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CAS NUMBER: 9004-32-4

EC NUMBER: 618-378-6



E467 (Sodiumcarboxymethylcellulose) is the sodium salt of carboxymethyl cellulose, an anionic cellulose ether in which some of the hydroxyl groups of the cellulose molecule have been replaced with a carboxy group. 
E467 (Sodiumcarboxymethylcellulose) is an efficient thickener and binder for water based applications including adhesives, coatings, inks, gel packs, drilling mud and battery electrodes.

E467 (Sodiumcarboxymethylcellulose) may be added to media at 0.1% to help to minimize mechanical damage caused by the shear force generated by the stirrer impeller. 
E467 (Sodiumcarboxymethylcellulose) can provide a protective effect to animal cells in stirred and sparged vessels. 

E467 (Sodiumcarboxymethylcellulose) may become more sensitive to direct bubble formation in the presence of an antifoam agent being used to supress foam formation.
E467 (Sodiumcarboxymethylcellulose) is one of the most important products of cellulose ethers, which are formed by natural cellulose modification as a kind of cellulose derivate with an ether structure. 

Due to the fact that the acid form of E467 (Sodiumcarboxymethylcellulose) has poor water solubility, E467 (Sodiumcarboxymethylcellulose) is usually preserved as sodium carboxymethylcellulose, which is widely used in many industries and regarded as monosodium glutamate in industry. 
E467 (Sodiumcarboxymethylcellulose) could be used as flocculating agent, chelating agent, emulsifier, thickening agent, water-retaining agent, sizing agent, and film-forming material, and so on. 

E467 (Sodiumcarboxymethylcellulose) is also widely applied in fields such as electronics, pesticides, leather, plastics, printing, ceramics, and the daily-use chemical industry. 
Moreover, due to its excellent properties, wide application, and the developing potential fields, E467 (Sodiumcarboxymethylcellulose) has broad application prospects.

E467 (Sodiumcarboxymethylcellulose) is used for its thickening and swelling properties in a wide range of complex formulated products for pharmaceutical, food, home, and personal care applications, as well as in paper, water treatment, and mineral processing industries. 
To design E467 (Sodiumcarboxymethylcellulose) solutions for applications, a detailed understanding of the concentration-dependent rheology and relaxation response is needed. 

It is address this here by investigating aqueous E467 (Sodiumcarboxymethylcellulose) solutions over a wide range of concentrations using rheology as well as static and dynamic light scattering. 
The concentration dependence of the solution specific viscosities ηsp could be described using a set of three power laws, as predicted from the scaling theory of polyelectrolytes. 

Alternatively, a simpler approach could be used, which interpolates between two power law regimes and introduces only one characteristic crossover concentration. 
E467 (Sodiumcarboxymethylcellulose) is interpreted the observed behavior as a transition from the semidilute nonentangled to the entangled concentration regimes; this transition behavior was not observed in the solution structure, as determined using static light scattering. 

Dynamic light scattering revealed three relaxation modes. 
The two fastest relaxations were assigned as the “fast” and “slow” relaxation modes typically observed in salt-free or not fully screened polyelectrolyte solutions within the semidilute concentration range. 

The third, typically weak mode, was attributed to the presence of a small amount of poorly dissolved cellulose residuals. 
Since filtration altered the solution behavior, without sufficiently removing the residuals, data collection and processing were adapted to account for this, which facilitated a detailed light scattering investigation of the original solutions, relevant for industrial applications. 

The relaxation time characterizing the fast mode, was concentration independent; whereas the relaxation time of the slow mode, τs, demonstrated similar crossover behavior as observed for the specific viscosity, further demonstrating the dynamic nature of the crossover.
E467 (Sodiumcarboxymethylcellulose) is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid.

The polar carboxyl groups render the cellulose soluble and chemically reactive.
Following the initial reaction, the resultant mixture produces about 60% E467 (Sodiumcarboxymethylcellulose) plus 40% salts (sodium chloride and sodium glycolate). 

This product is the so-called technical E467 (Sodiumcarboxymethylcellulose) which is used in detergents. 
A further purification process is used to remove these salts to produce the pure E467 (Sodiumcarboxymethylcellulose) used for food, pharmaceutical, and dentifrice (toothpaste) applications. 

An intermediate "semipurified" grade is also produced, typically used in paper applications such as restoration of archival documents.
The functional properties of E467 (Sodiumcarboxymethylcellulose) depend on the degree of substitution of the cellulose structure (i.e., how many of the hydroxyl groups have taken part in the substitution reaction), as well as the chain length of the cellulose backbone structure and the degree of clustering of the carboxymethyl substituents.

E467 (Sodiumcarboxymethylcellulose) is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol. 
E467 (Sodiumcarboxymethylcellulose) is the substituted product of cellulosic carboxymethyl group. 

According to their molecular weight or degree of substitution, E467 (Sodiumcarboxymethylcellulose) can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
E467 (Sodiumcarboxymethylcellulose) can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.

E467 (Sodiumcarboxymethylcellulose) is used in food under the E number E466 or E469 as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream. 
E467 (Sodiumcarboxymethylcellulose) is also a constituent of many non-food products, such as toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing, reusable heat packs, and various paper products. 

E467 (Sodiumcarboxymethylcellulose) is used primarily because it has high viscosity, is nontoxic, and is generally considered to be hypoallergenic as the major source fiber is either softwood pulp or cotton linter.
E467 (Sodiumcarboxymethylcellulose) is used extensively in gluten free and reduced fat food products.

In laundry detergents, E467 (Sodiumcarboxymethylcellulose) is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution. 
E467 (Sodiumcarboxymethylcellulose) is used as a lubricant in artificial tears.

E467 (Sodiumcarboxymethylcellulose) is also used as a thickening agent, for example, in the oil-drilling industry as an ingredient of drilling mud, where E467 (Sodiumcarboxymethylcellulose) acts as a viscosity modifier and water retention agent. 
E467 (Sodiumcarboxymethylcellulose) for example, is used as a negative control agent.

E467 (Sodiumcarboxymethylcellulose) is also used in ice packs to form a eutectic mixture resulting in a lower freezing point, and therefore more cooling capacity than ice.
Aqueous solutions of E467 (Sodiumcarboxymethylcellulose) have also been used to disperse carbon nanotubes. 

The long E467 (Sodiumcarboxymethylcellulose) molecules are thought to wrap around the nanotubes, allowing them to be dispersed in water. 
E467 (Sodiumcarboxymethylcellulose) is used as an adhesive or fixative.

E467 (Sodiumcarboxymethylcellulose) is used to achieve tartrate or cold stability in wine. 
This innovation may save megawatts of electricity used to chill wine in warm climates. 

E467 (Sodiumcarboxymethylcellulose) is more stable than metatartaric acid and is very effective in inhibiting tartrate precipitation. 
Their shape becomes flatter because they lose 2 of the 7 faces, changing their dimensions. 

E467 (Sodiumcarboxymethylcellulose) molecules, negatively charged at wine pH, interact with the electropositive surface of the crystals, where potassium ions are accumulated. 
The slower growth of the crystals and the modification of their shape are caused by the competition between E467 (Sodiumcarboxymethylcellulose) molecules and bitartrate ions for binding to the KHT crystals.

In veterinary medicine, E467 (Sodiumcarboxymethylcellulose) is used in abdominal surgeries in large animals, particularly horses, to prevent the formation of bowel adhesions.
E467 (Sodiumcarboxymethylcellulose) is sometimes used as an electrode binder in advanced battery applications, especially with graphite anodes. 

E467 (Sodiumcarboxymethylcellulose)'s water solubility allows for less toxic and costly processing than with non-water-soluble binders, like the traditional polyvinylidene fluoride (PVDF), which requires toxic n-methylpyrrolidone (NMP) for processing. 
E467 (Sodiumcarboxymethylcellulose) is often used in conjunction with styrene-butadiene rubber (SBR) for electrodes requiring extra flexibility, e.g. for use with silicon-containing anodes.

E467 (Sodiumcarboxymethylcellulose) powder is widely used in the ice cream industry, to make ice creams without churning or extreme low temperatures, thereby eliminating the need for the conventional churners or salt ice mixes.
E467 (Sodiumcarboxymethylcellulose) is used in preparing bakery products such as bread and cake. 

The use of E467 (Sodiumcarboxymethylcellulose) gives the loaf a much improved quality at a reduced cost to the baker, by economizing on the fat component. 
E467 (Sodiumcarboxymethylcellulose) is also used as an emulsifier in high quality biscuits. 

By dispersing fat uniformly in the dough, it improves the release of the dough from the moulds and cutters, achieving well-shaped biscuits without any distorted edges. It can also help to reduce the amount of egg yolk or fat used in making the biscuits, thus achieving economy. 
Use of E467 (Sodiumcarboxymethylcellulose) in candy preparation ensures smooth dispersion in flavour oils, and improves texture and quality. 

E467 (Sodiumcarboxymethylcellulose) is used in chewing gums, margarines and peanut butter as an emulsifier. 
E467 (Sodiumcarboxymethylcellulose) is also used in leather crafting to burnish the edges.

E467 (Sodiumcarboxymethylcellulose) has also been used extensively to characterize enzyme activity from endoglucanases. 
E467 (Sodiumcarboxymethylcellulose) is a highly specific substrate for endo-acting cellulases, as its structure has been engineered to decrystallize cellulose and create amorphous sites that are ideal for endoglucanase action. 

E467 (Sodiumcarboxymethylcellulose) is desirable because the catalysis product (glucose) is easily measured using a reducing sugar assay, such as 3,5-dinitrosalicylic acid. 
Using E467 (Sodiumcarboxymethylcellulose) in enzyme assays is especially important in regard to screening for cellulase enzymes that are needed for more efficient cellulosic ethanol conversion. 

E467 (Sodiumcarboxymethylcellulose) has also been misused in earlier work with cellulase enzymes, as many had associated whole cellulase activity with E467 (Sodiumcarboxymethylcellulose) hydrolysis. 
As the mechanism of cellulose depolymerization has become better understood, exo-cellulases are dominant in the degradation of crystalline and not soluble (e.g. E467 (Sodiumcarboxymethylcellulose) ) cellulose

E467 (Sodiumcarboxymethylcellulose) is an anionic, water-soluble cellulose derivative. 
Solubility of E467 (Sodiumcarboxymethylcellulose) depends on the DP as well as the degree of substitution and the uniformity of the substitution distribution. 

Water solubility of E467 (Sodiumcarboxymethylcellulose) would increase with decreased DP and increased carboxymethyl substitution and substitution uniformity. 
The viscosity of the solution increases with increasing DP and increasing concentration.

E467 (Sodiumcarboxymethylcellulose) is soluble in water at any temperature. 
Because of its highly hygroscopic nature, E467 (Sodiumcarboxymethylcellulose) hydrates rapidly. 

Rapid hydration may cause agglomeration and lump formation when the E467 (Sodiumcarboxymethylcellulose) powder is introduced into water.
Lump creation can be eliminated by applying high agitation while the powder is added into the water or preblending the E467 (Sodiumcarboxymethylcellulose) powder with other dry ingredients such as sugar before adding into water.

Due to E467 (Sodiumcarboxymethylcellulose) 's high solubility and clarity of its solutions, E467 (Sodiumcarboxymethylcellulose) is commonly used in beverages and beverage dry mixes to provide rich mouthfeel. 
E467 (Sodiumcarboxymethylcellulose) is also used in acidified protein drinks to stabilize protein and prevent it from precipitating. 

E467 (Sodiumcarboxymethylcellulose) is also added to syrup and sauce formulations to increase viscosity. 
Bakery is another application where E467 (Sodiumcarboxymethylcellulose) is commonly used to improve the quality and the consistency of the end product. 

E467 (Sodiumcarboxymethylcellulose) is used to improve the process ability of the dough and the textural properties of the end product, including foldability and rollability.
E467 (Sodiumcarboxymethylcellulose) is the major cellulose ether. 

By activating the noncrystalline regions of cellulose, selective regions of alkylating reagents can attack the cellulose. 
This is termed the concept of reactive structure fractions and is used widely for the production of E467 (Sodiumcarboxymethylcellulose) . 

Another route for carrying out the same reaction is by derivatization of cellulose in reactive microstructures, formed by induced phase separation. 
This process involves the usage of NaOH in anhydrous state in combination with solvents like DMA/LiCl. 

These E467 (Sodiumcarboxymethylcellulose) products have a distribution of substituents that deviate significantly from statistical prediction of the product theoretically.
E467 (Sodiumcarboxymethylcellulose) is used in several drug delivery and tissue engineering purposes. 

The release of apomorphine, a drug used to regulate motor responses in Parkinson's disease, was successfully incorporated into E467 (Sodiumcarboxymethylcellulose) powder formulation and exhibited a sustained nasal release, and performed better than starch-based delivery vehicle. 
Sodium E467 (Sodiumcarboxymethylcellulose) has been used successfully in gastrointestinal drug delivery. 

E467 (Sodiumcarboxymethylcellulose) is seen as a successful drug delivery system for mucosal tissue. 
E467 (Sodiumcarboxymethylcellulose) is useful as a scaffold in tissue engineering. 

E467 (Sodiumcarboxymethylcellulose) hydrogels having pH-dependent swelling characteristics were capable of releasing entrapped drug at the right pH present in the tissue of interest and showed great potential as a wound dressing material. 
E467 (Sodiumcarboxymethylcellulose) hydrogels could be used for encapsulating cells of nucleus pulposis and hence are a potential replacement for intervertebral disk degeneration. 

E467 (Sodiumcarboxymethylcellulose) has been combined with chitosan and hydroxyapatite for bone and dental regeneration purposes too.
E467 (Sodiumcarboxymethylcellulose) is a derivative of cellulose, containing carboxymethyl groups that are generated via the reaction of cellulose with chloroacetate in alkali to produce substitutions in the C2, C3, or C6 positions of glucose units. 

As a result, E467 (Sodiumcarboxymethylcellulose) is water soluble and more amenable to the hydrolytic activity of cellulases. 
E467 (Sodiumcarboxymethylcellulose) is therefore a useful additive to both liquid and solid medium for the detection of cellulase activity, and its hydrolysis can be subsequently determined by the use of the dye Congo red, which binds to intact β-d-glucans. 

The inoculation of isolates onto membrane filters placed on the surface of E467 (Sodiumcarboxymethylcellulose) agar plates is a useful modification of this technique, as the filter may subsequently be removed allowing visualization of clear zones in the agar underneath cellulolytic colonies.
E467 (Sodiumcarboxymethylcellulose) is used as a viscosity modifier or thickener, and to stabilize emulsions in various products including ice cream. 

E467 (Sodiumcarboxymethylcellulose) is known for its excellent water retaining capacity.
E467 (Sodiumcarboxymethylcellulose) is a thickener, binder and stabilizer in a variety of foods. 

E467 (Sodiumcarboxymethylcellulose) is considered a fiber source and as such is used in over-the-counter laxatives. 
Cellulose is the carbohydrate that makes up the woody parts and cell walls of plants. 

E467 (Sodiumcarboxymethylcellulose) is a thickening agent made by reacting cellulose  with a derivative of acetic acid. 
E467 (Sodiumcarboxymethylcellulose) is not absorbed or digested and is sometimes included in the "dietary fiber" on food labels however it is not as healthful as fiber obtained from real, natural foods.

E467 (Sodiumcarboxymethylcellulose) is an anionic water soluble polymer based on renewable cellulosic raw material. 
E467 (Sodiumcarboxymethylcellulose) functions as rheology modifier, retains water and is an excellent film former. 

These attributes make it a preferred choice as a bio-based hydrocolloid in multiple applications.
E467 (Sodiumcarboxymethylcellulose) or cellulose gum is a cellulose derivative with carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. 

E467 (Sodiumcarboxymethylcellulose) is the most often used form of cellulose gum. 
E467 (Sodiumcarboxymethylcellulose) is used in a variety of industries as a thickener and/or to prepare stable emulsions in both food and non-food products. 

Insoluble microgranular E467 (Sodiumcarboxymethylcellulose) is used as a cation-exchange resin in ion-exchange chromatography for purification of proteins. 
E467 (Sodiumcarboxymethylcellulose) has also been used extensively to characterize enzyme activity from endoglucanases.


E467 (Sodiumcarboxymethylcellulose) is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy. 
E467 (Sodiumcarboxymethylcellulose) is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement. 

E467 (Sodiumcarboxymethylcellulose) is used in refractory fiber, ceramic production molding bond. 
E467 (Sodiumcarboxymethylcellulose) is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing. 

E467 (Sodiumcarboxymethylcellulose) can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like. 
Quality product can be used for toothpaste, medicine, food and other industrial sectors.

Instructions: Warm water and cold water can be ok when prepares the solution, E467 (Sodiumcarboxymethylcellulose) can be used with stirring until it completely melts. 
The amout of added water depends on variety and the use of multiple requirements.

High viscosity E467 (Sodiumcarboxymethylcellulose) is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water. 
E467 (Sodiumcarboxymethylcellulose) is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.

E467 (Sodiumcarboxymethylcellulose) is used as a highly effective additive to improve the product and processing properties in various fields of application from foodstuffs, cosmetics and pharmaceuticals to products for the paper and textile industries.
Building material additives, printing inks, coatings, pharmaceuticals, food, cosmetics, paper or textiles – there’s a long and growing list of applications. 

Special-purpose cellulose derivatives produced to provide invisible yet indispensable benefits in countless everyday products.
E467 (Sodiumcarboxymethylcellulose) can significantly increase the viscosity of the solution as thickener, dispersion, emulsification, suspension, protective colloid and so on when it is dissolved in water, and it is physiologically harmless, it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.


-Water retention







-Forming films 


-Physical State: Solid

-Solubility: Soluble in water (20 mg/ml).

-Storage: Store at room temperature


Cellulose gum
Carboxymethyl cellulose, sodium salt
Carboxymethylcellulose sodium (USP)
Carboxymethylcellulose cellulose carboxymethyl ether
CMC powder
Celluvisc (TN)
Carmellose sodium (JP17)
C.M.C. (TN)
E467 (Sodiumcarboxymethylcellulose) sodium

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