PRODUCTS

E327 (Calcium lactate)

EC / List no.: 212-406-7
CAS no.: 814-80-2
Mol. formula: C3H6O3.1/2Ca

E327 (Calcium lactate) is a white crystalline salt with formula C6H10CaO6, consisting of two lactate anions H3C(CHOH)CO−2 for each calcium cation Ca2+.
E327 (Calcium lactate) forms several hydrates, the most common being the pentahydrate C6H10CaO6·5H2O.

E327 (Calcium lactate) is used in medicine, mainly to treat calcium deficiencies; and as a food additive with E number of E327.
Some cheese crystals consist of E327 (Calcium lactate).

Properties
The lactate ion is chiral, with two enantiomers, D (−,R) and L (+,S).
The L isomer is the one normally synthesized and metabolized by living organisms, but some bacteria can produce the D form or convert the L to D.
Thus E327 (Calcium lactate) also has D and L isomers, where all anions are of the same type.

Some synthesis processes yield a mixture of the two in equal parts, resulting in the DL (racemic) salt.
Both the L and the DL forms occur as crystals on the surface of aging Cheddar cheese.

The solubility of calcium L-lactate in water increases significantly in presence of d-gluconate ions, from 6.7 g/dl) at 25 °C to 9.74 g/dl or more.
Paradoxically, while the solubility of calcium L-lactate increases with temperature from 10 °C (4.8 g/dl) to 30 °C (8.5 g/dl), the concentration of free Ca2+ ions decreases by almost one half.
This is explained as the lactate and calcium ions becoming less hydrated and forming a complex C3H5O3Ca+.

The DL (racemic) form of the salt is much less soluble in water than the pure L or D isomers, so that a solution that contains as little as 25% of the D form will deposit racemic DL-lactate crystals instead of L-lactate.

The pentahydrate loses water in a dry atmosphere between 35 and 135 °C, being reduced to the anhydrous form and losing its crystalline character.
The process is reversed at 25 °C and 75% relative humidity.

Preparation
E327 (Calcium lactate) can be prepared by the reaction of lactic acid with calcium carbonate or calcium hydroxide.

Since the 19th century, the salt has been obtained industrially by fermentation of carbohydrates in the presence of calcium mineral sources such as calcium carbonate or calcium hydroxide.
Fermentation may produce either D or L lactate, or a racemic mixture of both, depending on the type of organism used.

Uses:
Medicine
E327 (Calcium lactate) has several uses in human and veterinary medicine.

E327 (Calcium lactate) is used in medicine as an antacid.

E327 (Calcium lactate) is also used to treat hypocalcaemia (calcium deficiencies).
E327 (Calcium lactate) can be absorbed at various pHs, thus it does not need to be taken with food. However, in this use it has been found to be less convenient than calcium citrate.

In the early 20th century, oral administration of E327 (Calcium lactate) dissolved in water (but not in milk or tablets) was found to be effective in prevention of tetany in humans and dogs with parathyroid insufficiency or who underwent parathyroidectomy.

The compound is also found in some mouth washes and toothpaste as an anti-tartar agent.

E327 (Calcium lactate) (or other calcium salts) is an antidote for soluble fluoride ingestion and hydrofluoric acid.

Food industry
The compound is a food additive classified by the United States FDA as Generally Recognized as Safe (GRAS), for uses as a firming agent, a flavor enhancer or flavoring agent, a leavening agent, a nutritional supplement, and a stabilizer and thickener.

E327 (Calcium lactate) is also known as cheese lactate because it coagulates milk, making the chhena used in the production of paneer cheese.
Chhena is also used to make various sweets and other milk proteins.

E327 (Calcium lactate) is an ingredient in some baking powders containing sodium acid pyrophosphate.
E327 (Calcium lactate) provides calcium in order to delay leavening.

E327 (Calcium lactate) is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, it increases the remineralization of tooth enamel.

The compound is also added to fresh-cut fruits, such as cantaloupes, to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.

E327 (Calcium lactate) is used in molecular gastronomy as a flavorless fat-soluble agent for plain and reverse spherification.
E327 (Calcium lactate) reacts with sodium alginate to form a skin around the food item.

Animal feeds
E327 (Calcium lactate) may be added to animal rations as a source of calcium.

Chemistry
The compound was formerly an intermediate in the preparation of lactic acid for food and medical uses.
The impure acid from various sources was converted to E327 (Calcium lactate), purified by crystallization, and then converted back to acid by treatment with sulfuric acid, which precipitated the calcium as calcium sulfate.
This method yielded a purer product than would be obtained by distillation of the original acid.
Recently ammonium lactate has been used as an alternative to calcium in this process.

Water treatment
E327 (Calcium lactate) has been considered as a coagulant for removing suspended solids from water, as a renewable, non-toxic, and biodegradable alternative to aluminum chloride AlCl3.

Bioconcrete
Addition of E327 (Calcium lactate) substantially increases the compressive strength and reduces water permeability of bioconcrete, by enabling bacteria such as Enterococcus faecalis, Bacillus cohnii, Bacillus pseudofirmus and Sporosarcina pasteurii to produce more calcite.

Uses:
E327 (Calcium lactate) is the calcium salt of lactic acid which is soluble in water. it has a solubility of 3.4 g/100 g of water at 20°c and is very soluble in hot water. it is available as a monohydrate, trihydrate, and pentahydrate.
The trihydrate and pentahydrate have solubilities of 9 g in 100 ml of water at 25°c.
E327 (Calcium lactate) contains approximately 14% calcium.
E327 (Calcium lactate) is used to stabilize and improve the texture of canned fruits and vegetables by converting the labile pectin to the less solu- ble calcium pectate.
E327 (Calcium lactate) thereby prevents structural collapse during cooking.
E327 (Calcium lactate) is used in angel food cake, whipped toppings, and meringues to increase protein extensibility which results in an increase of foam volume.
E327 (Calcium lactate) is also used in calcium fortified foods such as infant foods and is used to improve the properties of dry milk powder.

As a preservative in foods and beverages; in dentifrices.

Lactic Acid Calcium Salt is used in foods as an ingredient in baking powder.
Lactic Acid Calcium Salt is also used as an antacid and also to treat calcium deficiencies.

Description
E327 (Calcium lactate) is a black or white crystalline salt made by the action of lactic acid on calcium carbonate.
E327 (Calcium lactate) is used in foods (as an ingredient in baking powder) and given medicinally.
Its E number is E327. E327 (Calcium lactate) is created by the reaction of lactic acid with calcium carbonate or calcium hydroxide.
E327 (Calcium lactate) is often found in aged cheeses.
Small crystals of it precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.
In medicine, E327 (Calcium lactate) is most commonly used as an antacid and also to treat calcium deficiencies.
E327 (Calcium lactate) can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons.
E327 (Calcium lactate) is added to sugar-free foods to prevent tooth decay.
When added to chewing gum containing xylitol, it increases the remineralization of tooth enamel.
E327 (Calcium lactate) is also added to fresh-cut fruits such as cantaloupes to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.

Chemical Properties
White or almost white, crystalline or granular powder.
E327 (Calcium lactate) occurs as white or almost white, crystalline or granular powder.
E327 (Calcium lactate) is slightly efflorescent.

Production Methods
E327 (Calcium lactate) is prepared commercially by neutralization with calcium carbonate or calcium hydroxide of lactic acid obtained from fermentation of dextrose, molasses, starch, sugar, or whey.

Pharmaceutical Applications
E327 (Calcium lactate) is used as a bioavailability enhancer and nutrient supplement in pharmaceutical formulations.
A spray-dried grade of E327 (Calcium lactate) pentahydrate has been used as a tablet diluent in direct compression systems, and has been shown to have good compactability.
The properties of the pentahydrate form have been considered superior to those of E327 (Calcium lactate) trihydrate when used in direct compression tablet formulations.
Tablet properties may be affected by the hydration state of the E327 (Calcium lactate) and particle size of the material: reducing particle size increased crushing strength, whereas storage of tablets at elevated temperature resulted in dehydration accompanied by a reduction in crushing strength.
E327 (Calcium lactate) has also been used as the source of calcium ions in the preparation of calcium alginate microspheres for controlled- release delivery of active agents.
E327 (Calcium lactate) has been shown to result in lower calcium concentrations in the finished microspheres when compared with calcium acetate.
Therapeutically, E327 (Calcium lactate) has been used in preparations for the treatment of calcium deficiency.

E327 (Calcium lactate) is a salt that consists of two lactate anions for each calcium cation (Ca2+).
E327 (Calcium lactate) is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide.
Approved by the FDA as a direct food substance affirmed as generally recognized as safe, E327 (Calcium lactate) is used as a firming agent, flavoring agent, leavening agent, stabilizer, and thickener.
E327 (Calcium lactate) is also found in daily dietary supplements as a source of calcium.
E327 (Calcium lactate) is also available in various hydrate forms, where E327 (Calcium lactate) pentahydrate is the most common.

This medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
E327 (Calcium lactate) may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
E327 (Calcium lactate) may also be used in certain patients to make sure they are getting enough calcium (such as women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body.
E327 (Calcium lactate) is necessary for normal functioning of nerves, cells, muscle, and bone.
If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones.
Having the right amount of calcium is important for building and keeping strong bones.

How to use E327 (Calcium lactate)
Take this medication by mouth with food.
If your product contains calcium citrate, then E327 (Calcium lactate) may be taken with or without food.
Follow all directions on the product package, or take as directed by your doctor.
For best absorption, if your daily dose is more than 600 milligrams, then divide your dose and space E327 (Calcium lactate) throughout the day.

E327 (Calcium lactate) is a food additive that’s typically added to a wide variety of foods to enhance their texture and flavor or help extend their shelf life.

This compound can also be used as an ingredient in medications or certain types of calcium supplements.

What is E327 (Calcium lactate)?
E327 (Calcium lactate) is a white or cream, almost odorless food additive derived from lactic acid, a compound that cells naturally create when trying to produce energy in low oxygen conditions .

It’s produced commercially by neutralizing lactic acid with calcium carbonate or calcium hydroxide and most often used to stabilize, thicken, flavor, firm, or leaven foods.
E327 (Calcium lactate) is either referred to by its name or E number — E327 .

E327 (Calcium lactate) can also be added to calcium supplements or medications used to treat acid reflux, bone loss, a poorly functioning parathyroid gland, or certain muscle diseases.

E327 (Calcium lactate) may also be added to animal feed or used to treat water to make it suitable for human consumption.
Despite its similar name, E327 (Calcium lactate) does not contain lactose. As such, it’s safe for people with lactose intolerance.

E327 (Calcium lactate) is a commercially produced food additive used to stabilize, thicken, flavor, firm, or leaven foods. It’s also used in water treatment facilities or added to animal feed, calcium supplements, or pharmaceutical drugs.

What foods contain E327 (Calcium lactate)?
E327 (Calcium lactate) is commonly used as a food additive in packaged foods, such as:

nectars
jams, jellies, and marmalades
butter, margarine, and other types of fats used for cooking or frying
canned fruits and vegetables
beer
It’s sometimes also added to fresh foods, such as mozzarella cheese, fresh pastas, or precut fruit to help them maintain their firmness or extend their shelf life.

You can tell whether a food contains E327 (Calcium lactate) by looking for it on the ingredient label. E327 (Calcium lactate) may also be labeled as E327 .

E327 (Calcium lactate) can be found in a variety of packaged foods, including jams, beer, and cooking fats, as well as canned fruits and vegetables.
E327 (Calcium lactate) can also be added to certain cheeses, fresh pastas, or precut fruits.

Possible health benefits
Very few studies have specifically researched the health benefits of E327 (Calcium lactate).

That said, it can be used as a main source of calcium in calcium supplements, and some studies link calcium-rich diets to stronger and healthier bones, though research is inconsistent.

Though sourcing your calcium directly from foods remains the best way to ingest this mineral, supplements can be a helpful tool for those who are unable to get enough calcium through their diet alone .

When consumed as a supplement, E327 (Calcium lactate) may provide benefits similar to those associated with other calcium supplements, including:

Stronger bones. When taken together with vitamin D, calcium supplements are thought to contribute to the development and maintenance of strong, healthy bones.
Reduced blood pressure.
Calcium-rich diets may help slightly lower systolic blood pressure (the top number) in those with elevated blood pressure.
However, there seems to be little benefit among people with normal blood pressure levels.
Protection against preeclampsia.
High calcium intakes during pregnancy may lower the risk of preeclampsia, a serious complication that affects up to 14% of pregnancies worldwide.
Protection against colon cancer. Studies suggest that a high calcium intake from foods or supplements may reduce colon cancer risk.
Still, more research is needed to confirm these findings.

E327 (Calcium lactate) is sometimes added to calcium supplements, which may help improve bone strength, oral health, and blood pressure, as well as perhaps even lower the risk of colon cancer in people unable to get enough of this mineral through their diet alone.

About E327 (Calcium lactate)
Helpful information
E327 (Calcium lactate) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.

E327 (Calcium lactate) is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses
E327 (Calcium lactate) is used in the following products: cosmetics and personal care products.
Other release to the environment of E327 (Calcium lactate) is likely to occur from: indoor use as processing aid.
Article service life
ECHA has no public registered data on the routes by which E327 (Calcium lactate) is most likely to be released to the environment.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
E327 (Calcium lactate) is used in the following products: plant protection products, polishes and waxes and washing & cleaning products.
E327 (Calcium lactate) is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of E327 (Calcium lactate) is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.
Formulation or re-packing
E327 (Calcium lactate) is used in the following products: metal surface treatment products, non-metal-surface treatment products, plant protection products, semiconductors, washing & cleaning products and cosmetics and personal care products.
Release to the environment of E327 (Calcium lactate) can occur from industrial use: formulation of mixtures.
Uses at industrial sites
E327 (Calcium lactate) is used in the following products: metal surface treatment products, non-metal-surface treatment products and semiconductors.
E327 (Calcium lactate) is used for the manufacture of: chemicals and electrical, electronic and optical equipment.
Release to the environment of E327 (Calcium lactate) can occur from industrial use: in processing aids at industrial sites and as processing aid.
Manufacture
Release to the environment of E327 (Calcium lactate) can occur from industrial use: manufacturing of the substance.

E327 (Calcium lactate) is a mineral that is used to treat or prevent low blood calcium levels (hypocalcemia) in people who do not get enough calcium from food.

E327 (Calcium lactate) is also used in the treatment of conditions such as osteoporosis, disorders of the parathyroid gland, or certain muscle problems.

E327 (Calcium lactate) may also be used for purposes not listed in this medication guide.
E327 (Calcium lactate) is a calcium salt.
E327 (Calcium lactate) is a less concentrated form of calcium, and seems to be less bioavailable than other forms of supplemental calcium.
Because of this, E327 (Calcium lactate) is not the most practical form of oral supplemental calcium.
E327 (Calcium lactate) is often used as a food additive to enhance the calcium content of foods, replace other salts, or increase the overall pH (decrease acidity) of the food.

What Is E327 (Calcium lactate) Used For?
Calcium is the most abundant mineral in the body.
E327 (Calcium lactate) is required for heart, muscle, and nerve function. In the body, blood calcium levels remain relatively consistent and unchanged.
E327 (Calcium lactate) is acquired from dietary sources.

If you do not get enough calcium in your diet, your body takes calcium from your bones to maintain constant appropriate levels of calcium throughout the rest of the body.
If this continues on a long-term basis, it could weaken the bones and increase the risk of fracture.

Apart from calcium for bone health, additional possible benefits of E327 (Calcium lactate) supplementation include benefits to heart health, oral health, and exercise performance.

Calcium is a mineral that is found naturally in foods.
Calcium is necessary for many normal functions of your body, especially bone formation and maintenance.
Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

E327 (Calcium lactate) is used to prevent and to treat calcium deficiencies.

E327 (Calcium lactate) may also be used for other purposes not listed in this medication guide

E327 (Calcium lactate) is a mineral that is used to treat or prevent low blood calcium levels (hypocalcemia) in people who do not get enough calcium from food.

E327 (Calcium lactate) is also used in the treatment of conditions such as osteoporosis, disorders of the parathyroid gland, or certain muscle problems.

E327 (Calcium lactate) may also be used for purposes not listed in this medication guide.

What is E327 (Calcium lactate) (Ridactate) used for?
Hypocalcemia
Osteomalacia
Osteoporosis
Pseudohypoparathyroidism
Hypoparathyroidism
Hungry Bone Syndrome
Tumor Lysis Syndrome

IUPAC NAMES:
calcium bis(2-hydroxypropanoate)
calcium dilactate
Calcium dilactate
E327 (Calcium lactate) pentahydrate

SYNONYMS:
LACTIC ACID CALCIUM SALT, TRIHYDRATE
E327 (Calcium lactate), TRIHYDRATE
2-HYDROXYPROPANOIC ACID CALCIUM SALT, TRIHYDRATE
2-hydroxy-propanoicacicalciumsalt(2:1)
calciumlactate(1:2)
calphosan
Calcium DL-lactate
Conclyte Ca
Lactic acid, calcium salt (2:1) (8CI)
L-Cal
Pationic 1230
Pationic 1240
Prequist Powder
Tokal
CALCIUMGLUCONOLACTATE
Calcium dilactate
E327 (Calcium lactate)
Lactic acid calcium salt (2:1)
Calcium 2-hydroxypropanoate
Bis(2-hydroxypropanoic acid) calcium
Bis(2-hydroxypropanoic acid)calcium salt
CalciuM LaCLate
E327 (Calcium lactate) FOR SOIL TESTS
Purac Powder 60
Lactic acid (calcium)
Calcium 2-hydroxypropionate
calcium 2-hydroxypropanoate pentahydrate
conclytecalcium
-Hydroxypropanoicacidcalciumsaltpentahy-drate
Propanoicacid,2-hydroxy-,calciumsalt(2:1)
E327 (Calcium lactate) (Tri or Penta Hydrate)
E327 (Calcium lactate) BP
E327 (Calcium lactate), Granular
CalciumLactateExtraPure
CALCIUMLACTATEANHYDROUS
CALCIUMLACTATE,DRIED,USP
CALCIUMLACTATE,USP(BULK
E327 (Calcium lactate) or L-E327 (Calcium lactate) pentahydrate
E327 (Calcium lactate) USP/EP/BP
CAS 814-80-2
E327 (Calcium lactate)/ L-E327 (Calcium lactate)
E327 (Calcium lactate)
814-80-2
Calcium dilactate
Hemicalcium L-lactate
calcium 2-hydroxypropanoate
Propanoic acid, 2-hydroxy-, calcium salt (2:1)
calcium;2-hydroxypropanoate
Calcium 2-hydroxypropanoate (1:2)
calcium dl-lactate
2-Hydroxypropanoic acid calcium salt
5743-48-6
Calphosan
DSSTox_CID_236
28305-25-1
Conclyte calcium
DSSTox_RID_75451
DSSTox_GSID_20236
C6H10CaO6
Ca lactate
2-HYDROXYPROPANOICACIDCALCIUMSALT,TRIHYDRATE
UNII-2URQ2N32W3
Lactic acid, calcium salt (2:1)
CAS-814-80-2
E327 (Calcium lactate) [USAN:JAN]
CCRIS 3669HSDB 976
EINECS 212-406-7
AI3-04468
63690-56-2
calcium bis(2-hydroxypropanoate)
2URQ2N32W3
EINECS 227-266-2
Ins No.327
EC 212-406-7
SCHEMBL4319
CHEMBL2106111
DTXSID0020236
INS-327
Lactic acid calcium salt (2:1)
AMY37027
INS-327
Tox21_201378
Tox21_302896Bis(2-hydroxypropanoic acid) calcium
AKOS015837558
DB13231
NCGC00256365-01
NCGC00258929-01
P973
DB-023012
CS-0021602
E-327
FT-0623403
FT-0652809
F16480
A840142Q419693