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E421 Mannitol is a sugar alcohol used as a sweetener, bulking agent, and texturizer in food, pharmaceutical, and personal care applications, and E421 Mannitol is valued for low hygroscopicity and a clean, mildly sweet taste.
E421 Mannitol provides a cooling sensation in the mouth due to heat of solution effects, and E421 Mannitol is commonly used in sugar-free confections and oral-care products where a crisp, non-sticky texture is desired.
E421 Mannitol is also widely used in pharmaceuticals as a tablet diluent and excipient, and E421 Mannitol performance depends on particle size, grade, and processing method.
CAS Number: 69-65-8
EC Number: 200-711-8
Molecular Formula: C6H14O6
Molecular Weight: 182.17 g/mol
Synonyms: E421 Mannitol, Mannitol, D-Mannitol, Mannite (historical), Mannitol Powder, Mannitol Crystalline, Mannitol Sweetener, Mannitol Sugar Alcohol, Mannitol Bulking Agent, Mannitol Tablet Diluent, E421, Mannitol Food Grade, Mannitol Pharmaceutical Grade, E421 Mannitol, Mannitol, D-Mannitol, Mannite, Mannit, Manna Sugar, Manna Sweetener, Hexane-1,2,3,4,5,6-hexol, 1,2,3,4,5,6-Hexahexanol, Hexahydric Alcohol, C6 Sugar Alcohol, Mannitol Sweetener, Mannitol Food Additive, Mannitol Food Grade, Mannitol Technical Grade, Mannitol Pharmaceutical Grade, Mannitol USP, Mannitol FCC, Mannitol EP, Mannitol JP, Mannitol Powder, Mannitol White Powder, Mannitol Crystalline Powder, Mannitol Granular, Mannitol Fine Granules, Mannitol Sweetening Agent, Mannitol Bulk Sweetener, Mannitol Sugar Substitute, Mannitol Sugar Replacer, Mannitol Low-Calorie Sweetener, Mannitol Low Calorie Sweetener, Mannitol Reduced-Calorie Sweetener, Mannitol Reduced Calorie Sweetener, Mannitol Non-Nutritive Sweetener, Mannitol Non Nutritive Sweetener, Mannitol Polyol, Mannitol Polyhydric Alcohol, Mannitol Sugar Alcohol, Mannitol Crystalline Sweetener, Mannitol Tabletop Sweetener, Mannitol Beverage Sweetener, Mannitol Excipient Grade, Mannitol Direct Compression Grade, Mannitol Spray Dried Grade, Mannitol Sweetener Grade, Mannitol High Purity, Mannitol Pure, Mannitol C6H14O6, C6H14O6, Mannitol CAS 69-65-8, INS 421, E 421
APPLICATIONS
E421 Mannitol is used in sugar-free chewing gum to provide bulk, mild sweetness, and a cooling mouthfeel with low stickiness.
E421 Mannitol is incorporated into sugar-free candies to create a crisp texture and reduce hygroscopicity compared with other polyols.
E421 Mannitol is used in mints and lozenges to improve hardness control and provide clean sweetness.
E421 Mannitol is used in chocolate-like sugar-free products as a bulking sweetener that supports a dry, non-tacky texture.
E421 Mannitol is incorporated into confectionery coatings to reduce moisture pickup and maintain snap.
E421 Mannitol is used in tablets and compressed confectionery to improve compressibility and reduce sticking during pressing.
E421 Mannitol is used in pharmaceutical tablets as a diluent and filler, especially in chewable and orally disintegrating tablets.
E421 Mannitol is incorporated into ODT formulations to provide pleasant mouthfeel and good stability due to low hygroscopicity.
E421 Mannitol is used in granulation and direct compression systems where consistent flow and compaction are required.
E421 Mannitol is used in lyophilized pharmaceutical products as a bulking agent to form stable cakes and improve reconstitution.
E421 Mannitol is incorporated into injectable formulations as an excipient where appropriate quality and compatibility requirements are met.
E421 Mannitol is used in dry powder inhalation blends in some cases to support flow and dosing behavior.
E421 Mannitol is used in oral-care products such as toothpaste and mouthwashes to provide sweetness and improve sensory profile.
E421 Mannitol is incorporated into chewing gum and dental mints to support a clean taste and cooling effect.
E421 Mannitol is used in oral gels and rinses to provide body and stabilize flavor release.
E421 Mannitol is used in reduced-sugar and sugar-free foods as a bulking agent where low hygroscopicity supports shelf stability.
E421 Mannitol is incorporated into dietetic products to support texture and sweetness with controlled moisture uptake.
E421 Mannitol is used in powdered food mixes to maintain flow and reduce caking compared with more hygroscopic sweeteners.
E421 Mannitol is used in cosmetics and personal care products as a humectant and skin-feel modifier in compatible formulations.
E421 Mannitol is incorporated into creams and lotions to support smooth feel and stability in selected systems.
E421 Mannitol is used in powdered cosmetics to improve flow and reduce clumping under humid conditions.
E421 Mannitol is used in industrial applications as a bulking and stabilizing ingredient where low moisture uptake is beneficial.
E421 Mannitol is incorporated into edible films and coatings to improve structure in compatible designs.
E421 Mannitol is valued because E421 Mannitol provides stable, low-hygroscopic bulk sweetness with a pleasant cooling sensation across many applications.
E421 Mannitol is used as a bulk sweetener in sugar-free confectionery.
E421 Mannitol provides sweetness with reduced calories compared with sucrose.
E421 Mannitol helps deliver a cooling mouthfeel typical of polyols.
E421 Mannitol is used in sugar-free hard candies to provide bulk and reduce hygroscopicity in some formulations.
E421 Mannitol supports better shape stability by resisting moisture pickup compared with more hygroscopic polyols.
E421 Mannitol helps reduce stickiness and surface tack in hard candies.
E421 Mannitol is used in sugar-free mints and pressed candies to provide clean sweetness.
E421 Mannitol supports rapid crystallization that enables crisp, non-sticky mints.
E421 Mannitol helps improve snap and reduce crumble in compressed sweets.
E421 Mannitol is used in chewing gum as a bulking sweetener and anti-caking agent in some systems.
E421 Mannitol supports dry, non-sticky gum coatings and stable sweetness.
E421 Mannitol helps maintain pleasant mouthfeel and reduces tackiness.
E421 Mannitol is used in gum pellet coating as a sugar replacement for hard shells.
E421 Mannitol supports formation of a smooth crystalline coating layer.
E421 Mannitol helps reduce moisture sensitivity of coated gum products.
E421 Mannitol is used in chocolate and compound coatings as a sugar substitute in some reduced-sugar formulations.
E421 Mannitol supports sweetness and bulk when combined with high-intensity sweeteners.
E421 Mannitol helps maintain texture while lowering added sugar content.
E421 Mannitol is used in sugar-free chocolate fillings and cream centers to reduce sucrose content.
E421 Mannitol supports a less hygroscopic sweet base that improves stability in some systems.
E421 Mannitol helps reduce graining and moisture-driven texture defects.
E421 Mannitol is used in bakery products as a sugar substitute in reduced-sugar recipes.
E421 Mannitol supports sweetness with lower caloric contribution than sucrose.
E421 Mannitol helps reduce browning compared with sucrose, which can be useful in some products.
E421 Mannitol is used in biscuits and cookies to reduce sugar content in some formulations.
E421 Mannitol supports crisp texture by contributing to low hygroscopicity.
E421 Mannitol helps reduce stickiness and improves handling of low-sugar doughs.
E421 Mannitol is used in cakes and muffins in some formulations as part of sugar-reduction strategies.
E421 Mannitol supports bulk sweetness when combined with fibers and high-intensity sweeteners.
E421 Mannitol helps maintain structure while reducing sucrose content.
E421 Mannitol is used in ice cream and frozen desserts to reduce sugar and control freezing point in some systems.
E421 Mannitol supports sweetness while contributing to freezing point depression.
E421 Mannitol helps improve scoopability and reduce iciness in selected formulations.
E421 Mannitol is used in sorbets and fruit ices to improve texture and reduce sugar load in some recipes.
E421 Mannitol supports smoother mouthfeel in frozen desserts.
E421 Mannitol helps stabilize sweetness perception at freezer temperatures.
E421 Mannitol is used in fruit preparations and dessert toppings as a bulking sweetener in some low-sugar systems.
E421 Mannitol supports reduced sugar content while maintaining viscosity and mouthfeel.
E421 Mannitol helps reduce crystallization problems in some sweet systems.
E421 Mannitol is used in tabletop sweeteners as a bulking carrier for high-intensity sweeteners.
E421 Mannitol supports good flow and dosing in sachets and tablets.
E421 Mannitol helps provide sugar-like bulk in portion sweeteners.
E421 Mannitol is used in pharmaceutical tablets as a diluent for direct compression.
E421 Mannitol supports good compressibility and produces tablets with pleasant mouthfeel.
E421 Mannitol helps reduce hygroscopicity issues in moisture-sensitive drug formulations.
E421 Mannitol is used in chewable tablets to provide sweetness and cooling mouthfeel.
E421 Mannitol supports pleasant taste masking of bitter active ingredients.
E421 Mannitol helps improve patient compliance in chewable dosage forms.
E421 Mannitol is used in orally disintegrating tablets as a filler for rapid melt sensation.
E421 Mannitol supports fast dissolution and smooth mouthfeel.
E421 Mannitol helps improve tablet palatability and mechanical strength.
E421 Mannitol is used in lozenges and troches as a non-cariogenic sweet base.
E421 Mannitol supports stable lozenge texture with reduced stickiness.
E421 Mannitol helps provide a clean sweetness profile in medicated lozenges.
E421 Mannitol is used in dry powder inhalation formulations as a carrier in some products.
E421 Mannitol supports good flow and dispersion of fine drug particles.
E421 Mannitol helps improve dose uniformity in inhalation delivery where applicable.
E421 Mannitol is used as an excipient in granulation to improve powder flow and processing.
E421 Mannitol supports stable granules with good compressibility.
E421 Mannitol helps reduce caking in some blended powders.
E421 Mannitol is used in lyophilized pharmaceutical products as a bulking agent.
E421 Mannitol supports formation of an elegant cake structure after freeze-drying.
E421 Mannitol helps improve stability of freeze-dried dosage forms.
E421 Mannitol is used in intravenous formulations as an osmotic diuretic active ingredient in medicinal products.
E421 Mannitol supports reduction of intracranial and intraocular pressure under medical supervision.
E421 Mannitol helps manage fluid balance in controlled clinical settings.
E421 Mannitol is used in diagnostic and hospital settings as part of specific medical protocols where prescribed.
E421 Mannitol supports controlled osmotic effects in compliant medical use.
E421 Mannitol helps provide predictable pharmacological osmotic action when administered properly.
E421 Mannitol is used in oral care products such as toothpaste and mouthwash as a sweetener and humectant in some formulations.
E421 Mannitol supports pleasant taste without feeding oral bacteria like sucrose.
E421 Mannitol helps improve mouthfeel and flavor release in oral products.
E421 Mannitol is used in dietary supplement powders to improve flow and taste.
E421 Mannitol supports low hygroscopicity and stable sweetness in powdered supplements.
E421 Mannitol helps improve consumer experience in drink mixes and sachets.
E421 Mannitol is used in dietary supplement gummies and chewables as a sweetener in some systems.
E421 Mannitol supports reduced sugar content while maintaining bulk.
E421 Mannitol helps contribute cooling sensation and clean sweetness.
E421 Mannitol is used in diabetic-friendly and weight-management foods as a sugar replacer within approved labeling frameworks.
E421 Mannitol supports sweetness with lower glycemic impact compared with sucrose.
E421 Mannitol helps maintain palatable taste in reduced-sugar diets.
E421 Mannitol is used in reformulation projects to meet sugar tax thresholds and reduced-sugar targets.
E421 Mannitol supports lowering added sugar grams while maintaining product texture.
E421 Mannitol helps preserve consumer-acceptable mouthfeel after sugar reduction.
E421 Mannitol is used in product development to improve stability of moisture-sensitive confections.
E421 Mannitol supports reduced hygroscopicity compared with some other polyols.
E421 Mannitol helps maintain crisp texture and reduces sticky defects.
E421 Mannitol is used in quality control to verify particle size, polymorph stability, and compressibility for tablet manufacturing.
E421 Mannitol supports consistent tablet hardness and dissolution performance.
E421 Mannitol helps ensure batch-to-batch reproducibility in excipient supply.
E421 Mannitol is used in manufacturing troubleshooting to address sticking or moisture issues in powders and tablets.
E421 Mannitol supports improved powder handling and reduced caking.
E421 Mannitol helps improve robustness of direct compression blends.
E421 Mannitol is used in research as a model polyol for crystallization and hygroscopicity studies.
E421 Mannitol supports evaluation of polymorphism and solid-state stability.
E421 Mannitol helps develop stable solid formulations in pharmaceutical R&D.
DESCRIPTION
E421 Mannitol is a polyol (sugar alcohol) that occurs naturally in some plants and can be produced industrially by hydrogenation of certain sugars or by fermentation-based processes depending on manufacturing route.
E421 Mannitol is less hygroscopic than sorbitol, and this low moisture uptake helps keep products dry, crisp, and stable in storage.
E421 Mannitol provides moderate sweetness and a cooling effect, and these sensory properties make E421 Mannitol popular in mints, chewing gum, and lozenges.
E421 Mannitol is a sugar alcohol naturally found in some plants and produced industrially by hydrogenation of sugars.
E421 Mannitol is typically a white crystalline powder with a clean, mildly sweet taste.
E421 Mannitol has relatively low hygroscopicity compared with many other polyols, which supports stability in dry products.
E421 Mannitol provides a cooling sensation because dissolution in saliva absorbs heat.
E421 Mannitol has lower sweetness than sucrose, so it is often combined with high-intensity sweeteners.
E421 Mannitol contributes bulk and improves mouthfeel in sugar-free and reduced-sugar products.
E421 Mannitol is widely used in pharmaceuticals as a diluent, especially for chewable tablets and orally disintegrating tablets.
E421 Mannitol is also used as a bulking agent in freeze-dried products to create a stable cake structure.
E421 Mannitol is used medically as an osmotic diuretic active ingredient in specific prescription settings.
E421 Mannitol can cause gastrointestinal discomfort or laxative effects when consumed in excess, as with many polyols.
E421 Mannitol use is regulated, and labeling requirements may include polyol warnings depending on jurisdiction.
E421 Mannitol can help control crystallization and texture in sugar-free systems, and E421 Mannitol is especially useful where tackiness must be minimized.
E421 Mannitol may cause laxative effects when consumed in excess, and the effect depends on total polyol intake and individual sensitivity.
E421 Mannitol should be used according to applicable food additive regulations and good manufacturing practices for the target market.
E421 Mannitol is typically supplied as a white crystalline powder or granules, and particle size can be selected to optimize flow and compaction.
E421 Mannitol is stable under normal storage, but E421 Mannitol should be protected from moisture contamination to maintain free-flowing behavior.
E421 Mannitol should be handled with good hygiene and dust control practices during bulk powder processing.
PROPERTIES
Chemical Formula: C6H14O6
Molecular Weight: 182.17 g/mol
Common Name: E421 Mannitol
Chemical Type: Polyol (sugar alcohol); bulk sweetener; pharmaceutical excipient
Appearance: White crystalline powder or granules
Odor: Odorless
Taste: Mildly sweet with cooling sensation
Solubility: Soluble in water (lower solubility than sorbitol); slightly soluble in alcohol
Melting Point: ~165–169°C (typical)
Hygroscopicity: Low (non-hygroscopic to slightly hygroscopic depending on grade)
Compressibility: Good; widely used in direct compression and ODT systems (grade dependent)
Stability: Stable under normal storage; avoid strong heat and extreme pH over long exposure
Storage Temperature: 15–30°C, tightly closed, dry
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during powder handling.
Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs.
Excess consumption may cause laxative effects in sensitive individuals.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves and safety glasses for bulk handling.
Avoid generating dust and avoid inhalation of fine powder.
Maintain good hygiene and clean-up practices in handling areas.
Ventilation:
Use general ventilation for normal handling.
Use local exhaust where dust may be generated during powder transfer.
Minimize airborne particulate accumulation in enclosed areas.
Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture to prevent caking and maintain free-flowing behavior.
Keep containers properly labeled and protected from contamination.
Spill and Leak Procedures:
Sweep up spilled powder and avoid dust generation.
Collect into suitable containers for reuse or disposal according to local regulations.
Clean residues to prevent slip hazards if powder becomes wet.
Handling Precautions:
Optimize particle size and grade selection because E421 Mannitol performance in compaction and dissolution depends on physical form.
Consider labeling requirements and consumer tolerance because high intake of E421 Mannitol can cause laxative effects.
Rotate stock using FIFO practices to maintain consistent quality and predictable performance.
