PRODUCTS

DIETHYLETHANOLAMINE (DEEA)

DIMETHYLETHANOLAMINE (DMAE)

Dimethyleneanolamine (DMAE or DMEA) is an organic compound with the formula (CH 3 )2 NCH 2CH2OH. This bifunctional contains both tertiary amine and primary alcohol functional groups. It is a colorless viscous liquid. It is used in skin care products to improve skin tone and is also taken orally as a nootropic. It is prepared with dimethylamine ethoxylate.

Cas No: 108-01-0
Ec No: 203-542-8

Industrial uses
Nitrogen mustard is a precursor to other chemicals such as 2-dimethylinoethyl chloride. Acrylate ester is used as flocculating agent.
Related compounds are used in gas purification, for example, in the removal of hydrogen sulfide from sour gas streams.
Dimethylethanolamine is a transparent, slightly yellow liquid. Miscible with water, acetone, ether and benzene.
Deanol is often referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE), or dimethylethanolamine (DMEA). It retains tertiary amine and primary alcohol groups as functional groups. Diethylaminoethanol has been used to treat attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia. It has also been used as an ingredient in skin care and cognitive function and mood-improving products.
Densities for dilute aqueous solutions of N,N-dimethylethanolamine (DMEA), 3-methoxypropylamine (3-MPA) and their protonated salts were measured relative to water at 283.15 K ≤ T ≤ 363.15 K and 0.1 MPa using vibrating tube densimeters. Volumetric heat capacities of the same solutions 283.15 K ≤ T ≤ 393.1
Twin fixed cell, power compensation at 5 K and 0.4 MPa was measured using differential temperature scanning nanocalorimeters. From these measurements, apparent molar volumes, Vϕ and heat capacities, Cp, ϕ were calculated and corrected for speciation to obtain standard partial molar properties Vo and Cpo for DMEA (aq), DMEAH + Cl- (aq), 3 species. -MPA (aq) and 3-MPA + Cl- (aq). The experimental values of Vo and Cpo measured in this study, combined with the high temperature values reported by Bulemela and Tremaine (J. Phys. Chem. B 2008, 112, 5626-5645) in the range of 423.15 to 598.15 K, can demonstrate the standard partial molar thermodynamic properties of aqueous species with temperature and temperature. A quasi-experimental "density" model that expresses it as a function of solvent density. The fitted parameters were used to obtain the ionization constant values of N,N-dimethylethanolamine and 3-methoxypropylamine from 283.15 to 598.15 K, with standard partial molar Gibbs energy at 298.15 K and literature values considered critical for reaction enthalpy.
Young female Litomosoides sigmodontis secretes a highly modified protein (Juv-p120) with dimethylethanolamine (DMAE). In an attempt to identify the source of these decoration worms, they were vibrated with [3H]-choline and [3H]-ethanolamine, and radio-isotope-labeled products were analyzed. Both isotope tags were successfully taken up by the worms, as shown by the predominantly labeling of phospholipids with phosphatidylcholine and [3H]-choline incorporated into [3H]-ethanolamine phosphatidylethanolamine. The isotope labeling of phosphatidylethanolamine was particularly striking with worms receiving approximately 30 times as much labeled ethanolamine as choline. It was possible to detect weak labeling of Juv-p120 with [3H]-ethanolamine after prolonged periods of exposure, but it was much more easily labeled with [3H]-choline in contrast to the situation with phospholipids. When vibrated with [3H]-ethanolamine, it was also possible to detect isotope-labeled phosphatidylcholine, which may ultimately be responsible for low levels of labeling of Juv-p120. Overall, our results raise the previously unconsidered but intriguing possibility that choline may be a precursor of DMAE in L. sigmodontis.
Diethylaminoethanol. Appearance: Colorless liquid. Less dense than water. Steam is heavier than air. It produces toxic nitrogen oxides during combustion. Causes burns to the skin, eyes and mucous membranes.
Diethylaminoethanol Odour: Sharp fishy amine odor
Diethylaminoethanol Molecular Formula: C6H15NO
Diethylaminoethanol Molecular Weight: 117.189
Diethylaminoethanol Melting point: -70°C
Diethylaminoethanol Boiling point: 161°C (lit)
Diethylaminoethanol Flash point: 103-140°F
Diethylaminoethanol Freezing point -70℃
Diethylaminoethanol Density: 0.884 g/mL at 25°C (bright)
Diethylaminoethanol PH: 11.5 (100 g/l, H2O, 20°C)
Diethylaminoethanol Vapor density: 4.04 (vs. air)
Diethylaminoethanol Vapor pressure: 1 mm Hg (20 °C)
Diethylaminoethanol Refractive index: n20 / D 1.441 (lit.)
Diethylaminoethanol Viscosity, dynamic: 4,022 mPa.s (25 °C)
Diethylaminoethanol Solubility: soluble
Diethylaminoethanol Solubility in Water: miscible
Diethylaminoethanol Explosion limit 0.7% (V)

Dimethylethanolamine (DMAE or DMEA) is an organic compound with the formula (CH3)2NCH2CH2OH. It is bifunctional, containing both a tertiary amine and primary alcohol functional groups. It is a colorless viscous liquid. It is used in skin care products. It is prepared by ethoxylation of dimethylamine.
DMAE (also known as dimethylaminoethanol, dimethylethanolamine, or Deanol) is a compound sometimes used as an ingredient in lotions, creams, and other skin care products. It is also available in dietary supplement form.
Product description
Amietol™ M21 (DMAE) is a clear hygroscopic liquid with an amine-like odor. The fresh distillate is colorless, but prolonged storage may cause a yellowish discoloration.
Nutraceutical uses
The bitartrate salt of DMAE, namely 2-dimethylaminoethanol (+)-bitartrate, is sold as a dietary supplement. It is a white powder that provides 37% DMAE.
DMEA (N,N-DIMETHYLETHANOLAMINE) is a clear, colorless liquid catalyst with ammonia odor. Compatible with water, alcohols, ether and aromatic solvents. It is mainly used in the preparation of water-reducible coating formulations.
Also, Dimethylethanolamine is one of the raw materials used to make dimethylaminoethyl methacrylate. (Polymers produced from methacrylate are used in various fields such as antistatic agents, soil conditioners, electrically conductive materials, paper auxiliaries and flocculant agents.)
Apart from these applications, Dimethylethanolamine can be used to control the corrosion in the condensing boiler water return lines.
Flocculants
DMAE is an important intermediate in the production of dimethylaminoethyl-(meth)acrylate. Water-soluble polymers produced from this ester, mostly by copolymerization with acrylamide, are used as flocculants.
useful as a
Pulp and paper chemicals
The dry strength or wet strength of the paper is increased by adding a dimethylaminoethyl (meth)acrylate homopolymer to unbleached kraft paper.
Ion exchange resins
Anion exchange resins can be prepared by reacting tertiary amines such as DMAE or trimethylamine with chloromethylated vinyl or styrene resin.
Increased exchange capacity is obtained by reacting a cross-linked polymer containing haloalkyl functions with an amine.
Anion exchange membranes are aminated with DMAE.
STORAGE OF DIETHYLAMINOETHANOL
Diethylaminoethanol Make sure the container is tightly closed before and after use. Diethylaminoethanol Store in a well-ventilated place and do not store together with strong oxidizers or other incompatible materials. Do not allow the material to freeze. Diethylaminoethanol Room temperature - normal conditions. If it freezes, the product may separate. Diethylaminoethanol is completely dissolved at room temperature and mixed thoroughly before using Diethylaminoethanol.
First of all, "What is DEEA (Diethylaminoethanol)?" You have to answer the question. Diethylethanolamine (Diethylaminoethanol, DEEA) is a natural substance found in fish, mostly sardines and salmon. Diethylethanolamine (Diethylaminoethanol, DEEA) It facilitates the release of a substance called "Acetylcholine", which is responsible for nerve transmission. Diethylethanolamine (Diethylaminoethanol, DEEA) Stimulates the formation of "phosphatidyl choline", an important element of the cell wall. It reduces the accumulation of molecular residue lipofuscin that accumulates in the cell as we age.
Our body is always subject to gravity. Our skin is constantly pulled down by the effect of gravity. In addition, our subcutaneous support tissue also decreases over time. This makes sagging easier. Here, Diethylethanolamine (Diethylaminoethanol, DEEA) tightens the skin, significantly reducing existing sagging and slowing its progression. Alpha lipoic acid and Concentrated Vitamin C: Both contain Diethylethanolamine (Diethylaminoethanol, DEEA) diethylaminoethanol], which prevents sagging on the skin. Diethylethanolamine (Diethylaminoethanol, DEEA) complex provides a visible and pleasant improvement. Diethylethanolamine (Diethylaminoethanol, DEEA) is mixed with other nutrients in a cocktail – basically an antioxidant – and when applied topically it quickly and dramatically improves the appearance of sagging skin. As an added bonus, Diethylethanolamine (Diethylaminoethanol, DEEA) enhances the effects of other antioxidants, resulting in increased smoothness, shine and reduced lines. What exactly is methylethanolamine (Diethylaminoethanol, DEEA)? Unlike the antioxidants I've discussed so far, Diethylethanolamine (Diethylaminoethanol, DEEA) is a membrane stabilizer. Due to its unique structure, Diethylethanolamine (Diethylaminoethanol, DEEA) really mixes with it and becomes a part of the cell plasma membrane. In this case, the membrane becomes more resistant to pressure and stabilizes than thanks to Diethylethanolamine (Diethylaminoethanol, DEEA). Diethylethanolamine (Diethylaminoethanol, DEEA) also provides protection against free radicals. Diethylethanolamine (Diethylaminoethanol, DEEA) - possibly by protecting other parts of the cell membrane from free radical attack - may thus act as an antioxidant. Thus, Diethylethanolamine (Diethylaminoethanol, DEEA) is an antioxidant membrane stabilizer. Diethylethanolamine (Diethylaminoethanol, DEEA) Inhibits disruption of the cell plasma membrane and the production of a bundle mediator that promotes inflammation with arachidonic acid. Diethylethanolamine (Diethylaminoethanol, DEEA) When mixed with other amino acids and nutrients, Diethylethanolamine (Diethylaminoethanol, DEEA) has a striking firming effect on the skin. The best source for diethylethanolamine (Diethylaminoethanol, DEEA) is fish. Brain food offered by nature. Diethylethanolamine (Diethylaminoethanol, DEEA) increases chemicals in the central nervous system that make us think logically. Millions of people take Diethylethanolamine (Diethylaminoethanol, DEEA) capsules to boost their memory function. They applied a gel containing diethylethanolamine (Diethylaminoethanol, DEEA). By applying a technique they called shear wave propagation, they found that the formula Diethylethanolamine (Diethylaminoethanol, DEEA) caused an increased shear wave velocity. As a result, Diethylethanolamine (Diethylaminoethanol, DEEA) thickened and tightened the skin. It was stated that long-term oral use of diethylethanolamine (Diethylaminoethanol, DEEA) would give the same result. When using diethylethanolamine (Diethylaminoethanol, DEEA), it is recommended to start with low daily doses (125 mg.) and gradually increase to 500 mg as needed. Acetylcholine cannot only be produced in the presence of Diethylethanolamine (Diethylaminoethanol, DEEA), vitamin B is also required. (Biotin, Folic Acid, B6, etc.) Therefore, those who expect improvement in their cognitive skills should use these nutrients together. Those who want to renew their skin with diethylethanolamine (Diethylaminoethanol, DEEA), arachido
should not forget the vitamin C supplement, which inhibits the production of nic acid. It is important to start the dose of diethylethanolamine (Diethylaminoethanol, DEEA) slowly. Diethylethanolamine (Diethylaminoethanol, DEEA) can overstimulate the nervous system. The results can be headaches, tense muscles, and insomnia. Manic patients should not use diethylethanolamine (Diethylaminoethanol, DEEA) because it can deepen the depressive phase. Diethylethanolamine (Diethylaminoethanol, DEEA) is a molecule that occurs in the process of making acetylcholine, one of the neurotransmitter chemicals of the nervous system. The researchers found that when products containing the chemical were applied, the cells filled with water and diethylethanolamine (Diethylaminoethanol, DEEA) swelled rapidly and the epidermal layer thickened. On the other hand, Diethylethanolamine (Diethylaminoethanol, DEEA) has toxic effects on skin cells. Diethylethanolamine (Diethylaminoethanol, DEEA) does not prevent cell division.

Polyurethane
In the production of PU foam for insulation, the use of DMAE is a practical and effective way to reduce the total cost of formula.
resins
Epoxy
DMAE is an effective and versatile curing agent for epoxy resins. It also acts as a viscosity reducing agent for resinous polyamides and other viscous hardeners. DMAE is also an extremely good wetting agent for a variety of filters in epoxy formulations.
Acrylic
DMAE improves the acid dyeing properties of acrylonitrile polymers by copolymerization of DMAE esters.

Water-soluble DMAE salts are used to improve the behavior of coatings and films, making them water resistant or providing the desired specific sensitivity to water.
Textile - leather
The acid dyeing ability of polyacrylonitrile is enhanced by copolymerization of acrylonitrile with DMAE esters such as dimethylaminoethyl acrylate.
Cellulose modified with a homopolymer of dimethylaminoethyl methacrylate can be dyed with ester salts of a leucoboat dye.
Impregnation of cellulose with polydimethylaminoethyl methacrylate also improves the gas fade resistance of the fabric.
DMAE's long chain alkylphosphates form anti-static agents for non-cellulosic hydrophobic textile materials.
Paints, coatings and inks
DMAE is excellent for neutralizing free acidity in water-soluble coating resins. The resin can be acrylic, alkyd or styrene-maleic. DMAE is generally preferred to triethylamine when lower volatility is required, such as in electrodeposition. It also increases the wettability of the pigment.
Some synthetic enamels with a metallic appearance can be prepared from dimethylaminoethyl methacrylate polymers.
In flexographic inks, DMAE can be used to dissolve resins and inoxes.
Adhesion of latex coatings can be improved by copolymerization of acrylic monomers with dimethylam.
inoethyl acrylate.
Surfactants - detergents
Alkylethanolamine salts of anionic surfactants are generally much more soluble than the corresponding sodium salts in both water and oil systems. DMAE can be an excellent starting material for the production of shampoo from fatty acids. Fatty acid soaps are particularly effective as wax emulsifiers for water-resistant floor finishes.
DMAE titanates, zirconates and other group IV-A metal esters are useful as dispersants for polymers, hydrocarbons and waxes in aqueous or organic solvent systems.
INDUSTRIAL USES OF DIETHYLAMINOETHANOL
oethanol used in the pharmaceutical industry for the production of local anesthetics procaine and chloroquine; and in the chemical industry for the production of water-soluble salts, fatty acid derivatives, derivatives containing tertiary amine groups, emulsifiers, specialty soaps, cosmetics and textiles and fibers (HSDB 1988).
Diethylethanolamine (Diethylaminoethanol, DEEA) is a clear, colorless liquid catalyst with an ammonia odor. Diethylethanolamine (Diethylaminoethanol, DEEA) Compatible with water, alcohol, ether and aromatic solvents. Diethylethanolamine (Diethylaminoethanol, DEEA) Can be reduced predominantly with water. Diethylethanolamine (Diethylaminoethanol, DEEA) is used in the preparation of coating formulations. Also Diethylethanolamine (Diethylaminoethanol, DEEA) is one of the raw materials used to make diethylaminoethyl methacrylate. Diethylethanolamine (Diethylaminoethanol, DEEA) (polymers produced from methacrylate are used in various fields such as antistatic agents, soil conditioners, electrically conductive materials, paper aids and flocculants.) boiler water return lines. Diethylethanolamine (Diethylaminoethanol, DEEA) is used in cholinergic nootropy drugs used as dietary supplements and as a drug in the treatment of symptoms of Alzheimer's disease. Diethylethanolamine (Diethylaminoethanol, DEEA) and 4-chlorophenoxyacetic acid (pCPA) Diethylethanolamine (Diethylaminoethanol, DEEA) is a natural substance found in fish; Diethylethanolamine (Diethylaminoethanol, DEEA) pCPA is a synthetic compound similar to various plant hormones called auxins.
power. Meclofenoxate hydrochloride, an ester of diethylethanolamine (Diethylaminoethanol, DEEA) and 4-chlorophenoxyacetic acid (pCPA), has been shown to improve memory, have a mentally stimulating effect, and improve general consciousness. Meclofenoxate increases Diethylethanolamine (Diethylaminoethanol, DEEA) levels in the brain. Diethylethanolamine (Diethylaminoethanol, DEEA) is a precursor to acetylcholine, Diethylethanolamine (Diethylaminoethanol, DEEA) is an important neurotransmitter believed to be responsible for most cognitive processes in the brain. In many ways, it's seen as a more effective version of Diethylethanolamine (Diethylaminoethanol, DEEA) and an excellent source of choline for your brain, an ester of diethylethanolamine (Diethylaminoethanol, DEEA) and 4-chlorophenoxyacetic acid (pCPA), a mental stimulant effect. and improved general informatics.
Diethylethanolamine (Diethylaminoethanol, DEEA) is thought to increase the production of Acetylcholine (a chemical that helps nerve cells transmit signals). Because acetylcholine plays an important role in many brain functions such as learning and memory, proponents claim that taking Diethylethanolamine (Diethylaminoethanol, DEEA) in supplement form can improve brain health by raising acetylcholine levels.
Diethylethanolamine (Diethylaminoethanol, DEEA) is also said to reduce beta-amyloid accumulation (a pigment that impairs cognitive function and is associated with age-related cognitive decline). Some advocates claim that the use of Diethylethanolamine (Diethylaminoethanol, DEEA) supplements has potential in the prevention of Alzheimer's disease.
Dimethylethanolamine
Dimethylaminoethanol, also known as DMAE or dimethylethanolamine, is an organic compound. This compound is also referred to by the names N,N-dimethyl-2-aminoethanol, beta-dimethylaminoethyl alcohol, beta-hydroxyethyldimethylamine, and Deanol. It is a clear to pale yellow liquid.
Dimethylethanolamine, also known as 2-dimethylaminoethanol or DMEA, belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group attached to the C1 atom and an alcohol group attached to the C2 atom. Dimethylethanolamine is used as a food additive. Dimethylethanolamine is a very strong basic compound (based on its pKa). Dimethylethanolamine is a potentially toxic compound. Dimethylethanolamine has been used to treat attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia.
Dimethylethanolamine is often referred to as 2-(dimethylamino)ethanol, Dimethylethanolamine (DMAE), or dimethylethanolamine (DMEA). These are organic compounds containing an alkylamine group. Contains tertiary amine and primary alcohol
groups as functional groups. It has also been used as an ingredient in skin care and cognitive function and mood-improving products.
Dimethylethanolamine, also known as dimethylaminoethanol (DMEA and DMAE, respectively), is an organic compound produced industrially by the reaction of ethylene oxide with dimethylamine. It contains both an amine group and a hydroxyl group and can therefore react as an amine or an alcohol. It is a clear, pale yellow liquid.
It belongs to the class of organic compounds known as aminoalcohols. These are organic compounds containing an alkyl chain with an amine group attached to the C1 atom and an alcohol group attached to the C2 atom.

Diethanolamine
Diethanolamine
Diethanolamine
Skeletal formula of Diethanolamine
Ball and stick model of diethanolamine molecule

Related compounds Diethylhydroxylamine
Unless otherwise stated, data are given for materials in their standard form.
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Infobox references
Diethanolamine, often abbreviated as Diethanolamine or DEOA, is an organic compound with the formula HN (CH2CH2OH). Pure Diethanolamine is a white solid at room temperature, but its tendency to absorb water and supercool means it is often encountered as a colorless, viscous liquid. Diethanolamine is polyfunctional, it is a secondary amine and a diol. Like other organic amines, Diethanolamine acts as a weak base. Reflecting the hydrophilic character of the secondary amine and hydroxyl groups, diethanolamine is soluble in water. Amides prepared from diethanolamine are generally hydrophilic. chemica in 2013
Organic amines are corrosion control agents that raise the pH and remove corrosive contaminants. For example, dimethylethanolamine (DMEA) is a common corrosion inhibitor that removes dissolved CO2 and helps control pH in industrial boilers and nuclear power plants. Amines are also effective as hydrogen sulfide scavengers in oil and gas production and processing. On-site monitoring for amines can help maintain proper corrosion protection, extend system life, and prevent costly corrosion-induced shutdowns and failures.
Production
Dimethylaminoethanol, catalyst, corrosion inhibitor, paint strippers / boiler water / ami
no is used as an additive to resins and is used in cosmetic and biomedical products.
The reaction of ethylene oxide with aqueous ammonia first produces ethanolamine:
C2H4O + NH3 → H2NCH2CH2OH
reacts with the second and third equivalents of ethylene oxide to give diethanolamine and triethanolamine:
C2H4O + H2NCH2CH2OH → HN (CH2CH2OH) 2
C2H4O + HN (CH2CH2OH) 2 → N (CH2CH2OH) 3
In this way, approximately 300M kg is produced annually. The ratio of products can be controlled by changing the stoichiometry of the reactants.
Uses
Diethanolamine is used as a surfactant and corrosion inhibitor. It is used to remove hydrogen sulfide and carbon dioxide from natural gas.
Diethanolamine is widely used in the preparation of diethanolamides and diethanolamine salts of long chain fatty acids formulated as surfactants and soaps used in liquid laundry and dishwashing detergents.
cosmetics, shampoos and conditioners. In oil refineries, a water solution of Diethanolamine is commonly used to remove hydrogen sulfide from acidic gas. It has an advantage over ethanolamine, a similar amine, because a higher concentration can be used for the same corrosion potential. This allows refiners to clean hydrogen sulfide at a lower circulating amine rate with less overall energy use.
Diethanolamine is a chemical raw material used in the production of morpholine.
morpholine from DEA.png
Amides derived from fatty acids known as diethanolamine and diethanolamides are amphiphilic.
Reaction of 2-chloro-4,5-diphenyloxazole with Diethanolamingave increases Ditazole. The reaction of Diethanolamine and Isobutyraldehyde with the extracted water produces an Oxazolidine.
Commonly used ingredients that may contain DEA
Diethanolamine is used in the production of diethanolamides, which are common ingredients in cosmetics and shampoos added to provide a creamy texture and foaming effect. As a result, some cosmetics containing diethanolamides as ingredients contain DEA. Some of the most commonly used diethanolamides include:
Cocamide DEA
DEA-Cetyl Phosphate
DiethanolamineOleth-3 Phosphate
Lauramide DEA
Myristamide DEA
Oleamide DEA
Safety

Properties of diethanolamine
Molecular Formula: C4H11NO2
Molecular Weight: 105.137 g/mol
Flash Point: 176° (349°F)
Boiling Point: 268-270°
Flash Point: 176° (349°F)
Density: 1.097

Reactivity Profile
Diethanolamine is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that develops per mole of amine in a neutralization is largely independent of the strength of the amine as a base. May be incompatible with amines, isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides and acid halides. Combustible gaseous hydrogen is produced by amines along with strong reducing agents such as hydrides. This compound is hygroscopic. May be sensitive to air and light exposure. This compound can react with oxidizing materials, acids, CO2, copper alloys, aluminum, zinc, galvanized iron and copper.
Applications
Diethanolamine is used in the preparation of morpholine and diethanolamides, an active ingredient in cosmetics and shampoos. It acts as a surfactant and corrosion inhibitor. It is used to remove hydrogen sulfide and carbon dioxide from natural gas. It is also an intermediate used as a humectant and softener in rubber chemicals, and as an emulsifier and dispersing agent in agricultural chemicals. In addition, it is used to cut oils, cleaners, soaps, polishes and medicines.
The EPA has not set a Reference Concentration (RfC) or Reference Dose (RfD) for diethanolamine. The California Environmental Protection Agency (CalEPA) has established a chronic reference exposure level of 0.02 milligrams per cubic meter (mg/m) for diethanolamine based on effects on blood in mice. The CalEPA reference exposure level is a concentration at which adverse health effects are unlikely to occur. It is not a direct risk estimator, but a benchmark for measuring potential impacts. At lifetime exposures, the potential for adverse health effects increases progressively beyond the reference exposure level.

Air and Water Reactions
It is soluble in water.

CAMEO Chemicals
Diethanolamine is a member of the class of ethanolamines, ethanolamine with an N-hydroxyethyl substituent. It acts as a human xenobiotic metabolite. It is derived from an ethanolamine.
CHEBI
Diethanolamine is used in a number of consumer products such as shampoos, cosmetics and pharmaceuticals. Limited information is available on the health effects of diethanolamine. Acute (short-term) inhalation exposure to diethanolamine in humans may cause irritation of the nose and throat, and skin exposure may irritate the skin. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of diethanolamine in humans.
is l. Analysis
Diethanolamine can be determined in the workplace air by drawing the air sample through aqueous hexanesulfonic acid and analyzing it by ion chromatography. The range for this method is 0.30–19.5 mg per 100 L of air sample.
Diethanolamine can be determined in air by sampling air from sampling tubes containing XAD-2 resin coated with 10% 1-naphthylisothiocyanate. Samples are analyzed by desorbing the adsorbent with dimethylformamide and quantifying the amine derivative by high performance liquid chromatography using ultraviolet detection.
Exposure to diethanolamine from metalworking fluids was determined by high performance liquid chromatography / mass spectrometry analysis of aqueous handwash solutions and personal air samples collected in acid-treated glass fiber filters.
Diethanolamine levels in shampoo products can be determined by liquid chromatography / thermal energy analysis after conversion to N-nitrosodiethanolamine with acetic acid and sodium nitrite.
Production and use
Production
Diethanolamine is produced by reacting ethylene oxide with ammonia. In most manufacturing plants, ethylene oxide and ammonia are reacted in a batch process yielding a crude mixture of ethanolamine, diethanolamine, and triethanolamine. The mixture is then distilled to separate and purify the individual compounds.
Eth anolamines became commercially available in the early 1930s; Due to the large-scale production of ethylene oxide, they gained increasing commercial importance as intermediates after 1945. Economical production of very pure, colorless ethanolamines has been possible since the mid-1970s.
It is estimated that 45,900 and 75,400 tons of diethanolamine were produced in the USA in 1972 and 1983, respectively.

Worldwide production of ethanolamine in 1985 was approximately (one thousand tons per year): USA, 220; western Europe, 145; southeast Asia, 40; South America, 18; and Eastern Europe, 4. About 50% of world ethanolamine production in 1985 was mono-ethanolamine, 30-35% diethanolamine and 15-20% triethanolamine.
The annual world capacity for ethanolamines in 2005 was estimated at 1,500,000 tons, 400,000 tons for Europe (eight production sites), 780,000 tons for North and South America (seven production sites), Middle East (one production site) and Asia/Pacific region for 300,000 tons (11 production sites). Data on individual capacities for diethanolamine were not available.
Information obtained in 2010 showed that diethanolamine was produced by 29 companies in the USA, seven companies in Mexico, three companies in the People's Republic of China and the United Kingdom, and two companies in Canada, Germany, China (Hong Kong SAR) and Canada. One company each in India and Belgium, the Slovak Republic and Switzerland (Chemical Sources International, 2010). Other sources indicated that diethanolamine is produced by five companies in the US, five companies in Germany, three companies in the UK, three companies in the Netherlands, and one company each in Austria, Belgium, Denmark and Sweden.
Use
Diethanolamine is widely used in the preparation of diethanolamides and diethanolamine salts of long chain fatty acids formulated as surfactants and soaps used in liquid laundry and dishwashing detergents, cosmetics, shampoos and conditioners. Diethanolamine is also used in the manufacture of lubricants in the textile industry, to remove acid gases in industrial gas purification, and as an emulsifier and dispersing agent in the preparations of agricultural chemicals. Diethanolamine is used as a corrosion inhibitor in cutting, stamping and die casting processes in metalworking fluids. In the manufacture of detergents, cleaners, fabric solvents and metalworking fluids, diethanolamine is used for acid neutralization and soil deposition. Aqueous solutions of diethanolamine are used as solvents for numerous intravenously administered drugs. Shampoos and hair dyes may contain free diethanolamine as a component and/or contaminant of fatty acid alkanolamides, usually in the range of 0.2–10%. Diethanolamine is used together with sulfolane in the sulpholine process to absorb carbon dioxide and hydrogen sulfide gases.
The database for substances in preparations in the Nordic countries lists a wide variety of diethanolamine uses registered in Denmark, Norway, Sweden and Finland. In 2004, 520 preparations containing diethanolamine were registered in Denmark, accounting for a total volume of 19 865.8 tons. 103 (856.8 tons), 307 (459.0 tons) and 75 (132.7 tons) products were registered in Norway, Sweden and Finland, respectively. Use categories include intermediates, cleaning/washing agents, paints, lacquers and varnishes, surface treatments, cutting fluids, pH regulators, impregnations, surfactants, corrosion inhibitors, process regulators, coloring agents, reprographic agents, lubricants and additives. exists. . Indicated for products registered in Norway and Sweden for use in consumer preparations
is not.
Occurrence and exposure
natural event
Diethanolamine is not known to occur as a natural product.
Synonyms:
2-(Dimethylamino)ethanol
deanol
,N-Dimethylethanolamine
108-01-0
Dimethylaminoethanol
Dimethylethanolamine
norcholine
2-DIMETHYLAMINOETHANOL
DMAE
DMEA Bimanol
liparon
N,N-Dimethylaminoethanol
varesal
Propamine A
Ethanol, 2-(dimethylamino)-
(2-Hydroxyethyl)dimethylamine
Kalpur P
N-Dimethylaminoethanol
Dimethylmonoethanolamine
Dimethylaminoaethanol
N,N-Dimethyl-2-aminoethanol
Amietol M 21
N,N-Dimethyl-2-hydroxyethylamine
N,N-Dimethyl ethanolamine
2-(N,N-Dimethylamino)ethanol
Dimethyl(hydroxyethyl)amine
Texacat DME
Dimethylaethanolamine
Dimethyl(2-hydroxyethyl)amine
2-(Dimethylamino)-1-ethanol
N-(2-Hydroxyethyl)dimethylamine
N,N-Dimethyl-N-(2-hydroxyethyl)amine
2-(Dimethylamino)ethanol
(Dimethylamino)ethanol
Beta-Hydroxyethyldimethylamine
2-(dimethylamino)ethan-1-ol
2-Dimethylamino-ethanol
beta-Dimethylaminoethyl alcohol
2-Dwumetyloaminoethanol
N-(Dimethylamino)ethanol
N,N-Dimethyl-N-(beta-hydroxyethyl)amine
Tegoamine DMEA
NSC 2652
Dabco DMEA
UNII-2N6K9DRA24
Deanol [BAN]
2-Dimethylamino ethanol
N,N-Dimethyl(2-hydroxyethyl)amine
MFCD00002846
N,N'-Dimethylethanolamine
2-(dimethylamino)-ethanol
(CH3)2NCH2CH2OH
CHEMBL1135
beta.-(Dimethylamino)ethanol
2N6K9DRA24
beta.-Hydroxyethyldimethylamine
CHEBI:271436
Phosphatidyl-N-dimethylethanolamine
Deanol (BAN)
N,N-IMETHYLAMINOETHANOL (DMAE)
NCGC00159413-02
demanol
Demanyl
tonibral
N,N-Dimethyl-N-(.beta.-hydroxyethyl)amine
DSSTox_CID_505
DSSTox_RID_75628
SSTox_GSID_20505
N,N-Dimethylethanolamine (2-Dimethylaminoethanol)
N,N-Dimethylethanolamine, 99%
Deanol (N,N-Dimethylethanolamine)
CAS-108-01-0
Dimethylaethanolamine [German]
Dimethylamino ethanol
Dimethylaminoaethanol [German]
CCRIS 4802
2-Dwumetyloaminoethanol [Polish]; HSDB 1329
EINECS 203-542-8
UN2051
BRN 1209235
N,N-Dimethyl-N-ethanolamine
AI3-09209
Jeffcat DMEA
Dimethylethanoiamine
Toyocat -DMA
dimethyl ethanolamine
dimethyl-ethanolamine
Paresan (Salt/Mix)
dimethyl ethanol amine
2-dimethyamino-ethanol
n,n-dimethylethanolamine
Biocoline (Salt/Mix)
N,N dimethylaminoethanol
N,N-dimethyl-ethanolamine
N,N-dimethylamino ethanol
N,N-dimethylethanol amine
N,N-dimethylethanol-amine
ACMC-1C0DD
2-ydroxyethyldimethylamine
2-Dimethylaminoethanol [UN2051] [Corrosive]
EC 203-542-8
beta -(dimethylamino)ethanol
CN(C)CC[O]
Dimethylaminoaethanol(german)
Choline chloride (Salt/Mix)
Luridin chloride (Salt/Mix)
beta -hydroxyethyldimethylamine
N,N-imethylethanolamine/DMEA
beta-dimethylaminoethyl alcohol
2-(N,N-dimethyl amino)ethanol
-N,N-dimethylamino) ethanol
DTXSID2020505
N-hydroxyethyl-N,N-dimethylamine
beta.-Dimethylaminoethyl alcohol
2-(N,N-dimethyl amino) ethanol
Ni(1/4)OEN-Dimethylethanolamine
NSC2652
beta -(dimethylamino)ethyl alcohol
2-hydroxy-N,N-dimethylethanaminium
WLN: Q2N1 & 1
2-Dimethylaminoethanol, >=99.5%
BCP22017
CS-M3462; NSC-2652
ZINC1641058
beta.-(Dimethylamino)ethyl alcohol
N,N-Dimethyl(2-hydroxyethyl)amine
Tox21_113163
ox21_201821
Tox21_302844
ANW-56403
BDBM50060526
N,N-Dimethyl-beta-ydroxyethylamine
STL282730
Dimethylaminopropylamine Reagent Grade
AKOS000118738
N,N-Dimethyl-.beta.-hydroxyethylamine
DB13352
MCULE-7567469160
MP-2185
UN 2051
N,N-Dimethyl-N-(2-hydroxyethyl)amine
NCGC00159413-03
NCGC00256454-01
NCGC00259370-01
BP-13447
N,N-Dimethyl-N-(beta-hydroxyethyl)amine
DB-002821
N,N-Dimethyl-N-(beta-hydroxyethyl)amine
D0649
D07777
2-Dimethylaminoethanol [UN2051] [Corrosive]
2-Dimethylaminoethanol, purum, >=98.0% (GC)
115479-EP2275420A1
115479-EP2277875A2
115479-EP2280008A2
115479-EP2295416A2
Q241049
2-Dimethylaminoethanol, analytical reference material
2-Dimethylaminoethanol, SAJ first grade, >=99.0%
W-108727
F1908-0086
2-Dimethylaminoethanol, purified by redistillation, >=99.5%