PRODUCTS

E131 (Patent Blue V)

EC / List no.: 222-573-8
CAS no.: 3536-49-0
Mol. formula: C27H32N2O7S2.1/2Ca

E131 (Patent Blue V), also called Food Blue 5, Sulphan Blue, Acid Blue 3, L-Blau 3, C-Blau 20, Patentblau V, Sky Blue, or C.I. 42051, is a sky blue synthetic triphenylmethane dye used as a food coloring.
As a food additive, it has E number E131.
E131 (Patent Blue V) is a sodium or calcium salt of [4-(α-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenylmethylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt.

Use as dye
E131 (Patent Blue V) is not widely used, but in Europe it can be found in Scotch eggs, certain jelly sweets, blue Curaçao, certain gelatin desserts, among others.
An important advantage is the very deep color it produces even at low concentration, a disadvantage is that it fades fairly quickly when exposed to light.

In medicine, E131 (Patent Blue V) is used in lymphangiography and sentinel node biopsy as a dye to color lymph vessels.
E131 (Patent Blue V) is also used in dental disclosing tablets as a stain to show dental plaque on teeth.

The color of the dye is pH-dependent.
In aqueous solution, its color will vary from a deep blue in alkaline or weakly acidic medium to a yellow–orange in stronger acidic conditions.
E131 (Patent Blue V) is useful as a pH indicator for the range 0.8–3.0.
The structure is also redox-sensitive, changing from a reduced yellow form to an oxidized red form in solution.
The reduction potential of around 0.77 volts is similar to that of other triphenylmethane dyes.
E131 (Patent Blue V) is usable as a reversible redox indicator in some analytical methods.

Because of its pH-dependent color, E131 (Patent Blue V) was included in chemistry sets from Salter Science in the 1970s and 80s under the name Sky Blue.

Regulation
E131 (Patent Blue V) is banned as a food dye in Australia and US, because health officials in these countries suspect that it may cause allergic reactions, with symptoms ranging from itching and nettle rash to nausea, hypotension, and in rare cases anaphylactic shock; it is therefore not recommended in those countries for children.

Uses
double labeled product for electron microscopy and fluorescence research

Preparation
(a) 3-Nitrobenzaldehyde?and N,N-diethylbenzenamine (2 Moore) condensation, then reduction, then the amino diazotization and then translate into hydroxyl compound, and then two stlfonation, finally will product into calcium salt, and segregation and oxidation;
(b)3-Hydroxybenzaldehyde and N,N-diethylbenzenamine (2 Moore) condensation, and then two stlfonation, into calcium salt and oxidation.
The dyes can also be as sodium salting out.

Properties and Applications
colourful green light blue.
Soluble in cold water and hot water for the blue, soluble in ethanol for green light blue.
The strong sulfuric acid for olive tan.
In water solution to join sodium hydroxide low temperature discoloration, heat into deep purple.

E131 (Patent Blue V) sodium salt, also called as acid blue 3 sodium salt, exists as a blue powder or granules.
E131 (Patent Blue V) is mainly used as a food color.

Physical Description
E131 (Patent Blue V) is a dark bluish dye that provides a blue to greenish blue shade in applications. The colorant consists essentially of the calcium or sodium salt of 2-[(4-diethylaminophenyl)(4-diethylimino-2,5-cyclohexadien-1-ylidene)methyl]-4-hydroxy-1,5-benzenedisulfonate and subsidiary coloring matters. E131 (Patent Blue V) is soluble in water and slightly soluble in ethanol.

Common Uses
Typical applications include beverages, confectionery, bakery, dairy fats and oils, meat, seafood, snacks, dry mixes and seasonings, fruit preparation, convenient food, and flavors.

Consists essentially of the calcium or sodium salt of 2-[(4-diethylaminophenyl)(4-diethylimino-2,5-cyclo-hexadien-1-ylidene)methyl]-4-hydroxy-1,5-benzenedisulfonate and subsidiary colouring matters
together with water, sodium chloride and/or sodium sulfate and/or calcium chloride and/or calcium sulfate as the principal uncoloured components.

A synthetic dye with imaging and food coloring property.
E131 (Patent Blue V) is a sodium or calcium salt of [4-(alpha-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenyl-methylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt.
E131 (Patent Blue V) dye is used in sentinel lymph node (SLN) technique to guide nodal dissection or other imaging procedures.

PRODUCT USE
• Acid dyes, which are anionic, are used in the textile industry for dyeing of all natural fibres, e.g. wool, cotton, silk and synthetics, e.g. polyesters, acrylic and rayon.
To a less extent they are used in a variety of application fields such as in paints, inks, plastics and leather.
Blue,non-toxic colourant of the triarylmethane type.

Patent blue is aniline dye and it is one of the most common dyes used.
E131 (Patent Blue V) is a sodium or calcium salt of diethylammonium hydroxide inner salt.
E131 (Patent Blue V) has the chemical designation of (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzylidene)-2,5-cyclohexadiene-1-ylidene)diethylammonium hydroxide.
Patent blue was developed by Guerbet and approved by Health Canada on December 31, 1979.
The isomer isosulphan is used in the United States for the same indications than patent blue.

What E131 (Patent Blue V) is used for
Colours the lymph vessels so that they can then be injected with an X-ray contrast medium

How to take E131 (Patent Blue V)
The way to take this medicine is: Subcutaneous.
E131 (Patent Blue V) is injected, usually with a short needle or pen-like device, into the fat just beneath the skin.

Store below 25 degrees Celsius
Shelf lifetime is 3 Years.
You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label.
If symptoms persist see your healthcare professional.

Visual appearance
Deep, blue solution

E131 (Patent Blue V) is also known by the name of Sulphan Blue, Acid Blue 3, Food Blue 5, and comprises dark bluish synthetic dye that finds use as food coloring and food additive.
With appearance of violet powder, it comes in varying colors depending on pH value of medium (deep blue in basic medium and yellowish-green in acidic medium).

Further, in medicine, E131 (Patent Blue V) finds usage in lymphangiography as well as in sentinel node biopsy as dye to color lymph vessels so that these can further be injected with X-ray contrast medium.

About E131 (Patent Blue V)
Helpful information
E131 (Patent Blue V) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

E131 (Patent Blue V) is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses
E131 (Patent Blue V) is used in the following products: inks and toners, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), fertilisers, paper chemicals and dyes, plant protection products, textile treatment products and dyes, washing & cleaning products and water treatment chemicals.
Other release to the environment of E131 (Patent Blue V) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Article service life
Other release to the environment of E131 (Patent Blue V) is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
E131 (Patent Blue V) can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), leather (e.g. gloves, shoes, purses, furniture), metal (e.g. cutlery, pots, toys, jewellery), wood (e.g. floors, furniture, toys) and plastic (e.g. food packaging and storage, toys, mobile phones).
Widespread uses by professional workers
E131 (Patent Blue V) is used in the following products: inks and toners, paper chemicals and dyes, textile treatment products and dyes, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), fertilisers, non-metal-surface treatment products, leather treatment products, plant protection products, washing & cleaning products and water treatment chemicals.
E131 (Patent Blue V) is used in the following areas: agriculture, forestry and fishing, printing and recorded media reproduction and building & construction work.
E131 (Patent Blue V) is used for the manufacture of: textile, leather or fur, wood and wood products, food products and pulp, paper and paper products.
Other release to the environment of E131 (Patent Blue V) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Formulation or re-packing
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Release to the environment of E131 (Patent Blue V) can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
E131 (Patent Blue V) is used in the following products: inks and toners, paper chemicals and dyes, textile treatment products and dyes, biocides (e.g. disinfectants, pest control products), coating products, fillers, putties, plasters, modelling clay, fertilisers, metal surface treatment products, leather treatment products, plant protection products, washing & cleaning products and water treatment chemicals.
E131 (Patent Blue V) is used in the following areas: agriculture, forestry and fishing and building & construction work.
E131 (Patent Blue V) is used for the manufacture of: textile, leather or fur, wood and wood products, pulp, paper and paper products, chemicals and plastic products.
Release to the environment of E131 (Patent Blue V) can occur from industrial use: in the production of articles and in processing aids at industrial sites.
Manufacture
Release to the environment of E131 (Patent Blue V) can occur from industrial use: manufacturing of the substance.

E131 (Patent Blue V), also called Food Blue 5 or Sulphan Blue, is a dark bluish synthetic dye used as a food coloring. As a food additive, it has E number E131.
E131 (Patent Blue V) is a sodium or calcium salt of [4-(α-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenyl-methylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt. It has the appearance of a violet powder.

E131 (Patent Blue V)s CAS number is [3536-49-0] and its SMILES structure is CCN(CC)c1ccc(cc1)C(=C2C=CC(C=C2)=[N+](CC)CC)c3cc(O)c(OS([O-])=O)cc3OS([O-])=O.
E131 (Patent Blue V) is not widely used, but can be found in Scotch eggs.
E131 (Patent Blue V) is banned as a food dye in Australia, USA, and Norway.

In medicine, E131 (Patent Blue V) is used in lymphangiography as a dye to color lymph vessels.
E131 (Patent Blue V) is also used in dental disclosing tablets as a stain to show dental plaque on teeth.

E131 (Patent Blue V), also called Food Blue 5, Sulphan Blue, Acid Blue 3, L-Blau 3, C-Blau 20, Patentblau V, Sky Blue, or C.I. 42051, is a sky blue synthetic triphenylmethane dye used as a food coloring.
As a food additive, it has E number E131.
It is a sodium or calcium salt of [4-(α-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenylmethylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt.

Use as dye
E131 (Patent Blue V) is not widely used, but in Europe it can be found in Scotch eggs,[citation needed] certain jelly sweets, blue Curaçao, certain gelatin desserts, among others.
An important advantage is the very deep color it produces even at low concentration, a disadvantage is that it fades fairly quickly when exposed to light.

The color of the dye is pH-dependent.
In aqueous solution, E131 (Patent Blue V)s color will vary from a deep blue in alkaline or weakly acidic medium to a yellow–orange in stronger acidic conditions.
E131 (Patent Blue V) is useful as a pH indicator for the range 0.8–3.0.
The structure is also redox-sensitive, changing from a reduced yellow form to an oxidized red form in solution.
The reduction potential of around 0.77 volts is similar to that of other triphenylmethane dyes.
E131 (Patent Blue V) is usable as a reversible redox indicator in some analytical methods.

Because of its pH-dependent color, E131 (Patent Blue V) was included in chemistry sets from Salter Science in the 1970s and 80s under the name Sky Blue.

A synthetic dye with imaging and food coloring property.
E131 (Patent Blue V) is a sodium or calcium salt of [4-(alpha-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenyl-methylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt.
E131 (Patent Blue V) is used in sentinel lymph node (SLN) technique to guide nodal dissection or other imaging procedures.

IUPAC NAMES:
Bis[hydrogen [4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt
bis[hydrogen [4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt
Bis[hydrogen[4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt
Calcium 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate
calcium;4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate

SYNONYMS:
E131 (Patent Blue V)
3536-49-0
Acid blue 3
C.I. Food Blue 5
Carmine Blue V
Acidal Carmine V
Merantine Blue V
Solar Pure Blue VX
UNII-8QE473DV1Z
E131 (Patent Blue V) and L
C.I. Acid Blue 3
Mitsui Acid Pure Blue VX
Dai-ei Acid Pure Blue VX
New Patent Blue A-CE Extra
New Patent Blue Extra Pure A
8QE473DV1Z
Alphazurine 2 G (C.I. 42051)
C.I. 42051
E 131
E131
E131 (Patent Blue V) calcium salt (C.I. 42051)
Schultz No. 826
Blue ZN 3
L-Blau 3 [German]
Bleu patente V [French]
calcium;4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate
M-HYDROXYTETRAETHYLDIAMINOTRIPHENYLCARBINOL ANHYDRIDE DISULFONIC ACID CALCIUM SALT
PATENT BLUE
E131 (Patent Blue V)
E131 (Patent Blue V)IOLET CALCIUM SALT
XYLENE BLUE V
acidalcarminev
bleupatentev
bluezn3
c.i.712
c.i.acidblue3,calciumsalt(2:1)
E131 (Patent Blue V) Sodium Salt 36001
Sicovit Patent Blue 85E131
Vitasyn E131 (Patent Blue V) 50
Vitasyn E131 (Patent Blue V) 85
Disulfine blue Ⅴ
c.i.foodblue5
dai-eiacidpurebluevx
ene)-2,5-cyclohexadien-1-ylidene)-n-ethyl-,hydroxide,innersalt,calciumsal
ene]-2,5-cyclohexadien-1-ylidene]-n-ethyl-,hydroxide,innersalt,calciumsalt
ethanaminium,n-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methyl
Ethanaminium,N-[4-[[4-(diethylamino)phenyl](5-hydroxy-2,4-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-,innersalt,calciumsalt(2:1)
l-blau3
merantinebluev
m-hydroxytetraethyldiaminotriphenylcarbinolanhydridedisulfonicacidcalcium
mitsuiacidpurebluevx
newpatentbluea-ceextra
newpatentblueextrapurea
patentbluevcarminebluev
schultzno.826
solarpurebluevx
ACID BLUE 3
ACID BLUE 3 CALCIUM SALT
ACID BLUE V
CI 42051
CI NO 42051
DISULFINE BLUE
Ethanaminium, N-4-4-(diethylamino)phenyl(5-hydroxy-2,4-disulfophenyl)methylene-2,5-cyclohexadien-1-ylidene-N-ethyl-, inner salt, calcium salt (2:1)
Acid blue 3 (C.I. 42051)
C.I. Acid Blue 3
Acid Blue 3 calcium salt, Acid Blue V calcium salt, Food Blue 5, E131 (Patent Blue V) hemicalcium salt
bis[hydrogen [4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt
E131 (Patent Blue V)IOLET CALCIUM
E131 (Patent Blue V) CALCIUM SALT
Acid Blue V calcium salt
C.l.42051
Food Blue 5
E131 (Patent Blue V) hemicalcium salt
E-131 E131 (Patent Blue V)
calcium,4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate
E131 (Patent Blue V) (~85%)
E131 (Patent Blue V), AR
Bis[hydrogen[4-[4-(diethylamino)-5'-hydroxy-2',4'-disulfonatobenzhydryliden]cyclohexa-2,5-dien-1-yli
E131 (Patent Blue V) USP/EP/BP
C.I.Acid Blue 3:C.I.42051
C.I.Food Blue 5:C.I.42051