E131 PATENT BLUE V

E131 patent blue V is a synthetic, water-soluble triphenylmethane dye used to produce intense blue or green shades in foods like confectionery, beverages, and glazes. 
E131 patent blue V authorized in the EU, it is largely unabsorbed by the body but banned in the US and other countries due to allergic reaction concerns. 
E131 patent blue V is a synthetic triarylmethane dye used as a blue food colorant in food, pharmaceuticals, and cosmetics.

CAS Number: 3536-49-0
Molecular Formula: C27H34CaN2O7S2
Molecular Weight: 602.77
EINECS Number: 222-573-8

Synonyms:Patent Blue V, Acid blue 3, Carmine Blue V, Merantine Blue V, Solar Pure Blue VX, Schultz No. 826, Patent Blue V and L, Mitsui Acid Pure Blue VX, New Patent Blue A-CE Extra, New Patent Blue Extra Pure A, NSC 5010, EINECS 222-573-8, Patent Blue 5, NSC 75430, Alphazurine 2 G (C.I. 42051), 8QE473DV1Z, C.I. 712, CI 42051, C.I. 42051, E 131, CI FOOD BLUE 5, ARIAVIT PATENT BLUE V, PATENT BLUE V [FCC], m-Hydroxytetraethyldiaminotriphenylcarbinol anhydride disulfonic acid calcium salt, INS NO.131, PATENT BLUE V [MART.], CHEBI:59601, COGILOR BLUE 517.11, DTXSID00873918, INS-131, VITASYN PATENT BLUE V 50, VITASYN PATENT BLUE V 85, PATENT BLUE V (E 131), NSC-5010, NSC-75430, Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (2:1), Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, inner salt, calcium salt (2:1), E-131, CI (1975) NO. 42051, Bis(hydrogen (4-(4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene)cyclohexa-2,5-dien-1-ylidene)diethylammonium), calcium salt, Ethanaminium, N-[4-[4-(diethylamino)phenyl
methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, inner salt, calcium salt (2:1), PATENT BLUE V CI 42051 E131 [WHO-DD], PATENT BLUE V (MART.), Bis[hydrogen [4-[4-(diethylamino)-5'-hydroxy-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium], calcium salt, Ethanaminium, N-[4-[4-(diethylamino)phenyl
methylene]-2,5-cyclohexadien-1-ylidene]-N-ethyl-, hydroxide, inner salt, calcium salt (2:1), N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium, N-(4-{4-(diethylamino)phenyl
methylene}cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium, RefChem:552561, ACID BLUE 3 [INCI], DTXCID801012103, PATENT BLUE V CI 42051 E131, 222-573-8, Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methyl-ene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (2:1), N-(4-((4-(Diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methyl-ene)-2,5-cyclohexadien-1-ylidene)-N-ethylethanaminium, hydroxide, inner salt, calcium salt (2:1), 3536-49-0, Acidal Carmine V, C.I. Food Blue 5, C.I. Acid Blue 3, Blue ZN 3, Dai-ei Acid Pure Blue VX, Patent Blue V calcium salt, Acid Blue 3 calcium, C.I. Acid Blue 3, calcium salt (2:1), Acid Blue 3 calcium salt, calcium 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate, calcium;4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate, Calcium 4-((4-(diethylamino)phenyl)(4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene)methyl)-6-hydroxybenzene-1,3-disulfonate, L-Blau 3 [German], Bleu patente V [French], UNII-8QE473DV1Z, Epitope ID:131791, calcium bis(4-{[4-(diethylamino)phenyl][4-(diethyliminio)cyclohexa-2,5-dien-1-ylidene]methyl}-6-hydroxybenzene-1,3-disulfonate), SCHEMBL340120, Patent Blue V hemicalcium salt, SCHEMBL1697999, MSK5802, CHEBI:187511, MFCD00038746, AKOS000283050, C.I.Acid Blue 3 (C.I.42051), E131, Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methyl- ene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (2:1), N-(4-((4-(Diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methyl- ene)-2,5-cyclohexadien-1-ylidene)-N-ethylethanaminium, hydroxide, inner salt, calcium salt (2:1), DB-048788, NS00013500, Patent Blue V calcium salt (C.I. 42051), G12105, Patent Blue V calcium salt, analytical standard, Q420087, Patent blue V calcium salt (C.I. 42051), extra pure, calcium;4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulonate, M-HYDROXYTETRAETHYLDIAMINOTRIPHENYLCARBINOL ANHYDRIDE DISULFONIC ACID CALCIUM SALT;PATENT BLUE V;PATENT BLUE VIOLET CALCIUM SALT;XYLENE BLUE V;acidalcarminev;bleupatentev;bluezn3;c.i.712

E131 patent blue V provides bright blue coloration in various products.
It is part of the triphenylmethane dye family.
E131 patent blue V consists of a complex aromatic structure with multiple benzene rings and sulfonate groups.

These groups give it strong color and high water solubility.
This enables use in aqueous systems.
Physically, it appears as a dark blue to violet-blue powder or granules.

E131 patent blue V is highly soluble in water but not in oils.
It has little to no odor.

E131 patent blue V provides a bright blue coloration, often used alone or mixed with yellow dyes to create green shades.
It has high tinting strength.
This makes it efficient in formulations.

Patent Blue V is highly water-soluble, allowing uniform dispersion in beverages, gels, and syrups.
This ensures consistent coloring.
E131 patent blue V is mainly used in water-based systems.

E131 patent blue V shows good stability in acidic and neutral conditions, making it suitable for drinks and desserts.
However, it may degrade in strong alkaline environments.
This affects formulation limits.

The dye has moderate heat stability, allowing it to withstand common food processing conditions.
Prolonged high temperatures can reduce intensity.
This limits some applications.

E131 patent blue V has no nutritional value, serving only as a coloring agent.
Its role is purely aesthetic.
This is typical for synthetic dyes.

E131 patent blue V is best described as a water-soluble synthetic blue dye with strong color intensity, widely used in food, pharmaceutical, and cosmetic applications for blue and green coloration.
E131 patent blue V, also called Food Blue 5, Sulphan Blue, Acid Blue 3, L-Blau 3, C-Blau 20, Patentblau V, Sky Blue, or C.I. 42051, is a sky blue synthetic triphenylmethane dye used as a food coloring.
As a food additive, it has E number E131. It is a sodium or calcium salt of [4-(α-(4-diethylaminophenyl)-5-hydroxy- 2,4-disulfophenylmethylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide inner salt.

E131 patent blue V also exhibits excellent performance in clear liquid systems, producing a vivid blue color without cloudiness.
It maintains transparency in beverages and syrups.
This improves visual quality.

E131 patent blue V shows pH-dependent stability, remaining most stable in acidic to neutral conditions, while alkaline environments can reduce its color strength.
This affects formulation choices.
It guides product design.

The dye has good synergy with other synthetic colorants, especially yellow dyes like tartrazine, to create stable green shades.
This expands color options.
This improves formulation versatility.

E131 patent blue V can be used in instant drink powders and concentrates, where it dissolves rapidly upon mixing with water.
It ensures consistent coloration after preparation.
This improves consumer experience.

E131 patent blue V is often applied in surface coatings and decorative applications, such as confectionery glazes and sugar shells.
It provides strong, uniform color coverage.
This enhances product appearance.

E131 patent blue V demonstrates moderate resistance to oxidation, but strong oxidizing agents can degrade its structure over time.
Controlled processing conditions are needed.
This ensures stability.

E131 patent blue V is also used in laboratory and diagnostic applications, where its strong color visibility is useful as a tracer or indicator.
It helps visualize biological or chemical processes.
E131 patent blue V is highly water-soluble due to sulfonate groups, ensuring fast and even distribution in aqueous systems.

Melting point: 200 °C
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO: 83.33 mg/mL (143.49 mM)
Colour Index: 42051
form: Solid
color: Brown to black
Water Solubility: 20.98 g/L at 20℃
BRN: 4108121
Major Application: cleaning products; cosmetics; food and beverages; personal care
Cosmetics Ingredients Functions: HAIR DYEING; COLORANT
InChIKey: RTMBGDBBDQKNNZ-UHFFFAOYSA-L
LogP: -1.99 at 25℃

E131 patent blue V, then reduction, then the amino diazotization and then translate into hydroxyl compound, and then two stlfonation, finally will product into calcium salt, and segregation and oxidation; (b)3-Hydroxybenzaldehyde and N,N-diethylbenzenamine (2 Moore) condensation, and then two stlfonation, into calcium salt and oxidation. The dyes can also be as sodium salting out.
E131 patent blue V also shows high tinctorial strength, meaning very small amounts can produce strong blue coloration.
It reduces required dosage.

E131 patent blue V is widely used in color blending systems, especially combined with yellow dyes to produce green shades.
This allows a wide range of color customization.
This improves formulation flexibility.

E131 patent blue V performs well in aqueous systems such as beverages, gels, and syrups.
Its high water solubility ensures even distribution.
This provides uniform coloration.

E131 patent blue V demonstrates good compatibility with hydrocolloids, making it suitable for jellies, desserts, and gel-based products.
It disperses evenly in gel matrices.
This ensures consistent appearance.

The dye shows moderate light sensitivity, meaning prolonged exposure to light may cause gradual fading.
Protective packaging helps maintain color intensity.
This improves shelf life.

E131 patent blue V has moderate resistance to heat, allowing use in pasteurized or mildly heated foods.
However, extreme heat can degrade the dye.
This limits high-temperature applications.

Patent Blue V is often used in pharmaceutical applications, including tablets, capsules, and diagnostic preparations.
E131 patent blue V provides clear visual identification.
This improves usability.

E131 patent blue V is applied in cosmetic products, especially water-based formulations such as shampoos and bath products.
It provides bright blue shades.
This enhances product appearance.

The dye is not suitable for fat-based systems unless emulsified, due to its hydrophilic nature.
This defines its main application range.
E131 patent blue V is a highly water-soluble synthetic blue dye with strong color intensity, good compatibility in aqueous systems, and broad use in food, pharmaceutical, and cosmetic applications.

E131 patent blue V is increasingly subject to regulatory monitoring and labeling requirements in food applications, depending on the region.
This reflects safety evaluations.
E131 patent blue V (Patent Blue V) is a strong, water-soluble synthetic blue dye with high color intensity and wide use in aqueous food, pharmaceutical, cosmetic, and technical applications, especially for blue and green coloration systems.

Uses Of E131 patent blue V:
E131 patent blue V is double labeled product for electron microscopy and fluorescence research
E131 patent blue V is used in the food industry as a synthetic blue colorant.
It provides strong blue shades in various products.

In beverages such as soft drinks, flavored drinks, and syrups, it is commonly used due to its high water solubility.
E131 patent blue V dissolves evenly in liquids.
This ensures consistent coloration.

E131 patent blue V is applied in confectionery products, including candies, gummies, jellies, and chewing gum.
It provides stable and bright blue coloring.
This enhances product attractiveness.

E131 patent blue V is used in desserts such as puddings, jelly products, and ice creams.
It disperses well in aqueous and gel systems.
This improves appearance consistency.

In bakery decorations and icings, it provides blue or mixed green shades when combined with yellow dyes.
E131 patent blue V maintains color stability in sugar-based systems.
This improves decorative quality.

E131 patent blue V is used in processed dairy and dairy-like products, such as flavored yogurts and desserts.
It enhances visual appeal in colored varieties.
This improves product presentation.

E131 patent blue V is widely used in pharmaceutical products, including tablets, capsules, and syrups.
It helps with coloring and identification.
This improves usability.

In cosmetics and personal care products, such as shampoos, soaps, and bath products, it provides blue coloration.
E131 patent blue V enhances aesthetic properties.
This improves consumer appeal.

E131 patent blue V is also used in instant drink powders and beverage concentrates, where it dissolves quickly and evenly.
It ensures uniform color after preparation.
This improves product quality.

E131 patent blue V is used wherever strong, stable blue coloration in water-based systems is required across food, beverage, cosmetic, and pharmaceutical applications.
E131 patent blue V is a water-soluble food colouring. 
E131 patent blue V has also been used as a standard for high-performance liquid chromatography-diode array detection for dating of paper ink. 

It is not widely used, but in Europe it can be found in Scotch eggs, certain jelly sweets, blue Curaçao, and certain gelatin desserts, among others. 
An important advantage is the very deep color it produces even at low concentration; a disadvantage is that it fades fairly quickly when exposed to light.

E131 patent blue V is also used in sports and energy drinks, where it helps create bright blue or turquoise branding colors.
It blends well with acidic beverage formulations.
This improves product recognition.

In ice creams and frozen desserts, it is used to produce blue-themed or flavored varieties.
E131 patent blue V remains stable under freezing conditions.
This ensures consistent appearance.

E131 patent blue V is applied in jelly sweets and gelatin desserts, where it distributes evenly in gel matrices.
It produces uniform coloration throughout the product.
This improves visual consistency.

E131 patent blue V is used in chewing gum coatings and sugar shells, where it provides strong surface color.
It adheres well to sugar-based layers.
This enhances decorative effect.

In fruit-flavored fillings and sauces, it is sometimes used for visual differentiation or themed products.
E131 patent blue V helps achieve specific color concepts.
This improves marketing appeal.

E131 patent blue V is used in pharmaceutical syrups and oral solutions, where it assists with product identification and branding.
It helps distinguish formulations.
This improves usability and safety.

E131 patent blue V is also applied in cosmetic bath products such as shower gels and bubble baths.
It provides stable blue coloration in aqueous systems.
This enhances product aesthetics.

E131 patent blue V can be used in laboratory and analytical applications, where its strong color visibility is useful for tracking and tracing processes.
It supports visualization tasks.
This extends technical applications.

In some regions, its use is restricted or monitored due to safety evaluations, which may limit concentration levels in food products.
This affects regulatory compliance.
E131 patent blue V is used wherever intense, stable blue coloration in aqueous systems is required, particularly in food, beverage, cosmetic, pharmaceutical, and technical applications.

Safety Profile Of E131 patent blue V:
E131 patent blue V is a synthetic dye with moderate hazard concerns, mainly related to allergic reactions and sensitivity in certain individuals, rather than acute toxicity at regulated levels.
Its use is controlled under food safety regulations.
Permitted intake levels vary by region.

One of the main concerns is hypersensitivity reactions, including skin rash, itching, or urticaria in sensitive individuals.
These reactions are uncommon but documented.
People with dye allergies may be more at risk.

In some cases, it may cause pseudo-allergic reactions, such as asthma-like symptoms or nasal irritation.
This is more likely in individuals sensitive to azo or synthetic dyes.
Avoidance is recommended for sensitive groups.

Eye contact may cause mild irritation, especially with concentrated solutions.
It is not corrosive but should still be avoided.
Rinsing with water is recommended if exposure occurs.

Skin contact is generally low risk, but may cause mild irritation or staining in concentrated forms.
Prolonged exposure should be minimized.
Protective handling is advised in industrial use.

Inhalation of dust may cause respiratory irritation, particularly in occupational environments.
Fine particles can irritate the nose and throat.
Adequate ventilation reduces risk.

At approved food levels, E131 patent blue V is considered safe for general consumption, and no significant toxicity is expected in healthy individuals.
However, intake must remain within regulatory limits.
E131 patent blue V is not highly flammable, but as an organic compound it may contribute to combustion under extreme conditions.