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E961 Neotame is a high-intensity sweetener used in foods and beverages to provide strong sweetness with negligible calories at typical use levels, and E961 Neotame is valued for very high potency and clean sweetness in many formulations.
E961 Neotame is structurally related to aspartame but is much sweeter, and E961 Neotame is generally more stable than aspartame under a wider range of processing and storage conditions, which supports broader application use.
E961 Neotame is typically used at extremely low levels and is often blended with other sweeteners to optimize sweetness profile and cost efficiency, and E961 Neotame performance depends on pH, temperature, and overall flavor system design.
CAS Number: 165450-17-9
EC Number: 605-408-3
Molecular Formula: C20H30N2O5
Molecular Weight: 378.46 g/mol
Synonyms: E961 Neotame, Neotame, Sweetener E961, Neotame High Intensity Sweetener, Neotame Food Additive, Neotame Sweetener, Neotame Powder, Neotame Sweetener Blend Ingredient, N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester, E961, Neotame Tabletop Sweetener, Neotame in Beverages, E961 Neotame, Neotame, N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester, N-[N-(3,3-Dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester, Neotame Sweetener, Neotame Food Additive, Neotame High-Intensity Sweetener, Neotame High Intensity Sweetener, Neotame Non-Nutritive Sweetener, Neotame Non Nutritive Sweetener, Neotame Low-Calorie Sweetener, Neotame Low Calorie Sweetener, Neotame Intense Sweetener, Neotame Artificial Sweetener, Neotame Food Grade, Neotame Technical Grade, Neotame Additive Grade, Neotame Powder, Neotame White Powder, Neotame Crystalline Powder, Neotame Sweetening Agent, Neotame Flavor Enhancer, Neotame Sugar Substitute, Neotame Sugar Replacer, Neotame Reduced-Calorie Sweetener, Neotame Reduced Calorie Sweetener, Neotame Tabletop Sweetener, Neotame Beverage Sweetener, Neotame Sweetener Blend Component, Neotame Sweetener Ingredient, Neotame Food Ingredient, Neotame Intense Sweetener Ingredient, Neotame E961 Sweetener, E961 Sweetener, INS 961, E 961, Neotame INS 961, Neotame E-961, Neotame High Potency Sweetener, Neotame Potent Sweetener, Neotame Calorie-Free Sweetener, Neotame Calorie Free Sweetener, Neotame Sweetener Grade, Neotame Pure, Neotame High Purity
APPLICATIONS
E961 Neotame is used in carbonated soft drinks and flavored waters to provide sweetness without added sugar and with good stability in acidic beverages.
E961 Neotame is incorporated into sports drinks and energy drinks to reduce sugar while maintaining sweetness.
E961 Neotame is used in beverage concentrates and syrups to deliver stable sweetness after dilution.
E961 Neotame is used in baked goods and bakery mixes to provide sweetness that remains stable under typical baking conditions.
E961 Neotame is incorporated into sugar-free cookies, cakes, and muffins to reduce calories while maintaining sweet taste.
E961 Neotame is used in bakery fillings and dessert toppings to provide sweetness with good processing tolerance.
E961 Neotame is used in dairy products such as flavored milk, yogurt, and dairy desserts to reduce sugar while maintaining sweetness.
E961 Neotame is incorporated into puddings and custards to provide sweetness through processing and storage.
E961 Neotame is used in ice cream and frozen desserts to support sweetness in reduced-sugar formulations.
E961 Neotame is used in sugar-free confectionery to provide sweetness and improve taste profile in candies, mints, and chewing gum.
E961 Neotame is incorporated into chewing gum to provide long-lasting sweetness and improved flavor perception.
E961 Neotame is used in sugar-free candies and mints to deliver intense sweetness without added sugar.
E961 Neotame is used in tabletop sweeteners and sweetener blends to provide very high sweetness intensity at very low dosage.
E961 Neotame is incorporated into sweetener systems with sucralose or acesulfame K to optimize sweetness curve and reduce aftertaste.
E961 Neotame is used in powdered drink mixes to provide intense sweetness after reconstitution.
E961 Neotame is used in sauces, dressings, and condiments to provide sweetness and balance acidity in reduced-sugar formulations.
E961 Neotame is incorporated into jams and fruit preparations to lower sugar content while maintaining sweet taste profile.
E961 Neotame is used in protein shakes and meal replacement products to support sweetness in low-sugar nutritional formats.
E961 Neotame is used in pharmaceutical syrups and chewable tablets to mask bitterness and improve palatability.
E961 Neotame is incorporated into oral care products such as toothpaste and mouthwash to provide sweetness without sugar.
E961 Neotame is used in supplements and nutraceuticals to improve taste in reduced-sugar formats.
E961 Neotame is valued because E961 Neotame provides extremely potent, stable sweetness that can reduce sweetener cost and allow strong sugar reduction while maintaining taste quality.
E961 Neotame is used as a high-intensity sweetener in sugar-free beverages.
E961 Neotame provides very strong sweetness at extremely low dosage.
E961 Neotame helps reduce calories while maintaining sweetness impact.
E961 Neotame is used in diet carbonated soft drinks to replace sucrose sweetness.
E961 Neotame supports sweetness in acidic beverage systems with proper flavor balancing.
E961 Neotame helps reduce sugar while maintaining taste acceptance.
E961 Neotame is used in flavored waters and vitamin drinks to provide sweetness without added sugar.
E961 Neotame supports low-calorie sweetness in still beverage applications.
E961 Neotame helps maintain palatability in lightly flavored drinks.
E961 Neotame is used in powdered beverage mixes for instant reconstitution.
E961 Neotame supports easy dosing in dry blends due to very high potency.
E961 Neotame helps deliver consistent sweetness after dilution.
E961 Neotame is used in sports drink powders and electrolyte sachets to reduce sugar load.
E961 Neotame supports palatable sweetness in functional hydration products.
E961 Neotame helps reduce sugar while maintaining taste acceptance.
E961 Neotame is used in energy drink concepts to mask bitter notes from caffeine and botanicals in some formulations.
E961 Neotame supports improved flavor balance in high-flavor systems.
E961 Neotame helps reduce sugar while keeping sweetness intensity.
E961 Neotame is used in dairy beverages and flavored milk products in some formulations where permitted.
E961 Neotame supports sweetness with low added sugar in flavored dairy.
E961 Neotame helps maintain taste while reducing calories in dairy beverages.
E961 Neotame is used in reduced-sugar yogurt and fermented dairy desserts in some formulations.
E961 Neotame supports sweetness without increasing fermentable sugar level.
E961 Neotame helps maintain sweetness intensity after fermentation.
E961 Neotame is used in sugar-free chewing gum.
E961 Neotame supports long-lasting sweetness in gum bases due to high potency.
E961 Neotame helps reduce overall sweetener load when used in blends.
E961 Neotame is used in sugar-free mints and lozenges.
E961 Neotame supports high sweetness intensity in small-dose confections.
E961 Neotame helps maintain pleasant taste when combined with flavor systems.
E961 Neotame is used in reduced-sugar gummies and jellies in some formulations.
E961 Neotame helps balance sweetness in combination with polyols and fibers.
E961 Neotame is used in tabletop sweetener blends and portion sachets.
E961 Neotame supports convenient dosing for coffee and tea sweetening.
E961 Neotame helps deliver sweetness with minimal bulking agent addition.
E961 Neotame is used in reduced-sugar jams and fruit spreads in some formulations.
E961 Neotame supports sweetness while lowering sucrose contribution.
E961 Neotame helps maintain fruit flavor balance in light spreads.
E961 Neotame is used in reduced-sugar sauces and condiments to lower sugar content.
E961 Neotame supports sweetness adjustment in ketchup-style and barbecue sauces.
E961 Neotame helps maintain palatability in low-sugar savory sauces.
E961 Neotame is used in sugar-free gelatin desserts and pudding mixes.
E961 Neotame supports clean sweetness in instant dessert powders.
E961 Neotame helps improve flavor release in gelled desserts.
E961 Neotame is used in flavored syrups and low-calorie dessert toppings.
E961 Neotame supports sweetness in syrups while reducing sugar solids.
E961 Neotame helps maintain sweetness profile with reduced calories.
E961 Neotame is used in bakery fillings and cream fillings to reduce sugar while keeping sweetness.
E961 Neotame supports sweetness correction in reduced-sugar fillings.
E961 Neotame helps maintain sensory quality in light bakery products.
E961 Neotame is used in baked goods to reduce sugar content while maintaining sweetness in some formulations.
E961 Neotame supports sweetness through processing because it has relatively good heat stability.
E961 Neotame helps reduce calories while maintaining consumer-acceptable taste.
E961 Neotame is used in baked goods mixes to deliver sweetness after baking in some recipe designs.
E961 Neotame supports sweetness carry-through when stability is validated.
E961 Neotame helps simplify formulation compared with less stable sweeteners.
E961 Neotame is used in reduced-sugar ice cream and frozen desserts in some formulations.
E961 Neotame supports sweetness while using polyols or fibers for bulk.
E961 Neotame helps reduce added sugar while maintaining taste.
E961 Neotame is used in protein shakes and meal replacement drinks to provide sweetness with low sugar.
E961 Neotame supports masking of protein bitterness in some formulations.
E961 Neotame helps improve flavor balance in high-protein beverages.
E961 Neotame is used in dietary supplements such as effervescent tablets and sachets for taste masking.
E961 Neotame supports improved palatability of vitamin and mineral products.
E961 Neotame helps reduce sugar and improve compliance for consumers.
E961 Neotame is used in pharmaceutical syrups and oral liquids as a sweetener in some products where permitted.
E961 Neotame supports taste masking of bitter APIs.
E961 Neotame helps improve patient acceptance without adding sugar load.
E961 Neotame is used in orally disintegrating tablets and chewables for taste masking in some designs.
E961 Neotame supports quick sweetness perception in the mouth.
E961 Neotame helps improve sensory acceptance of medicated chewables.
E961 Neotame is used in mouthwashes and oral care products as a sweetener in some formulations.
E961 Neotame supports pleasant taste without feeding oral bacteria like sugar.
E961 Neotame helps improve consumer experience in oral care.
E961 Neotame is used in toothpaste to improve taste profile in some formulations.
E961 Neotame supports sweetness masking of bitter actives such as fluoride salts.
E961 Neotame helps improve flavor retention during brushing.
E961 Neotame is used in reduced-sugar breakfast cereals and cereal coatings in some formulations.
E961 Neotame supports sweetness perception with less added sugar.
E961 Neotame helps maintain flavor impact in light cereal products.
E961 Neotame is used in flavored snack seasonings that include sweet notes in some designs.
E961 Neotame supports sweet flavor balancing in seasoning blends.
E961 Neotame helps reduce sugar dusting while maintaining sweetness.
E961 Neotame is used in reduced-sugar fruit preparations for dairy and bakery applications.
E961 Neotame supports sweetness adjustment without increasing soluble solids too much.
E961 Neotame helps maintain fruit-forward flavor profile in light products.
E961 Neotame is used in low-calorie product development to achieve sugar-like sweetness curves when blended with other sweeteners.
E961 Neotame supports sweetness synergy with acesulfame K, sucralose, or steviol glycosides in many formulas.
E961 Neotame helps reduce aftertaste in blended sweetener systems.
E961 Neotame is used in flavor houses as a standardized sweetener tool for rapid prototyping.
E961 Neotame supports quick sweetness calibration in beverage bases.
E961 Neotame helps speed up development cycles for reduced-sugar products.
E961 Neotame is used in quality control to verify sweetener content and compliance with permitted levels.
E961 Neotame supports analytical methods such as HPLC for assay.
E961 Neotame helps ensure consistent sweetness and correct labeling in finished goods.
E961 Neotame is used in manufacturing to reduce sucrose while maintaining sweetness with minimal change to product appearance.
E961 Neotame supports calorie reduction in beverages and desserts.
E961 Neotame helps maintain palatable taste in reduced-sugar recipes.
E961 Neotame is used in export products to meet sugar-reduction targets and labeling requirements in multiple markets.
E961 Neotame supports consistent sweetness during long logistics chains.
E961 Neotame helps reduce calories while maintaining flavor impact.
E961 Neotame is used in products targeting weight-management needs within approved labeling frameworks.
E961 Neotame supports sweetness with minimal effect on blood glucose compared with sugar.
E961 Neotame helps maintain palatable taste in reduced-sugar diets.
E961 Neotame is used in pilot trials to optimize sweetener level alongside acids and flavors.
E961 Neotame supports tuning of sweetness–sourness balance in beverages.
E961 Neotame helps manage sweetness perception in acidic drink systems.
E961 Neotame is used in reformulation projects to meet sugar tax thresholds and reduced-sugar targets.
E961 Neotame supports reduction of sugar grams per serving while keeping sweetness.
E961 Neotame helps maintain consumer-acceptable taste after sugar reduction.
E961 Neotame is used in training and education as an example of ultra-high-potency sweeteners and formulation tradeoffs.
E961 Neotame supports teaching about sweetener potency, stability, and sensory design.
E961 Neotame helps illustrate why bulking agents are needed in sugar replacement.
DESCRIPTION
E961 Neotame is a high-intensity sweetener that is significantly sweeter than sucrose, and only very small amounts are needed to achieve desired sweetness.
E961 Neotame is more potent than aspartame, and E961 Neotame typically provides improved stability in certain processing conditions compared with aspartame.
E961 Neotame is generally stable across a wide range of pH and temperature conditions used in food processing, but extreme heat exposure and long processing times can still affect sweetness and flavor interactions.
E961 Neotame is often used in blends because blends can improve sweetness curve and reduce aftertaste while optimizing cost and performance.
E961 Neotame does not require phenylalanine warning labeling in many markets because use levels are extremely low, but regulatory requirements should be followed for the target market.
E961 Neotame should be used according to applicable food additive regulations and good manufacturing practices for the target market.
E961 Neotame is typically supplied as a white to off-white powder with controlled purity and assay.
E961 Neotame should be protected from moisture contamination to maintain free-flowing behavior.
E961 Neotame should be stored in tightly closed containers in a cool, dry place away from strong odors and heat sources.
E961 Neotame is a high-intensity sweetener related to aspartame chemistry but modified for much higher potency.
E961 Neotame is extremely sweet, so it is used at very low concentrations to achieve desired sweetness.
E961 Neotame provides sweetness with negligible caloric contribution at use levels.
E961 Neotame can be used alone or blended with other sweeteners to shape sweetness curve and reduce aftertaste.
E961 Neotame does not provide bulk, so it is often paired with polyols, fibers, or sugars for texture and body.
E961 Neotame stability depends on formulation conditions such as pH, heat exposure, and storage time.
E961 Neotame is used in beverages, desserts, confectionery, and tabletop sweeteners depending on regulatory approvals.
E961 Neotame use is regulated, and permitted applications and maximum levels vary by country and product category.
E961 Neotame is not labeled as a phenylalanine source for PKU in the same way as aspartame in many jurisdictions, but local rules should be followed.
E961 Neotame is generally stable in dry form, but stability in solution depends on acidity and heat exposure.
E961 Neotame should be stored in tightly closed containers in a cool, dry place to protect quality.
E961 Neotame is valued for very high potency, flexibility in blends, and usefulness for major sugar reduction in modern formulations.
PROPERTIES
Chemical Formula: C20H30N2O5
Molecular Weight: 378.46 g/mol
Common Name: E961 Neotame
Chemical Type: High-intensity sweetener; aspartame-related derivative
Appearance: White to off-white crystalline powder
Odor: Odorless
Taste: Very sweet; clean sweetness profile at optimized dosage
Sweetness Intensity: Approximately 7,000–13,000 times sweeter than sucrose (application dependent)
Solubility: Slightly soluble to soluble in water (grade dependent)
Heat Stability: Generally good; more stable than aspartame in many applications
pH Stability: Stable in acidic and neutral food systems; formulation dependent
Stability: Stable under normal storage; protect from moisture and excessive heat exposure
Storage Temperature: 15–25°C, tightly closed, dry
Shelf Life: Typically 24–60 months in original sealed packaging (supplier dependent)
FIRST AID
Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during powder handling.
Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.
Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.
Ingestion:
Rinse mouth with water.
Seek medical attention if discomfort occurs or if a large amount is swallowed.
Never give anything by mouth to an unconscious person.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.
HANDLING AND STORAGE
Handling:
Use appropriate PPE including gloves and safety glasses for bulk handling.
Avoid generating dust and avoid inhalation of fine powder.
Maintain good hygiene and clean-up practices in handling areas.
Ventilation:
Use general ventilation for normal handling.
Use local exhaust where dust may be generated during powder transfer.
Minimize airborne particulate accumulation in enclosed areas.
Storage:
Store in tightly closed containers in a cool, dry place.
Protect from moisture to prevent caking and maintain free-flowing behavior.
Keep containers properly labeled and protected from contamination.
Spill and Leak Procedures:
Sweep up spilled powder and avoid dust generation.
Collect into suitable containers for reuse or disposal according to local regulations.
Clean residues to prevent slip hazards if powder becomes wet.
Handling Precautions:
Use precise dosing because E961 Neotame is extremely potent and small changes can noticeably affect sweetness and flavor balance.
Optimize blending and flavor design because E961 Neotame is often used in combination with other sweeteners to achieve a sugar-like sweetness curve.
Confirm regulatory permission and maximum use levels because permitted uses vary by market and product category.
