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Crocin is a carotenoid chemical compound that is found in the flowers of crocus and gardenia.
Crocin's oxygen content also chemically makes it a xanthene.
Crocin is the chemical primarily responsible for the color of saffron.
CAS: 42553-65-1
MF: C44H64O24
MW: 976.97
EINECS: 255-881-6
Synonyms
saffron(natural);ucopyranosyl)ester;Crocin ,98%;CrocinⅡ ,98%;Crocin ,96%;Crocin,Crocetin digentiobiose ester;Crocetin digentiobioside;Crocin 1
Chemically, crocin is the diester formed from the disaccharide gentiobiose and the branched-chain dicarboxylic acid crocetin.
When isolated as a pure chemical compound, Crocin has a deep red color and forms crystals with a melting point of 186 °C.
When dissolved in water, Crocin forms an orange solution.
Crocin is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters.
Crocin is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food.
Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol.
Crocin has a role as an antioxidant, a food colouring, a plant metabolite and a histological dye.
Crocin is a diester, a disaccharide derivative and a diterpenoid.
Crocin is functionally related to a beta-D-gentiobiosyl crocetin and a gentiobiose.
The term crocins may also refer to members of a series of related hydrophilic carotenoids that are either monoglycosyl or diglycosyl polyene esters of crocetin.
The crocin underlying saffron's aroma is α-crocin (a carotenoid pigment that may compose more than 10% of dry saffron's mass): trans-crocetin di-(β-D-gentiobiosyl) ester; Crocin bears the systematic (IUPAC) name 8,8-diapo-8,8-carotenoic acid.: 20
The major active component of saffron is the yellow pigment crocin 2 (three other derivatives with different glycosylations are known) containing a gentiobiose (disaccharide) group at each end of the molecule.
The five major biologically active components of saffron, namely the four crocins and crocetin, can be measured with HPLC-UV.
Crocin is a water-soluble carotenoid found in Gardenia jasmi-noides Ellis and Crocus sativus (saffron).
Crocin has two D-gentiobioside glycosyl esters in its structure.
Crocin is one of the major bioactive compounds of saffron contributing to its red color.
A highly unsaturared diterpene dicarboxylic acid ester found in saffron.
Crocin is also known as a-crocin and crocetin.
Crocin is a series of ester glycosides combining water-soluble carotenoids crocetin and different sugars.
Crocin is one of the main active ingredients of saffron, including crocin -1, crocin -2, crocin -3, crocin-4 and crocetin.
Crocin is centrally acting antihypertensive and can prevent atherosclerosis and be of antithrombosis, antiplatelet aggregation, and anti myocardial ischemia.
Crocin is a pain-relieving medicine manufactured in India by GSK Consumer Healthcare Ltd. The active ingredient present in crocin is paracetamol.
Paracetamol is an analgesic and antipyretic.
Crocin is quickly absorbed from the gastrointestinal tract after oral administration.
Crocin acts by inhibiting the formation of prostaglandins (chemicals) in the body which are accountable for fever and pain.
Crocin has the benefits of relieving mild to moderate pain, including toothache, headache, muscle ache, and menstrual pain.
Crocin is a pharmaceutical product which is an antipyretic and analgesic medication, primarily composed of paracetamol (acetaminophen).
Crocin is synthesized through chemical processes originally derived from coal tar, although modern production predominantly utilizes petrochemical sources.
The mode of action of Crocin involves the inhibition of cyclooxygenase (COX) enzymes, particularly COX-2, in the central nervous system.
This action leads to a decrease in the synthesis of prostaglandins, which are responsible for pain and fever.
Crocin is extensively used for the alleviation of mild to moderate pain and the reduction of fever.
Crocin's applications include treatment for headaches, muscle aches, arthritis, backaches, toothaches, colds, and the regulation of fever related to infections.
Its efficacy and safety profile make Crocin a common choice for both acute and chronic conditions involving pain and fever.
Scientists continue to investigate its pharmacokinetics and potential therapeutic applications beyond its traditional uses, aiming to optimize its clinical benefits and minimize any adverse effects.
Crocin is a household name in pain relief and fever management, offering products like Crocin Advance, Crocin 650, and Crocin syrup.
These formulations contain paracetamol, a widely used analgesic (pain reliever) and antipyretic (fever reducer).
The Crocin formula is designed to effectively address conditions such as headaches, body aches, toothaches, and fever associated with the common cold, flu, or other viral infections.
When taken at the prescribed dosage, Crocin rarely causes adverse effects, making it a reliable choice for adults and children (with medical guidance).
Crocin is generally considered safe for use during pregnancy and breastfeeding, though consulting a healthcare provider is recommended to ensure safety.
Crocin tablet is a versatile medication, and its various forms cater to different needs, ensuring accessibility for all age groups.
Crocin Chemical Properties
Melting point: 186° (effervescence)
Boiling point: 1169.0±65.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
Storage temp.: 2-8°C
Solubility: DMSO (Slightly, Heated), Methanol (Very Slightly, Sonicated)
Form: Powder
Pka: 12.20±0.70(Predicted)
Color: Orange to Very Dark Purple
Merck: 14,2589
Stability: Light Sensitive
InChIKey: OXNHRKGZZFWUQZ-QORFUXSJSA-N
LogP: -4.742 (est)
CAS DataBase Reference: 42553-65-1
Crocin is a reddish brown needle-like crystal.
Slightly odor.
Easily soluble in hot water, becomes the orange solution.
Slightly soluble in anhydrous ethanol, ether, and other organic solvents.
Insoluble in oil.
The aqueous solution is weakly acidic or neutral transparent bright yellow, with a maximum absorption wavelength of 442nm.
Color is almost unaffected by pH value.
Light and heat resistance is good in neutral or alkaline, and poor in acidic.
Metal ion resistance (except iron, blackened by iron) is good.
The coloring of protein is better than that of starch and is not affected by pH (pH4-10).
Crocin is a brand of paracetamol, a non-opioid analgesic and antipyretic used to temporarily relieve mild to moderate pain and reduce fever.
Available in forms like Crocin Advance (500mg paracetamol), Crocin 650 (650mg paracetamol), and Crocin syrup for children, it is designed for ease of use and effectiveness.
The Crocin formula is free from gluten, lactose, and sugar, making it suitable for a wide range of users.
Crocin tablets are swallowed whole with water, while the syrup is ideal for younger patients, dosed based on weight and age.
Crocin Advance and Crocin 650 are tailored for adults, while Crocin syrup is formulated for children, ensuring safe administration under medical supervision.
Efficacy and effect
The traditional medicine believes that the stigma croci can dredge and activate the collaterals, remove blood stasis, eradicate depression and relieve swelling and pain.
Crocin is mainly used for the treatment of anxiety depression, chest distention, irregular menstruation, postpartum haemorrhage and traumatic injury.
The main effective components are crocetin and crocin, which has many pharmacological activities, such as being anti-inflammatory and analgesic, antitumor, antidepressant, hypoglycemic and lowering blood pressure.
Because the water solution of stigma croci is bright yellow with sweet smell, Crocin is often used as a food additive and high-grade edible pigment, but also can be used as high dye for silk, cotton and wool products.
In recent years, pharmacological researches indicate that stigma croci has good control effect for a variety of diseases, including cancer, coronary heart disease, atherosclerosis and hyperlipidemia.
Pharmacological effects
Crocin has the effect of the anti-inflammation and treatment of soft tissue injury, gall liver protection, anti-tumor and other pharmacological effects.
Crocin is widely used in food, medicine, chemical industry and other industries.
Crocin is used in the treatment of patients with cardiovascular disease and fatty liver with good medicinal value.
Uses
Crocin, is a natural carotenoid derived the flowers crocus and gardenia. Crocin has been shown to be a potent antioxidant. It has also been shown to have an antiproliferative action against cancer cells in vitro, and also possessing possible antidepressant properties.
Crocin treats many conditions like temporary pain relief associated with headache, sinus pain, backache, painful menstruation, musculoskeletal pain, sore throat, rheumatic pain, neuralgia, arthritis, osteoarthritis, respiratory tract infections, migraine headache, tennis elbow, and cold and flu.
Crocin is also used to reduce fever without treating its underlying causes.
In pediatric patients, Crocin has the benefit of relieving pain associated with an earache, teething, or immunization.
Biochem/physiol Actions
Crocin alleviates some ethanol-induced impairments of learning and prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP), a form of activity-dependent synaptic plasticity that may underly learning and memory.
Related CNS effects are specific to the digentiobiose ester; crocetin glucose gentiobiose ester is half as potent, and the diglucose ester has no effect at all.
