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E306 tocopherols are a group of natural fat-soluble antioxidants belonging to the vitamin E family, widely used to protect fats and oils from oxidation in food, cosmetics, and pharmaceutical applications.
E306 tocopherols consist of several isomers.
E306 tocopherols are derived mainly from vegetable oils.
CAS Number: 1406-66-2
Molecular Formula: C28H48O2
Molecular Weight: 416.67952
EINECS Number: 604-195-9
Synonyms:Tocopherols, 1406-66-2, Methyltocols, R0ZB2556P8, Lasar, UnoVit, VitaE, Vitamin Emp, E Vicotrat, Micorvit E, E Mulsin, VitaPlus E, Vitamin E mp, Vitamin E-mp, Uno Vit, Vitamin E Dragees, Dal E, Vitamin E, Mowivit, Vitamin E, Togasan, Antioxidans E-Hevert, Vitamin E, Vitagutt, VitaminE EVIMIRALE, Vitamin E EVI MIRALE, BatanaOil, Conju Princess, Tocopherol 5%, CVC Hair Vitamin, Q7 Carrot Body, Stretch Warks Cream, Cocoa Butter Formula, TUREMRIC, VITAMINOIL, Massage Eaethworm Cream, GZE LIP BALM, DRUGGIST HAIR VITAMIN, COVI-OX T 50 C, COVI-OX T 70 C, MIXED TOCOPHEROLS 95, Conju Princess Cleansing Balm, Skin Care and Hair Care Set, CVC VITAMIN C VITAMIN E, ORISTAR MIXED TOCOPHEROLS, DTXSID8021357, CHEBI:27013, Guangzhou Yilong Cosmetics Co., Ltd, 604-195-9, 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol, Tocopherol, Vita Plus E, 7616-22-0, 73980-80-0, Rac-gamma-tocopherol, (+/-)-gamma-Tocopherol, 3,4-Dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol, E-MIX 80, 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-, delta-A-Tocopherol, C28H48O2, (Rac)-gamma-Tocopherol, UNII-ECY0XG64DO, 7,8-Dimethyltocolo-xylotocopherol, CCRIS 3610, CCRIS 4506, gamma-Tocopherol, EINECS 231-523-4, DL-gamma-tocopherol, Tocopherol [JAN], gamma-Tocopherol DL-form, SCHEMBL39640, CHEMBL420898, MFCD00036172, (+/-)-7,8-Dimethyltocol, ALL-RAC-gamma-Tocopherol, DB-323925, EC 604-195-9, 2,7,8-Trimethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol, 2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol;Controx VP;Covi-Ox T 30P;Covi-Ox T 50;Covi-Ox T 70;Dry E-Mix 20;E 306;E-Mix 40A
E306 tocopherols include alpha-, beta-, gamma-, and delta-tocopherol, all sharing a chromanol ring with a hydroxyl group and a hydrophobic phytyl side chain.
Differences in methyl group substitution define each isomer.
This affects their antioxidant behavior.
Physically, E306 tocopherols appear as viscous oily liquids ranging from light yellow to brown.
E306 tocopherols are insoluble in water but soluble in fats and organic solvents.
They have a mild characteristic odor.
E306 tocopherols exhibit strong antioxidant activity, protecting lipids by scavenging free radicals.
E306 tocopherols interrupt oxidation chain reactions.
This prevents rancidity.
E306 tocopherols are particularly effective in stabilizing unsaturated fats and oils, which are prone to oxidative degradation.
E306 tocopherols slow peroxide formation.
This extends shelf life.
E306 tocopherols also have vitamin E activity, playing a role in biological antioxidant defense systems.
They support cellular protection.
This adds nutritional value.
E306 tocopherols show good stability under moderate processing conditions, but are sensitive to oxygen, light, and prolonged high heat.
Proper storage is required.
E306 tocopherols are best described as natural, lipid-soluble antioxidants with vitamin E activity, widely used to protect fats and oils and improve stability in food and industrial systems.
E306 tocopherols also provide protection against secondary oxidation products, meaning they not only slow initial lipid oxidation but also reduce formation of aldehydes and ketones that cause off-flavors.
This improves overall sensory stability.
E306 tocopherols maintains product quality.
E306 tocopherols are highly effective in bulk oils and fats, where oxidation occurs throughout the matrix.
They distribute evenly in lipid phases.
This enhances protection uniformity.
E306 tocopherols can act as oxygen scavengers indirectly, reducing available oxygen in lipid environments through radical termination reactions.
This slows oxidative stress.
It improves shelf life.
E306 tocopherols are commonly used in refined vegetable oils, especially those rich in polyunsaturated fatty acids.
They stabilize oils during storage and transport.
This prevents rancidity.
E306 tocopherols are also used in animal-derived fats, such as fish oil and lard.
E306 tocopherols help prevent rapid oxidation of highly unsaturated marine oils.
E306 tocopherols show compatibility with emulsifiers and phospholipids, allowing use in complex food systems such as dressings and spreads.
They distribute well in emulsions.
This improves formulation performance.
E306 tocopherols are widely used in nutritional supplements and fortified foods, contributing both antioxidant protection and vitamin E intake.
This supports functional nutrition.
E306 tocopherols are multi-functional natural antioxidants with strong lipid protection, synergistic regeneration ability, and dual nutritional and preservative roles, widely used in food, cosmetic, and pharmaceutical systems.
Density: 0.930 g/mL at 25 °C
refractive index: n20/D 1.501
Flash point: >200℃
form: Viscous
color: Colorless to light yellow
biological source: vegetable oil
Boiling point: >200°C
Major Application: flavors and fragrances
Cosmetics Ingredients Functions: FRAGRANCE; SKIN CONDITIONING - MISCELLANEOUS; ANTIOXIDANT; SKIN CONDITIONING - OCCLUSIVE
InChI: InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3
InChIKey: QUEDXNHFTDJVIY-UHFFFAOYSA-N
SMILES: C1(C)(CCCC(C)CCCC(C)CCCC(C)C)OC2=C(C=C(O)C(C)=C2C)CC1
LogP: 10.724 (est)
E306 tocopherols is stable to heat and alkalis in the presence of oxygen, and is not affected by acids up to 212° F.
E306 tocopherols is slowly oxidized by atmospheric oxygen and rapidly oxidized by ferric and silver salts.
E306 tocopherols gradually darkens on exposure to light. .
E306 tocopherols function as chain-breaking antioxidants, donating hydrogen atoms from their phenolic hydroxyl group to neutralize lipid radicals.
This interrupts oxidation propagation.
E306 tocopherols slows rancidity formation.
E306 tocopherols are highly lipophilic, allowing them to localize in fat and oil phases where oxidation primarily occurs.
This ensures targeted protection.
E306 tocopherols improves efficiency in lipid systems.
Different isomers show varying antioxidant performance, with gamma- and delta-tocopherol often more effective in food preservation, while alpha-tocopherol has higher vitamin activity.
This allows tailored use.
E306 tocopherols improves formulation flexibility.
E306 tocopherols exhibit synergistic effects with other antioxidants, such as ascorbic acid and citric acid.
E306 tocopherols are particularly effective in unsaturated and polyunsaturated fatty acid systems, which are highly prone to oxidation.
This improves product quality.
E306 tocopherols demonstrate carry-through activity, meaning they remain active after processing steps like baking or mild frying.
They continue protecting during storage.
This extends shelf life.
E306 tocopherols have low volatility, so they are retained in products during storage and moderate heating.
This ensures long-lasting effectiveness.
This improves reliability.
E306 tocopherols may interact with oxygen and trace metals, helping reduce oxidative pathways indirectly.
This supports comprehensive antioxidant systems.
E306 tocopherols improves performance.
E306 tocopherols are often used as mixed tocopherols, providing broader antioxidant coverage than a single isomer.
This increases stability across different conditions.
E306 tocopherols are natural, fat-soluble antioxidants with strong radical-scavenging ability, synergistic performance, and dual role as preservatives and nutrients, widely used in food, cosmetic, and pharmaceutical applications.
E306 tocopherols exhibit temperature-dependent stability, remaining effective at moderate heat but gradually degrading under prolonged high-temperature exposure.
This limits their use in extreme frying conditions.
E306 tocopherols defines application boundaries.
Tocopherols can be recycled in antioxidant cycles when combined with other compounds like ascorbate.
This regenerates active antioxidant forms.
E306 tocopherols show compatibility with emulsifiers and phospholipids, allowing use in complex food systems such as dressings and spreads.
Uses:
E306 tocopherols are a class or organic molecules. Many exhibit the activity of Vitamin E. They are commonly found in Olive and sunflower oils.
E306 tocopherols are widely used in the food industry as natural antioxidants to prevent oxidation of fats and oils.
They help stop rancidity and off-flavor formation.
In edible oils and fats, they stabilize vegetable oils, fish oils, and animal fats.
E306 tocopherols protect unsaturated fatty acids from degradation.
This improves storage stability.
E306 tocopherols are applied in processed foods such as snacks, baked goods, and ready meals.
They preserve fat quality during storage and distribution.
This maintains product taste.
Tocopherols are used in nut and seed products, such as nut butters and mixed nuts.
They prevent oxidation of natural oils.
This improves freshness.
In frozen foods, they help protect fats during long-term storage at low temperatures.
E306 tocopherols remain active during freezing and thawing.
This improves product consistency.
E306 tocopherols are widely used in cosmetics and personal care products, including creams, lotions, and oils.
They stabilize lipid components and fragrances.
This improves product durability.
E306 tocopherols are applied in pharmaceutical formulations, especially lipid-based capsules and ointments.
In animal feed, they help preserve fat-rich ingredients and provide vitamin E nutrition.
They prevent spoilage during storage.
E306 tocopherols are also used in industrial applications, such as lubricants and specialty oils.
They slow oxidative degradation of materials.
E306 tocopherols are used wherever natural antioxidant protection, lipid stabilization, and vitamin E enrichment are needed across food, cosmetic, pharmaceutical, feed, and industrial systems.
E306 tocopherols are also used in functional foods and fortified products to combine antioxidant protection with nutritional vitamin E value.
E306 tocopherols support both preservation and health benefits.
This improves product functionality.
In infant and specialized nutrition formulas, they help stabilize sensitive fats such as polyunsaturated fatty acids.
E306 tocopherols protect essential nutrients from oxidation.
This ensures product safety and quality.
E306 tocopherols are applied in fish oil and omega-3 supplements, where oxidation risk is very high.
They prevent formation of fishy odors and rancid compounds.
This improves supplement stability.
E306 tocopherols are used in confectionery products containing fats, such as chocolate, coatings, and fillings.
E306 tocopherols reduce fat bloom and oxidative flavor loss.
This improves appearance and taste.
In bakery fillings and creams, they stabilize oils and fat-based ingredients.
E306 tocopherols prevent rancidity during storage.
This extends shelf life.
E306 tocopherols are widely used in cosmetic serums, sunscreens, and anti-aging creams.
They protect oils and active ingredients from oxidative damage.
This improves product performance.
In pharmaceutical lipid emulsions and softgel capsules, they help maintain chemical stability of active compounds.
E306 tocopherols reduce oxidation of carriers.
This supports formulation integrity.
E306 tocopherols are used in pet food products, especially those containing fish oils or high-fat content.
They preserve nutritional quality during storage.
This improves feed stability.
E306 tocopherols are also applied in biodegradable packaging materials and bio-based polymers.
They slow oxidative degradation of natural components.
E306 tocopherols are used wherever natural, multifunctional protection of fats, oils, and sensitive nutrients is required, particularly in food, cosmetic, pharmaceutical, feed, and emerging bio-based industrial systems.
Safety Profile:
E306 tocopherols present very low hazard potential, as they are natural vitamin E compounds widely used in foods, cosmetics, and supplements.
They are generally recognized as safe at approved dietary levels.
However, some precautions apply in concentrated or industrial forms.
Skin contact is typically low risk, and tocopherols are often used in topical skincare products.
Rarely, they may cause mild irritation or allergic reactions in sensitive individuals.
Patch testing may be useful for sensitive users.
Eye contact may cause mild irritation, especially with concentrated oily formulations.
Symptoms can include redness or slight discomfort.
Rinsing with water is recommended if exposure occurs.
E306 tocopherols inhalation is generally not a concern, as tocopherols have very low volatility.
However, aerosolized formulations may cause minor irritation in sensitive respiratory systems.
