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E464 (HYDROXYPROPYL METHYL CELLULOSE)

CAS Number: 9004-65-3

E464 (Hydroxypropyl methyl cellulose) is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.

E464 (Hydroxypropyl methyl cellulose) is a kind of nonionic cellulose ether prepared from cellulose, a natural macromolecule material, by a series of chemical processes.
E464 (Hydroxypropyl methyl cellulose) is a white, odorless, tasteless, off-white to beige granular powder with high viscosity.

E464 (Hydroxypropyl methyl cellulose) is a non-toxic white powder that can be dissolved in cold water.
E464 (Hydroxypropyl methyl cellulose) has thickening, adhesion, dispersion, emulsification, film formation, suspension, adsorption, gelling, surface activity, water retention and protective colloid properties.

E464 (Hydroxypropyl methyl cellulose) is a thickener, binder, film former.
E464 (Hydroxypropyl methyl cellulose), which is the most preferred in the construction chemicals industry, facilitates the making of the mortar, plays an important role in increasing work efficiency and adhesion and strength.

E464 (Hydroxypropyl methyl cellulose) is widely used in construction, medicine, food, cosmetics, detergent, dyes, textile etc.
Hydroxypropyl methylcellulose traps a certain amount of water for a certain period of time, thus allowing the working time of the mortar to be adjusted.
By improving the consistency of the mortar, they facilitate the carding process and increase the slip resistance.

E464 (Hydroxypropyl methyl cellulose) belongs to the group of cellulose ethers in which hydroxyl groups have been substituted with one or more of the three hydroxyl groups present in the cellulose ring.
E464 (Hydroxypropyl methyl cellulose) is hydrophilic (water soluble), a biodegradable, and biocompatible polymer having a wide range of applications in drug delivery, dyes and paints, cosmetics, adhesives, coatings, agriculture, and textiles.

E464 (Hydroxypropyl methyl cellulose) is also soluble in polar organic solvents, making E464 (Hydroxypropyl methyl cellulose) possible to use both aqueous and nonaqueous solvents.
E464 (Hydroxypropyl methyl cellulose) has unique solubility properties with solubility in both hot and cold organic solvents.

E464 (Hydroxypropyl methyl cellulose) possesses increased organo-solubility and thermo-plasticity compared to other methyl cellulose counterparts.
E464 (Hydroxypropyl methyl cellulose) forms gel upon heating with gelation temperature of 75–90C.

By reducing the molar substitution of hydroxyl propyl group, the glass transition temperature of E464 (Hydroxypropyl methyl cellulose) can be reduced to 40C.
E464 (Hydroxypropyl methyl cellulose) forms flexible and transparent films from aqueous solution.

E464 (Hydroxypropyl methyl cellulose) films are generally odorless and tasteless, and can be effectively used in reducing absorption of oil from fried products such as French fries because of their resistance to oil migration.
E464 (Hydroxypropyl methyl cellulose) is extensively used in the food industry as a stabilizer, as an emulsifier, as a protective colloid, and as a thickener.

E464 (Hydroxypropyl methyl cellulose) is used as a raw material for coatings with moderate strength, moderate moisture and oxygen barrier properties, elasticity, transparency, and resistance to oil and fat.
E464 (Hydroxypropyl methyl cellulose) is also used as a tablet binder and as a tablet matrix for extended release.

Biopolymer composites are very promising materials because they are easy to process, eco-friendly in nature, and offer better properties.
E464 (Hydroxypropyl methyl cellulose), being a biodegradable polymer, has also been used to prepare biocomposites. Several studies have been carried out to investigate the influence of different additives on the physicochemical properties of E464 (Hydroxypropyl methyl cellulose).

The E464 (Hydroxypropyl methyl cellulose)/ZnO composites showed promising bacterial resistance.
The contact angle was decreased when ZnO content was increased.

Prepared graphene oxide (GO) reinforced E464 (Hydroxypropyl methyl cellulose) nanocomposite films using solution casting technique.
The content of GO was varied from 0.02 to 1.3 wt.%.

The obtained results confirmed the formation of exfoliated E464 (Hydroxypropyl methyl cellulose)/GO composites with enhanced mechanical properties (tensile strength, Young’s modulus, and elongation at break) of E464 (Hydroxypropyl methyl cellulose) film with respect to GO loading.
In addition, the thermal stability of E464 (Hydroxypropyl methyl cellulose)/GO composites has improved as compared to neat E464 (Hydroxypropyl methyl cellulose) which is ascribed to the excellent thermal stability of GO.

(Hydroxypropyl)methyl cellulose is a thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.
Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface actuce and enzyme resistant.
Solutions are pseudoplastic.

Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong E464 (Hydroxypropyl methyl cellulose) therapeutic effect.
Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years.

When used in matrix tablets, these polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet.
The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose and rate of hypromellose gel erosion.

Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye.
Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose.

Hypromellose is effective in improving the blood glucose metabolism and suppressing oxidative stress in mice fed with a high fat diet.
The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes.
Hypromellose may be useful as biomaterials in the development of functional food or as therapeutic agents against high fat-induced hyperglycemia and oxidative stress.

Hydroxypropyl Methylcellulose is a nonionic water-soluble cellulosic polymers which provides thickening in a wide range of applications.
Viscosity 60,000 - 90,000cP in 2% solution.

Effectively thickens the water phase of shampoos, conditioners, topical gels and other kinds of emulsions.
Often used as foam enhancer and anti-caking agent.
Has good foam enhancement properties in cleansing applications.

Hydroxypropyl methylcellulose (E464 (Hydroxypropyl methyl cellulose) or hypromellose) is a derivative of cellulose in which some of the hydroxyl groups in the repeating glucose units have been methoxylated or hydroxypropylated.
E464 (Hydroxypropyl methyl cellulose) is a thickening and binding agent approved for food use in the USA and the EU.

As a food additive, E464 (Hydroxypropyl methyl cellulose) is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
E464 (Hydroxypropyl methyl cellulose) is used in deep fried batter.

E464 (Hydroxypropyl methyl cellulose) Codex Alimentarius code (E number) is E464.
Since E464 (Hydroxypropyl methyl cellulose) solution is a non-Newtonian solution and exhibits pseudoplastic behaviour (specifically, thixotropic behaviour) various test methods are available, and the results of different methods and viscometers do not necessarily correspond to each other.

Due to viscometer acceptable ranges of error, the viscosity is typically given as a mean or as a range.
The degree of substitution is the average level of methoxy substitution on the cellulose chain.

Since there is a maximum of three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3.
However, the degree of substitution is often expressed in percentages.

Hypromellose (INN) is a semisynthetic, inert, viscoelastic polymer used as an ophthalmic lubricant, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.
Hypromellose is a solid and slightly off-white to beige powder and may be formed into granules.

The compound forms colloids when dissolved in water.
Although non-toxic, E464 (Hydroxypropyl methyl cellulose) is combustible and can react vigorously with oxidizing agents.

Hypromellose solutions were patented as a semisynthetic substitute for tear-film.
E464 (Hydroxypropyl methyl cellulose) molecular structure is predicated upon a base celluloid compound that is highly water-soluble.

Post-application, celluloid attributes of good water-solubility reportedly aid in visual clarity.
When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film.

Hypromellose augmentation therefore results in extended lubricant time presence on the cornea, which theoretically results in decreased eye irritation, especially in dry climates, home, or work environments.
On a molecular level, this polymer contains beta-linked D-glucose units that remain metabolically intact for days to weeks.

On a manufacturing note, since hypromellose is a vegetarian substitute for gelatin, E464 (Hydroxypropyl methyl cellulose) is slightly more expensive to produce due to semisynthetic manufacturing processes.
Aside from E464 (Hydroxypropyl methyl cellulose) widespread commercial and retail availability over the counter in a variety of products, hypromellose 2% solution has been documented to be used during surgery to aid in corneal protection and during orbital surgery.

E464 (Hydroxypropyl methyl cellulose) is multifunctional as a lubricant, foam enhancer and stabilizer, thickener, emulsion stabilizer and film former for hair and skin care products.
E464 (Hydroxypropyl methyl cellulose) is especially useful in surfactant systems for E464 (Hydroxypropyl methyl cellulose) foam enhancing properties, helping with the formation of bubble structure, leading to richer, longer lasting lather.
E464 (Hydroxypropyl methyl cellulose) has a high tolerance for both salt and alcohol.

E464 (Hydroxypropyl methyl cellulose) are cellulose ethers that have had hyrdroxyl groups on the cellulose chain substituted for a methoxy or hydroxypropyl group.
E464 (Hydroxypropyl methyl cellulose) is used as a thickener, binder, and film former in agrochemicals, coatings, ceramics, adhesives, inks, and various other applications.
Aqueous solutions of E464 (Hydroxypropyl methyl cellulose) will reversibly gel when exposed to heat allowing for a controllable boost is green strength of green ceramic bodies.

Hydroxypropyl Methylcellulose (HMPC) is a polysaccharide additive used in frosting, coatings, gluten-free baking and dietary supplements.
E464 (Hydroxypropyl methyl cellulose) is also a stabilizer, thickener, fat replacer, bulking and binding agent.

Several types of E464 (Hydroxypropyl methyl cellulose) are available commercially in several degrees of substitution, mainly:
E464 (Hydroxypropyl methyl cellulose) – type C: high methyl and hydroxypropyl content.
E464 (Hydroxypropyl methyl cellulose) – type D: high methyl and medium hydroxypropyl content.
E464 (Hydroxypropyl methyl cellulose) – type E: medium methyl and hydroxypropyl content.

Techniques for Dispersion of Hydroxypropyl methylcellulose:
The preferred method is to begin by heating approximately 1/3 of the total formulation water to 167°F (75°C) or higher.
Add the E464 (Hydroxypropyl methyl cellulose) to the vortex of agitated and heated water.
Mix until fully dispersed.
HMPC will not dissolve at this temperature.
After complete dispersion, add the remaining water at room temperature or colder and continue mixing for 30 minutes after the total solution has cooled to 77°F. (25°C) or less.
Proceed with the formulation.

If heating is impossible, E464 (Hydroxypropyl methyl cellulose) is preferred to slurry the E464 (Hydroxypropyl methyl cellulose) in a non-solvating media, such as glycerin or PEG, then add the slurry to the vortex of vigorously agitated water.
Adding E464 (Hydroxypropyl methyl cellulose) directly to cold water is not preferred, but if necessary, must be done very slowly under vigorous agitation.
Expect longer mixing times for complete dissolution.

Origin of Hydroxypropyl methylcellulose:
Hydroxypropyl Methylcellulose is obtained from various natural sources, mainly wood pulp and cotton linters.

Since 1985, E464 (Hydroxypropyl methyl cellulose) has been used as a gluten replacement for the manufacture of baked goods.

Commercial production of Hydroxypropyl methylcellulose:
E464 (Hydroxypropyl methyl cellulose) is manufactured following this process:

Alkalinization: wood pulp cellulose is treated with a 50 wt% sodium hydroxide solution in a reactor.

Etherification: addition of methyl chloride followed by propylene oxide to introduce methoxy and propylene glycol groups, respectively.

Neutralization: using hydrogen chloride solution.

Purification: E464 (Hydroxypropyl methyl cellulose) is washed several times with hot water, and filtered.

Drying and sizing: the purified product is dried, ground to desirable particle size followed by packaging.

Nutrition of Hydroxypropyl methylcellulose:
E464 (Hydroxypropyl methyl cellulose) is considered a non-fermentable soluble dietary fiber, thus providing several health benefits including reduction of total and low density lipoprotein cholesterol, reducing risk factors of type 2 diabetes and aiding intestinal movements.

Using E464 (Hydroxypropyl methyl cellulose) in gluten-free baked goods helps with diet management for patients with celiac disease.

Function of Hydroxypropyl methylcellulose:

E464 (Hydroxypropyl methyl cellulose) can serve several functions in baked goods such as:
Stabilizer of emulsions and foams: critical for dough development during baking.
Thickener: increases viscosity by thickening the aqueous phase.
Fat-replacer: acts as a lubricant to help maintain creamy mouthfeel.
Gluten-substitute: most effectively when combined with carboxymethylcellulose (CMC) in baked goods.
Bulking agent
Coating agent: film and barrier formation for coating.
Binder
Water retention: extends shelf-life.
Controls water balance during freezing and thawing.

Features and Benefits of Hydroxypropyl methylcellulose:
Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant.
Solutions are pseudoplastic.

Application of Hydroxypropyl methylcellulose:
Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

E464 (Hydroxypropyl methyl cellulose) can be used in the manufacture of several baked products, fillings, foams and coatings.
E464 (Hydroxypropyl methyl cellulose) is a great alternative for gluten substitution in gluten-free baked products in combination with CMC.

Some considerations when adding E464 (Hydroxypropyl methyl cellulose) to food products include:
Solubilizing E464 (Hydroxypropyl methyl cellulose)/CMC before addition for full performance.
Consider the water activity of the systems, 5-10% of water may be needed in some formulations.

E464 (Hydroxypropyl methyl cellulose) should be added after proteins are activated.
E464 (Hydroxypropyl methyl cellulose) accommodates high sugar levels, up to 50%.

Methods of incorporating of E464 (Hydroxypropyl methyl cellulose)/CMC mixtures in food products:
E464 (Hydroxypropyl methyl cellulose)/CMC should be dispersed in one third of the required water.
Add the rest of E464 (Hydroxypropyl methyl cellulose)/CMC with the dry ingredients to avoid lump formation.
Disperse the blend in the required oil and then add to the bakery mix.

Usage area of Hydroxypropyl methylcellulose:
E464 (Hydroxypropyl methyl cellulose) is used as an additive in interior and exterior wall coating applications, tile adhesives, sheathing adhesives and plasters, thermal insulation plasters and adhesives (EIFS), repair mortars and joint fillers, exterior insulation mortar, self-leveling mortar, decorative mortar, waterproof mortars.
Thanks to E464 (Hydroxypropyl methyl cellulose) improved consistency, E464 (Hydroxypropyl methyl cellulose) provides easier spreading and sagging resistance.

Uses of Hydroxypropyl methylcellulose:
There are many fields of application for hypromellose, including:
Tile adhesives
Cement renders
Gypsum products
Pharmaceutical
Paints & coatings
Food
Cosmetics
Detergents & cleaners
Eye drops
Contact lenses

Dairy Products
Sauces & Baked Goods
Vitamin & Supplement Tablets
Shampoo & Conditioner
Toothpaste & Mouthwash
Liquid Soaps
Lotions
Sunscreen
Hair Products

Use in whole grain breads:
Agricultural Research Service scientists are investigating using the plant-derived E464 (Hydroxypropyl methyl cellulose) as a substitute for gluten in making all-oat and other grain breads.
Gluten, which is present in wheat, rye, and barley, is absent (or present only in trace quantities) in oat and other grains.
Like gluten, E464 (Hydroxypropyl methyl cellulose) can trap air bubbles formed by the yeast in bread dough, causing the bread to rise.

Use in construction materials:
E464 (Hydroxypropyl methyl cellulose) is used primarily in construction materials like tile adhesives and renders where E464 (Hydroxypropyl methyl cellulose) is used as a rheology modifier and water retention agent.

Functionally E464 (Hydroxypropyl methyl cellulose) is very similar to HEMC (hydroxy ethyl methyl cellulose) Trade names include Methocel and Walocel.
The global leading producer is now DuPont, formerly manufactured under Dow Wolff Cellulosics GmbH.

Ophthalmic applications:
Hypromellose solutions were patented as a semisynthetic substitute for tear-film.
E464 (Hydroxypropyl methyl cellulose) molecular structure is predicated upon a base celluloid compound that is highly water-soluble.

Post-application, celluloid attributes of good water solubility reportedly aid in visual clarity.
When applied, a hypromellose solution acts to swell and absorb water, thereby expanding the thickness of the tear-film.

Excipient/tableting ingredient:
In addition to E464 (Hydroxypropyl methyl cellulose) use in ophthalmic liquids, hypromellose has been used as an excipient in oral tablet and capsule formulations, where, depending on the grade, E464 (Hydroxypropyl methyl cellulose) functions as controlled release agent to delay the release of a medicinal compound into the digestive tract.
E464 (Hydroxypropyl methyl cellulose) is also used as a binder and as a component of tablet coatings.
There is a growing body of anecdotal evidence that hypromellose can cause intestinal problems in some humans, even as far as an allergic reaction.

Chemistry of Hydroxypropyl methylcellulose:
Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules.
The compound forms colloids when dissolved in water.
This non-toxic ingredient is combustible and can react vigorously with oxidizing agents.

Hypromellose in an aqueous solution, like methylcellulose, exhibits a thermal gelation property.
That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass.

Typically, this critical (congealing) temperature is inversely related to both the solution concentration of E464 (Hydroxypropyl methyl cellulose) and the concentration of the methoxy group within the E464 (Hydroxypropyl methyl cellulose) molecule (which in turn depends on both the degree of substitution of the methoxy group and the molar substitution).
That is, the higher the concentration of the methoxy group, the lower the critical temperature.
The inflexibility/viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group (the higher the concentration is, the more viscous or less flexible the resulting mass is).

Test methods of Hydroxypropyl methylcellulose:
Various benchmark tests are used to qualify hypromellose:
Viscosity
Degree of substitution (DS)
Molar substitution (MS)
Salt content
Moisture

Viscosity test methods:
Because hypromellose solution is a non-newtonian solution and exhibits pseudoplastic, more specifically, thixotropic behavior, various test methods are available, and the results of different methods and viscosimeters do not necessarily correspond to each other.
Also, due to viscometer acceptable ranges of error, viscosity is typically given as a mean, or as a range.

Typical viscosity test will specify the following:
Solution concentration (1%, 2%, 1.9% bone dry, etc.)
Viscometer (RheoSense m-VROC and microVISC, Brookfield LV or RV, Höppler falling ball, Haake Rotovisco, etc.)

Viscometer spindle number (1 ~ 4 for Brookfield LV, 1 ~ 7 for Brookfield RV, etc.)
Solution Temperature (20 °C, 25 °C, etc.)

Degree of substitution:
Degree of substitution is the average level of methoxy substitution on the cellulose chain.
Since there are maximum three possible sites of substitution with each cellulose molecule, this average value is a real number between 0 and 3.
However, degree of substitution is often expressed in percentages.

Molar substitution:
Molar substitution is the average level of hydroxypropoxy substitution on the cellulose chain.
Since hydroxypropoxy base can be attached to each other on side chains and does not each require a base substitution site on the cellulose molecule, this number can be higher than 3.
However, molar substitution is also often expressed in percentages.

Moisture:
Since all cellulose ethers are hygroscopic, they will absorb moisture from surroundings if left exposed from original packaging.
Thus, moisture must be tested and weight corrected to ensure adequate amount of dry active material are apportioned for usage.
Moisture is tested by weighing a sample of X grams on an analytic scale, and drying the sample in an oven at 105 °C for 2 hours, then weighing the sample again on the same scale.

Regulations of Hydroxypropyl methylcellulose:
E464 (Hydroxypropyl methyl cellulose) is permitted for E464 (Hydroxypropyl methyl cellulose) direct addition to food products by the FDA.

In the EU, E464 (Hydroxypropyl methyl cellulose) (E 464) is considered safe when used for E464 (Hydroxypropyl methyl cellulose) intended purpose.
Accepted E464 (Hydroxypropyl methyl cellulose) types must have between 19 -30 % methyl and 3 -12% hydroxyprop(ox)yl groups content.

Handling and Storage of Hydroxypropyl methylcellulose:
Precautions for safe handling: Provide appropriate exhaust ventilation at places where dust is formed.

Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.
Store under inert gas.
Hygroscopic.
Keep in a dry place.

Safety Information of Hydroxypropyl methylcellulose:
Storage Class Code: 13 - Non Combustible Solids
WGK: WGK 1
Flash Point(F): Not applicable
Flash Point(C): Not applicable
Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves

First Aid Measures of Hydroxypropyl methylcellulose:
Inhalation: If breathed in, move person into fresh air.
If not breathing, give artificial respiration.

Skin contact: Wash off with soap and plenty of water.

Eye contact: Flush eyes with water as a precaution.

Ingestion: Never give anything by mouth to an unconscious person.
Rinse mouth with water.

Indication of any immediate medical attention and special treatment needed: No data available

Firefighting Measures of Hydroxypropyl methylcellulose:
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.

Special hazards arising from the substance or mixture: Carbon oxides

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Further information: No data available

Accidental Release Measures of Hydroxypropyl methylcellulose:
Personal precautions, protective equipment, and emergency procedures: Avoid dust formation.
Avoid breathing vapors, mist, or gas.

Environmental precautions: Do not let product enter drains.

Methods and materials for containment and cleaning up: Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Hydroxypropyl methylcellulose:
CAS Number: 9004-65-3
ChemSpider: 21241863
ECHA InfoCard: 100.115.379
EC Number: 618-389-6
E number: E464 (thickeners, ...)
UNII: 36SFW2JZ0W
CompTox Dashboard (EPA): DTXSID7037054
InChI:
InChI=1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1 check
Key: PUSNGFYSTWMJSK-GSZQVNRLSA-N check
InChI=1/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1
Key: PUSNGFYSTWMJSK-GSZQVNRLBE

Properties of Hydroxypropyl methylcellulose:
Chemical formula: variable
Molar mass: variable

Biological source: plant
Quality Level: 200
Form: powder
Mol wt: ~86 kDa
Viscosity: 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
Storage temp.: room temp

Molecular Weight: 1261.4
Hydrogen Bond Donor Count: 8
Hydrogen Bond Acceptor Count: 30
Rotatable Bond Count: 40
Exact Mass: 1260.69254202
Monoisotopic Mass: 1260.69254202
Topological Polar Surface Area: 365 Å²
Heavy Atom Count: 86
Complexity: 1480
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 20
Undefined Atom Stereocenter Count: 8
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specifications of Hydroxypropyl methylcellulose:
Appearance: White and off-white powder
Methyl content ( % ): 19.0~ 24.0
Hydroxypropoxy ( % ): 4.0 ~ 12.0
pH: 4.0~8.0
Moisture content(%): ≤ 5.0
Ash residue (%): ≤ 5.0
Part size: min.99% — 100
Viscosity brookfield 2% solution: 55 000- 85 000 m rust
Viscosity NDJ 2% solution: 120 000-200 000 m rust
Solubility: in cold water

Pharmacology of Hydroxypropyl methylcellulose:
ATC code: S01KA02 (WHO)

Names of Hydroxypropyl methylcellulose:

Other names of Hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose
hydroxypropyl methyl cellulose
E464 (Hydroxypropyl methyl cellulose)
E464

Synonyms of Hydroxypropyl methylcellulose:
hydroxypropylmethylcellulose
HYDROXY PROPYL METHYL CELLULOSE
2-HYDROXYPROPYL METHYL ETHER CELLULOSE
CARBOHYDRATE GUM
CELLULOSE
2-HYDROXYPROPYL METHYL ETHER
CELLULOSE
2HYDROXYPROPYL METHYL ETHER
HYDROXYPROPYL METHYCELLULOSE
HYDROXYPROPYL METHYLCELLULOSE
HYDROXYPROPYL METHYLCELLULOSE 2208
HYDROXYPROPYL METHYLCELLULOSE 2906
HYDROXYPROPYL METHYLCELLULOSE 2910
HYPROMELLOSE
METHYL HYDROXYPROPYL CELLULOSE

Depositor-Supplied Synonyms of Hydroxypropyl methylcellulose:
hydroxypropylmethylcellulose
HYDROXY PROPYL METHYL CELLULOSE

MeSH of Hydroxypropyl methylcellulose:
Derivative, Hypromellose
Derivatives, Hypromellose
hydroxypropyl methylcellulose
hydroxypropylmethylcellulose
hypromellose
Hypromellose Derivative
Hypromellose Derivatives
K 8515
K-8515
K8515
Methocel E
methoxyhydroxypropylcellulose
methyl hydroxypropyl cellulose
methyl-hydroxypropyl-cellulose
MHPC polymer