandruff body washes for areas prone to yeast-related odor or flaking in compatible cosmetic concepts.
Climbazole is incorporated into cleansing bars and syndet products when antifungal scalp or skin benefits are desired.
Climbazole is used in multifunctional cleansers that target both scalp dandruff and general skin cleanliness.

Climbazole is used in formulations with anti-itch claims where controlling fungal load helps reduce itch triggers.
Climbazole is incorporated into scalp cooling and soothing products to improve comfort during flare-ups.
Climbazole is used in products designed to reduce recurrence by maintaining balanced scalp microbiome conditions.

Climbazole is used in cosmetic formulations that pair antifungal action with keratolytic or conditioning ingredients for better flake removal.
Climbazole is incorporated into zinc-based or piroctone-based systems when multi-active dandruff strategies are employed.
Climbazole is used in anti-dandruff systems where careful compatibility design supports clarity, stability, and efficacy.

Climbazole is used in clear shampoo formulations when proper solubilizers are selected to keep Climbazole fully dissolved.
Climbazole is incorporated into pearlescent shampoos where uniform distribution supports consistent dosing.
Climbazole is used in low-viscosity scalp liquids where stability and crystal control are important.

Climbazole is used in product development studies to compare antifungal efficacy against common dandruff-associated yeasts.
Climbazole is incorporated into stability screening programs to ensure no crystallization occurs over shelf life.
Climbazole is valued in anti-dandruff formulations because Climbazole provides strong efficacy at low dosage with good cosmetic performance.

Climbazole is used as an anti-dandruff active in rinse-off hair care products.
Climbazole helps control Malassezia-related scalp flaking in dandruff management concepts.
Climbazole supports clearer-looking scalp appearance with regular use.

Climbazole is used in anti-dandruff shampoos to reduce visible flakes and itch perception.
Climbazole supports scalp comfort by helping manage microbial imbalance on the scalp.
Climbazole helps maintain a cleaner scalp feel between washes.

Climbazole is used in daily-use dandruff shampoos where mild but effective antifungal action is desired.
Climbazole supports frequent washing regimens without overly harsh sensory impact.
Climbazole helps sustain anti-flake performance in gentle surfactant bases.

Climbazole is used in intensive anti-dandruff shampoos for stronger performance positioning.
Climbazole supports short-contact treatment routines under rinse-off conditions.
Climbazole helps reduce recurrence of dandruff when used in a structured regimen.

Climbazole is used in scalp tonics and leave-on scalp lotions in regions where leave-on use is permitted.
Climbazole supports targeted application to problem areas on the scalp.
Climbazole helps extend time-on-scalp for improved efficacy in suitable formats.

Climbazole is used in anti-dandruff hair masks to provide conditioning plus scalp care.
Climbazole supports dual-benefit products combining anti-flake action with softness.
Climbazole helps maintain scalp comfort while improving hair manageability.

Climbazole is used in conditioner systems designed to support dandruff-prone scalps.
Climbazole supports gentle maintenance products used between shampoo treatments.
Climbazole helps reduce flake visibility while preserving hair softness.

Climbazole is used in 2-in-1 shampoo and conditioner products to simplify dandruff routines.
Climbazole supports combined cleansing and conditioning with anti-dandruff benefit.
Climbazole helps maintain scalp clarity without separate treatment steps.

Climbazole is used in scalp exfoliating shampoos combined with keratolytic agents.
Climbazole supports improved efficacy by addressing microbial and flake components together.
Climbazole helps maintain balance when exfoliating ingredients are present.

Climbazole is used in formulations with salicylic acid to improve dandruff control performance.
Climbazole supports antifungal action while salicylic acid supports flake removal.
Climbazole helps create synergistic anti-dandruff systems in rinse-off products.

Climbazole is used in sensitive-scalp dandruff products where low irritation perception is important.
Climbazole supports efficacy at relatively low use levels depending on regulations.
Climbazole helps achieve anti-dandruff benefit with gentle sensory design.

Climbazole is used in scalp care lines aimed at reducing itch and discomfort associated with dandruff.
Climbazole supports reduction of visible flakes that can aggravate itch perception.
Climbazole helps improve scalp comfort as part of a complete routine.

Climbazole is used in men’s anti-dandruff shampoos with fresh, clean sensory profiles.
Climbazole supports performance claims targeted to male consumers.
Climbazole helps maintain scalp clarity in frequent-use grooming products.

Climbazole is used in professional salon anti-dandruff treatments in rinse-off formats.
Climbazole supports add-on scalp services designed to reduce flaking.
Climbazole helps provide noticeable results when combined with proper application technique.

Climbazole is used in travel-size and convenience anti-dandruff products for consistent regimen adherence.
Climbazole supports portable routines for dandruff control.
Climbazole helps maintain results during travel and seasonal changes.

Climbazole is used in anti-dandruff shampoos for colored hair where compatibility is required.
Climbazole supports scalp care while maintaining cosmetic performance on dyed hair.
Climbazole helps reduce flakes without sacrificing shine and feel.

Climbazole is used in anti-dandruff shampoos for curly and textured hair types.
Climbazole supports scalp clarity while formulas are tailored for moisture and slip.
Climbazole helps manage flakes without increasing dryness perception.

Climbazole is used in anti-dandruff products positioned for oily scalp conditions.
Climbazole supports microbial control associated with oily dandruff presentations.
Climbazole helps improve scalp freshness and reduce greasy feel between washes.

Climbazole is used in anti-dandruff products positioned for dry scalp flaking.
Climbazole supports reduction of Malassezia-associated flakes while moisturizers improve comfort.
Climbazole helps balance scalp condition when dryness contributes to discomfort.

Climbazole is used in scalp care systems combined with zinc PCA or niacinamide concepts.
Climbazole supports scalp balance claims by addressing microbial contributors.
Climbazole helps complement barrier-support and sebum-management actives.

Climbazole is used in anti-dandruff formulations with piroctone olamine in multi-active concepts.
Climbazole supports broader antifungal coverage and improved performance claims.
Climbazole helps deliver stronger anti-flake benefit when actives are compatible and permitted.

Climbazole is used in anti-dandruff shampoo prototypes to reduce visible flaking in consumer testing.
Climbazole supports claim substantiation studies when paired with clinical grading.
Climbazole helps generate measurable improvements in flake scores in controlled trials.

Climbazole is used in stability and compatibility testing for anti-dandruff actives in surfactant systems.
Climbazole supports evaluation of solubility across pH and salt levels.
Climbazole helps optimize formulation robustness and shelf stability.

Climbazole is used in formulation work to improve clarity or controlled opacity in shampoos.
Climbazole supports transparent or pearly shampoo concepts depending on solubilization approach.
Climbazole helps maintain aesthetic targets alongside efficacy.

Climbazole is used in anti-dandruff shampoos requiring strong preservative and microbial robustness design.
Climbazole supports products that must remain stable under humid bathroom storage.
Climbazole helps maintain consistent performance over shelf life when properly formulated.

Climbazole is used in surfactant systems with amphoterics and mild anionics for balanced cleansing.
Climbazole supports anti-dandruff performance without overly stripping the scalp.
Climbazole helps maintain foam quality and sensory feel in mild bases.

Climbazole is used in sulfate-free anti-dandruff shampoos to support modern mild-cleanse positioning.
Climbazole supports efficacy in alternative surfactant systems when solubility is addressed.
Climbazole helps deliver anti-flake benefits in silicone-free or minimalist concepts.

Climbazole is used in anti-dandruff dry shampoo concepts in limited research and prototype work.
Climbazole supports exploration of leave-on scalp freshness systems where allowed.
Climbazole helps evaluate feasibility of antifungal benefit in low-water formats.

Climbazole is used in scalp sprays and mists for targeted application in permitted markets.
Climbazole supports convenient leave-on delivery aimed at stubborn areas.
Climbazole helps maintain scalp control between wash days.

Climbazole is used in anti-dandruff cleansers for beard and facial hair in specialized grooming.
Climbazole supports flake control in beard dandruff concepts.
Climbazole helps improve skin comfort beneath facial hair.

Climbazole is used in medicated-style scalp care products under cosmetic or quasi-drug frameworks depending on region.
Climbazole supports compliant product design aligned with local regulations.
Climbazole helps deliver antifungal activity in consumer-friendly formats.

Climbazole is used in clinical research comparing different anti-dandruff actives.
Climbazole supports benchmark studies against ketoconazole, zinc pyrithione alternatives, and other agents.
Climbazole helps evaluate relative efficacy and tolerability in scalp models.

Climbazole is used in in vitro antifungal assays against Malassezia species.
Climbazole supports screening and MIC determination in laboratory settings.
Climbazole helps characterize antifungal potency under standardized conditions.

Climbazole is used in formulation R&D to minimize recrystallization and maintain active availability.
Climbazole supports solubilization strategies using glycols and solubilizers.
Climbazole helps maintain consistent dosing and performance throughout shelf life.

Climbazole is used in products designed for seasonal dandruff flare-ups.
Climbazole supports short-term regimens during winter dryness or stress-related flaking.
Climbazole helps maintain scalp clarity through climate changes.

Climbazole is used in anti-dandruff routines combined with scalp massage tools and structured usage guidance.
Climbazole supports behavior-driven regimens that improve contact time and coverage.
Climbazole helps maximize perceived results when users follow proper application.

Climbazole is used in anti-dandruff products targeting adolescents with visible flaking concerns.
Climbazole supports gentle, cosmetically acceptable products for younger users.
Climbazole helps improve confidence by reducing visible flakes on hair and clothing.

Climbazole is used in anti-dandruff products for older consumers with recurring scalp issues.
Climbazole supports maintenance routines that keep flaking under control.
Climbazole helps provide consistent scalp comfort with regular use.

Climbazole is used in product development to create low-odor anti-dandruff solutions with good user acceptance.
Climbazole supports consumer-friendly sensory design compared with some medicinal actives.
Climbazole helps maintain pleasant fragrance profiles when properly solubilized.

Climbazole is used in shampoo concentrates and refills where solubility and stability must remain strong.
Climbazole supports robust performance in high-active or high-surfactant concentrates.
Climbazole helps ensure consistent dosing after dilution during consumer use.

Climbazole is used in anti-dandruff products intended for humid climates where Malassezia growth can be more pronounced.
Climbazole supports scalp control under high-humidity conditions.
Climbazole helps reduce recurrence of flaking in challenging environments.

Climbazole is used in anti-dandruff products designed to pair with hair styling products that can build up on scalp.
Climbazole supports scalp cleansing and microbial control in style-heavy routines.
Climbazole helps counteract scalp imbalance linked to occlusive product buildup.

Climbazole is used in routine quality control to assay active content in finished shampoos.
Climbazole supports batch release testing and stability monitoring.
Climbazole helps ensure label compliance and consistent consumer performance.

Climbazole is used in regulatory-compliant anti-dandruff cosmetics where zinc pyrithione is restricted or unavailable.
Climbazole supports reformulation strategies to maintain efficacy under changing regulatory landscapes.
Climbazole helps brands keep anti-dandruff claims with alternative active systems.

Climbazole is used in new product innovation for scalp microbiome-friendly positioning.
Climbazole supports controlled antifungal activity while avoiding overly aggressive cleansing.
Climbazole helps balance performance with mildness in modern scalp care.

Climbazole is used in combination with conditioning polymers to maintain hair feel in medicated-style shampoos.
Climbazole supports formulas that reduce flaking without compromising softness.
Climbazole helps achieve salon-like sensory performance in treatment shampoos.

Climbazole is used in anti-dandruff products that aim for improved foam quality and rinse profile.
Climbazole supports stable foaming systems while delivering antifungal benefit.
Climbazole helps reduce residue perception through good rinseability design.

Climbazole is used in scalp care education materials to guide proper anti-dandruff product use.
Climbazole supports instructions emphasizing contact time and consistent regimen.
Climbazole helps improve outcomes by reducing under-dosing and irregular use.

Climbazole is used in laboratory work to study antifungal mechanisms related to sterol biosynthesis inhibition.
Climbazole supports research on azole-like activity in fungal models.
Climbazole helps explore structure–activity relationships for antifungal agents.

DESCRIPTION

Climbazole is typically a white to off-white crystalline powder with low odor.
Climbazole is an imidazole antifungal active that interferes with fungal membrane function, reducing growth of dandruff-associated yeasts.
Climbazole is poorly soluble in water and typically requires solubilizers, solvents, or surfactant micelles to achieve stable, effective delivery in aqueous products.

Climbazole is commonly used in rinse-off hair care, and Climbazole can also be used in leave-on scalp products when formulation and regulatory requirements are met.
Climbazole performance depends on dose, contact time, scalp condition, and how effectively Climbazole is solubilized and distributed in the product.
Climbazole can crystallize if not properly solubilized, so temperature cycling and long-term stability testing are important during development.

Climbazole should be handled to minimize dust exposure and should be stored in tightly closed containers to maintain quality.
Climbazole should be protected from excessive heat, moisture, and direct sunlight to preserve stability.
Climbazole is typically used within regulated cosmetic limits and according to local ingredient and labeling requirements.

Climbazole is an imidazole-based antifungal agent commonly used in anti-dandruff cosmetic products.
Climbazole is typically supplied as a white to off-white crystalline powder.
Climbazole has low water solubility and is usually solubilized using glycols or suitable solvents.

Climbazole is designed to inhibit the growth of Malassezia yeasts associated with dandruff.
Climbazole supports reduction of flaking by addressing microbial contributors on the scalp.
Climbazole activity depends on concentration, contact time, and formulation availability.

Climbazole is commonly used in rinse-off products such as shampoos and scalp washes.
Climbazole can also be used in leave-on formats only where permitted by local regulations.
Climbazole performance is influenced by pH, surfactant system, and solubilization strategy.

Climbazole can recrystallize if not properly solubilized, which may reduce efficacy and affect appearance.
Climbazole formulation work typically includes solvent selection and stability testing to prevent precipitation.
Climbazole is often paired with conditioning agents to maintain hair feel in treatment products.

Climbazole is generally used at low levels, so accurate dosing and uniform distribution are important.
Climbazole should be incorporated with appropriate mixing and temperature control to ensure full dissolution.
Climbazole finished-product testing commonly includes active assay and stability under temperature cycling.

Climbazole can cause irritation in some individuals depending on concentration and personal sensitivity.
Climbazole products should avoid eye contact and be rinsed thoroughly when used in shampoos.
Climbazole safety and allowable use levels depend on regional cosmetic regulations.

PROPERTIES

Chemical Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol
Common Name: Climbazole
Chemical Type: Imidazole antifungal (cosmetic active)
Appearance: White to off-white crystalline powder
Odor: Slight characteristic odor
Solubility: Low in water; soluble in many organic solvents and solubilizer systems (formulation dependent)
Melting Point: ~94–96°C (typical)
LogP: Moderate to high lipophilicity (typical; supports oil-phase and micellar solubilization)
Stability: Stable under normal storage; avoid prolonged exposure to heat and strong oxidizers
pH Compatibility: Typically used in mildly acidic to near-neutral cosmetic pH ranges (formulation dependent)
Flash Point: Not applicable for solid active; solvent systems vary
Storage Temperature: 15–25°C, dry, tightly closed, protected from light
Shelf Life: Typically 24 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if coughing or respiratory irritation persists.
Avoid breathing dust during handling and weighing.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Do not induce vomiting unless directed by medical personnel.
Seek medical attention if a large amount is swallowed or discomfort occurs.

Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care based on exposure route and symptoms.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses.
Avoid generating dust during weighing and charging.
Wash hands after handling and before eating, drinking, or smoking.

Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Maintain good airflow during charging and mixing operations.
Minimize airborne particulate accumulation in enclosed areas.

Storage:
Store in a cool, dry place in tightly closed containers.
Protect from moisture, excessive heat, and direct sunlight.
Keep containers properly labeled and secured to prevent contamination.

Spill and Leak Procedures:
Avoid dust generation and collect spilled powder using methods that minimize airborne particles.
Place collected material into suitable containers for disposal according to local regulations.
Clean the area with wet wiping or vacuum systems designed for fine powders.

Handling Precautions:
Use clean, dedicated equipment to prevent cross-contamination in cosmetic production.
Ensure proper solubilization strategy during formulation to prevent crystallization during storage.
Rotate stock using FIFO practices to maintain consistent quality and performance.