PRODUCTS

DIPOTASSIUM GUANYLATE

Dipotassium guanylate is commonly used in the production of processed foods, meats, soups, condiments, as well as in powdered products such as instant soups and sauces.
Dipotassium guanylate is also used in the pharmaceutical industry as a flavor regulator in medicines.
In the flavor manufacturing industry, dipotassium guanylate is widely incorporated into savory flavor systems, meat flavor formulations, seafood flavor preparations, bouillon products, seasoning powders, and culinary flavor concentrates.

CAS Number: 3254-39-5
EC Number: 221-849-5
IUPAC name: Dipotassium 5′-guanylate (dipotassium guanosine‑5′‑monophosphate)
E number: E628 (flavour enhancer)
Molecular formula: K₂C₁₀H₁₂N₅O₈P
Molecular weight: ~439.40 g/mol

SYNONYMS:
Potassium 5′-guanylate, Potassium guanylate, 5′-Guanosine monophosphate dipotassium salt, 5′-Guanylic acid dipotassium salt, dipotassium 5′-O-phosphonatoguanosine, E628, INS 628, Dipotassium 5′-guanylate, Dipotassium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5′-Guanosine monophosphate dipotassium salt, 5′-Guanylic acid dipotassium salt, E628, Dipotassium 5'-guanylate, 3254-39-5, Dipotassium guanylate, UNII-R87C8160YV, R87C8160YV, potassium guanylate, EINECS 221-849-5, POTASSIUM 5'-GUANYLATE, INS NO.628, INS NO. 628, INS-628, E-628, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, Potassium guanylatePotassium 5'-guanylate, 221-849-5, 5'-Guanylic acid, dipotassium salt, dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, E628, SCHEMBL3802708, DTXSID80954279, 5'-Guanylic acid,dipotassium salt, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), Q5280047, dipotassium guanosine-5'-monophosphate, dipotassium guanylate, dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5'-guanylic acid dipotassium salt, potassium 5'-guanylate, potassium guanylate, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), DIPOTASSIUM 5'-GUANYLATE, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, DIPOTASSIUM GUANYLATE, E628, E-628, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, INS NO. 628, INS NO.628, INS-628, POTASSIUM 5'-GUANYLATE, POTASSIUM GUANYLATE, dipotassium guanosine-5'-monophosphate, dipotassium guanylate, dipotassium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5'-guanylic acid dipotassium salt, potassium 5'-guanylate, potassium guanylate, Dipotassium 5'-guanylate, 3254-39-5, Dipotassium guanylate, UNII-R87C8160YV, R87C8160YV, potassium guanylate, EINECS 221-849-5, POTASSIUM 5'-GUANYLATE, INS NO.628, INS NO. 628, INS-628, E-628, DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT, RefChem:134793, Potassium guanylate, Potassium 5'-guanylate, 221-849-5, 5'-Guanylic acid, dipotassium salt, dipotassium,[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, E628, SCHEMBL3802708, DTXSID80954279, 5'-Guanylic acid,dipotassium salt, Dipotassium 5'-O-phosphonatoguanosine, 5'-GUANYLIC ACID, POTASSIUM SALT (1:2), Q5280047, dipotassium guanosine-5'-monophosphate, dipotassium guanylate, dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate, 5'-guanylic acid dipotassium salt, potassium 5'-guanylate, potassium guanylate, Dipotassium Guanylate, Dipotassium 5′-Guanylate, Dipotassium 5'-Guanylate, Dipotassium Guanosine-5′-Monophosphate, Dipotassium Guanosine 5′-Monophosphate, Dipotassium GMP, Guanylic Acid Dipotassium Salt, Guanosine Monophosphate Dipotassium Salt, Potassium Guanylate, E628, INS 628, Dipotassium 5′-GMP, GMP Dipotassium Salt

Dipotassium guanylate is a compound with formula K2(C10H12O4N5PO4).
Dipotassium guanylate is a potassium salt of guanylic acid.
Dipotassium guanylate is an organic chemical compound that belongs to the group of flavor enhancers.

Dipotassium guanylate is the potassium salt of guanylic acid, which is produced synthetically.
Dipotassium guanylate is in the form of a white powder with very fine grains.
Dipotassium guanylate is water-soluble, which makes it easy to use in the food industry.

Dipotassium guanylate has the ability to enhance the flavor of foods, especially when combined with other flavor enhancers such as monosodium glutamate (E621) and disodium inosinate (E631).
Dipotassium guanylate is an approved food additive used as a flavor enhancer that intensifies the umami taste in processed foods.

E628, also known as Dipotassium guanylate or dipotassium 5-guanylate, is a food additive belonging to the group of nucleotide flavor enhancers.
Dipotassium guanylate is the dipotassium salt of guanylic acid (GMP, guanosine 5-monophosphate).
Dipotassium guanylate is approved as a food additive in the European Union and is primarily used to intensify the savory umami taste in processed foods.

Dipotassium guanylate has food additive with flavor enhancing role.
Dipotassium guanylate is the potassium salt of guanylic acid, a natural acid, component of ribonucleic acid.

USES and APPLICATIONS of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate is primarily used as a flavor enhancer in a wide range of food products.
Dipotassium guanylate is commonly added to soups, broths, instant noodles, savory snacks, seasoning blends, sauces, processed meats, frozen meals, ready-to-eat foods, and convenience products.

Dipotassium guanylate's primary function is to strengthen umami perception and improve the overall flavor profile of foods without substantially altering their composition.
Dipotassium guanylate is widely used as a food additive.
Dipotassium guanylate is commonly used in the production of processed foods, meats, soups, condiments, as well as in powdered products such as instant soups and sauces.

Dipotassium guanylate is also used in the pharmaceutical industry as a flavor regulator in medicines.
In the flavor manufacturing industry, dipotassium guanylate is widely incorporated into savory flavor systems, meat flavor formulations, seafood flavor preparations, bouillon products, seasoning powders, and culinary flavor concentrates.

Dipotassium guanylate helps create rich and long-lasting savory notes that enhance consumer acceptance and product quality.
Dipotassium guanylate is particularly valuable in reduced-sodium formulations.
Because Dipotassium guanylate significantly increases flavor intensity, food manufacturers can lower salt content while preserving desirable taste characteristics.

This application has become increasingly important as consumers and regulatory authorities focus on reducing dietary sodium intake.
Dipotassium guanylate is frequently used in combination with Disodium guanylate (E627) or Disodium inosinate (E631), as these combinations produce a particularly strong synergistic flavor effect.

For industrial use, Dipotassium guanylate is obtained from yeast or from sardines, having plant or animal origin.
Guanylates do not give the “umami” taste specific to glutamates, but have the ability to enhance a lot of natural flavors and tastes, thus allowing the required amount of salt to be reduced.

Dipotassium guanylate is used in the quantities on the recipes in all types of food, including alcoholic and non-alcoholic beverages.
Dipotassium guanylate is also used in plant-based meat alternatives and vegetarian savory products to improve flavor complexity and mimic the taste characteristics traditionally associated with meat and meat-derived ingredients.

Uses of Dipotassium guanylate: Canned vegetables
Common applications of Dipotassium guanylate: Chips, snacks, powder soups, pâtés, pizza, sauces, spices, rice, pre-cooked foods, olives, charcuterie, meat products, fish derivatives, dietetic products to reduce salt content
E628 is the European food-additive number for Dipotassium guanylate.

Dipotassium guanylate (E628) is a food additive used as a food additive.
Dipotassium Guanylate is the potassium salt of guanylic acid E626.
Guanylic acid is a natural acid, which is part of RNA, one of the genetic carrier molecules in the cell.

Dipotassium guanylate is thus part of all cells in all living organisms.
Dipotassium guanylate is commercially prepared from yeast extract or sardines.
Dipotassium guanylate has food additive with flavor enhancing role.

Dipotassium guanylate is the potassium salt of guanylic acid, a natural acid, component of ribonucleic acid.
For industrial use, Dipotassium guanylate is obtained from yeast or from sardines, having plant or animal origin.
Guanylates do not give the “umami” taste specific to glutamates, but have the ability to enhance a lot of natural flavors and tastes, thus allowing the required amount of salt to be reduced.

Dipotassium guanylate is used in the quantities on the recipes in all types of food, including alcoholic and non-alcoholic beverages
Dipotassium Guanylate is found in instant noodles, potato chips and snacks, savoury rice, tinned vegetables, cured meats, packet soup.
Asthmatic people should avoid guanylic acid and guanylates.

As guanylates are metabolised to purines, they should be avoided by people suffering from gout.
Guanylates are generally produced from yeasts, but partly also from fish.
They may thus not be suitable for vegans and vegetarians.

Dipotassium Guanylate is the dipotassium salt of guanylic acid (guanosine-5′-monophosphate, GMP), a naturally occurring nucleotide found in RNA and in many biological organisms.
Dipotassium guanylate is widely used as a flavor enhancer in the food industry and is identified by the food additive number E628.

Dipotassium guanylate is valued for its ability to intensify savory and umami flavors, particularly when used in combination with glutamates such as monosodium glutamate (MSG).
Dipotassium guanylate is commonly incorporated into processed foods, seasonings, soups, snacks, and meat products to improve overall flavor perception while allowing reduced salt usage.
As a food additive, Dipotassium guanylate is used as a flavor enhancer and has the E number E628.

-Use in Food Products
Dipotassium guanylate is used in the food industry to improve flavor profiles and to reduce the amount of other additives such as monosodium glutamate (E621).
Typical applications of Dipotassium guanylate include: Instant soups and sauces, Seasoning blends and snacks, Ready meals and processed meat products, Savory crackers and snack foods, Soy sauces and other condiments.

CHARACTERISTICS of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate belongs to a group of compounds known as flavor-enhancing nucleotides.
Dipotassium guanylate is one of the most potent umami enhancers used in food technology and functions primarily by amplifying existing savory flavors rather than contributing a strong flavor of its own.

Dipotassium guanylate is especially effective when combined with glutamate-containing ingredients.
This synergistic relationship dramatically increases umami intensity and creates a richer, fuller taste profile.
As a result, dipotassium guanylate is frequently used alongside monosodium glutamate, yeast extracts, hydrolyzed vegetable proteins, and fermented flavor ingredients.

Because guanylic acid naturally occurs in living organisms as a component of RNA, dipotassium guanylate is chemically related to substances already present in many foods.
Dipotassium guanylate is highly effective at very low concentrations, making it an economical and efficient flavor enhancer.

Another important characteristic is Dipotassium guanylate's potassium content.
Unlike sodium-based flavor enhancers, dipotassium guanylate may be used in formulations designed to reduce sodium levels while maintaining desirable flavor intensity.

MECHANISM OF ACTION of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate enhances taste by binding to specific taste receptors on the tongue, particularly the umami receptors (T1R1/T1R3).
This intensifies the perception of savory, meaty flavors without having a strong taste of its own.
In combination with glutamates, a synergistic effect is created that significantly amplifies the overall taste of a dish.

ORIGIN AND PRODUCTION of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate is produced industrially, often through yeast fermentation or chemical synthesis from natural starting materials.
Guanylic acid itself occurs naturally in many foods, particularly in dried mushrooms such as shiitake, as well as in fish and meat.

DIPOTASSIUM GUANYLATE AND ITS FUNCTIONS IN FOODS
Dipotassium guanylate plays an important role as a flavor enhancer in the food industry.
Dipotassium guanylate's addition to food allows to increase the intensity of flavor and improve the organoleptic qualities of food products.
Dipotassium guanylate can make foods appear more aromatic and tasty, which contributes to their appeal to consumers.

ADDITIONAL TECHNICAL INFORMATION of DIPOTASSIUM GUANYLATE:
Dipotassium guanylate belongs to a family of nucleotide flavor enhancers that includes guanylic acid (GMP), disodium guanylate (E627), calcium guanylate (E629), disodium inosinate (E631), and dipotassium inosinate (E632).
These compounds are among the most effective umami-enhancing substances used in modern food technology.

The flavor-enhancing activity of dipotassium guanylate originates from the guanosine monophosphate (GMP) structure.
GMP naturally occurs in many foods, including mushrooms, yeast extracts, and various fermented products, where it contributes to desirable savory flavor characteristics.

Commercial production generally involves the purification of guanylic acid obtained through fermentation or biological extraction, followed by neutralization with potassium compounds to form the dipotassium salt.
Due to its strong effectiveness at low concentrations and excellent compatibility with other flavor ingredients, dipotassium guanylate remains an important component of modern food formulation and flavor development.

BENEFITS of DIPOTASSIUM GUANYLATE:
One of the primary benefits of dipotassium guanylate is its exceptional flavor-enhancing potency.
Very small quantities can significantly improve savory taste perception and increase the richness of food products.
Another important benefit is Dipotassium guanylate's powerful synergistic interaction with glutamates.

When combined with MSG or naturally occurring glutamate sources, dipotassium guanylate produces a flavor-enhancing effect much greater than either ingredient alone.
Dipotassium guanylate contributes to fuller mouthfeel, greater flavor depth, and improved overall taste balance.
Dipotassium guanylate can also help mask undesirable flavor notes in certain processed foods and improve consumer acceptance of reduced-sodium products.

Because it contains potassium rather than sodium, dipotassium guanylate can support formulation strategies aimed at lowering sodium content while maintaining flavor quality.
Dipotassium guanylate is also highly effective at low concentrations, making it a cost-efficient ingredient in food manufacturing.

PHYSICAL and CHEMICAL PROPERTIES of DIPOTASSIUM GUANYLATE:
IUPAC name: Dipotassium 5′-guanylate (dipotassium guanosine‑5′‑monophosphate)
CAS: 3254-39-5
EC / EINECS: 221‑849‑5
PubChem CID: 22841446
ChemSpider ID: 18598953
Molecular formula: K₂C₁₀H₁₂N₅O₈P
Molecular weight: ~439.40 g/mol
Appearance: White or colorless crystalline powder; odorless
Solubility: Freely soluble in water; practically insoluble in ethanol

Structure details: Sugar-phosphate backbone with guanine base, two K⁺ counterions
Chemical formula: C10H12K2N5O8P
Molar mass: 439.403 g·mol−1
Molecular Weight: 439.40 g/mol
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 3
Exact Mass: 438.9697623 Da
Monoisotopic Mass: 438.9697623 Da

Topological Polar Surface Area: 207 Å²
Heavy Atom Count: 26
Formal Charge: 0
Complexity: 586
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)
ECHA EINECS - REACH Pre-Reg: 221-849-5
FDA UNII: R87C8160YV
Molecular Weight: 439.40460200
Formula: C10 H12 K2 N5 O8 P
Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No

Soluble in: water, 1e+006 mg/L @ 25 °C (est)
Ingredients: Dipotassium Guanylate (E628)
Solubility: Freely Soluble in Water
Application: Flavor Enhancer, Food Industry
Source: Other, Chemical Synthesis
Chemical Composition: C10H12K2N5O8P
Product Type: Food Additive
Form: Powder
Color: White
Shelf Life: 2 Years
Moisture: <5.0%
Flavor: Umami

ECHA EINECS - REACH Pre-Reg: 221-849-5
FDA UNII: R87C8160YV
Molecular Weight: 439.40460200
Formula: C10 H12 K2 N5 O8 P
Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 1e+006 mg/L @ 25 °C (est)

Common Name: Dipotassium Guanylate
Food Additive Number: E628
INS Number: INS 628
IUPAC Name: Dipotassium Guanosine-5′-Monophosphate
Chemical Type: Potassium salt of guanylic acid
CAS Number: 5550-12-9
EC Number: 226-914-1
Molecular Formula: C10H12K2N5O8P
Molecular Weight: 443.39 g/mol
PubChem CID: 23672367
Chemical Classification: Purine nucleotide salt
Parent Compound: Guanylic Acid (GMP)

Appearance: White to off-white crystalline powder
Physical State: Solid
Odor: Odorless or nearly odorless
Taste: Strong umami and flavor-enhancing effect
Solubility in Water: Freely soluble
Solubility in Ethanol: Slightly soluble to practically insoluble
Hygroscopicity: Slightly hygroscopic
Crystal Form: Fine crystalline powder
Stability: Stable under normal storage conditions

Melting Point: Decomposes upon heating rather than exhibiting a distinct melting point
Storage Conditions: Cool, dry, tightly sealed container
Chemical Class: Purine nucleotide
Nucleotide Type: Ribonucleotide
Parent Acid: Guanylic Acid (GMP)
Ionic Character: Dipotassium salt

Molecular Structure: Guanosine monophosphate associated with two potassium ions
pH Characteristics: Slightly acidic to neutral aqueous solutions
Thermal Stability: Stable under normal food-processing temperatures
Hydrolysis Behavior: Slowly hydrolyzes under strongly acidic or alkaline conditions
Reactivity: Low reactivity under normal conditions
Flavor Synergy: Extremely strong synergy with glutamates
Biological Origin: Derived from naturally occurring guanylic acid found in RNA

FIRST AID MEASURES of DIPOTASSIUM GUANYLATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DIPOTASSIUM GUANYLATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of DIPOTASSIUM GUANYLATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DIPOTASSIUM GUANYLATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DIPOTASSIUM GUANYLATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of DIPOTASSIUM GUANYLATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available