DISODIUM EDTA

CAS No.: 139-33-3
EC No.: 205-358-3

Synonyms:
DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disodium EDTA; Disodium ethylenediaminetetraacetic acid; 139-33-3; SCHEMBL33500; disodium ethylenediamine tetracetic acid; ethylenediaminetetraacetic acid disodium; disodium ethylene diaminetetraacetic acid; disodium ethylenediamine tetraacetic acid; 139D333; Ethylenediaminetetraacetic acid disodium salt solution, 0.01 M; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, 0.02 M; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, 0.05 M; Ethylenediaminetetraacetic acid disodium salt solution, 0.1 M; Ethylenediaminetetraacetic acid disodium salt solution, 2%, solution; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, for molecular biology, 0.5 M in H2O, DNase, RNase, NICKase and protease, none detected; EDTA disodium salt; 139-33-3; Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Edta disodium; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disodium ethylenediaminetetraacetate; EDTA 2Na; Disodium ethylenediaminetetraacetic acid; Ethylenediaminetetraacetic acid disodium salt solution; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6; ethylenediamine tetraacetic acid disodium salt; ETA Solution; EDTA 2Na Solution; SCHEMBL33501; EDTA disodium salt 139-33-3; AKOS015900960; AKOS016016390; CS-W019532; KS-0000058S; AK164289; SC-65716; D3789; E0091; E0103; ethylenediamine tetra-acetic acid disodium salt; N-[2-[Bis(sodiooxycarbonylmethyl)amino]ethyl]iminobis(acetic acid); sodium 2,2'-(2-(bis(carboxymethyl)amino)ethylazanediyl)diacetate; Edetate disodium; EDTA disodium salt; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; 139-33-3; Disodium edetate; Titriplex III; Edta disodium; Disodium EDTA; Disodium salt of EDTA; Chelest B; Komplexon III; Clewat N; Disodium edathamil; Disodium edta, anhydrous; Zonon D; Dotite 2NA; Selekton B 2; Tetracemate disodium; Cheladrate; Mavacid ED 4; Versonol 120; Ethylenediaminetetraacetic acid disodium salt; Chelest 200; Disodium versene; Endrate disodium; Sodium versenate; Metaquest B; Kiresuto B; Veresene disodium salt; Chelaplex III; Complexon III; Diso-Tate; Chelaton III; Versene NA; Ethylenediaminetetraacetic acid, disodium salt; Triplex III; Chelaton 3; Disodium versenate; Edathamil disodium; Trilon BD; Versene Na2; Disodium sequestrene; Disodium tetracemate; F 1 (complexon); Sequestrene sodium 2; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disotate; Disodium EDTA dihydrate; Perma Kleer Di Crystals; CCRIS 3658; E.D.T.A. disodique [French]; Edetic acid disodium salt; Disodium edetate dihydrate; Disodium ethylenediaminetetraacetate; F 1 (VAN); NSC 2760; Disodium dihydrogen ethylenediaminetetraacetate; Edetate disodium anhydrous; EINECS 205-358-3; Disodium ethylenediamine-N,N,N',N'-tetraacetate; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt; Dinatrium ethylendiamintetraacetat [Czech]; EDTA-Na2; EDTA disodium dihydrate; AI3-18049; EDTA disodium salt (anhydrous); Ethylenebis(iminodiacetic acid) disodium salt; Perma kleer 50 crystals disodium salt; UNII-8NLQ36F6MM; Disodium ethylenediaminetetraacetic acid; Ethylene diamine tetraacetic acid, disodium salt; Disodium (ethylenedinitrilo)tetraacetate; SODIUM ETHYLENEDIAMINETETRAACETATE; (Ethylenedinitrilo)-tetraacetic acid disodium salt; CBC 50152966; DR-16133; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetate, disodium salt; Disodium diacid ethylenediaminetetraacetate; Disodium (ethylenedinitrilo)tetraacetic acid; 6381-92-6; Trilon B; N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt; Disodium dihydrogen(ethylenedinitrilo)tetraacetate; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt; Endrate (TN); Na2-EDTA; Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine); ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT; 8NLQ36F6MM; Disodium (ethylenedinitrilo)tetraacetate dihydrate; Edetate Disodium (anhydrous); edta, disodium; Ethylenediaminetetraacetic acid disoium salt dihydrate; disodium 2-({2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate; Disodium dihydrogen ethylenediaminetetraacetate dihydrate; CHEBI:64734; NSC-2760; ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT, DIHYDRATE; E.D.T.A. disodique; ethylenediamine tetraacetic acid disodium salt; Edetate Disodium [USAN:BAN]; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:2); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2); Dinatrium ethylendiamintetraacetat; HSDB 8013; disodium 2-([2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl](carboxymethyl)amino)acetate; Na2EDTA; Disodium edetate (TN); Na2.EDTA; Disodium edetate hydrate; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt, dihydrate; Anhydrous disodium edetate; EC 205-358-3; Edetate disodium, anhydrous; Edetic Acid, Disodium Salt; Edta disodium salt anhydrous; CHEMBL1749; C10H14N2O8.2Na; DTXSID9027073; CTK8E5804; disodium ethylenediamine-tetraacetate; C10H14N2O8.2H2O.2Na; Edetic Acid, Disodium Salt, Dihydrate; DB14600; LS-2377; MCULE-3011053235; E386; LS-12111; LS-54439; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; ethylenediaminetetracetic acid disodium salt; DB-042467; ethylenediaminetetra-acetic acid disodium salt; D03945; J-007267; J-521348; Q4532977; Ethylenediaminetetraacetic acid disodium salt, 0.050M Standardized solution; Ethylenediaminetetraacetic acid disodium salt; 139-33-3; EDTA Na2; AKOS015960366; AC-10616; disodium 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid; Edta disodium; MFCD00070672; Disodium edetate; Disodium EDTA; EDTA disodium salt; Na2-EDTA; Edetate Disodium (anhydrous); 139-33-3; CHEBI:64734; Na2H2EDTA; disodium EDTA (anh.); EDTA disodium (anh.); disodium edetate (anh.); edetate disodium (anh.); disodium EDTA (anhydrous); EDTA disodium (anhydrous); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; disodium edetate (anhydrous); EDTA disodium salt (anh.); ethylenebis(iminodiacetic acid) disoidum salt; disodium 2,2',2'',2'''-(ethane-1,2-diyldiammonio)tetraacetate; N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycine], disodium salt; 1,2-DIAMINOETHANE-N,N,N',N'-TETRA-ACETIC ACID DISODIUM SALT; 1,2-DIAMINOETHANE-N,N,N',N'-TETRA-ACETIC ACID DISODIUM SALT 2H2O; 4C EDTA; COMPLEXONE III; COMPLEXONE III(R); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM DIHYDROGEN ETHYLENEDIAMINE TETRAACETATE; DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRAACETATE DIHYDRATE; DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRA-ACETIC DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDETATE; DISODIUM EDETATE DIHYDRATE; DISODIUM EDTA; DISODIUM ETHYLENEDIAMINETETRAACETATE; DISODIUM ETHYLENEDIAMINETETRAACETATE DIHYDRATE; Disodium ethylenediaminetetraacetic acid; DISODIUM (ETHYLENEDINITRILO)TETRAACETATE, DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; EDATHAMIL DISODIUM SALT DIHYDRATE; EDETATE DISODIUM; EDETATE DISODIUM, DIHYDRATE; EDETATE DISODIUM DIHYDROGEN, DIHYDRATE; EDETATE DISODIUM SALT DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disodium EDTA; Disodium ethylenediaminetetraacetic acid; 139-33-3; SCHEMBL33500; disodium ethylenediamine tetracetic acid; ethylenediaminetetraacetic acid disodium; disodium ethylene diaminetetraacetic acid; disodium ethylenediamine tetraacetic acid; 139D333; Ethylenediaminetetraacetic acid disodium salt solution, 0.01 M; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, 0.02 M; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, 0.05 M; Ethylenediaminetetraacetic acid disodium salt solution, 0.1 M; Ethylenediaminetetraacetic acid disodium salt solution, 2%, solution; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetic acid disodium salt solution, for molecular biology, 0.5 M in H2O, DNase, RNase, NICKase and protease, none detected; EDTA disodium salt; 139-33-3; Disodium EDTA; Ethylenediaminetetraacetic acid disodium salt; Edta disodium; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disodium ethylenediaminetetraacetate; EDTA 2Na; Disodium ethylenediaminetetraacetic acid; Ethylenediaminetetraacetic acid disodium salt solution; Disodium dihydrogen ethylenediaminetetraacetate; 6381-92-6; ethylenediamine tetraacetic acid disodium salt; ETA Solution; EDTA 2Na Solution; SCHEMBL33501; EDTA disodium salt 139-33-3; AKOS015900960; AKOS016016390; CS-W019532; KS-0000058S; AK164289; SC-65716; D3789; E0091; E0103; ethylenediamine tetra-acetic acid disodium salt; N-[2-[Bis(sodiooxycarbonylmethyl)amino]ethyl]iminobis(acetic acid); sodium 2,2'-(2-(bis(carboxymethyl)amino)ethylazanediyl)diacetate; Edetate disodium; EDTA disodium salt; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; 139-33-3; Disodium edetate; Titriplex III; Edta disodium; Disodium EDTA; Disodium salt of EDTA; Chelest B; Komplexon III; Clewat N; Disodium edathamil; Disodium edta, anhydrous; Zonon D; Dotite 2NA; Selekton B 2; Tetracemate disodium; Cheladrate; Mavacid ED 4; Versonol 120; Ethylenediaminetetraacetic acid disodium salt; Chelest 200; Disodium versene; Endrate disodium; Sodium versenate; Metaquest B; Kiresuto B; Veresene disodium salt; Chelaplex III; Complexon III; Diso-Tate; Chelaton III; Versene NA; Ethylenediaminetetraacetic acid, disodium salt; Triplex III; Chelaton 3; Disodium versenate; Edathamil disodium; Trilon BD; Versene Na2; Disodium sequestrene; Disodium tetracemate; F 1 (complexon); Sequestrene sodium 2; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Disotate; Disodium EDTA dihydrate; Perma Kleer Di Crystals; CCRIS 3658; E.D.T.A. disodique [French]; Edetic acid disodium salt; Disodium edetate dihydrate; Disodium ethylenediaminetetraacetate; F 1 (VAN); NSC 2760; Disodium dihydrogen ethylenediaminetetraacetate; Edetate disodium anhydrous; EINECS 205-358-3; Disodium ethylenediamine-N,N,N',N'-tetraacetate; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt; Dinatrium ethylendiamintetraacetat [Czech]; EDTA-Na2; EDTA disodium dihydrate; AI3-18049; EDTA disodium salt (anhydrous); Ethylenebis(iminodiacetic acid) disodium salt; Perma kleer 50 crystals disodium salt; UNII-8NLQ36F6MM; Disodium ethylenediaminetetraacetic acid; Ethylene diamine tetraacetic acid, disodium salt; Disodium (ethylenedinitrilo)tetraacetate; SODIUM ETHYLENEDIAMINETETRAACETATE; (Ethylenedinitrilo)-tetraacetic acid disodium salt; CBC 50152966; DR-16133; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Ethylenediaminetetraacetate, disodium salt; Disodium diacid ethylenediaminetetraacetate; Disodium (ethylenedinitrilo)tetraacetic acid; 6381-92-6; Trilon B; N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt; Disodium dihydrogen(ethylenedinitrilo)tetraacetate; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt; Endrate (TN); Na2-EDTA; Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine); ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT; 8NLQ36F6MM; Disodium (ethylenedinitrilo)tetraacetate dihydrate; Edetate Disodium (anhydrous); edta, disodium; Ethylenediaminetetraacetic acid disoium salt dihydrate; disodium 2-({2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate; Disodium dihydrogen ethylenediaminetetraacetate dihydrate; CHEBI:64734; NSC-2760; ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT, DIHYDRATE; E.D.T.A. disodique; ethylenediamine tetraacetic acid disodium salt; Edetate Disodium [USAN:BAN]; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:2); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2); Dinatrium ethylendiamintetraacetat; HSDB 8013; disodium 2-([2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl](carboxymethyl)amino)acetate; Na2EDTA; Disodium edetate (TN); Na2.EDTA; Disodium edetate hydrate; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt, dihydrate; Anhydrous disodium edetate; EC 205-358-3; Edetate disodium, anhydrous; Edetic Acid, Disodium Salt; Edta disodium salt anhydrous; CHEMBL1749; C10H14N2O8.2Na; DTXSID9027073; CTK8E5804; disodium ethylenediamine-tetraacetate; C10H14N2O8.2H2O.2Na; Edetic Acid, Disodium Salt, Dihydrate; DB14600; LS-2377; MCULE-3011053235; E386; LS-12111; LS-54439; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; ethylenediaminetetracetic acid disodium salt; DB-042467; ethylenediaminetetra-acetic acid disodium salt; D03945; J-007267; J-521348; Q4532977; Ethylenediaminetetraacetic acid disodium salt, 0.050M Standardized solution; Ethylenediaminetetraacetic acid disodium salt; 139-33-3; EDTA Na2; AKOS015960366; AC-10616; disodium 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid; Edta disodium; MFCD00070672; Disodium edetate; Disodium EDTA; EDTA disodium salt; Na2-EDTA; Edetate Disodium (anhydrous); 139-33-3; CHEBI:64734; Na2H2EDTA; disodium EDTA (anh.); EDTA disodium (anh.); disodium edetate (anh.); edetate disodium (anh.); disodium EDTA (anhydrous); EDTA disodium (anhydrous); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; disodium edetate (anhydrous); EDTA disodium salt (anh.); ethylenebis(iminodiacetic acid) disoidum salt; disodium 2,2',2'',2'''-(ethane-1,2-diyldiammonio)tetraacetate; N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycine], disodium salt; 1,2-DIAMINOETHANE-N,N,N',N'-TETRA-ACETIC ACID DISODIUM SALT; 1,2-DIAMINOETHANE-N,N,N',N'-TETRA-ACETIC ACID DISODIUM SALT 2H2O; 4C EDTA; COMPLEXONE III; COMPLEXONE III(R); DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM DIHYDROGEN ETHYLENEDIAMINE TETRAACETATE; DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRAACETATE DIHYDRATE; DISODIUM DIHYDROGEN ETHYLENEDIAMINETETRA-ACETIC DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; DISODIUM EDETATE; DISODIUM EDETATE DIHYDRATE; DISODIUM EDTA; DISODIUM ETHYLENEDIAMINETETRAACETATE; DISODIUM ETHYLENEDIAMINETETRAACETATE DIHYDRATE; Disodium ethylenediaminetetraacetic acid; DISODIUM (ETHYLENEDINITRILO)TETRAACETATE, DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA; EDATHAMIL DISODIUM SALT DIHYDRATE; EDETATE DISODIUM; EDETATE DISODIUM, DIHYDRATE; EDETATE DISODIUM DIHYDROGEN, DIHYDRATE; EDETATE DISODIUM SALT DIHYDRATE; DISODIUM EDTA; disodium Edta; DİSODYUM EDTA; Disodyum EDTA

DISODIUM EDTA

Overview(active tab)
Safety
Resources

What Is It?
EDTA (ethylenediamine tetraacetic acid) and its salts, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium EDTA, and the related ingredients HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt, Trisodium HEDTA, are crystalline powders often sold as aqueous solutions.

In cosmetics and personal care products, these ingredients are widely used and can be found in moisturizers, skin care and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other product types.

Why is it used in cosmetics and personal care products?
Disodium EDTA and the related ingredients bind to metal ions which inactivates them. The binding of metal ions helps prevent the deterioration of cosmetics and personal care products. It also helps to maintain clarity, protect fragrance compounds, and prevent rancidity.

Safety Information: 
The Food and Drug Administration (FDA) reviewed the safety of Disodium EDTA and Calcium Disodium EDTA and approved the use of these ingredients as food preservatives for direct addition to food.

The safety of Disodium EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, EDTA, HEDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium HEDTA was assessed by the Cosmetic Ingredient Review (CIR) Expert Panel.

The CIR Expert Panel evaluated the scientific data and concluded that Disodium EDTA and related ingredients were safe as used in cosmetics and personal care products.

More safety Information: 
CIR Safety Review: EDTA and the related ingredients at the concentrations used in cosmetic and personal care products were not dermal irritants or sensitizers. Studies indicated that these ingredients were not carcinogens. Because these ingredients bind metals required for normal cell division, some studies that indicated that these compounds were weakly mutagenic. Some studies showed reproductive and developmental effects following oral exposure to large doses of metal chelators, likely an effect of the binding of metals required for normal reproduction and development.

The CIR Expert Panel reviewed data that indicated that EDTA and the related ingredients were not well absorbed through the skin. Therefore, dermal exposures to EDTA or HEDTA from the use of cosmetics and personal care products containing these ingredients would result in very little skin penetration and systemic levels well below those shown to produce adverse effects in oral studies. Because no data were available regarding the absorption of these ingredients following inhalation exposure, the CIR Panel expressed concern about EDTA in products that may be inhaled. They conducted an exposure assessment assuming 25% EDTA in a product. The calculated dose of EDTA via inhalation of an aerosolized product based on this assessment did not raise concerns about adverse effects of EDTA or its salts in cosmetics and personal care products that may be inhaled.

The CIR Expert Panel also recognized that EDTA, HEDTA and their salts are penetration enhancers. Therefore, formulators should be aware of this when combining these ingredients with those found to be safe primarily because they were not significantly absorbed. 

FDA: Code of Federal Regulations for Disodium EDTA

Calcium Disodium EDTA

Is Calcium Disodium EDTA a Safe Additive?
What It Is
Applications
Cancer
Birth Defects
Side Effects
Safety
Bottom Line
Calcium disodium EDTA is a common food additive and an ingredient in cosmetic and industrial products.

It’s used in food to preserve flavor, color and texture. However, like many food additives, it has become quite controversial.

This article reviews calcium disodium EDTA, its applications, safety and side effects.

What Is Calcium Disodium EDTA?
Calcium disodium EDTA is an odorless crystalline powder with a slightly salty flavor (1).

It’s a popular food additive, used as a preservative and flavoring agent.

Calcium disodium EDTA works as a chelating agent. This means it binds to metals and prevents them from participating in chemical reactions that might cause discoloration or flavor loss.

The FDA has approved calcium disodium EDTA as a safe food additive but has set limitations on the amount of the substance a food can contain (2).

Calcium disodium EDTA is poorly absorbed by your digestive tract and the maximum Acceptable Daily Intake (ADI) is 1.1 mg per pound (2.5 mg per kg) of body weight per day (3Trusted Source).

SUMMARY
Calcium disodium EDTA is a crystalline powder with a slightly salty flavor. It’s a popular food additive that prevents spoilage and preserves flavor and color.

What Is Calcium Disodium EDTA Used For?
Calcium disodium EDTA is found in food, cosmetic and industrial productions. It’s also used for chelation therapy.

Food Products
Calcium disodium EDTA can be used to preserve texture, flavor and color of many food products.

It’s also used to promote stability and increase the shelf life of certain foods.

The following are common foods that contain calcium disodium EDTA (2):

Salad dressings, sauces and spreads
Mayonnaise
Pickled vegetables, such as cabbage and cucumbers
Canned beans and legumes
Canned carbonated soft drinks
Distilled alcoholic beverages
Canned crab, clam and shrimp
Cosmetic Products
Calcium disodium EDTA is widely used in beauty and cosmetic products. It allows for better cleaning use, as it enables cosmetic products to foam.

What’s more, as it binds with metal ions, it prevents metals from accumulating on the skin, scalp or hair (4Trusted Source).

Soaps, shampoos, lotions and contact lens solutions are examples of cosmetic and personal care products that may contain calcium disodium EDTA.

Industrial Products
Calcium disodium EDTA is also found in many industrial products, such as paper and textile, due to its ability to prevent discoloration.

In addition, it’s frequently used in products like laundry detergents, industrial germicides and other cleaning products.

Chelation Therapy
Chelation therapy uses calcium disodium EDTA to treat metal toxicity, such as lead or mercury poisoning.

The substance binds to the excessive metal in your blood, which is then excreted through urine.

While calcium disodium EDTA is only FDA-approved to treat metal poisoning, some holistic healthcare providers suggest chelation therapy as an alternative treatment for conditions like autism, heart disease and Alzheimer’s.

However, current research is unsupportive, and further studies are needed before any conclusions on chelation therapy and certain health conditions can be made (5Trusted Source, 6Trusted Source, 7Trusted Source).

SUMMARY
Calcium disodium EDTA is used in many food, cosmetic and industrial products, due to its preserving and stabilizing abilities. It’s also used for chelation therapy to treat lead and mercury toxicity.

ADVERTISEMENT
Weight management options have evolved
Take our quiz to learn more about techniques and tips that will help you achieve your goals.

Not Associated With Cancer
Although research is limited, there is currently no scientific data that associates consumption of calcium disodium EDTA with an increased risk of cancer (8).

Additionally, studies have shown that it’s very poorly absorbed by the digestive tract in both animals and humans (9Trusted Source).

One study that looked at chelating agents, including calcium disodium EDTA, concluded that calcium disodium did not have cancer-causing potential. Researchers even observed that the substance decreased the carcinogenicity of chromium oxide (10Trusted Source).

Furthermore, the Environmental Protection Agency (EPA) has declared that there is no concern for increased cancer risk with consumption of EDTA (11).

SUMMARY
Though research is limited, scientific evidence currently does not suggest that calcium disodium EDTA has cancer-causing effects.

Not Associated With Birth Defects
Multiple studies have evaluated the possible effects of calcium disodium EDTA on reproduction and its association with birth defects.

In one four-generation rat study, calcium disodium EDTA doses of up to 114 mg per pound (250 mg per kg) of body weight per day did not result in increased rates of reproductive or birth defects in any of the three generations of rat offsprings (12Trusted Source).

In another rat study, animals who received oral calcium disodium EDTA were at no higher risk of delivering offspring with birth defects than the control group (13Trusted Source).

Moreover, another rat study found no negative reproductive effects of calcium disodium EDTA, as long as zinc levels were adequate (14Trusted Source).

Lastly, based on older case reports, there have been no adverse birth defects associated with women treated with chelation therapy of calcium disodium EDTA for lead toxicity (15Trusted Source).

SUMMARY
Multiple studies involving rats, along with human case reports, do not associate calcium disodium EDTA intake with reproductive or birth defects.

May Cause Digestive Issues in High Doses
Based on current research, the only potential negative effect of calcium disodium EDTA as a food additive appears to be digestive upset.

Many rat studies have shown that large oral doses of the substance caused frequent and loose bowel movements along with decreased appetite (14Trusted Source, 16Trusted Source).

However, these side effects only seem to transpire if calcium disodium EDTA is consumed in high amounts — amounts that would be very difficult to achieve through a normal diet.

Chelation therapy — which is not the focus of this article — requires higher doses, which may cause more and potentially more serious adverse effects.

SUMMARY
Calcium disodium EDTA as a food additive may cause diarrhea and decreased appetite if consumed at high doses. However, such high doses would be difficult to achieve through a typical diet.

Is It Safe?
For most individuals, eating foods that contain calcium disodium EDTA appears to be safe.

While many packaged foods contain this preservative, the absorption rate of oral calcium disodium EDTA is minimal.

In fact, your digestive tract absorbs no more than 5% (11).

Additionally, it’s estimated that a typical person consumes only 0.1 mg per pound (0.23 mg per kg) of body weight per day — much less than the ADI of 1.1 mg per pound (2.5 mg per kg) of body weight established by the Joint Expert Committee on Food Additives (17, 18).

Though high doses have been associated with digestive distress, the amount that you get from food alone is so small that it’s very unlikely that you would experience these adverse effects.

SUMMARY
Many packaged foods contain calcium disodium EDTA. However, the amount found in food is found in such small amounts that it’s unlikely to negatively impact your health.

The Bottom Line
Calcium disodium EDTA is found in food, cosmetic and industrial products and used to treat metal toxicity.

Ingredient to Avoid: Disodium EDTA
Disodium EDTA is in many products as a preservative, to stabilise it, or to enhance the foaming action. It’s also used as a chelating agent, which means it us used to precipitate out metals from the formulation (if tap water were used to make the formulation instead purified water, for example, and it can bind with metals dissolved in your shower water).

One reason we recommend to NOT use products containing Disodium EDTA, is because it is a ‘penetration enhancer’. Although it doesn’t absorb particularly well into the skin, it disrupts the surface of skin cells so that other chemicals can get in more easily – ie other chemicals in your product, and chemicals in your shower water, etc.

So if you see Disodium EDTA, then look at what else is in the ingredients list, because you might not be too thrilled at those chemicals getting a free ride.

For example, here are the ingredients for a hand balm from a ‘natural’ brand:

Water, Glycerin, Prunus amygdalus dulcis (sweet almond) oil, Stearic Acid, Cetearyl Alcohol, Ceteareth-20, Cocos nuciferus (coconut) oil, Macadamia ternifolia seed oil, d-limonene, Citrus nobilis (mandarin orange) peel oil, Glyceryl stearate, Cerus Atlantica (cedarwood) bark oil, Lavandula angustifolia (lavender) oil, Tocopherol, Aloe barbadensis leaf juice, Butyrospermum parkii (shea) butter, Theobroma cacao (cocoa) seed butter, Citrus aurantium dulcis (orange) oil, Phenoxyethanol, Rosmarinus officinalis (rosemary) leaf oil, Citrus grandis (grapefruit) seed extract, Triticum vulgare (wheat) germ oil, Glycine soja (soybean) oil, linalool, Disodium EDTA, Daucus carota sativa (carrot) root extract, Betacarotene.