PRODUCTS

E341 TRI CALCIUM PHOSPHATE

E341 Tri Calcium Phosphate is the calcium salt of phosphoric acid with widely used applications.
E341 Tri Calcium Phosphate occur abundantly in nature in several forms and are the principal minerals for the production of phosphate fertilizers and for a range of phosphorus compounds.
For example, the tribasic variety (precipitated calcium phosphate), Ca3(PO4)2, is the principal inorganic constituent of bone ash.

CAS:   7758-87-4
MF:   Ca3O8P2
MW:   310.18
EINECS:   231-840-8

Synonyms
APATITE TTCP, MONOCLINIC;calcium phosphate，tertiary;tricalcium phosphate for technical grade;bonarka;calcigenolsimple;calciumorthophosphate,tri-(tert);calciumphosphate(3:2);calciumphosphate(ca3(po4)2)

E341 Tri Calcium Phosphate Ca(H2PO4)2, produced by treating mineral phosphates with sulfuric acid, is employed as a plant food and stabilizer for plastics.
E341 Tri Calcium Phosphate is a natural constituent of mammals, and it is a component of bone replacement transplants in much higher amounts with no toxicological problems.
Calcium phosphates are the largest group of artificial bone graft substitutes.
E341 Tri Calcium Phosphate is mainly due to their close resemblance to the mineral components of bone.
E341 Tri Calcium Phosphate can be used as a countermeasure for exposure to strontium and radium radionuclides.
Upon oral uptake, E341 Tri Calcium Phosphate competes for and blocks the absorption of radium (Ra-226) and strontium (Sr-90) in the gastrointestinal (GI) tract.
E341 Tri Calcium Phosphate is a calcium phosphate.

E341 Tri Calcium Phosphate belongs to the category of calcium-phosphate based ceramics, which has been involved in the preparation of a new biosynthetic material possessing morphogenetic activity that is used as a bone implant.
E341 Tri Calcium Phosphate is a tricalcium salt of phosphoric acid with the chemical formula Ca3(PO4)2.
In food, E341 Tri Calcium Phosphate is used as an anticaking agent in powdered food and a nutritional supplement of calcium and phosphorus in infant formulae and cereals.
The European food additive number for E341 Tri Calcium Phosphate is E341(iii).
E341 Tri Calcium Phosphate, more commonly known as Calcium phosphate, is a calcium salt of phosphoric acid with the chemical formula Ca3(PO4)2.
E341 Tri Calcium Phosphate is also known as tribasic calcium phosphate and bone phosphate of lime (BPL).
E341 Tri Calcium Phosphate is a white solid of low solubility.
Most commercial samples of "tricalcium phosphate" are in fact hydroxyapatite.
E341 Tri Calcium Phosphate exists as three crystalline polymorphs α, α′, and β. The α and α′ states are stable at high temperatures.

E341 Tri Calcium Phosphate Chemical Properties
Melting point: 1670°C
Density: 3.14
Refractive index: 1.63
FEMA: 3081 | TRICALCIUM PHOSPHATE
Storage temp.: room temp
Solubility: Practically insoluble in water.
E341 Tri Calcium Phosphate dissolves in dilute hydrochloric acid and in dilute nitric acid.
Form: aqueous suspension
Color: White
PH: 6-8 (50g/l, H2O, 20°C) suspension
Odor: Odorless
Water Solubility: 0.1 g/L (25 ºC)
Merck: 13,1699
Solubility Product Constant (Ksp): pKsp: 28.68
InChIKey: QORWJWZARLRLPR-UHFFFAOYSA-H
LogP: -2.15
CAS DataBase Reference: 7758-87-4(CAS DataBase Reference)
EPA Substance Registry System:
Tricalcium phosphate (7758-87-4)

E341 Tri Calcium Phosphate is white solid, insoluble in water; reactive with silicon oxide and carbon at electric furnace temperature yielding phosphorus vapor; reactive with H2SO4 to form, according to the proportions used, phosphoric acid, or dicalcium hydrogen phosphate, CaHPO4, white solid, insoluble; or calcium dihydrogen phosphate, Ca(H2PO4)2·H2O, white solid, soluble. pKsp = 28.70.
White amorphous powder; refractive index 1.63; density 3.14 g/cm3; melts at 1,670°C; insoluble in water; KSP 1.0x10-25; soluble in acids.

E341 Tri Calcium Phosphate is a subclass of calcium phosphates and makes up of a variable mixture of calcium phosphates and having the approximate composition of 10CaO·3P2O5 ·H2O.
E341 Tri Calcium Phosphate can be used in vegan food and supplement for its mineral origin.
Food grade E341 Tri Calcium Phosphate can be produced by the reaction of phosphoric acid with calcium carbonate or calcium hydroxide (see following reaction equation) OR the reaction between calcium chloride solution and trisodium phosphate.

6H3PO4+ 10CaCO3=10CaO·3P2O5·H2O + 10CO2

Uses
E341 Tri Calcium Phosphate manufacture of fertilizers, H3PO4 and P Compounds; manufacture of milk-glass, polishing and dental powders, porcelains, pottery; enameling; clarifying sugar syrups; in animal feeds; as noncaking agent; in the textile industry.
E341 Tri Calcium Phosphate is a compound existing in several forms which include the monobasic, dibasic, and tribasic forms of calcium phos- phate. as calcium phosphate monobasic, also termed monocalcium phosphate, calcium biphosphate, and acid calcium phosphate, E341 Tri Calcium Phosphate is used as a leavening agent and acidulant.
E341 Tri Calcium Phosphate diba- sic, also termed dicalcium phosphate dihydrate, is used as a dough conditioner and mineral supplement.
E341 Tri Calcium Phosphate, also termed tricalcium phosphate and precipitated calcium phos- phate, is used as an anticaking agent, mineral supplement, and con- ditioning agent.

E341 Tri Calcium Phosphate is an anticaking agent and calcium source that is a white powder that is almost insoluble in water.
E341 Tri Calcium Phosphate is used as an anticaking agent in table salt and dry vinegar.
E341 Tri Calcium Phosphate is used as a source of calcium and phosphorus in cereals and desserts.
E341 Tri Calcium Phosphate functions as a bleaching agent in flour and in lard, and prevents undesirable coloring and improves stability for frying.
E341 Tri Calcium Phosphate is also termed tribasic calcium phosphate, tricalcium orthophosphate, calcium phosphate tribasic, and precipitated calcium phosphate.
E341 Tri Calcium Phosphate occurs in nature as minerals, oxydapatite, whitlockite, voelicherite, apatite, phosphorite.
E341 Tri Calcium Phosphate has many industrial applications.

Some are similar to the monobasic and dibasic salts.
E341 Tri Calcium Phosphate is used in fertilizers, dental products, ceramics and polishing powder.
Some other important applications are in plastics as a stabilizer; as an anticaking agent; as a nutrient supplement in cattle food; for clarifying sugar syrup; as a mordant in dyeing textiles; and as a buffer to control pH.
E341 Tri Calcium Phosphate finds applications as a supplement for animal feed, as a fertiliser, in the manufacture of glass and in dental products.
E341 Tri Calcium Phosphate is an ingredient used in many applications.
Its food grade is commonly used as an anticaking agent to make powdered food free-flowing, also as a nutritional supplement supplies both calcium and phosphorus minerals in fortified foods.
Meanwhile, E341 Tri Calcium Phosphate can be used as a whitening color to replace titanium dioxide.
Other applications like in baby powder, toothpaste, and pharmaceuticals.

Feed
E341 Tri Calcium Phosphate can also be a dietary supplement of calcium and phosphorus in pet food, e.g. in cat and dog food.
E341 Tri Calcium Phosphate benefits cat and dog in building bones, nerve impulse transmission and other benefits.

Cosmetics
Per “European Commission database for information on cosmetic substances and ingredients”, E341 Tri Calcium Phosphate functions as an abrasive, anticaking, masking, opacifying amd oral care agent in cosmetic and personal care products.

Toothpaste
E341 Tri Calcium Phosphate and fluoride will join together to form calcium fluoride in toothpaste, which makes the fluoride less effective in preventing tooth decay.
Functionalized E341 Tri Calcium Phosphate produced by beta-tricalcium phosphate and sodium lauryl sulfate can prevent this reaction during the storage of toothpaste and thus generate more fluoride and calcium ions to remineralize enamel and protect the dental from caries.

Food additive
E341 Tri Calcium Phosphate is used in powdered spices as an anticaking agent, e.g. to prevent table salt from caking.
The E341 Tri Calcium Phosphate have been assigned European food additive number E341.

Health and beauty products
E341 Tri Calcium Phosphate is also found in baby powder, antacids and toothpaste.
Toothpastes with functionalized E341 Tri Calcium Phosphate may help remineralize tooth enamel.

Biomedical
E341 Tri Calcium Phosphate is also used as a nutritional supplement and occurs naturally in cow milk, although the most common and economical forms for supplementation are calcium carbonate (which should be taken with food) and calcium citrate (which can be taken without food).
There is some debate about the different bioavailabilities of the different calcium salts.

E341 Tri Calcium Phosphate can be used as a tissue replacement for repairing bony defects when autogenous bone graft is not feasible or possible.
E341 Tri Calcium Phosphate may be used alone or in combination with a biodegradable, resorbable polymer such as polyglycolic acid.
E341 Tri Calcium Phosphate may also be combined with autologous materials for a bone graft.
E341 Tri Calcium Phosphate scaffolds are employed as drug carrier systems for local drug delivery in bone.

Preparation
E341 Tri Calcium Phosphate is obtained from naturally occurring minerals for fertilizer applications.
E341 Tri Calcium Phosphate may be prepared in the laboratory by the reaction of sodium phosphate with calcium chloride with excess of ammonia.
Also, E341 Tri Calcium Phosphate can be prepared by treatment of calcium hydroxide with phosphoric acid:
2H3PO4 + 3Ca(OH)2 → Ca3(PO4)2 + 6H2O

Preparation
E341 Tri Calcium Phosphate is produced commercially by treating hydroxyapatite with phosphoric acid and slaked lime.

E341 Tri Calcium Phosphate cannot be precipitated directly from aqueous solution.
Typically double decomposition reactions are employed, involving a soluble phosphate and calcium salts, e.g. (NH4)2HPO4 + Ca(NO3)2. is performed under carefully controlled pH conditions.
The precipitate will either be "amorphous tricalcium phosphate", ATCP, or calcium deficient hydroxyapatite, CDHA, Ca9(HPO4)(PO4)5(OH), (note CDHA is sometimes termed apatitic calcium triphosphate).
Crystalline tricalcium phosphate can be obtained by calcining the precipitate.
β-Ca3(PO4)2 is generally formed, higher temperatures are required to produce α-Ca3(PO4)2.
An alternative to the wet procedure entails heating a mixture of a calcium pyrophosphate and calcium carbonate:

CaCO3 + Ca2P2O7 → Ca3(PO4)2 + CO2