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E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a synthetic food additive used as a preservative, antioxidant, and sequestrant.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA's primary function is to bind with metal ions in processed foods, which prevents discoloration, preserves flavor, and extends shelf life.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is an organic calcium salt of EDTA diisodium.
CAS: 62-33-9
MF: C10H12CaN2Na2O8.xH2O
MW: 374.27
EINECS: 200-529-9
Synonyms
calciate(2-),((n,n’-1,2-ethanediylbis(n-(carboxymethyl)glycinato))(4-)-n,n’,o,;calcitetracematedisodium;EDTA DISODIUM-CALCIUM SALT;EDETATE CALCIUM DISODIUM SALT;DISODIUM CALCIUM ETHYLENEDIAMINETETRAACETATE;DISODIUM CALCIUM SALT TRIHYDRATE;ETHYLENEDIAMINETETRAACETIC ACID CALCIUM DISODIUM SALT;ETHYLENEDIAMINETETRAACETIC ACID DISODIUM CALCIUM
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a chelating agent that is used for the treatment of lead poisoning.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA has a role as a geroprotector, a chelator and an antidote.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA contains an EDTA disodium salt (anhydrous).
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA, with the CAS number 62-33-9, is a chelating agent commonly used in various applications, including medicine, food preservation, and industrial processes.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a white, crystalline powder that is highly soluble in water, making it effective in binding metal ions.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a calcium salt of ethylenediaminetetraacetic acid (EDTA), which allows it to form stable complexes with divalent and trivalent metal ions, such as lead, mercury, and calcium.
This property makes E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA valuable in treating heavy metal poisoning and in various analytical chemistry applications to prevent metal ion interference.
In the food industry, E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA acts as a preservative and stabilizer, enhancing the shelf life of products by preventing oxidation.
Additionally, E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is recognized for its low toxicity and is generally regarded as safe when used appropriately.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA's ability to sequester metal ions also finds utility in water treatment and in the formulation of cosmetics and personal care products.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA, also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA came into medical use in the United States in 1953.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA Chemical Properties
Melting point: >300°C
storage temp.: room temp
solubility: Freely soluble in water, practically insoluble in ethanol (96 per cent).
color: Off white
Odor: Odorless
Merck: 14,3517
Stability: Stable. Incompatible with strong oxidizing agents.
Major Application: pharmaceutical (small molecule)
Cosmetics Ingredients Functions: CHELATING
Cosmetic Ingredient Review (CIR): EDTA calcium disodium (62-33-9)
InChI: InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
InChIKey: SHWNNYZBHZIQQV-UHFFFAOYSA-J
LogP: -0.434 (est)
CAS DataBase Reference: 62-33-9(CAS DataBase Reference)
EPA Substance Registry System: E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA (62-33-9)
Uses
Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors.
As this form is already chelated with Ca2+, E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is selective for divalent cations with greater affinity for EDTA, which it will exchange for Ca2+.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a sequestrant and chelating agent whose complete name is disodium calcium ethylenediamine tetraacetate.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels.
A 1% solution has a ph of 6.5–7.5.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is used to control the reaction of trace metals with some organic and inorganic components in food; to prevent deterioration of color, texture, and development of precipitates; and to prevent oxidation.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA's function is comparable to that of disodium dihydrogen edta.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is also termed calcium disodium edta.
Pharmaceutical Applications
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA, also referred to as calcium sodium EDTA, stands for the chemical compound 2,2 ,2 ,2 -(ethane-1,2-diyldinitrilo)tetraacetic acid, which is a synthetic amino acid.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA refers to the calcium disodium salt of the chelating agent with the formula (HO2CCH2)2NCH2CH2N(CH2CO2H)2.
In the United States, E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is found under the name calcium disodium versenate. Edetate is mainly used to complex di and trivalent metal ions.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA can bind to metals via the four carboxylate and two amine groups, and it forms specially strong complexes with Co(III), Cu(II), Mn(II) and Fe(III).
Dimercaprol (BAL, British anti-Lewisite), E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA and penicillamine are the three most common chelating agents used in the treatment of heavy-metal poisoning.
Medical use
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA's primary use is to treat lead poisoning, for which it is an alternative to succimer.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is given by slow injection into a vein or into a muscle.
For lead encephalopathy E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA is typically used together with dimercaprol.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA may also be used to treat plutonium poisoning.
E385 Calcium disodium ethylene diamine tetra-acetate, calcium disodium EDTA does not appear to be useful for poisoning by tetra-ethyl lead.
Side effects
Common side effects include pain at the site of injection.
Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.
Benefits when needed in pregnancy are likely greater than the risks.
