E641 L-LEUCINE

E641 L-Leucine is an essential branched-chain amino acid used in food and beverage applications as a nutrient and, in some formulations, as a flavor-related ingredient, and E641 L-Leucine is valued for contributing amino acid nutrition and supporting protein fortification strategies.
E641 L-Leucine is used in dietary supplements, sports nutrition, and specialized foods where amino acid profile and functional nutrition claims are important, and E641 L-Leucine may require formulation work to manage taste because branched-chain amino acids can be bitter at higher levels.
E641 L-Leucine is typically supplied as a white crystalline powder, and E641 L-Leucine performance depends on purity, particle size, dispersion, and overall formulation design.

CAS Number: 61-90-5
EC Number: 200-522-0
Molecular Formula: C6H13NO2
Molecular Weight: 131.17 g/mol

Synonyms: E641 L-Leucine, L-Leucine, Leucine, (S)-2-Amino-4-methylpentanoic acid, Branched-Chain Amino Acid (Leucine), BCAA Leucine, L-Leucine Food Grade, L-Leucine Supplement Grade, E641, L-Leucine Amino Acid, Leucine Powder, Essential Amino Acid Leucine, E641 L-Leucine, L-Leucine, Leucine, L-2-Amino-4-Methylpentanoic Acid, 2-Amino-4-Methylpentanoic Acid, (S)-2-Amino-4-Methylpentanoic Acid, L-α-Aminoisocaproic Acid, Alpha-Aminoisocaproic Acid, α-Aminoisocaproic Acid, L-Isobutylglycine, Isobutylglycine, Leu, L-Leu, Branched Chain Amino Acid Leucine, BCAA Leucine, E641 Leucine, E641 L-Leucine, E641 Amino Acid, E641 Flavor Enhancer, L-Leucine Food Grade, Leucine Food Grade

APPLICATIONS

E641 L-Leucine is used in sports nutrition powders to support amino acid fortification and muscle-related nutrition positioning.
E641 L-Leucine is incorporated into BCAA blends with L-isoleucine and L-valine for amino acid supplementation products.
E641 L-Leucine is used in pre-workout and post-workout formulations to increase leucine content in compatible designs.

E641 L-Leucine is used in dietary supplements as a standalone amino acid in capsules, tablets, and powders.
E641 L-Leucine is incorporated into amino acid complexes for nutritional support products.
E641 L-Leucine is used in chewable supplement formats in selected applications where taste masking and sweetness balancing are effective.

E641 L-Leucine is used in protein-fortified foods to improve essential amino acid profile in compatible formulations.
E641 L-Leucine is incorporated into nutrition bars to support amino acid claims and protein quality positioning.
E641 L-Leucine is used in meal replacement products to enhance amino acid composition and support functional nutrition design.

E641 L-Leucine is used in medical and clinical nutrition products in selected applications where precise amino acid composition is required.
E641 L-Leucine is incorporated into specialized formulas to support nutritional protocols under professional guidance.
E641 L-Leucine is used in enteral nutrition products where amino acid balance is carefully controlled.

E641 L-Leucine is used in plant-based protein products in selected applications to complement amino acid profile and support protein quality.
E641 L-Leucine is incorporated into vegan protein powders to raise leucine content for sports nutrition positioning.
E641 L-Leucine is used in plant-based nutrition bars to balance amino acid composition in compatible designs.

E641 L-Leucine is valued because E641 L-Leucine provides an essential amino acid in a concentrated, standardized form, enabling targeted amino acid fortification for supplements and functional nutrition products.

E641 L-leucine is used in dietary supplements as an essential amino acid for sports nutrition.
E641 L-leucine supports muscle protein synthesis signaling in many nutrition strategies.
E641 L-leucine helps improve amino acid profile completeness in supplement blends.

E641 L-leucine is used in BCAA supplements together with isoleucine and valine.
E641 L-leucine supports formulation of classic 2:1:1 or higher-leucine BCAA ratios in some products.
E641 L-leucine helps provide the key branched-chain amino acid often emphasized in muscle support products.

E641 L-leucine is used in EAA supplements to strengthen the essential amino acid composition.
E641 L-leucine supports improved label claims for essential amino acid content.
E641 L-leucine helps improve consumer-perceived efficacy in some EAA formulas.

E641 L-leucine is used in whey, casein, and plant protein powders to boost leucine content.
E641 L-leucine supports “leucine threshold” positioning in some sports nutrition concepts.
E641 L-leucine helps improve nutritional density in high-protein products.

E641 L-leucine is used in ready-to-drink protein beverages to increase essential amino acid levels in some formulations.
E641 L-leucine supports fortification of protein drinks with targeted amino acid profiles.
E641 L-leucine helps improve athlete-oriented positioning in RTD nutrition products.

E641 L-leucine is used in meal replacement shakes to improve amino acid quality in some products.
E641 L-leucine supports improved essential amino acid balance in complete nutrition drinks.
E641 L-leucine helps enhance protein quality perception in formulated meals.

E641 L-leucine is used in medical nutrition products to support protein and amino acid intake in some formulas.
E641 L-leucine supports specialized nutrition for older adults in some diet designs.
E641 L-leucine helps improve amino acid completeness in clinical nutrition blends.

E641 L-leucine is used in elderly nutrition powders to support maintenance of muscle mass in some programs.
E641 L-leucine supports protein synthesis signaling in nutrition approaches targeting sarcopenia risk.
E641 L-leucine helps strengthen amino acid profile of daily nutrition supplements.

E641 L-leucine is used in recovery products designed for post-exercise consumption.
E641 L-leucine supports muscle recovery positioning in training nutrition.
E641 L-leucine helps improve formulation differentiation in recovery blends.

E641 L-leucine is used in endurance nutrition products to support amino acid availability in some formulations.
E641 L-leucine supports supplement strategies aimed at reducing muscle breakdown during prolonged exercise in some programs.
E641 L-leucine helps enhance amino acid profile in endurance drink powders.

E641 L-leucine is used in tablet and capsule supplements as a standalone amino acid.
E641 L-leucine supports flexible dosing in sports and wellness supplements.
E641 L-leucine helps provide a compact ingredient for high-potency formulas.

E641 L-leucine is used in powdered supplement blends where rapid mixing is required.
E641 L-leucine supports formulation of instantized amino acid drink powders.
E641 L-leucine helps improve nutritional profile of flavored powder mixes.

E641 L-leucine is used in flavored amino acid drinks to deliver BCAA content in some products.
E641 L-leucine supports workout beverage positioning for gym consumers.
E641 L-leucine helps improve amino acid delivery in convenient drink formats.

E641 L-leucine is used in protein bars to improve amino acid content in some formulations.
E641 L-leucine supports fortification of bars with essential amino acids.
E641 L-leucine helps improve label claims for amino acid content in sports bars.

E641 L-leucine is used in high-protein bakery products to improve nutritional profile in some recipes.
E641 L-leucine supports formulation of protein cookies and fortified snacks.
E641 L-leucine helps increase essential amino acid content in protein-enriched bakery.

E641 L-leucine is used in infant formula and specialized nutrition in some contexts where amino acid profiles are adjusted under strict standards.
E641 L-leucine supports amino acid balancing in controlled nutrition formulations.
E641 L-leucine helps meet target essential amino acid ratios in regulated nutrition products.

E641 L-leucine is used in fermentation and biotechnology as a nutrient for microbial growth in some processes.
E641 L-leucine supports cell culture media formulations in selected bioprocesses.
E641 L-leucine helps maintain consistent growth conditions in some fermentations.

E641 L-leucine is used in cell culture media to support growth of mammalian cells in biotechnology applications.
E641 L-leucine supports amino acid supply in serum-free media designs.
E641 L-leucine helps stabilize culture performance in controlled biomanufacturing.

E641 L-leucine is used in enzyme production fermentations to support microbial metabolism in some nutrient systems.
E641 L-leucine supports improved fermentation consistency in selected processes.
E641 L-leucine helps reduce variability in bioprocess outcomes when nutrients are controlled.

E641 L-leucine is used in pharmaceutical manufacturing as an excipient in some dry powder inhalation formulations.
E641 L-leucine supports improved powder flow and dispersion in some DPI systems.
E641 L-leucine helps improve aerosolization performance in selected inhalation powders.

E641 L-leucine is used in spray-dried inhalation particles to improve dispersibility in some designs.
E641 L-leucine supports surface enrichment that reduces cohesion in some particles.
E641 L-leucine helps improve emitted dose and fine particle fraction in some formulations.

E641 L-leucine is used in granulation and tableting as a functional amino acid excipient in some formulations.
E641 L-leucine supports powder flow and compressibility in selected blends.
E641 L-leucine helps improve manufacturing robustness in some solid dosage processes.

E641 L-leucine is used in food applications as a nutrient and flavor-related amino acid ingredient in some regulated uses.
E641 L-leucine supports amino acid enrichment in specialized foods in some markets.
E641 L-leucine helps improve nutritional labeling for essential amino acids.

E641 L-leucine is used in medical foods where amino acid composition is customized for patient needs.
E641 L-leucine supports controlled essential amino acid delivery in specialized diets.
E641 L-leucine helps meet specific amino acid targets in formula design.

E641 L-leucine is used in research on metabolism and amino acid signaling pathways.
E641 L-leucine supports studies of mTOR signaling and protein synthesis regulation.
E641 L-leucine helps serve as a standard amino acid in metabolic experiments.

E641 L-leucine is used in laboratory standards for amino acid analysis and method validation.
E641 L-leucine supports calibration of chromatography-based amino acid profiling.
E641 L-leucine helps ensure accurate quantification of amino acids in analytical testing.

E641 L-leucine is used in quality control labs to verify amino acid content in supplements and nutrition products.
E641 L-leucine supports specification checks for potency and purity.
E641 L-leucine helps ensure label compliance and batch consistency in amino acid products.

E641 L-leucine is used in product development to optimize sensory and solubility of amino acid drink powders.
E641 L-leucine supports screening of flavor masking and sweetener systems for bitter amino acids.
E641 L-leucine helps refine formulation for better consumer acceptance.

E641 L-leucine is used in manufacturing troubleshooting to improve powder flow and reduce caking in supplement blends.
E641 L-leucine supports improved handling in mixing and packaging.
E641 L-leucine helps reduce segregation issues in blended powders.

E641 L-leucine is used in education and training as an example of essential amino acids and branched-chain amino acids.
E641 L-leucine supports teaching about amino acid nutrition and protein synthesis.
E641 L-leucine helps illustrate the difference between essential and nonessential amino acids.

E641 L-leucine is used in export sports nutrition products to maintain standardized amino acid content across markets.
E641 L-leucine supports consistent formulation performance during long logistics chains.
E641 L-leucine helps reduce customer complaints related to taste and quality variability.

DESCRIPTION

E641 L-Leucine is an essential amino acid that the human body cannot synthesize, and E641 L-Leucine must be obtained from diet or supplementation.
E641 L-Leucine is one of the branched-chain amino acids, and E641 L-Leucine is commonly used in sports nutrition products because branched-chain amino acids are associated with muscle protein metabolism in nutrition science contexts.
E641 L-Leucine is typically produced by fermentation or chemical synthesis followed by purification to food or supplement grade, resulting in high-purity crystalline powder.

E641 L-Leucine has limited solubility in water, so E641 L-Leucine may require strong mixing, fine particle size, or suitable carriers for uniform dispersion in beverages and powders.
E641 L-Leucine can taste bitter at higher levels, so taste masking, sweeteners, flavors, and acid balance are commonly used to improve palatability in oral products.
E641 L-Leucine should be used according to applicable food additive regulations and good manufacturing practices for the target market.

E641 L-Leucine should be stored in tightly closed containers to prevent moisture pickup and contamination, and E641 L-Leucine should be handled with good hygiene and dust control practices during bulk powder processing.
E641 L-Leucine is stable under normal storage conditions, and E641 L-Leucine is compatible with many dry blending operations when moisture is controlled.
E641 L-Leucine should be used with appropriate labeling and nutritional calculations because E641 L-Leucine contributes nitrogen and amino acid nutrition content.

E641 L-leucine is an essential branched-chain amino acid required in the human diet.
E641 L-leucine is typically supplied as a white crystalline powder and has limited water solubility compared with some amino acids.
E641 L-leucine is widely used in sports nutrition because it is a key amino acid involved in muscle protein synthesis signaling.

E641 L-leucine is commonly included in BCAA and EAA supplements and in fortified protein powders and nutrition beverages.
E641 L-leucine is also used in biotechnology and analytical labs as a nutrient component and amino acid standard.
E641 L-leucine may be used as a functional excipient in some pharmaceutical inhalation powders to improve dispersibility.

E641 L-leucine should be stored in tightly closed containers in a cool, dry place to prevent moisture pickup and preserve powder handling.
E641 L-leucine is valued for essential nutrition role, broad supplement demand, and usefulness in research and specialized formulations.

PROPERTIES

Chemical Formula: C6H13NO2
Molecular Weight: 131.17 g/mol
Common Name: E641 L-Leucine
Chemical Type: Essential amino acid; branched-chain amino acid; nutrient ingredient
Appearance: White crystalline powder
Odor: Odorless
Taste: Slightly bitter (concentration dependent)
Solubility: Slightly soluble in water; better dispersion with fine particle size and agitation
pH (solution behavior): Amphoteric amino acid; pH depends on concentration and system composition
Stability: Stable under normal storage; compatible with dry processing
Hygroscopicity: Low
Storage Temperature: 15–30°C, tightly closed, dry
Shelf Life: Typically 24–60 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during powder handling.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a large amount is swallowed.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses for bulk handling.
Avoid generating dust and avoid inhalation of fine powder.
Use clean, dry equipment and prevent cross-contamination with allergens or other actives.

Ventilation:
Use general ventilation for normal handling.
Use local exhaust where dust may be generated during powder transfer.
Minimize airborne particulate accumulation in enclosed areas.

Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture and contamination to maintain purity and flow.
Keep containers properly labeled and protected from strong odors.

Spill and Leak Procedures:
Sweep up spilled powder and avoid dust generation.
Collect into suitable containers for reuse or disposal according to local regulations.
Clean residues with water if needed and dry the area to prevent slip hazards.

Handling Precautions:
Optimize taste masking because E641 L-Leucine can be bitter at higher levels in oral products.
Control dispersion because E641 L-Leucine has limited water solubility and can settle if not properly formulated.
Rotate stock using FIFO practices to maintain consistent quality and predictable nutritional performance.