PRODUCTS

DIBUTYL SEBACATE

CAS NO:109-43-3
EC NO:203-672-5

SYNONYMS:
DIBUTYL SEBACATE; Dibutyl decanedioate; 109-43-3; Butyl sebacate; Di-n-butyl sebacate; Decanedioic acid, dibutyl ester; Polycizer DBS; Kodaflex DBS; Dibutyl sebacinate; Staflex DBS; Monoplex DBS; Bis(n-butyl) sebacate; Sebacic acid, dibutyl ester; Di-n-butylsebacate; Bis(n-butyl)sebacate; 1,10-dibutyl decanedioate; Dibutylester kyseliny sebakove; Di(n-butyl) sebacate; PX 404; Dibutyl 1,8-octanedicarboxylate; UNII-4W5IH7FLNY; n-Butyl sebacate; Plasthall DBS; Sebacic acid dibutyl ester; Uniflex DBS; NSC 3893; Reomol DBS; Decanedioic acid, 1,10-dibutyl ester; Decanedioic Acid Dibutyl Ester; Dibutyl sebacate (NF); Dibutyl sebacate [NF]; MFCD00027218; 4W5IH7FLNY; Dibutyl sebacate, 93%; DSSTox_CID_21847; DSSTox_RID_79856; DSSTox_GSID_41847; CAS-109-43-3; Di-n-butyl-sebacate; FEMA No. 2373; HSDB 309; Di-n-butyl decanedioate; EINECS 203-672-5; Dibutylester kyseliny sebakove [Czech]; BRN 1798308; AI3-00393; CCRIS 8264; di-butyl sebacate; ACMC-1BUY3; EC 203-672-5; Dibutyl sebacate, >=90%; Di-n-butyl sebacate, 90%; SCHEMBL42655; 4-02-00-02081 (Beilstein Handbook Reference); CHEMBL2106225; DTXSID1041847; FEMA 2373; Sebacic acid, bis-n-butyl ester; Dibutyl sebacate, technical grade; NSC3893; CHEBI:165632; NSC-3893; ZINC3875764; Tox21_113651; Tox21_300154; ANW-16045; Dibutyl sebacate, analytical standard; LMFA07010828; s6041; Dibutyl sebacate, >=97.0% (GC); AKOS015915581; CS-W014523; HY-W013807; NCGC00247910-01; NCGC00247910-02; NCGC00254088-01; BS-14305; I839; DB-040869; FT-0624681; D03782; Dibutyl sebacate, SAJ first grade, >=98.0%; Dibutyl sebacate, Selectophore(TM), >=97.0%; Q411272; SR-01000944769; J-002279; J-520240; SR-01000944769-1; Dibutyl sebacate, United States Pharmacopeia (USP) Reference Standard; Dibutyl sebacate, Pharmaceutical Secondary Standard; Certified Reference Material

Dibutyl sebacate (DBS) is an organic chemical, a dibutyl ester of sebacic acid. Its main use is as a plasticizer in production of plastics, namely cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, polyvinyl butyral, polyvinyl chloride, polystyrene, and many synthetic rubbers (especially nitrile rubber and neoprene) and other plastics. It can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications, e.g. as a plasticizer for film coating of tablets, beads, and granules.[2] It is also used as a lubricant in shaving lotions, and a flavoring additive in non-alcoholic beverages, ice cream, ices, candy, and baked goods. It provides excellent compatibility[citation needed] with a range of plastic materials, superior properties at low temperatures, and good oil resistivity. Its other names include Morflex, Kodaflex, polycizer, Proviplast 1944 and PX 404. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.colourless to oily liquid; fruity but very mild odour with a very faint fruity oily taste.IN VITRO PANCREATIC LIPASE HYDROLYZES DIBUTYL SEBACATE AS RAPIDLY AS IT DOES TRIOLEIN, & FROM THIS IT CAN BE CONCLUDED THAT THE PLASTICIZER IS METABOLIZED IN THE BODY BY SAME ROUTE AS FATS.BY DISTILLATION OF SEBACIC ACID WITH BUTYL ALCOHOL IN PRESENCE OF CONCN HCL IN BENZENE SOLN OR BY REACTING BUTYL ALCOHOL & SEBACYL CHLORIDE.DIBUTYL SEBACATE, ADDITIVE IN PVDC FILM, WAS EXTRACTED BY SOLVENTS IN FATTY FOODS & DETERMINED BY GAS CHROMATOGRAPHY.GAS-CHROMATOGRAPHIC DETERMINATION OF DIBUTYL SEBACATE IN AIR OF INDUSTRIAL PREMISES.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Use water spray, powder, carbon dioxide.Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations.At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C; on spraying or dispersing, however, much faster.Dibutyl sebacate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.Dibutyl sebacate's production and use as a plasticizer, rubber softener, flavoring agent and cosmetic and perfume additive may result in its release to the environment through its use and from various waste streams. If released to air, a vapor pressure of 4.7X10-6 mm Hg at 25 °C indicates dibutyl sebacate will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dibutyl sebacate will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 21 hours. Particulate-phase dibutyl sebacate will be removed from the atmosphere by wet and dry deposition. Dibutyl sebacate may also undergo direct photolysis since it contains a functional group that can absorb light greater than 290 nm, but the kinetics of this reaction are unknown. If released to soil, dibutyl sebacate is expected to have low mobility based upon an estimated Koc of 575. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 4.8X10-8 atm-cu m/mole. Volatilization from dry soil surfaces is not expected to be an important fate process based upon the vapor pressure. Dibutyl sebacate and other plasticizers were readily biodegraded by pure cultures. If released into water, dibutyl sebacate is expected to adsorb to suspended solids and sediment in water based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. Hydrolysis is expected to occur slowly in the environment based on estimated hydrolysis half-lives of 166 days and 4.5 years at pH 8 and 7, respectively. An estimated BCF of 77 suggests the potential for bioconcentration in aquatic organisms is moderate. Occupational exposure to dibutyl sebacate may occur through inhalation and dermal contact with this compound at workplaces where dibutyl sebacate is produced or used. The general population is exposed to dibutyl sebacate through the use of consumer products that contain this compound.Dibutyl sebacate's production and use as a plasticizer, rubber softener, flavoring agent and cosmetic and perfume ingredient(1) may result in its release to the environment through various waste streams. Based on a classification scheme(1), an estimated Koc value of 575(SRC), determined from a water solubility of 40 mg/l(2) and a regression-derived equation(3), indicates that dibutyl sebacate is expected to have low mobility in soil(SRC). Volatilization of dibutyl sebacate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.8X10-8 atm-cu m/mole(SRC), calculated from a vapor pressure of 4.7X10-6 mm Hg(4) and water solubility of 40 mg/l(2). Dibutyl sebacate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Dibutyl sebacate and other plasticizers were readily biodegraded by pure bacterial and fungal cultures.Based on a classification scheme(1), an estimated Koc value of 575(SRC), determined from a water solubility of 40 mg/l(2) and a regression-derived equation(3), indicates that dibutyl sebacate is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected to be an important fate process(3) based upon an estimated Henry's Law constant of 4.8X10-8 atm-cu m/mole(SRC), calculated from a vapor pressure of 4.7X10-6 mm Hg(4) and water solubility of 40 mg/l(2). A base-catalyzed second-order hydrolysis rate constant of 0.05 L/mole-sec(SRC) was estimated using a structure estimation method(5); this corresponds to half-lives of 4.5 years and 166 days at pH values of 7 and 8, respectively(5). Dibutyl sebacate and other plasticizers were readily biodegraded by pure bacterial and fungal cultures(6,7). According to a classification scheme(8),an estimated BCF of 77(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is moderate.According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dibutyl sebacate, which has a vapor pressure of 4.7X10-6 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase dibutyl sebacate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 21 hours(SRC), calculated from its estimated rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Particulate-phase dibutyl sebacate may be removed from the air by wet and dry deposition(SRC). Dibutyl sebacate may also undergo direct photolysis in the environment since this compound contains functional groups that can absorb light greater than 290 nm(4).Dibutyl sebacate was degraded by pure bacterial and fungal cultures over 1 to 4 week incubation periods in shake flask experiments(1). Pure strains of the fungus Fusarium were shown to degrade dibutyl sebacate and several other plasticizers(2).The rate constant for the vapor-phase reaction of dibutyl sebacate with photochemically-produced hydroxyl radicals has been estimated as 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 21 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). A base-catalyzed second-order hydrolysis rate constant of 0.05 L/mole-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 4.5 years and 166 days at pH values of 7 and 8, respectively(2). The expected hydrolysis products are butanol and sebacic acid. Dibutyl sebacate may also undergo direct photolysis in the environment since this compound contain a functional group that can absorb light greater than 290 nm(3).An estimated BCF of 77 was calculated for dibutyl sebacate(SRC), using a water solubility of 40 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).The Koc of dibutyl sebacate is estimated as 575(SRC), using a water solubility of 40 mg/l(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that dibutyl sebacate is expected to have low mobility in soil(SRC).The Henry's Law constant for dibutyl sebacate is estimated as 4.8X10-8 atm-cu m/mole(SRC) from its vapor pressure, 4.7X10-6 mm Hg(1), and water solubility, 40 mg/l(2). This Henry's Law constant indicates that dibutyl sebacate is expected to be essentially nonvolatile from water surfaces(3). Dibutyl sebacate's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces is not expected to be an important environmental fate process(SRC). Volatilization from dry soil surfaces is not expected to be an important fate process(SRC) based on the vapor pressure of this compound(1).Dibutyl sebacate was identified, not quantified, in drinking water from the US(1).NIOSH (NOES Survey 1981-1983) has statistically estimated that 4,826 workers (2,128 of these are female) are potentially exposed to dibutyl sebacate in the US(1). Occupational exposure to dibutyl sebacate may occur through inhalation and dermal contact with this compound at workplaces where dibutyl sebacate is produced or used(SRC). The general population is exposed to dibutyl sebacate through the use of consumer products that contain this compound(SRC).DBS are non-toxic and can be used in contact with food packaging materials, cold auxiliary plasticizer. And used as a lot of synthetic rubber plasticizer, can make products with excellent low temperature performance and oil resistance.DBS is colorless or light yellow transparent liquid, slightly soluble in water, soluble in ethanol, ether, and benzene. Can be used in contact with food packaging materials, cold auxiliary plasticizer. Compatible with resins and synthetic rubber, can be used as the main plasticizer. The goods are non-toxic and can be used in with food packaging materials, products feel good. The product used as a lot of synthetic rubber plasticizer, can make products with excellent low temperature performance and oil resistance. The main drawback of the product is the large loss of volatile, easy to be water, soapy water and detergent solution out, so often with phthalate plasticizer and use.DBS has been used as a typical cold-resistance plasticizer, with good cryogenic performance and plastifying efficiency for the application of plastic, PVC, rubber, cable and the lubricant of the jet engine.Stored in a cool, ventilated place. Casks should be sealed with nitrogen. Avoid heat and exposure. The shelf life is 12 months after manufacturer date. It is still available if retest result is qualified after expire date.Dibutyl sebacate has been used as a plasticizer to prepare free ethylcellulose films.It can be utilized as a core in liquid-core capsules with cross-linked alginate/polyacrylamide membrane prepared via co-extrusion jet-break-up method for the extraction of the pesticide, atrazine.Dibutyl sebacate is used for plasticization: PVC, polyvinyl butyral, cellulose acetate, rubber. DBS gives products a high cold-resistance at low temperatures, light and water resistance.Dibutyl sebacate is intended for plasticization of vinyl resins and other polymers in the production of the cable plasticates, artificial leather, industrial rubber products, polymeric building materials, linoleums, film and sheet materials, packaging films, PVC seals, gaskets for refrigerators, crown cork gaskets, and other purposes.Dibutyl sebacate is used for plasticization of paint and varnish materials on the base of cellulose esters and polyvinyl chloride. It provides coatings with a high frost-resistance.Dibutyl sebacate is insoluble in water, soluble in organic solvents and hydrocarbons. It is used as plasticizer for vinyl polymers, particularly for polyvinyl chloride and vinyl chloride copolymers, as well as for cellulose nitrate, ethyl- and benzyl-cellulose. DBS is not toxic and can be used in products contacting with foodstuffs.Cold plasticizer, compatible with most resins and synthetic rubber, can be used as the main plasticizer. The product is non-toxic, can be used in contact with food packaging materials, products feel good. The product is used as a plasticizer for many synthetic rubber products, which can make the products have excellent low temperature performance and oil resistance. The main disadvantage of this product is a large volatile loss, easy to be water, soap water and detergent solution out, so often with phthalate ester plasticizer.Dibutyl sebacate (DBS). Acts as a cold resistant plasticizer. Has good resistance to cold and oil. It is oily, colorless and transparent liquid. Can dissolve in ethyl hydrate, ethyl ether, methyl benzene and other organic solvents.Dibutyl sebacate (DBS) is an organic chemical which is mainly used as a plasticizer in the production of such plastics as cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, polyvinyl butyral, polyvinyl chloride, polystyrene, and many synthetic rubbers and other plastics. It is used for plastics in the food packaging industry, in medical devices, and for pharmaceutical applications. It is classified as mildly toxic by ingestion in humans and has shown experimental reproductive effects in animals; however, it is also approved by the US-FDA as a food additive to be used with the minimum quantity needed to produce the intended effect.Dibutyl sebacate was selected as a plasticiser in the formulation of sustained-release matrix tablets. Dibutyl sebacate was added to a dichloromethane/EC solution and subsequently spray-dried, or was mixed as a liquid with EC powder. Hydrated tablets were evaluated by frequency sweep and creep rheological tests to correlate the results with drug release.Dibutyl Sebacate (DBS) was diluted with dimethyl sulfoxide. Estrogenic activity was measured using a yeast two-hybrid system and a fluorescence polarization system within a concentration range of 10^-7 to 10^-3 M. Yeast strain Y190 was transformed with the pGBT9-receptors and pGAD424-coactivators using the lithium acetate method, and an S9 hepatic microsomal fraction was used to implement the mediating influence of metabolic bioactivation. DBS was tested for its ability to displaceflourescent non-steroid estrogen from the estrogen receptor. A threshold of B-galactosidase activity above 0.1, greater than 50% inhibition and a 1.5 fold increase in cell growth over controls was considered estrogenic activity. DBS showed the weakest cytotoxicity among tested compounds and an IC50 value for B-galactosidase that was higher than the applicable measurement range.Dibutyl phthalate (DBP) is most commonly used as a plasticizer in a variety of household products. It has the ability to leach and evaporate into the environment while using or disposing of these products.Therefore, studies are being conducted to assess its toxic and apoptotic effects.Studies have also indicated that exposure to high doses of DBP may interfere with progesterone and estradiol production.Dibutyl sebacate (DBS) is an organic chemical, a dibutyl ester of sebacic acid. It is from vegetable origin since it is processed from castor oil. Dibutyl decanedioate, also known as DBS or butyl sebacate, belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. Dibutyl decanedioate is an extremely weak basic (essentially neutral) compound (based on its pKa). Dibutyl decanedioate is a potentially toxic compound.DBS, NF is Morflex’s trade designation for Dibutyl Sebacate, National Formulary. DBS, NF has an excellent history of use as a pharmaceutical excipient in both aqueous and solvent-based formulations.Dibutyl Sebacate is a plasticizer permitted in the field of food contact material, medical, and pharmaceutical. It is used as a plasticiser for polymers and synthetic rubbers.There are almost infinite esters obtained from thousands of potential starting materials. Esters are formed by removal of water from an acid and an alcohol, e.g., carboxylic acid esters, phosphoric acid esters, and sulfonic acid esters. Carboxylic acid esters are used as in a variety of direct and indirect applications. Lower chain esters are used as flavouring base materials, plasticizers, solvent carriers and coupling agents. Higher chain compounds are used as components in metalworking fluids, surfactants, lubricants, detergents, oiling agents, emulsifiers, wetting agents textile treatments and emollients, They are also used as intermediates for the manufacture of a variety of target compounds. The almost infinite esters provide a wide range of viscosity, specific gravity, vapor pressure, boiling point, and other physical and chemical properties for the proper application selections.The Dibutyl Sebacate Market has encountered significant development over the recent years and is anticipated to grow tremendously over the forecast period. It is an organic chemical, and is a dibutyl ester of sebacic acid. Dibutyl Sebacate mainly used as a plasticizer in production of plastics, namely cellulose acetate butyrate, cellulose acetate propionate, ethyl cellulose, polyvinyl butyral, polyvinyl chloride, polystyrene, and many synthetic rubbers. This organic compound is oftenly used as a lubricant in shaving lotions, and a flavoring additive in non-alcoholic beverages, ice cream, ices, candy, and baked goods.Dibutyl Sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.

Dibutyl sebacate Quick Details
Product Name: Dibutyl sebacate
CAS No: 109-43-3
Molecular Formula: C18H34O4
Molecular Weight: 314.46
Appearance: Colorless transparent liquid, no visible impurity
Assay: 99.5%min
Dibutyl sebacate Typical Properties
Test Items   Specification
Appearance   Colorless transparent oily liquid
Ester(≥)   99.0%
Density(g/cm3)   0.9405-0.9410
Acid Value(KOH)）（mg/g）   0.1
Flash point(≥)   202℃
Chroma,(platinum-Co)≤   30
Water   0.20%
Heating reduction 125℃，2h   0.30%

CAS no. 109-43-3
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EC no.
Value
203-672-5
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Molecul formula
Value
C18H34O4
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REACH status
Value
01-2119970603-36
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Synonyms
Value
DBS, decanedioic acid dibutyl ester, dibutyl decanedioate, di-n-butyl sebacate
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E-number / INCI name
Value
N.A. / DIBUTYL SEBACATE