CLIMBAZOLE

Climbazole is an imidazole-derived antifungal active widely used in anti-dandruff and scalp-care formulations to control Malassezia-associated dandruff and reduce scalp flaking, itching, and irritation.
Climbazole is commonly used in shampoos, conditioners, leave-on tonics, and scalp treatments where targeted antifungal performance supports long-lasting dandruff control and improved scalp comfort.
Climbazole is valued for strong activity at low use levels, good compatibility with many surfactant systems, and effective performance in rinse-off and leave-on cosmetic formulations when properly solubilized.

CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol

Synonyms: Climbazole, 1-(4-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, Climbazol (variant spelling), Climbazole Antifungal, Climbazole Anti-Dandruff Active, Imidazole Antimycotic Climbazole, Climbazole Cosmetic Active, Climbazole Scalp Care Active, Climbazole CAS 38083-17-9, Climbazole Anti-Flaking Agent, Climbazole Dandruff Control Active, Climbazole Imidazole Antifungal, Climbazole 98%, Climbazole 99%, Climbazole Assay 98%, Climbazole Assay 99%, Climbazole USP grade (labeling variant), Climbazole EP grade (labeling variant), Climbazole BP grade (labeling variant), Climbazole Cosmetic Grade, Climbazole Personal Care Grade, Climbazole Pharmaceutical Grade, Climbazole Technical Grade, Climbazole Industrial Grade, Climbazole Micronized, Micronized Climbazole, Climbazole Fine Powder, Climbazole Crystalline Powder, Climbazole Raw Material, Climbazole Active, Climbazole Active Substance, Climbazole Active Ingredient, Climbazole Antifungal Agent, Climbazole Antifungal API (labeling variant), Climbazole Anti-Dandruff Active, Anti-Dandruff Active (Climbazole), Climbazole Scalp Antifungal Active, Climbazole Anti-Malassezia Active, Climbazole Anti-Yeast Agent, Climbazole Anti-Fungal Compound, Climbazole Imidazole Antimycotic, Imidazole Antimycotic (Climbazole), Imidazole-Derived Antifungal (Climbazole), Chlorophenoxy Imidazole (Climbazole), 4-Chlorophenoxy Imidazole Ketone (Climbazole), Climbazole Imidazolyl Ketone (descriptive), 1-(4-Chlorophenoxy)-1H-imidazol-1-yl-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, 1-(4-Chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)butan-2-one, 4-Chlorophenoxy Imidazole Butanone (descriptive), Climbazole Standard, Climbazole Reference Standard, Climbazole Analytical Standard, Climbazole QC Standard, Climbazole Reagent Grade, Climbazole for Analysis, Climbazole for Synthesis, Climbazole Bulk Powder, Climbazole Concentrate (formulation), Climbazole Solution (formulation), Climbazole in DPG, Climbazole in Propylene Glycol (variant), Climbazole in Dipropylene Glycol (variant), Climbazole in Ethanol (variant), Climbazole Solubilized (formulation), Solubilized Climbazole, Climbazole Scalp-Care Ingredient, Climbazole Hair-Care Ingredient, Climbazole Dandruff Control Ingredient

APPLICATIONS

Climbazole is used as an anti-dandruff active in rinse-off hair care products.
Climbazole helps control Malassezia-related scalp flaking in dandruff management concepts.
Climbazole supports clearer-looking scalp appearance with regular use.

Climbazole is used in anti-dandruff shampoos to reduce visible flakes and itch perception.
Climbazole supports scalp comfort by helping manage microbial imbalance on the scalp.
Climbazole helps maintain a cleaner scalp feel between washes.

Climbazole is used in daily-use dandruff shampoos where mild but effective antifungal action is desired.
Climbazole supports frequent washing regimens without overly harsh sensory impact.
Climbazole helps sustain anti-flake performance in gentle surfactant bases.

Climbazole is used in intensive anti-dandruff shampoos for stronger performance positioning.
Climbazole supports short-contact treatment routines under rinse-off conditions.
Climbazole helps reduce recurrence of dandruff when used in a structured regimen.

Climbazole is used in scalp tonics and leave-on scalp lotions in regions where leave-on use is permitted.
Climbazole supports targeted application to problem areas on the scalp.
Climbazole helps extend time-on-scalp for improved efficacy in suitable formats.

Climbazole is used in anti-dandruff hair masks to provide conditioning plus scalp care.
Climbazole supports dual-benefit products combining anti-flake action with softness.
Climbazole helps maintain scalp comfort while improving hair manageability.

Climbazole is used in conditioner systems designed to support dandruff-prone scalps.
Climbazole supports gentle maintenance products used between shampoo treatments.
Climbazole helps reduce flake visibility while preserving hair softness.

Climbazole is used in 2-in-1 shampoo and conditioner products to simplify dandruff routines.
Climbazole supports combined cleansing and conditioning with anti-dandruff benefit.
Climbazole helps maintain scalp clarity without separate treatment steps.

Climbazole is used in scalp exfoliating shampoos combined with keratolytic agents.
Climbazole supports improved efficacy by addressing microbial and flake components together.
Climbazole helps maintain balance when exfoliating ingredients are present.

Climbazole is used in formulations with salicylic acid to improve dandruff control performance.
Climbazole supports antifungal action while salicylic acid supports flake removal.
Climbazole helps create synergistic anti-dandruff systems in rinse-off products.

Climbazole is used in sensitive-scalp dandruff products where low irritation perception is important.
Climbazole supports efficacy at relatively low use levels depending on regulations.
Climbazole helps achieve anti-dandruff benefit with gentle sensory design.

Climbazole is used in scalp care lines aimed at reducing itch and discomfort associated with dandruff.
Climbazole supports reduction of visible flakes that can aggravate itch perception.
Climbazole helps improve scalp comfort as part of a complete routine.

Climbazole is used in men’s anti-dandruff shampoos with fresh, clean sensory profiles.
Climbazole supports performance claims targeted to male consumers.
Climbazole helps maintain scalp clarity in frequent-use grooming products.

Climbazole is used in professional salon anti-dandruff treatments in rinse-off formats.
Climbazole supports add-on scalp services designed to reduce flaking.
Climbazole helps provide noticeable results when combined with proper application technique.

Climbazole is used in travel-size and convenience anti-dandruff products for consistent regimen adherence.
Climbazole supports portable routines for dandruff control.
Climbazole helps maintain results during travel and seasonal changes.

Climbazole is used in anti-dandruff shampoos for colored hair where compatibility is required.
Climbazole supports scalp care while maintaining cosmetic performance on dyed hair.
Climbazole helps reduce flakes without sacrificing shine and feel.

Climbazole is used in anti-dandruff shampoos for curly and textured hair types.
Climbazole supports scalp clarity while formulas are tailored for moisture and slip.
Climbazole helps manage flakes without increasing dryness perception.

Climbazole is used in anti-dandruff products positioned for oily scalp conditions.
Climbazole supports microbial control associated with oily dandruff presentations.
Climbazole helps improve scalp freshness and reduce greasy feel between washes.

Climbazole is used in anti-dandruff products positioned for dry scalp flaking.
Climbazole supports reduction of Malassezia-associated flakes while moisturizers improve comfort.
Climbazole helps balance scalp condition when dryness contributes to discomfort.

Climbazole is used in scalp care systems combined with zinc PCA or niacinamide concepts.
Climbazole supports scalp balance claims by addressing microbial contributors.
Climbazole helps complement barrier-support and sebum-management actives.

Climbazole is used in anti-dandruff formulations with piroctone olamine in multi-active concepts.
Climbazole supports broader antifungal coverage and improved performance claims.
Climbazole helps deliver stronger anti-flake benefit when actives are compatible and permitted.

Climbazole is used in anti-dandruff shampoo prototypes to reduce visible flaking in consumer testing.
Climbazole supports claim substantiation studies when paired with clinical grading.
Climbazole helps generate measurable improvements in flake scores in controlled trials.

Climbazole is used in stability and compatibility testing for anti-dandruff actives in surfactant systems.
Climbazole supports evaluation of solubility across pH and salt levels.
Climbazole helps optimize formulation robustness and shelf stability.

Climbazole is used in formulation work to improve clarity or controlled opacity in shampoos.
Climbazole supports transparent or pearly shampoo concepts depending on solubilization approach.
Climbazole helps maintain aesthetic targets alongside efficacy.

Climbazole is used in anti-dandruff shampoos requiring strong preservative and microbial robustness design.
Climbazole supports products that must remain stable under humid bathroom storage.
Climbazole helps maintain consistent performance over shelf life when properly formulated.

Climbazole is used in surfactant systems with amphoterics and mild anionics for balanced cleansing.
Climbazole supports anti-dandruff performance without overly stripping the scalp.
Climbazole helps maintain foam quality and sensory feel in mild bases.

Climbazole is used in sulfate-free anti-dandruff shampoos to support modern mild-cleanse positioning.
Climbazole supports efficacy in alternative surfactant systems when solubility is addressed.
Climbazole helps deliver anti-flake benefits in silicone-free or minimalist concepts.

Climbazole is used in anti-dandruff dry shampoo concepts in limited research and prototype work.
Climbazole supports exploration of leave-on scalp freshness systems where allowed.
Climbazole helps evaluate feasibility of antifungal benefit in low-water formats.

Climbazole is used in scalp sprays and mists for targeted application in permitted markets.
Climbazole supports convenient leave-on delivery aimed at stubborn areas.
Climbazole helps maintain scalp control between wash days.

Climbazole is used in anti-dandruff cleansers for beard and facial hair in specialized grooming.
Climbazole supports flake control in beard dandruff concepts.
Climbazole helps improve skin comfort beneath facial hair.

Climbazole is used in medicated-style scalp care products under cosmetic or quasi-drug frameworks depending on region.
Climbazole supports compliant product design aligned with local regulations.
Climbazole helps deliver antifungal activity in consumer-friendly formats.

Climbazole is used in clinical research comparing different anti-dandruff actives.
Climbazole supports benchmark studies against ketoconazole, zinc pyrithione alternatives, and other agents.
Climbazole helps evaluate relative efficacy and tolerability in scalp models.

Climbazole is used in in vitro antifungal assays against Malassezia species.
Climbazole supports screening and MIC determination in laboratory settings.
Climbazole helps characterize antifungal potency under standardized conditions.

Climbazole is used in formulation R&D to minimize recrystallization and maintain active availability.
Climbazole supports solubilization strategies using glycols and solubilizers.
Climbazole helps maintain consistent dosing and performance throughout shelf life.

Climbazole is used in products designed for seasonal dandruff flare-ups.
Climbazole supports short-term regimens during winter dryness or stress-related flaking.
Climbazole helps maintain scalp clarity through climate changes.

Climbazole is used in anti-dandruff routines combined with scalp massage tools and structured usage guidance.
Climbazole supports behavior-driven regimens that improve contact time and coverage.
Climbazole helps maximize perceived results when users follow proper application.

Climbazole is used in anti-dandruff products targeting adolescents with visible flaking concerns.
Climbazole supports gentle, cosmetically acceptable products for younger users.
Climbazole helps improve confidence by reducing visible flakes on hair and clothing.

Climbazole is used in anti-dandruff products for older consumers with recurring scalp issues.
Climbazole supports maintenance routines that keep flaking under control.
Climbazole helps provide consistent scalp comfort with regular use.

Climbazole is used in product development to create low-odor anti-dandruff solutions with good user acceptance.
Climbazole supports consumer-friendly sensory design compared with some medicinal actives.
Climbazole helps maintain pleasant fragrance profiles when properly solubilized.

Climbazole is used in shampoo concentrates and refills where solubility and stability must remain strong.
Climbazole supports robust performance in high-active or high-surfactant concentrates.
Climbazole helps ensure consistent dosing after dilution during consumer use.

Climbazole is used in anti-dandruff products intended for humid climates where Malassezia growth can be more pronounced.
Climbazole supports scalp control under high-humidity conditions.
Climbazole helps reduce recurrence of flaking in challenging environments.

Climbazole is used in anti-dandruff products designed to pair with hair styling products that can build up on scalp.
Climbazole supports scalp cleansing and microbial control in style-heavy routines.
Climbazole helps counteract scalp imbalance linked to occlusive product buildup.

Climbazole is used in anti-dandruff shampoos to reduce Malassezia growth and decrease visible scalp flaking.
Climbazole is incorporated into daily-use shampoos to provide ongoing dandruff control with gentle cleansing systems.
Climbazole is used in clarifying shampoos to support scalp reset routines while maintaining antifungal efficacy.

Climbazole is used in scalp therapy shampoos formulated for itchy, irritated scalps to help reduce discomfort linked to dandruff.
Climbazole is incorporated into shampoos for oily scalps to reduce dandruff recurrence in sebum-rich conditions.
Climbazole is used in salon and professional haircare products to deliver targeted scalp anti-flaking performance.

Climbazole is used in conditioners to provide antifungal activity while improving hair softness and combability.
Climbazole is incorporated into 2-in-1 shampoo-conditioner products to simplify dandruff-care routines.
Climbazole is used in scalp conditioners to reduce flaking while supporting a comfortable scalp feel.

Climbazole is used in leave-on scalp tonics to provide extended contact time and long-lasting dandruff control.
Climbazole is incorporated into scalp serums to support anti-flaking performance without heavy residue.
Climbazole is used in scalp lotions designed for sensitive scalps when properly solubilized and stabilized.

Climbazole is used in anti-dandruff hair masks to provide scalp-care benefits during deep-conditioning treatments.
Climbazole is incorporated into scalp exfoliation products to help manage flaking while supporting scalp balance.
Climbazole is used in pre-shampoo scalp treatments to enhance anti-dandruff routines and improve comfort.

Climbazole is used in men’s grooming shampoos and scalp products where dandruff control is a key consumer need.
Climbazole is incorporated into sports and active-lifestyle shampoos to help control dandruff associated with sweating and frequent washing.
Climbazole is used in travel-size anti-dandruff products where high efficacy at low dosage supports compact formulations.

Climbazole is used in sulfate-free shampoo systems when compatibility and solubilization are properly engineered.
Climbazole is incorporated into low-irritation surfactant blends to maintain dandruff control while improving mildness.
Climbazole is used in fragrance-containing products when the solvent system maintains Climbazole stability and clarity.

Climbazole is used in clear shampoos when solubilizers are selected to keep Climbazole fully dissolved and avoid haze.
Climbazole is incorporated into pearlescent shampoos where dispersion and stability are balanced with sensory aesthetics.
Climbazole is used in high-foaming systems when surfactant selection supports both foam and antifungal performance.

Climbazole is used in scalp sprays to deliver light, leave-on antifungal support with minimal residue.
Climbazole is incorporated into scalp wipes and on-the-go scalp-care formats when permitted and properly stabilized.
Climbazole is used in post-styling scalp refreshers to help manage flaking between washes.

Climbazole is used in combination systems with other anti-dandruff actives to broaden performance and reduce recurrence.
Climbazole is incorporated into scalp-care lines that include both rinse-off and leave-on steps for comprehensive control.
Climbazole is used in supportive scalp microbiome-balancing concepts where targeted antifungal control is part of the strategy.

Climbazole is used in dandruff-control products for curly and textured hair to support scalp health without stripping hair oils.
Climbazole is incorporated into low-build-up routines where lightweight deposition helps maintain hair feel.
Climbazole is valued because Climbazole delivers strong antifungal performance at low levels and supports effective, consumer-friendly anti-dandruff formulations.

DESCRIPTION

Climbazole is an imidazole-based antifungal agent commonly used in anti-dandruff cosmetic products.
Climbazole is typically supplied as a white to off-white crystalline powder.
Climbazole has low water solubility and is usually solubilized using glycols or suitable solvents.

Climbazole is designed to inhibit the growth of Malassezia yeasts associated with dandruff.
Climbazole supports reduction of flaking by addressing microbial contributors on the scalp.
Climbazole activity depends on concentration, contact time, and formulation availability.

Climbazole is commonly used in rinse-off products such as shampoos and scalp washes.
Climbazole can also be used in leave-on formats only where permitted by local regulations.
Climbazole performance is influenced by pH, surfactant system, and solubilization strategy.

Climbazole can recrystallize if not properly solubilized, which may reduce efficacy and affect appearance.
Climbazole formulation work typically includes solvent selection and stability testing to prevent precipitation.
Climbazole is often paired with conditioning agents to maintain hair feel in treatment products.

Climbazole is generally used at low levels, so accurate dosing and uniform distribution are important.
Climbazole should be incorporated with appropriate mixing and temperature control to ensure full dissolution.
Climbazole finished-product testing commonly includes active assay and stability under temperature cycling.

Climbazole can cause irritation in some individuals depending on concentration and personal sensitivity.
Climbazole products should avoid eye contact and be rinsed thoroughly when used in shampoos.
Climbazole safety and allowable use levels depend on regional cosmetic regulations.

Climbazole should be stored in tightly closed containers away from moisture, heat, and direct light.
Climbazole is stable under normal storage conditions when protected from contamination.
Climbazole is valued because it provides effective anti-dandruff action with good cosmetic acceptability.

Climbazole is a crystalline solid typically supplied as a white to off-white powder with low water solubility and good solubility in many organic solvents and selected solubilizer systems.
Climbazole works by inhibiting fungal growth, and Climbazole is especially effective against Malassezia species associated with dandruff and seborrheic scalp conditions.
Climbazole is generally used at low concentrations, and Climbazole performance depends on achieving adequate solubilization, uniform distribution, and sufficient contact time on the scalp.

Climbazole stability depends on formulation pH, temperature, solvent system, and packaging, so stability testing is recommended for finished products.
Climbazole is commonly formulated in rinse-off products and can also be used in leave-on systems when designed to minimize irritation and maintain product clarity.
Climbazole can be combined with conditioning polymers and mild surfactants to improve scalp comfort while maintaining antifungal efficacy.

Climbazole should be stored in tightly closed containers in a cool, dry place protected from heat and strong light.
Climbazole should be handled with appropriate PPE to avoid dust inhalation and unnecessary skin or eye contact during manufacturing.
Climbazole should be used in compliance with applicable cosmetic regulations and concentration limits for the target market.

PROPERTIES

Chemical Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol
Common Name: Climbazole
Chemical Type: Imidazole-derived antifungal active
Appearance: White to off-white crystalline powder
Odor: Mild characteristic odor
Solubility: Practically insoluble in water; soluble in many organic solvents and selected solubilizer systems
Melting Point: ~94–98°C (typical)
pH Stability: Stable in typical cosmetic pH ranges when properly formulated (system dependent)
Partitioning: Lipophilic active requiring solubilization in surfactant or solvent phases
Stability: Stable under recommended storage; sensitive to unsuitable solvent systems and high heat
Storage Temperature: 15–25°C, dry, tightly closed, protected from light
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during handling and powder charging.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a significant amount is swallowed.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care based on exposure route and symptoms.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses, and use dust protection as needed.
Avoid generating dust and avoid inhalation of fine powder.
Wash hands after handling and before eating, drinking, or smoking.

Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Maintain good airflow during weighing and charging operations.
Minimize airborne particulate accumulation in enclosed areas.

Storage:
Store in tightly closed containers in a cool, dry place.
Protect from heat, moisture, and direct light to maintain stability and appearance.
Keep containers properly labeled and protected from contamination.

Spill and Leak Procedures:
Avoid dust generation and collect spilled material using methods that minimize airborne particles.
Place collected material into suitable containers for disposal according to local regulations.
Clean the area with wet wiping or HEPA vacuum methods to remove residues.

Handling Precautions:
Ensure complete solubilization of Climbazole in the formulation to maximize efficacy and avoid crystallization.
Conduct stability testing across temperature cycles to confirm clarity and active retention.
Use Climbazole according to applicable regulatory limits and good manufacturing practices for cosmetic active ingredients.