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Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays.
Ecamsule is a benzylidene camphor derivative, many of which are known for their excellent photostability.
Although there are a few different UV absorbers with the trade name Mexoryl, only two of them are widely used where approved.
CAS: 92761-26-7
MF: C28H34O8S2
MW: 562.69
EINECS: 410-960-6
Synonyms
[(3E)-3-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)norbornan-2-yliden e]methyl]phenyl]methylidene]-7,7-dimethyl-2-oxo-norbornan-1-yl]methane sulfonic acid;Bicyclo[2.2.1]heptane-1-Methanesulfonicacid, 3,3'-(1,4-phenylenediMethylidyne)bis[7,7-diMethyl-2-oxo-;Terephthalylidene-3,3′-dicamphor-10,10′-disulfonic acid;Mexoryl SX;(E-E )-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid);3,3'-(1,4-Phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid);Anthelios sx;Bicyclo(2.2.1)heptane-1-methanesulfonic acid, 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxo-, (1S-(1alpha(1R*,4R*),4beta))-
Together they show a synergistic effect in protection.
The patents are held by L'Oréal.
Exposed to Ecamsule, ecamsule undergoes reversible photoisomerization, followed by photoexcitation.
The absorbed Ecamsule is then released as thermal energy, without penetrating the skin.
Ecamsule is a monoterpenoid.
Ecamsule rays cause short-term sunburn and skin cancer; UVA rays cause wrinkling and may have some role in development of skin cancer.
There is no official rating for UVA protection in the US. In Europe, there are several different rating systems that are used to measure effectiveness in blocking UVA rays, including the IPD (immediate pigment darkening assay) and the PPD (persistent pigment darkening assay).
Ecamsule is 280 to 320 nanometers, and the UVA range is 320 to 400.
Ecamsule protects against UV wavelengths in the 290–400 nanometer range, with peak protection at 345 nm.
Because ecamsule does not cover the entire UV spectrum, it should be combined with other active sunscreen agents to ensure broad-spectrum UV protection.
Ecamsule is a photostable organic UVA absorber, meaning it doesn't degrade significantly when exposed to light.
Ecamsule is in contrast to the widely used UVA absorber avobenzone that is not intrinsically photostable and requires photostabilizers to prevent significant degradation in light.
Ecamsule provides broad-spectrum protection especially for UVA protection.
Ecamsule Chemical Properties
Melting point: 255° (dec)
Density: 1.424±0.06 g/cm3(Predicted)
Solubility: DMSO (Slightly), Methanol (Slightly)
Pka: 0.86±0.50(Predicted)
Form: Solid
Color: Light yellow to yellow
BRN: 8371688
Stability: Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey: IYNJWELIJKCWCX-DJOQCHOTSA-N
Uses
Ecamsule can be used in biological study and cosmetic use of polyhydroxy fullerene sunscreen active agents and compositions.
Ecamsule is very photostable and has excellent water solubility.
Ecamsule also improves UVA protection and skin feel of the product.
Ecamsule is ideal for use in sunscreens and daily skin care products.
Ecamsule provides broad-spectrum protection especially for UVA protection.
Ecamsule is very photostable and has excellent water solubility.
Ecamsule also improves UVA protection and skin feel of the product.
Ecamsule is ideal for use in sunscreens and daily skin care products.
Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product.
Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression.
Ecamsule has the potential for the research of polymorphous light eruption (PMLE).
