DRUGCOAT L 30D

Drugcoat L 30D is used for enteric coating, protective coating, taste masking and sustained release formulation.
Drugcoat L 30D is compatible with a wide range of excipients, pigments, and fillers, allowing formulators to customize coating compositions for appearance, performance, and stability.
Drugcoat L 30D can be combined with anti-tacking agents and pigments to produce elegant, uniform coatings with good adhesion and minimal processing defects.

CAS Number: 25212-88-8 
EC Number: Not typically assigned a unique EC number as a dispersion; the underlying copolymer category may be covered by broader polymer listings in regulatory inventories. (Specific EC entries for complex copolymers are not always available or unique.)
Molecular Formula: Copolymer of methacrylic acid and ethyl acrylate (variable composition) — general repeat unit formulae include combinations of C₉H₁₄O₄ for constituent monomer units, but no single fixed formula exists due to its polymeric nature. 
Molecular Weight: Not defined as a single value (polymer dispersions have a distribution of chain lengths).
Molecular Formula: [(C4H6O2)x(C5H8O2)y]n
Molecular Weight: About 250000 (Average value)

SYNONYMS:
Methacrylic acid–ethyl acrylate copolymer, Ethyl acrylate-methacrylic acid copolymer, Partially neutralized methacrylic acid and ethyl acrylate copolymer, Methacrylic acid copolymer dispersion, Kollicoat MAE 30 DP (related coating polymer), Methacrylic acid copolymer LD, Aqueous enteric coating polymer L30D

Drugcoat L 30D has excellent potential as versatile & unique in different applications in NDDS including customized and newer applications.
Drugcoat L 30D is a white or almost white, opaque, slightly viscous liquid.
Drugcoat L 30D is an aqueous polymer dispersion widely used in the pharmaceutical industry as a functional coating material for solid oral dosage forms.

Drugcoat L 30D belongs to the group of methacrylic acid–ethyl acrylate copolymers and is primarily designed to provide enteric and protective film coatings.
Because Drugcoat L 30D is supplied as a ready-to-use water-based dispersion, it offers significant safety, environmental, and processing advantages compared with solvent-based coating systems.

From a formulation perspective, Drugcoat L 30D is valued for its pH-dependent solubility.
Drugcoat L 30D remains intact and insoluble in the acidic environment of the stomach, helping to protect acid-sensitive active pharmaceutical ingredients or to prevent gastric irritation.

Once the dosage form reaches the higher pH of the small intestine, Drugcoat L 30D film dissolves, enabling targeted and predictable drug release.
This makes Drugcoat L 30D especially suitable for enteric-coated tablets, pellets, and granules.

USES and APPLICATIONS of DRUGCOAT L 30D:
Drugcoat L 30D is used for enteric coating, protective coating, taste masking and sustained release formulation.
Applications of Drugcoat L 30D: enteric coating
Drugcoat L 30D is a rare and elite pharmaceutical chemical, distinguished by its ephemeral yet stable nature when stored correctly.

Renowned for its incomparable purity (99% minimum) and sterling solubility in water, Drugcoat L 30D is highly sought-after among laboratories and industries alike.
The synthetically derived powder, Drugcoat L 30D, is odorless, tasteless, and reliably non-poisonous, conforming to rigorous analytical specifications.

Drugcoat L 30D features a neutral pH, minimal loss on drying, and minute heavy metal content, making it an indispensable choice for those demanding top-tier technical grade quality from their chemical sources in India.
Drugcoat L 30D is used in enteric coatings, protective coatings, taste masking and sustained release formulations.

In addition to enteric functionality, Drugcoat L 30D can be used as a protective coating to improve the stability of formulations against moisture, oxygen, and light.
By forming a continuous, flexible film, Drugcoat L 30D helps preserve the integrity of hygroscopic or oxidation-prone actives during storage and distribution.

Drugcoat L 30D film also contributes to improved mechanical strength, reducing chipping, cracking, or abrasion during handling and packaging.
Processing performance is another key advantage of Drugcoat L 30D.
Drugcoat L 30D's low viscosity and fine particle size distribution support uniform spraying and smooth film formation in conventional coating equipment such as perforated pan coaters and fluid bed coaters.

Because Drugcoat L 30D is an aqueous system, it reduces operator exposure to organic solvents and simplifies compliance with environmental and regulatory requirements.
However, the formulation typically requires the addition of suitable plasticizers to enhance film flexibility and prevent brittleness, especially under low-humidity conditions.

Drugcoat L 30D is compatible with a wide range of excipients, pigments, and fillers, allowing formulators to customize coating compositions for appearance, performance, and stability.
Drugcoat L 30D can be combined with anti-tacking agents and pigments to produce elegant, uniform coatings with good adhesion and minimal processing defects.

This flexibility supports Drugcoat L 30D's use across multiple dosage forms, including single-unit tablets and multiparticulate systems such as pellets and capsules.
Drugcoat L 30D represents a modern, next-generation coating polymer that aligns with current pharmaceutical trends toward safer, more efficient, and environmentally friendly manufacturing.

Its balance of enteric protection, processing ease, and formulation versatility makes Drugcoat L 30D a reliable choice for both generic and innovative oral drug products.

-Dosage Form Application of Drugcoat L 30D:
Enteric-coated tablets Film-forming/enteric material
Solid preparations Moisture-proof/taste-masking coating
Sustained-release preparations pH-dependent sustained-release excipient

AREAS OF APPLICATION AND DISTINCTIVE FEATURES of DRUGCOAT L 30D:
Drugcoat L 30D is engineered for broad laboratory and industrial usage, making it suitable for analytical research, formulation processes, and controlled industrial production.
Drugcoat L 30D's key features include a neutral pH, superior solubility, and stable white powder appearance.

Drugcoat L 30D is used for applications requiring technical grade accuracy, it supports environments where indomitable quality, safety, and purity standards are paramount.
Thanks to its tasteless and odourless profile, Drugcoat L 30D integrates seamlessly into various protocols.

ADVANTAGES of DRUGCOAT L 30D:
Drugcoat L 30D is insoluble in gastric juice, and forms a salt when exposed to alkali, and is soluble in weakly alkaline solutions, so it can be dissolved in intestinal fluid environments with a pH of 5.5 or above, and is used for enteric coatings.
Drugcoat L 30D is insoluble in water, low permeability, low water vapor permeability.

FEATURES of DRUGCOAT L 30D:
Drugcoat L 30D is an aqueous dispersion of methacrylic acid and ethyl acrylate copolymer.
Calculated by the dry weight of the dispersion, Drugcoat L 30D should contain 46.0%~50.6% methacrylic acid units.
Drugcoat L 30D swells at pH 5.5 or below and is easily soluble at pH 5.5 or above.
Drugcoat L 30D is insoluble in gastric juice and is rapidly released in the duodenum and below.

PHYSICAL and CHEMICAL PROPERTIES of DRUGCOAT L 30D:
Physical state: Liquid (aqueous dispersion)
Appearance: Milky to opaque white liquid
Odor: Slight, characteristic
Solids content: Approximately 30 % (w/w)
Density (20 °C): Approximately 1.06–1.07 g/cm³
Viscosity (23 °C): Low viscosity, typically < 100 mPa·s
pH (as supplied): Approximately 2.0–3.0
Particle size: Colloidal polymer particles (sub-micron range)
Film formation temperature: Typical of methacrylic acid copolymer dispersions (dependent on plasticizer)
Solubility in water: Dispersible (not truly soluble)
Solubility of dried film: Insoluble in acidic media; soluble at pH ≥ 5.5

Color stability: Stable under normal storage conditions
Freeze–thaw stability: Limited; freezing may cause coagulation
Chemical nature: Methacrylic acid–ethyl acrylate copolymer
Chemical class: Enteric coating polymer
Substance type: Polymeric UVCB substance
Monomer composition: Methacrylic acid and ethyl acrylate (approximately 1:1 ratio)
Molecular structure: Long-chain acrylic copolymer
Molecular formula: Not fixed (polymeric substance)
Molecular weight: Not defined (distribution of polymer chain lengths)
pH-dependent solubility: Insoluble below pH ~5.5; soluble above pH ~5.5

Reactivity: Low; chemically stable under normal conditions
Stability: Stable under recommended storage conditions
Hydrolysis: Not readily hydrolyzed under normal use
Polymerization: Will not polymerize further
Incompatibilities: Strong oxidizing agents, strong alkalis (may destabilize dispersion)
Decomposition products: Carbon oxides and acrylate derivatives upon thermal decomposition
Flammability: Not flammable as supplied (aqueous dispersion)
Composition: Methacrylic Acid-Ethyl Acrylate Copolymer(1:1) Dispersion 30%
Physical form: Liquid

FIRST AID MEASURES of DRUGCOAT L 30D:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of DRUGCOAT L 30D:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of DRUGCOAT L 30D:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of DRUGCOAT L 30D:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of DRUGCOAT L 30D:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of DRUGCOAT L 30D:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available