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Diethyl Phthalate is a member of the group of esters of phthalic acid known as phthalates, used ubiquitously as solvents and plasticisers worldwide.
Diethyl Phthalate can increases the flexibility of plastics.
Diethyl Phthalate is also contained in deodorant formulations, perfumes, emollients and insect repellents.
CAS Number: 84-66-2
Molecular Formula: C12H14O4
Molecular Weight: 222.24
EINECS Number: 201-550-6
Synonyms: DIETHYL PHTHALATE, 84-66-2, Ethyl phthalate, phthalic acid diethyl ester, Anozol, diethyl benzene-1,2-dicarboxylate, Diethylphthalate, Neantine, Phthalol, Solvanol, Diethyl o-phthalate, Palatinol A, Placidol E, Unimoll DA, Phthalsaeurediaethylester, o-Bis(ethoxycarbonyl)benzene, Diethyl 1,2-benzenedicarboxylate, 1,2-Diethyl phthalate, Estol 1550, 1,2-Benzenedicarboxylic acid, diethyl ester, Di-n-ethyl phthalate, o-Benzenedicarboxylic acid diethyl ester, Diethyl o-phenylenediacetate, Phthalic acid, diethyl ester, RCRA waste number U088, diethyl phtalate, Diethylester kyseliny ftalove, NCI-C60048, NSC 8905, 1,2-benzenedicarboxylic acid diethyl ester, CCRIS 2675, HSDB 926, CHEBI:34698, DPX-F5384, NSC-8905, EINECS 201-550-6, UNII-UF064M00AF, Diethyl-o-phthalate, 1,2-diethyl benzene-1,2-dicarboxylate, BRN 1912500, O-phthalic acid, diethyl ester, UF064M00AF, DTXSID7021780, AI3-00329, Diethyl phthalate (NF), Diethyl phthalate [NF], DTXCID901780, PHTHALIC ACID ETHYL ESTER, EC 201-550-6, 1,2-Benzenedicarboxylic acid, 1,2-diethyl ester, 4-09-00-03172 (Beilstein Handbook Reference), NCGC00090974-03, o-Benzenedicarboxylic acid, diethyl ester, Diethyl phthalate, 99%, DIETHYL PHTHALATE (II), DIETHYL PHTHALATE [II], DIETHYL PHTHALATE (MART.), DIETHYL PHTHALATE [MART.], DIETHYL PHTHALATE (USP-RS), DIETHYL PHTHALATE [USP-RS], CAS-84-66-2, DIETHYL PHTHALATE (EP MONOGRAPH), DIETHYL PHTHALATE [EP MONOGRAPH], SMR000857334, Phthalsaeurediaethylester [German], Diethyl phthalate, PESTANAL(R), analytical standard, Diethylester kyseliny ftalove [Czech], RCRA waste no. U088, Diethy phthalate, Phthalic acid, bis-ethyl ester, Kodaflex DEP, MFCD00009111, Diethyl phthalic acid, Diethyl Phthalate, NF, diethyl 1,2-benzenedioate, bmse000846, Epitope ID:140105, WLN: 2OVR BVO2, Diethyl phthalate, >=99%, Diethyl phthalate, 99.5%, SCHEMBL22296, MLS001336021, MLS001336022, MLS002152901, MLS002177800, BIDD:ER0639, DIETHYL PHTHALATE (0), CHEMBL388558, Diethyl phthalate, >=99.5%, DIETHYL PHTHALATE [HSDB], Diethyl-1,2-benzenedicarboxylate, DIETHYL PHTHALATE [VANDF], ETHYL PHTHALATE [WHO-DD], NSC8905, Diethyl phthalate, LR, >=99%, Phthalic acid, bis-isodecyl ester, HMS2233J05, HMS3369G01, PHTHALIC ACID,DIETHYL ESTER, Diethyl phthalate/dimethyl phthalate, STR04116, Tox21_111050, Tox21_201874, Tox21_300183, BBL011577, STL163320, AKOS000119867, PHTHALIC ACID ETHYL ESTER [MI], NCGC00090974-01, NCGC00090974-02, NCGC00090974-04, NCGC00090974-05, NCGC00090974-06, NCGC00254098-01, NCGC00259423-01, benzene-1,2-dicarboxylic acid diethyl ester, CS-0013981, NS00009893, P0296, Diethyl ester of 1,2-Benzenedicarboxylic acid, EN300-20094, D03804, Diethyl phthalate, SAJ special grade, >=98.0%, Q419811, Q-200982, F1908-0104, Diethyl phthalate, European Pharmacopoeia (EP) Reference Standard, Diethyl phthalate, United States Pharmacopeia (USP) Reference Standard, Diethyl Phthalate, Pharmaceutical Secondary Standard; Certified Reference Material, InChI=1/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H, 1,2-benzenedioicacid,diethylester;1,2-diethyl phthalate;Anozol;-Benzenedicarboxylic acid diethyl ester;Diethyl ester;Diethyl ester of 1,2-Benzenedicarboxylic acid;Diethyl-1,2-benzenedicarboxylate;diethyl1,2-benzenedicarboxylate
Diethyl Phthalate can cross react with dimethyl phtalate.
Diethyl phthalate is a clear, colorless, oily liquid.
It is practically odorless, or with a very slight aromatic odor and a bitter, disagreeable taste.
Diethyl Phthalate is miscible with ethanol and ethyl ether. Diethyl phthalate is soluble in acetone, benzene, carbon tetrachloride, alcohols, ketones, esters, and aromatic hydrocarbons and partly miscible with aliphatic solvents.
Diethyl Phthalate, when exposed to heat, decomposes and emits acrid smoke and irritating fumes.
It is incompatible with strong oxidisers, strong acids, nitric acid, permanganates, and water and attacks some forms of plastics.
Diethyl Phthalate is produced in the reaction of phthalic anhydride with ethanol in the presence of concentrated sulphuric acid catalyst.
Diethyl Phthalate exhibited low to very lowacute toxicity in laboratory animals.
Inges tion produced somnolence and hypotension.
Inhalation of its vapors may result in lacrima tion, coughing, and irritation of the throatin humans.
Diethyl Phthalate administeredto pregnant rats at 5% concentration in thefeed showed no adverse effect upon embryoor fetal growth, viability, or the incidence ofmalformations.
Diethyl Phthalate is a colorless, nearly odorless, and oily liquid chemical compound with the formula C₁₂H₁₄O₄.
It belongs to the family of phthalate esters, which are used as plasticizers—substances added to plastics to increase their flexibility, transparency, durability, and longevity.
The molecular structure of Diethyl Phthalate includes a benzene ring bonded to two ethyl ester groups, which gives it its characteristic properties.
Diethyl Phthalate is a phthalate ester.
It occurs as a colourless liquid without significant odour but has a bitter, disagreeable taste.
It is more dense than water and insoluble in water; hence, it sinks in water.
Diethyl phthalate occurs as a colourless liquid without signicant odour but has a bitter, disagreeable taste.
Diethyl phthalate is more dense than water and insoluble in water; hence, Diethyl phthalate sinks in water.
Diethyl phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst.
Diethyl phthalate has good compatibility with most resins such as vinyl resin and cellulose.
Diethyl Phthalate is produced by the reaction of ethanol with phthalic anhydride, in the presence of a strong acid catalyst:
Diethyl Phthalate can be used as a solvent for the antimony reduction of aluminum chloride-phosphorus trichloride-alkyl chloride complexes to form the corresponding alkylphosphonous dichlorides.
It can undergo condensation with o-phenylenediamine in the presence of sodium hydride to form dibenzo (b,f)(1,4)diazocine-6,11(5H, 12H)-dione.
Diethyl phthalate is a phthalate ester, appears as a clear colorless liquid without signicant odor.
More dense than water and insoluble in water.
Diethyl Phthalate is one of a number of phthalates (pronounced thalates), all of which have dierent uses and safety proles.
Diethyl phthalate appears as a clear, colorless liquid without signicant odor.
More dense than water and insoluble in water
Diethyl phthalate is commonly used as a vehicle for fragrances and cosmetic ingredients.
Diethyl Phthalate is one of the volatile compounds found in rice cultivars and starfruit.
Diethyl phthalate is used ass denaturant for alcohol.
Diethyl Phthalate is used ass a camphor substitute.
Diethyl Phthalate is commonly used to make plastics more exible.
Products in which Diethyl phthalate is found include toothbrushes, automobile parts, tools, toys, and food packaging.
Diethyl Phthalate can be released fairly easily from these products, as Diethyl phthalate is not part of the chain of chemicals (polymers) that makes up the plastic.
Diethyl Phthalate is also used in cosmetics, insecticides, and aspirin.
Diethyl Phthalateis used as a plasticizer for cellulose ester plastic lms and sheets (photographic, blister packaging, and tape applications) and moulded and extruded articles (consumer articles such as toothbrushes, automotive components, tool handles, and toys).
Diethyl Phthalate is an aromatic diester of ethyl alcohol and phthalic acid.
Diethyl phthalate is a phthalate ester.
Diethyl phthalate is a colourless liquid with a slight aromatic odour and low volatility.
Diethyl Phthalate is a colorless liquid without a signicant odor.
Diethyl phthalate is a diethyl ester of phthalic acid and is a chemical compound belonging to the phthalate ester family.
Diethyl phthalate is clear colorless liquid which is marginally denser than water.
Diethyl phthalate has low volatility.
Diethyl phthalate is also known as solvanol or phthalol in industry.
Generally diethyl phthalate is synthesized by either Ald-Ox process, or by Oxo process.
Diethyl phthalate can also be produced by reacting phthalic anhydride with ethanol in the presence of concentrated sulfuric acid which acts as a catalyst.
The purity of diethyl phthalate generally ranges from 98% to 99.5%.
Diethyl Phthalate belongs to the short-chain phthalates.
Melting point: -3 °C (lit.)
Boiling point: 298-299 °C (lit.)
Density: 1.12 g/mL at 25 °C (lit.)
vapor density: 7.66 (vs air)
vapor pressure: 1 mm Hg ( 100 °C)
refractive index: n20/D 1.502(lit.)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: Practically insoluble in water, miscible with ethanol (96 per cent).
form: Liquid
Specific Gravity: 1.118
color: APHA: ≤15
Odor: water-wh. oily liq., odorless, bitter taste
Viscosity: 11.53mm2/s
explosive limit 0.75%, 187°F
Water Solubility: 1 g/L (20 ºC)
Merck: 14,7371
BRN: 1912500
Henry's Law Constant: At 25 °C: 5.01, 4.54, 4.78, 4.94, 2.21, and 2.44 (x 10-5 atm?m3/mol)at pH values of 2.96, 2.98, 6.18, 6.19, 8.98, and 9.00, respectively (Hakuta et al., 1977).
Dielectric constant: 7.1（45℃）
Exposure limits TLV-TWA air 5 mg/m3 (ACGIH). .
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, alkalies.
LogP: 2.2 at 41℃
Diethyl Phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Can generate electrostatic charges.
A clear, colorless liquid without significant odor.
More dense than water and insoluble in water.
Hence sinks in water primary hazard is to the environment.
Spread to the environment should be immediately stopped.
Diethyl Phthalate easily penetrates soil, contaminates groundwater and nearby waterways.
Severely irritates eyes and mildly irritates skin.
Diethyl Phthalate is used in the manufacture of perfumes, plastics, mosquito repellents and many other products.
Biodegradation of Diethyl Phthalate in soil occurs by sequential hydrolysis of the two diethyl chains of the phthalate to produce monoethyl phthalate, followed by phthalic acid.
This reaction occurs very slowly in an abiotic environment.
Thus there exists an alternative pathway of biodegradation which includes transesterification or demethylation by microorganisms, if the soil is also contaminated with methanol, that would produce another three intermediate compounds, ethyl methyl phthalate, dimethyl phthalate and monomethyl phthalate.
This biodegradation has been observed in several soil bacteria.
Some bacteria with these abilities have specific enzymes involved in the degradation of phthalic acid esters such as phthalate oxygenase, phthalate dioxygenase, phthalate dehydrogenase and phthalate decarboxylase.
The developed intermediates of the transesterification or demethylation, ethyl methyl phthalate and dimethyl phthalate, enhance the toxic effect and are able to disrupt the membrane of microorganisms.
Recent studies show that Diethyl Phthalate, a phthalic acid ester (PAE), is enzymatically hydrolyzed to its monoesters by pancreatic cholesterol esterase (CEase) in pigs and cows.
These mammalian pancreatic CEases have been found to be nonspecific for degradation in relation to the diversity of the alkyl side chains of PAEs.
Little is known about the chronic toxicity of diethyl phthalate, but existing information suggests only a low toxic potential.
Studies suggest that some phthalates affect male reproductive development via inhibition of androgen biosynthesis.
In rats, for instance, repeated administration of Diethyl Phthalate results in loss of germ cell populations in the testis.
However, diethyl phthalate does not alter sexual differentiation in male rats.
Dose response experiments in fiddler crabs have shown that seven-day exposure to diethyl phthalate at 50 mg/L significantly inhibited the activity of chitobiase in the epidermis and hepatopancreas.
Chitobiase plays an important role in degradation of the old chitin exoskeleton during the pre-moult phase.
Diethyl Phthalate belongs to the class of organic compounds known as benzoic acid esters.
These are ester derivatives of benzoic acid.
Diethyl phthalate (C12H14O4), or DEP is a diethyl ester of phthalic acid.
Diethyl phthalate is a colorless, oily liquid.
Diethyl phthalate is an ester.
Diethyl Phthalate was reported as an ingredient in 67 cosmetic formulations.
Diethyl Phthalate is used as a component in insecticide sprays and mosquito repellents.
Diethyl Phthalate is likely to undergo biodegradation in the environment.
Diethyl Phthalate is primarily used as a plasticizer in products such as automobile parts, tools, and food packaging.
In addition, Diethyl phthalate can be used as a solvent for various organic molecules.
Because of this, Diethyl Phthalate is useful in binding cosmetic additives and fragrances.
Diethyl phthalate is also used in the manufacture of mosquito repellent.
Due to Diethyl phthalate’s make up of solely carbon, hydrogen, and oxygen, Diethyl Phthalate is also desirable as a combustible and is used as a stabilizer for solid rocket propellant.
Diethyl Phthalate is used as a binder in dierent types of cosmetics and fragrances.
Diethyl Phthalate is also used in the formulation of bathing soaps, toiletries, aftershave lotions and skin care products.
Diethyl Phthalate is used as component in insecticides and mosquito repellent sprays.
Diethyl Phthalate can also be used as a plasticizer for solid rocket propellants.
Diethyl Phthalate has also found its application as coating ingredient in aspirin and as a diluent in polysulde dental impression materials.
Among others, Diethyl phthalate is used as plasticizers in cellulose based polymers.
However, Diethyl phthalate is also used in cosmetics, textiles, pesticides, lubricants, and glues.
Diethyl Phthalate is used as a plasticizer in a wide variety of consumer products, including plastic packaging lms, cosmetic formulations, and toiletries, as well as in medical treatment tubing.
Diethyl Phthalate is used as a plasticizer in consumer goods, including plastic packaging lms, cosmetics, solvent for fragrances, a surface lubricant in food and pharmaceutical packaging, and in tubing used for medical purposes.
Diethyl Phthalate is used in toys and baby bottles, cosmetics, personal care products, glue, food packaging and insect repellants.
Diethyl Phthalate has various industrial uses including as a wetting agent, varnish solvent, dye carrier, plasticizer, and a denaturing agent in soaps.
Diethyl Phthalate is a phthalic anhydride ester (PAE) that is commonly used as a solvent in cosmetics and also as a plasticizer.
Diethyl Phthalate acts as plasticizer and lubricating agent.
Diethyl Phthalate imparts exibility and impacts strength of plastics.
Diethyl Phthalate is used in rocket propellants and cellulose ester plastics.
Diethyl Phthalate is used in plastics manufacture and processing.
Diethyl Phthalate is an ingredient of insect repellent.
Diethyl Phthalate is a colourless liquid that is used as a solvent in nail polish remover, detergent and cleaning agents and as a xative in fragrances.
Diethyl Phthalate may also be used as an ‘alcohol denaturant’ – that is, an additive to products containing alcohol that gives it a foul smell, making Diethyl phthalate unt to drink.
Diethyl Phthalate is currently used through direct addition in cosmetic products and personal care products and indirectly in fragrances.
Uses:
Diethyl Phthalate is a Plasticizer for cellulose ester plastic films and sheets; in molded plastics; manufacturing varnishes; cosmetics.
Diethyl Phthalate is an intermediate of the rodenticides dimouse, murine, and chlorpyrone, and is also an important solvent.
Diethyl phthalate is used as a plasticizer for plastics.
Diethyl phthalate is used as an analytical reagent, a gas chromatography stationary solution, a solvent for cellulose and esters, a plasticizer and a lubricant.
Diethyl phthalate is used as plasticizer, solvent, lubricant, fixative, foaming agent for colored or rare metal mine flotation, gas chromatography fixative, alcohol denaturant, spray insecticide.
This product is mixed with cellulose acetate, cellulose acetate butyrate, polyvinyl acetate, nitrocellulose, ethyl cellulose, polymethyl methacrylate, polystyrene, polyvinyl butyral, vinyl chloride-vinyl acetate Most resins such as copolymers have good compatibility.
It is mainly used as a plasticizer for cellulose resin, but the product has high volatility, which limits its wide application.
Diethyl Phthalate has been used as a substitute for camphor in the manufacture of celluloid, as a solvent for cellulose acetate in the manufacture of varnishes and dopes, as a ftxative for perfumes, and for denaturing ethanol.
It finds some use as a specialist plasticiser in PVC, it has also been used as a blender and fixative in perfume.
Diethyl Phthalate is used in the following products: perfumes and fragrances, washing & cleaning products, laboratory chemicals, air care products, cosmetics and personal care products, polishes and waxes, pharmaceuticals, polymers, coating products and fillers, putties, plasters, modelling clay.
Other release to the environment of Diethyl Phthalate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Release to the environment of Diethyl Phthalate can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and formulation of mixtures.
Other release to the environment of Diethyl Phthalate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Diethyl Phthalate can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).
Diethyl Phthalate is intended to be released from scented: eraser, toys, paper products, CDs and clothes.
Diethyl Phthalate is used in the following products: laboratory chemicals, washing & cleaning products, perfumes and fragrances, cosmetics and personal care products, pharmaceuticals, polymers, polishes and waxes, air care products, coating products and fillers, putties, plasters, modelling clay.
Diethyl Phthalate is used in the following areas: health services, formulation of mixtures and/or re-packaging and scientific research and development.
Diethyl Phthalate is used for the manufacture of: plastic products and .
Other release to the environment of Diethyl Phthalate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Diethyl Phthalate is used in the following products: washing & cleaning products, cosmetics and personal care products, laboratory chemicals, polishes and waxes, pharmaceuticals, perfumes and fragrances, coating products, fillers, putties, plasters, modelling clay and air care products.
Release to the environment of Diethyl Phthalate can occur from industrial use: formulation of mixtures and formulation in materials.
Diethyl Phthalate is used in the following products: polymers, washing & cleaning products, cosmetics and personal care products, pharmaceuticals, air care products, coating products, fillers, putties, plasters, modelling clay, polishes and waxes, laboratory chemicals and perfumes and fragrances.
Diethyl Phthalate is used in the following areas: health services, formulation of mixtures and/or re-packaging and mining.
Diethyl Phthalate is used for the manufacture of: plastic products and chemicals.
Release to the environment of Diethyl Phthalate can occur from industrial use: in processing aids at industrial sites, as processing aid, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.
Diethyl Phthalate is commonly used to enhance the flexibility, durability, and workability of plastics, particularly in products such as film, sheet, and molded items.
It is especially used in the manufacturing of flexible polyvinyl chloride (PVC).
Diethyl Phthalate is a common ingredient in cosmetics, perfumes, and personal care products like lotions and deodorants.
It acts as a fixative in perfumes, helping to stabilize and prolong the fragrance.
Diethyl Phthalate is used in lacquers, varnishes, and inks to improve flexibility and performance, making these coatings less brittle and more resistant to cracking.
Diethyl Phthalate is utilized as a plasticizer in the formulation of enteric coatings for tablets and capsules, which are designed to prevent dissolution in the acidic environment of the stomach.
It is used as a solvent and carrier for pesticides and insect repellents, improving the distribution and effectiveness of these products.
Diethyl Phthalate is employed as a solvent for various chemical reactions and processes, including the manufacturing of dyes, pigments, and cellulose esters.
Diethyl Phthalate is used in the production of cellulose acetate, cellulose nitrate, and other resins to enhance flexibility and reduce brittleness.
Diethyl Phthalate serves as an additive in certain lubricants and hydraulic fluids, improving their performance under different conditions.
Safety Profile:
Poison by intravenous route.
Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes.
Human systemic effects by inhalation: lachrymation, respiratory obstruction, and other unspecified respiratory system effects.
An eye irritant and systemic irritant by inhalation.
Diethyl Phthalate an experimental teratogen.
Other experimental reproductive effects.
Combustible when exposed to heat or flame.
To fight fire, use water spray, mist, foam.
When heated to decomposition it emits acrid smoke and irritating fumes.
Diethyl phthalate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient.
However, if consumed in large quantities it can act as a narcotic and cause paralysis of the central nervous system.
Although some animal studies have suggested that high concentrations of diethyl phthalate may be teratogenic, other studies have shown no adverse effects.
