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E627 Disodium Guanylate is the disodium salt of 5'-guanylic acid used in food and beverage applications as a flavor enhancer, and E627 Disodium Guanylate is valued for delivering strong umami synergy when combined with glutamates such as E621 Monosodium Glutamate.
E627 Disodium Guanylate intensifies savory flavor by enhancing meaty, brothy, and mushroom-like notes, and E627 Disodium Guanylate is widely used in seasonings, soups, sauces, snacks, and processed foods where high-impact umami is desired.
E627 Disodium Guanylate is typically supplied as a white to off-white crystalline powder, and E627 Disodium Guanylate performance depends on dosage, solubility, pH, and the presence of glutamates and other nucleotides.
CAS Number: 5550-12-9
EC Number: 226-914-1
Molecular Formula: C10H12N5Na2O8P
Molecular Weight: 407.18 g/mol
Synonyms: E627 Disodium Guanylate, Disodium Guanylate, Disodium 5'-Guanylate, Disodium GMP, GMP-Na2, Guanosine 5'-Monophosphate Disodium Salt, Disodium Guanosine Monophosphate, Disodium Guanylic Acid Salt, Umami Nucleotide E627, Flavor Enhancer E627, E627, Disodium Guanylate Food Grade, E627 Disodium Guanylate, Disodium Guanylate, Sodium Guanylate, Disodium 5'-Guanylate, Sodium 5'-Guanylate, Guanosine 5'-Monophosphate Disodium Salt, Guanosine Monophosphate Disodium Salt, 5'-Guanylic Acid Disodium Salt, Guanylic Acid Disodium Salt, Disodium Guanosine 5'-Monophosphate, Disodium GMP, GMP Disodium Salt, 5'-GMP Disodium Salt, E627 Sodium Guanylate, E627 Disodium 5'-Guanylate, E627 Guanosine Monophosphate Disodium Salt, Disodium Guanylate Food Grade, Disodium Guanylate Food Additive, Disodium Guanylate Flavor Enhancer, Disodium Guanylate Taste Enhancer, Disodium Guanylate Umami Agent, Sodium Guanylate Flavor Enhancer, Sodium Guanylate Taste Enhancer, Sodium Guanylate Umami Seasoning, Disodium Guanylate Seasoning Ingredient, Disodium Guanylate Food Ingredient, Sodium Guanylate Food Ingredient, Disodium Guanylate Powder, Disodium Guanylate Crystals, Disodium Guanylate Granules, Sodium Guanylate Powder, Sodium Guanylate Crystals, Sodium Guanylate Granules, Disodium Guanylate Seasoning, Sodium Guanylate Seasoning, Disodium Guanylate Savory Flavor Agent, Disodium Guanylate Beverage Ingredient
APPLICATIONS
E627 Disodium Guanylate is used in seasoning blends to intensify umami and improve savory taste persistence.
E627 Disodium Guanylate is incorporated into bouillon cubes and powders to create rich meaty flavor impact at low dosage.
E627 Disodium Guanylate is used in soup and broth concentrates to strengthen savory notes and improve overall palatability.
E627 Disodium Guanylate is used in sauces such as gravies, meat sauces, and savory condiments to boost umami and enhance flavor depth.
E627 Disodium Guanylate is incorporated into soy-style sauces and marinades to increase meaty perception and reduce flat taste.
E627 Disodium Guanylate is used in tomato-based sauces to increase savory complexity and improve taste balance.
E627 Disodium Guanylate is used in snack seasonings to intensify roasted and cheese-like savory profiles.
E627 Disodium Guanylate is incorporated into chips and extruded snack coatings to improve umami impact and taste persistence.
E627 Disodium Guanylate is used in popcorn seasonings to create fuller savory flavor with reduced salt strategies in compatible systems.
E627 Disodium Guanylate is used in processed meats to enhance meaty flavor and improve taste uniformity in cooked products.
E627 Disodium Guanylate is incorporated into sausages and deli meats in selected formulations to strengthen savory notes.
E627 Disodium Guanylate is used in meat analog products to improve umami character and reduce blandness.
E627 Disodium Guanylate is used in seafood seasonings to enhance natural savory notes and improve taste balance.
E627 Disodium Guanylate is incorporated into fish paste and surimi seasonings to strengthen overall flavor.
E627 Disodium Guanylate is used in canned seafood and seafood sauces to improve savory intensity.
E627 Disodium Guanylate is used in instant noodle seasonings to enhance broth richness and increase overall taste satisfaction.
E627 Disodium Guanylate is incorporated into snack soups and cup noodles to create strong savory profiles.
E627 Disodium Guanylate is valued because E627 Disodium Guanylate provides very strong umami synergy with glutamates, allowing lower overall flavor enhancer dosage while achieving high savory impact.
E627 Disodium guanylate is used as a flavor enhancer to increase umami intensity in foods.
E627 Disodium guanylate supports savory depth and fullness in soups and broths.
E627 Disodium guanylate helps strengthen meaty flavor perception when used appropriately.
E627 Disodium guanylate is used in seasoning systems to create strong umami synergy with glutamates.
E627 Disodium guanylate supports powerful taste enhancement when combined with E621 Monosodium glutamate.
E627 Disodium guanylate helps reduce the amount of glutamate needed to achieve target umami impact in some formulations.
E627 Disodium guanylate is used in formulations with E631 Disodium inosinate to build balanced nucleotide umami systems.
E627 Disodium guanylate supports improved flavor roundness when paired with inosinate.
E627 Disodium guanylate helps deliver long-lasting savory taste in many processed foods.
E627 Disodium guanylate is used in instant noodle seasonings to boost broth-like taste.
E627 Disodium guanylate supports strong savory notes in soup bases.
E627 Disodium guanylate helps improve consumer-perceived richness in instant foods.
E627 Disodium guanylate is used in snack seasonings to increase savory intensity.
E627 Disodium guanylate supports more rounded flavor in chips and extruded snacks.
E627 Disodium guanylate helps improve flavor linger and satisfaction in savory snacks.
E627 Disodium guanylate is used in bouillon cubes and powders to strengthen meat-like taste.
E627 Disodium guanylate supports umami backbone in stock formulations.
E627 Disodium guanylate helps improve flavor consistency across production batches.
E627 Disodium guanylate is used in canned soups to enhance savory taste and reduce blandness.
E627 Disodium guanylate supports improved flavor perception after thermal processing.
E627 Disodium guanylate helps maintain palatability over shelf life in shelf-stable soups.
E627 Disodium guanylate is used in sauces and gravies to deepen savory notes.
E627 Disodium guanylate supports richer taste in tomato-based sauces and meat sauces.
E627 Disodium guanylate helps round off harsh acidic notes by improving flavor balance.
E627 Disodium guanylate is used in savory dressings to boost umami in some formulations.
E627 Disodium guanylate supports fuller taste in creamy and oil-based dressings.
E627 Disodium guanylate helps improve flavor intensity in reduced-fat dressings in some designs.
E627 Disodium guanylate is used in processed meat products to enhance meaty flavor in some formulations.
E627 Disodium guanylate supports savory taste in sausages, patties, and deli meats.
E627 Disodium guanylate helps improve overall flavor acceptance in cooked meat products.
E627 Disodium guanylate is used in plant-based meat alternatives to boost savory and meat-like perception.
E627 Disodium guanylate supports umami taste that improves meat analog flavor profiles.
E627 Disodium guanylate helps mask vegetal notes in some plant protein systems.
E627 Disodium guanylate is used in vegan and vegetarian soups to create a more meat-like broth character.
E627 Disodium guanylate supports savory depth in mushroom and vegetable stocks.
E627 Disodium guanylate helps improve flavor satisfaction in meat-free products.
E627 Disodium guanylate is used in fermented foods and savory sauces to enhance umami in some formulations.
E627 Disodium guanylate supports taste reinforcement in soy sauce-type and fermented seasoning products.
E627 Disodium guanylate helps strengthen the savory profile in fermented recipes.
E627 Disodium guanylate is used in mushroom-flavored products to strengthen guanylate-driven umami character.
E627 Disodium guanylate supports enhanced savory perception in mushroom soups and sauces.
E627 Disodium guanylate helps deliver stronger mushroom taste impression in processed foods.
E627 Disodium guanylate is used in cheese-flavored snacks to intensify savory notes in seasonings.
E627 Disodium guanylate supports richer cheese perception when combined with glutamates.
E627 Disodium guanylate helps improve flavor impact while controlling sodium in some designs.
E627 Disodium guanylate is used in seafood-flavored products to enhance natural savory character.
E627 Disodium guanylate supports stronger fish and shellfish taste perception in soups and snacks.
E627 Disodium guanylate helps improve overall savory complexity in seafood seasonings.
E627 Disodium guanylate is used in tomato-based products to amplify umami and fullness.
E627 Disodium guanylate supports fuller taste in ketchup, pasta sauces, and tomato soups.
E627 Disodium guanylate helps improve flavor strength in lower-sugar or lower-salt tomato recipes.
E627 Disodium guanylate is used in spice rubs and marinades to enhance savory notes.
E627 Disodium guanylate supports deeper flavor in grilled and roasted products.
E627 Disodium guanylate helps improve flavor performance after cooking.
E627 Disodium guanylate is used in ready meals to restore savory taste after freezing or reheating.
E627 Disodium guanylate supports improved flavor perception in microwavable meals.
E627 Disodium guanylate helps maintain consistent taste across different heating conditions.
E627 Disodium guanylate is used in snack mixes to enhance savory taste and reduce flatness.
E627 Disodium guanylate supports a more rounded flavor profile in mixed-seasoning snacks.
E627 Disodium guanylate helps improve consumer liking in savory snack mixes.
E627 Disodium guanylate is used in reduced-sodium formulations to maintain savory intensity.
E627 Disodium guanylate supports sodium reduction by boosting perceived saltiness through umami synergy.
E627 Disodium guanylate helps maintain taste acceptance when salt is reduced.
E627 Disodium guanylate is used in culinary concentrates to deliver strong umami taste in small dosages.
E627 Disodium guanylate supports high flavor density in professional kitchen products.
E627 Disodium guanylate helps improve consistency of chef-style seasoning pastes.
E627 Disodium guanylate is used in catering and institutional foods to enhance taste in large-batch cooking.
E627 Disodium guanylate supports improved palatability in cost-controlled menus.
E627 Disodium guanylate helps improve acceptance of vegetable-heavy dishes.
E627 Disodium guanylate is used in pet food to enhance palatability in some formulations.
E627 Disodium guanylate supports improved aroma and taste acceptance in wet pet foods.
E627 Disodium guanylate helps improve intake in picky animals in some products.
E627 Disodium guanylate is used in animal feed additives in some formulations to improve flavor acceptance.
E627 Disodium guanylate supports better consumption of fortified feeds in some systems.
E627 Disodium guanylate helps reduce bitterness perception from added minerals in some feeds.
E627 Disodium guanylate is used in flavor houses to build nucleotide-based savory systems for different cuisines.
E627 Disodium guanylate supports formulation of chicken, beef, seafood, and vegetable umami profiles.
E627 Disodium guanylate helps standardize savory impact across regional flavor variants.
E627 Disodium guanylate is used in R&D to evaluate nucleotide synergy with glutamates across pH and processing conditions.
E627 Disodium guanylate supports sensory testing versus inosinate and mixed nucleotides.
E627 Disodium guanylate helps optimize dosage for maximum umami impact and cost efficiency.
E627 Disodium guanylate is used in manufacturing troubleshooting to correct weak savory flavor in processed foods.
E627 Disodium guanylate supports rapid flavor adjustment to meet target taste profiles.
E627 Disodium guanylate helps reduce reformulation time in savory product lines.
E627 Disodium guanylate is used in quality control to confirm additive levels and taste consistency in seasonings.
E627 Disodium guanylate supports specification checks for nucleotide content.
E627 Disodium guanylate helps ensure stable sensory performance across lots.
E627 Disodium guanylate is used in education and training as an example of umami nucleotides and taste synergy.
E627 Disodium guanylate supports teaching about 5’-nucleotides and glutamate synergy.
E627 Disodium guanylate helps illustrate why very small doses can strongly boost savory taste.
DESCRIPTION
E627 Disodium Guanylate is the disodium salt of 5'-guanylic acid, and E627 Disodium Guanylate is a 5'-ribonucleotide used in flavor systems for its potent umami synergy.
E627 Disodium Guanylate has limited umami effect alone, but E627 Disodium Guanylate strongly amplifies umami when combined with glutamate, producing a much stronger savory effect than either component alone.
E627 Disodium Guanylate is often used together with E631 Disodium Inosinate, and the blend provides broad savory enhancement and improved taste rounding in many seasoning applications.
E627 Disodium Guanylate is more soluble and easier to handle than the free acid form, and this is why E627 Disodium Guanylate is a common commercial form for guanylate flavor enhancement.
E627 Disodium Guanylate should be used according to applicable food additive regulations and good manufacturing practices for the target market.
E627 Disodium Guanylate should be dosed carefully because E627 Disodium Guanylate is highly potent in synergy systems and small dosage changes can significantly affect taste.
E627 Disodium Guanylate is typically supplied as a white to off-white crystalline powder, and moisture control is important to prevent caking and preserve flow.
E627 Disodium Guanylate should be protected from high humidity and excessive heat to maintain consistent performance.
E627 Disodium Guanylate is generally compatible with typical seasoning processes, but pH and ionic strength can affect solubility in some systems.
E627 Disodium guanylate is the sodium salt of guanylic acid (a guanine-based 5’-ribonucleotide) used as a flavor enhancer for umami taste.
E627 Disodium guanylate is typically supplied as a white crystalline powder with good water solubility.
E627 Disodium guanylate is used at very low levels because it has strong taste synergy with glutamates.
E627 Disodium guanylate delivers umami enhancement most effectively when combined with glutamic acid or monosodium glutamate.
E627 Disodium guanylate is commonly used together with E631 Disodium inosinate as mixed nucleotides in savory foods.
E627 Disodium guanylate is used in soups, seasonings, snacks, sauces, and processed foods to increase savory intensity.
E627 Disodium guanylate performance depends on formulation matrix, pH, salt balance, and processing conditions.
E627 Disodium guanylate should be stored in tightly closed containers in a cool, dry place to prevent moisture pickup and preserve quality.
E627 Disodium guanylate is valued for strong umami synergy, high efficiency at low dosage, and broad usefulness in savory flavor systems.
PROPERTIES
Chemical Formula: C10H12N5Na2O8P
Molecular Weight: 407.18 g/mol
Common Name: E627 Disodium Guanylate
Chemical Type: 5'-ribonucleotide salt; flavor enhancer; umami synergist
Appearance: White to off-white crystalline powder
Odor: Odorless
Taste: Mild alone; strong umami synergy with glutamates
Solubility: Soluble in water (pH and ionic strength dependent)
Stability: Stable under normal dry storage; sensitive to moisture and high humidity
Functional Effects: Umami enhancement; synergy with glutamates; taste rounding and savory depth
Storage Temperature: 15–30°C, tightly closed, dry
Shelf Life: Typically 24–48 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during powder handling.
Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves and safety glasses for bulk handling.
Avoid generating dust and avoid inhalation of fine powder.
Use clean, dry equipment to prevent moisture pickup and clumping.
Ventilation:
Use general ventilation for normal handling.
Use local exhaust where dust may be generated during powder transfer.
Minimize airborne particulate accumulation in enclosed areas.
Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture to prevent caking and maintain potency and flow.
Keep away from strong odors and contaminants to preserve sensory neutrality.
Spill and Leak Procedures:
Sweep up spilled powder and avoid dust generation.
Collect into suitable containers for reuse or disposal according to local regulations.
Clean residues with water if needed and dry the area to prevent slip hazards.
Handling Precautions:
Formulate with glutamates because E627 Disodium Guanylate is most effective as an umami synergist rather than a standalone enhancer.
Optimize dosage carefully because small changes in E627 Disodium Guanylate can strongly affect savory intensity in synergy systems.
Rotate stock using FIFO practices to maintain consistent quality and predictable flavor enhancement performance.
