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E356 Sodium adipate is a chemical organic compound with formula Na2C6H8O4.
E356 Sodium adipate is the sodium salt of adipic acid.
E356 Sodium adipate has the E number E356 as is used as a buffering agent and as an acidity regulator.
CAS Number: 7486-38-6
Molecular Formula: C6H8Na2O4
Molecular Weight: 190.1
EINECS Number: 231-293-5
Synonyms: Sodium adipate, Disodium adipate, 7486-38-6, Hexanedioic acid, disodium salt, ADIPIC ACID, DISODIUM SALT, 1,4-Butanedicarboxylic acid disodium salt, 3XG6T5KYKM, INS NO.356, INS-356, E-356, RefChem:887237, 231-293-5, Adipic Acid Disodium Salt, disodium;hexanedioate, disodium hexanedioate, Hexanedioic acid, sodium salt, Adipic acid, sodium salt, MFCD00070498, EINECS 231-293-5, UNII-3XG6T5KYKM, di-sodium adipate, EINECS 245-577-1, Hexanedioic acid, sodium salt (1:2), EC 231-293-5, C6H8Na2O4, SCHEMBL107905, DTXSID1044726, AKOS025295713, AS-75598, E356, SY054630, A0592, CS-0455468, NS00078434, D88288, F775847, Q423296, 1,4-butanedicarboxylicaciddisodiumsalt;Hexanedioicacid,disodiumsalt;SODIUM ADIPATE;ADIPIC ACID, SODIUM SALT;ADIPIC ACID DISODIUM SALT;DISODIUM ADIPATE;Disodium Adipate 7486-38-6 Adipic Acid Disodium Salt;Hexanedioic acid, sodium salt (1:2)
E356 Sodium adipate is the sodium salt of adipic acid.
In the European Union, it is used as a synthetic food additive acting as an acidity regulator, buffering agent, and flavor enhancer.
E356 Sodium adipate provides a sour, tart taste and helps maintain pH levels in food products.
E356 Sodium adipate is the sodium salt of adipic acid, a synthetic organic compound derived from hexanedioic (adipic) acid, and it is mainly used as an acidity regulator, buffering agent, and stabilizer in food, pharmaceutical, cosmetic, and industrial applications because it helps maintain stable pH levels and supports formulation consistency without significantly affecting taste or chemical balance.
It is closely related to other adipates such as potassium adipate (E357).
This improves pH control and product stability.
Chemically, sodium adipate consists of an adipic acid backbone neutralized with sodium ions (Na⁺), which makes it highly water-soluble and effective in buffering systems that resist sudden changes in acidity or alkalinity.
Its dicarboxylic structure allows it to interact with hydrogen ions and metal ions in solution.
E356 Sodium adipate improves buffering capacity and chemical stability.
E356 Sodium adipate appears as a white crystalline powder, and it dissolves easily in water to form neutral to mildly alkaline solutions depending on concentration, making it suitable for use in both liquid and dry formulations.
It is stable under normal storage conditions and non-volatile.
E356 Sodium adipate improves handling and formulation convenience.
E356 Sodium adipate acts primarily as a pH stabilizer and acidity regulator, helping maintain consistent acidity levels in products, which is important for flavor balance, microbial stability, and chemical integrity during processing and storage.
It can also help reduce unwanted reactions such as oxidation or precipitation.
This improves shelf life and product quality.
E356 Sodium adipate is best described as a water-soluble sodium salt of adipic acid used to regulate acidity, stabilize formulations, and support buffering systems in food, pharmaceutical, cosmetic, and industrial applications through controlled pH management.
E356 Sodium adipate is also relevant in advanced buffer formulation design, where it is used when formulators need a stable, predictable buffering system that can maintain pH over time without introducing strong flavor changes or reactive chemical behavior, especially in systems that undergo heating, cooling, or long-term storage.
E356 Sodium adipates adipate backbone provides a relatively stable acid–base equilibrium in aqueous solutions.
This improves long-term pH stability and formulation robustness.
In food processing engineering, E356 Sodium adipate helps reduce quality loss caused by pH drift during manufacturing steps such as pasteurization, sterilization, or mixing, where temperature changes can otherwise shift acidity and affect texture or stability.
It is especially useful in large-scale industrial food production where consistency is critical.
E356 Sodium adipate improves process stability and product uniformity.
E356 Sodium adipate helps maintain consistent acidity even when mineral content or dissolved gases in water might otherwise cause slight changes in pH, which can influence taste perception and product clarity over time.
It works subtly to maintain equilibrium without altering flavor strongly.
E356 Sodium adipate improves beverage consistency and sensory stability.
In protein-based systems and emulsions, E356 Sodium adipate can help maintain ionic balance in formulations, reducing the risk of protein aggregation, precipitation, or phase separation in complex liquid systems such as nutritional drinks or processed dairy alternatives.
This is important in products sensitive to calcium and pH shifts.
E356 Sodium adipate improves texture stability and emulsion integrity.
In pharmaceutical liquid and semi-solid systems, it is used to stabilize formulations containing multiple active ingredients that may have different pH sensitivities, ensuring that the overall system remains chemically compatible and does not degrade during storage.
E356 Sodium adipate also helps maintain consistent dissolution behavior.
This improves drug formulation stability and compatibility.
E356 Sodium adipate supports pH control in systems containing active ingredients like vitamins, alpha hydroxy acids, or botanical extracts, helping maintain their stability while ensuring the preservative system remains effective.
It also helps reduce degradation caused by metal-catalyzed reactions.
E356 Sodium adipate improves cosmetic efficacy and shelf life.
In industrial detergent formulations, it acts as a buffering component that stabilizes cleaning performance across different water conditions, helping maintain consistent pH even when hardness or contamination levels vary significantly.
This is especially useful in automated or large-scale cleaning systems.
E356 Sodium adipate improves detergent reliability and cleaning consistency.
Boiling point: 300℃ [at 101 325 Pa]
pka: 4.43 [at 20 ℃]
form: powder to crystal
color: White to Almost white
Water Solubility: almost transparency
InChI: InChI=1S/C6H10O4.2Na/c7-5(8)3-1-2-4-6(9)10;;/h1-4H2,(H,7,8)(H,9,10);;/q;2*+1/p-2
InChIKey: KYKFCSHPTAVNJD-UHFFFAOYSA-L
SMILES: C([O-])(=O)CCCCC([O-])=O.[Na+].[Na+]
LogP: -5.03
E356 Sodium adipate is widely used in food technology systems, where it helps maintain stable acidity in processed foods that undergo long storage, heating, or packaging processes, ensuring that the product retains its intended flavor and chemical structure over time.
Its buffering behavior helps reduce unwanted pH fluctuations during shelf life.
E356 Sodium adipate improves food stability and consistency.
E356 Sodium adipate is used to maintain a stable pH environment that prevents changes in taste, color, or clarity caused by chemical instability or mineral interactions in liquid systems.
It is especially useful in drinks that require long shelf life without refrigeration.
E356 Sodium adipate improves beverage quality and storage stability.
E356 Sodium adipate can contribute indirectly to antimicrobial stability by maintaining pH conditions that inhibit microbial growth when used alongside other preservatives and acidity regulators.
It is typically part of a combined formulation strategy rather than a standalone preservative.
E356 Sodium adipate improves preservation effectiveness and product safety.
In pharmaceutical formulations, E356 Sodium adipate is used as a buffering agent in liquid medicines and syrups, helping protect active ingredients from degradation caused by pH changes during storage or administration.
It also helps maintain compatibility between multiple dissolved components.
This improves drug stability and formulation reliability.
In cosmetic and personal care products, E356 Sodium adipate is used to stabilize pH in creams, lotions, gels, and liquid formulations, ensuring that sensitive active ingredients remain stable and effective over time.
It also helps maintain preservative performance by keeping the formulation within an optimal pH range.
E356 Sodium adipate improves cosmetic shelf life and formulation stability.
In industrial cleaning systems, E356 Sodium adipate helps maintain stable pH in detergent formulations, improving performance in removing residues and preventing instability caused by varying water hardness or contamination levels.
It supports consistent cleaning efficiency across different conditions.
E356 Sodium adipate improves detergent performance and reliability.
In chemical processing industries, E356 Sodium adipate is used as a buffering additive in aqueous systems where controlled pH is required to maintain reaction stability and prevent unwanted side reactions.
Its high water solubility makes it easy to incorporate into industrial formulations.
This improves process control and chemical stability.
E356 Sodium adipate can help stabilize metal ion concentrations in solution, preventing precipitation and ensuring more uniform behavior in coating, cleaning, or finishing processes.
This is important in precision industrial systems.
E356 Sodium adipate improves surface quality and process consistency.
In environmental and green chemistry contexts, E356 Sodium adipates are studied because they may be more biodegradable compared to some persistent synthetic additives, making them relevant for more sustainable formulation design.
E356 Sodium adipate supports development of lower-impact industrial chemicals.
This improves environmental compatibility and sustainability.
In formulation science, E356 Sodium adipate is often selected when a neutral-tasting, low-reactivity buffering system is required, especially in sensitive products where stronger acids or salts could negatively affect flavor, texture, or stability.
E356 Sodium adipate gives formulators more control over product behavior.
This improves formulation flexibility and product design.
E356 Sodium adipate helps maintain stable chemical conditions by controlling pH and limiting unwanted precipitation of metal ions, which can otherwise affect coating quality or surface uniformity.
This is important in precision industrial finishing processes.
E356 Sodium adipate improves surface quality and process control.
In biodegradability and sustainable chemistry research, adipate salts are of interest because they are derived from relatively simple dicarboxylic acids and are more environmentally manageable compared to some persistent synthetic additives.
This makes them candidates for greener formulation strategies.
E356 Sodium adipate improves environmental compatibility and sustainability potential.
E356 Sodium adipate is often chosen when a neutral, non-reactive buffering system is required that will not interfere with taste, color, or active ingredients, making it useful in highly sensitive formulations where even small chemical interactions must be minimized.
This gives manufacturers greater control over product behavior.
E356 Sodium adipate improves formulation precision and design flexibility.
Uses:
E356 Sodium adipate is mainly used as an acidity regulator, buffering agent, and stabilizer because it helps maintain stable pH conditions and supports product consistency and shelf life.
In food and beverages, it is used to control acidity and improve stability without affecting taste.
E356 Sodium adipate improves flavor balance and product quality.
E356 Sodium adipate is used to support preservation systems and reduce spoilage.
This improves shelf life and safety.
In pharmaceuticals, it is used as a buffering agent in liquid formulations.
E356 Sodium adipate improves drug stability and effectiveness.
In cosmetics, it is used to stabilize pH and protect sensitive ingredients.
E356 Sodium adipate improves product longevity and performance.
E356 Sodium adipate is used for pH control and formulation stability.
This improves process reliability and consistency.
E356 Sodium adipate is mainly used as an acidity regulator, buffering agent, and stabilizer because it maintains stable pH conditions and supports consistent product quality across different applications.
In food and beverages, it is used to regulate acidity without changing taste.
E356 Sodium adipate improves flavor stability and product consistency.
In processed foods, it is used to support preservation systems and prevent spoilage.
E356 Sodium adipate improves shelf life and safety.
In pharmaceuticals, it is used as a buffering agent in liquid formulations.
This improves drug stability and effectiveness.
In cosmetics, it is used to stabilize pH and protect sensitive ingredients.
E356 Sodium adipate improves product longevity and performance.
In industrial systems, it is used for pH control and formulation stability.
E356 Sodium adipate improves process reliability and consistency.
E356 Sodium adipate is mainly used as an acidity regulator, buffering agent, and stabilizer because it helps maintain a stable pH environment, prevents unwanted chemical changes during processing and storage, and supports consistent quality in a wide range of formulated products.
E356 Sodium adipate is used to control acidity while having a very mild or almost neutral sensory impact, which is important when producers want to preserve the original taste profile without introducing noticeable sourness or off-flavors.
This improves flavor stability, sensory balance, and shelf-life consistency.
In processed and packaged foods, it is used as part of multi-additive preservation systems where it helps maintain a stable pH that slows down spoilage reactions and reduces conditions that favor microbial growth over time.
E356 Sodium adipate improves food safety and long-term storage stability.
In pharmaceutical liquid formulations, it is used as a buffering agent to maintain a controlled pH range, which is essential for protecting active pharmaceutical ingredients from degradation and ensuring that the medicine remains effective throughout its shelf life.
E356 Sodium adipate improves drug stability, compatibility, and therapeutic reliability.
E356 Sodium adipate is used to stabilize pH in emulsions, gels, and lotions, ensuring that sensitive ingredients such as vitamins, botanical extracts, and preservatives remain chemically stable and effective over time.
This improves product durability, safety, and performance.
E356 Sodium adipate is mainly used as an acidity regulator, buffering agent, and stabilizer because it helps maintain a steady pH level in formulations, prevents unwanted chemical changes during storage, and supports overall product consistency in food, pharmaceutical, cosmetic, and industrial systems.
E356 Sodium adipate is used to control acidity without noticeably changing taste, which is important when manufacturers want to keep the original flavor profile intact while still improving chemical stability and shelf life.
This improves flavor neutrality and long-term product stability.
In processed and packaged foods, it is used as part of preservation systems where it helps maintain a stable pH environment that reduces spoilage reactions and limits conditions that allow microbial growth.
E356 Sodium adipate improves food safety and storage durability.
In pharmaceutical formulations, it is used as a buffering agent in liquid medicines and syrups to keep pH within a narrow range, protecting active ingredients from degradation and ensuring consistent drug performance.
This improves drug stability and therapeutic reliability.
In cosmetic and personal care products, it is used to stabilize pH in creams, lotions, gels, and liquid formulations, helping preserve the effectiveness of active ingredients and preservative systems over time.
This improves product shelf life and formulation performance.
E356 Sodium adipate is used to maintain stable pH in detergent formulations, ensuring consistent cleaning efficiency even when water hardness or environmental conditions vary.
E356 Sodium adipate improves cleaning performance and product reliability.
E356 Sodium adipate is used as a buffering and stabilizing additive in aqueous systems where controlled acidity is necessary to maintain reaction stability and prevent unwanted side reactions.
This improves process control and formulation consistency.
Safety Profile:
E356 Sodium adipate can lead to high levels of sodium and gastrointestinal problems.
It can also cause allergic reactions which may lead to swelling, itching, difficulty breathing. Sodium adipate has no proven health benefits.
E356 Sodium adipate is generally considered a low hazard substance, because it is a stable organic salt with relatively low reactivity, although concentrated exposure can still cause mild irritation.
The main hazard is mild irritation of skin, eyes, and respiratory system, especially from dust or concentrated solutions during industrial handling.
Proper ventilation and protective equipment are recommended.
E356 Sodium adipate improves workplace safety.
Skin contact is generally low risk, though prolonged exposure may cause mild irritation or dryness.
Washing with water is sufficient.
Eye contact may cause moderate irritation, especially from powder exposure.
Protective eyewear is recommended.
Inhalation of dust may cause temporary respiratory irritation, particularly in poorly ventilated environments.
Dust control measures are recommended.
E356 Sodium adipate is not flammable and is stable under normal storage conditions.
This improves handling safety.
From a toxicological perspective, adipate salts are generally considered safe within regulated limits for food and industrial use due to their low toxicity and predictable breakdown behavior.
However, excessive exposure should still be avoided.
This requires standard industrial hygiene practices.
From an environmental perspective, sodium adipate is considered relatively low risk and potentially biodegradable, though industrial discharge should still be managed responsibly.
E356 Sodium adipate improves environmental safety and sustainability.
