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EDTA 2Na is a chelating agent that binds metal ions such as calcium, magnesium, iron, and copper to form stable, water-soluble complexes.
EDTA 2Na is commonly used to control metal ion activity in chemical, biological, cosmetic, food, and industrial systems by preventing metal-catalyzed reactions.
EDTA 2Na improves formulation stability, enhances product performance, and prevents discoloration, oxidation, and scale formation caused by trace metals.
CAS Number: 139-33-3
Molecular Formula: C10H14N2Na2O8
Molecular Weight: 336.21
EINECS Number: 205-358-3
Synonyms:EDTA disodium salt, 139-33-3, Ethylenediaminetetraacetic acid disodium salt, Disodium EDTA, Disodium ethylenediaminetetraacetate, EDTA 2Na, MFCD00070672, disodium;2-[2-[bis(carboxymethyl)amino]ethyl-(carboxylatomethyl)amino]acetate, ethylenediamine tetraacetic acid disodium salt, EDTAdisodiumsalt, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, EDTA disodium salt, 95%, SCHEMBL33501, C10H14N2Na2O8, AKOS015900960, AKOS016016390, CS-W019532, FE30588, D3789, E0091, E0103, ethylenediamine tetra-acetic acid disodium salt, F464458, Dissolvine NA2P;Ethylenediaminetetraacetic acid disodium salt BP, SEQUESTRENE NA2;SODIUM (DI) ETHYLENEDIAMINE TETRAACETATE DIHYDRATE;VERSENE NA, DIHYDRATE;VERSENE DISODIUM;WANKLYN'S EDTA;Ceftriaxone Impurity 21（EDTA Disodium）;disodium ethylenediamintetraacetate;EDTA two sodium
EDTA 2Na is used in several industrial applications attributing to its high ability to bind to most of metal cations.
EDTA 2Na is produced as several salts, e.g. ethylenediaminetetra-acetic acid disodium salt (EDTAS).
EDTA and its salts are used as chelating agents in cosmetic formulations.
EDTA 2Na is a preservative, sequestrant, and stabilizer in foods.
EDTA 2Na is added to ascorbic acid-disodium benzoate containing soft drinks to mitigate the formation of benzene.
EDTA 2Na and its salts are used as a component in the production of food-contact paper and paperboard.
EDTA 2Na is permitted in the feed and drinking water of animals and/or for the treatment of food-producing animals.
In the textile industry, EDTA 2Na and its salts prevent metal ion impurities from changing colors of dyed products.
In the pulp and paper industry, EDTA 2Na and its salts inhibit the ability of metal ions from catalyzing the disproportionation of hydrogen peroxide (a typical bleaching agent).
EDTA 2Na is used in synthetic rubber manufacture.
EDTA 2Na is also used as a corrosion inhibitor to carbon steel in the industries.
As an anticoagulant, EDTA 2Na and tripotassium salts of EDTA are most commonly used.
EDTA 2Na is incorporated in personal care products to chelate and sequester metal ions, in an effort to increase shelf life and enhance the products foaming properties.
EDTA 2Na is used in shampoo, dyes, lotion, gel, cosmetics.
It is a hexadentate ligand, meaning each molecule can attach to a metal ion at six donor sites, forming a stable chelate ring structure.
Dissolving two acidic protons with sodium ions increases water solubility and makes it suitable for direct use in aqueous systems.
It appears as a white crystalline powder or granules, odorless, highly soluble in water, and stable under normal storage conditions.
EDTA 2Na is a synthetic aminopolycarboxylate chelator engineered to selectively and strongly bind metal ions through six electron-donating sites (two nitrogen atoms + four carboxylate oxygens).
It forms highly stable 1:1 metal complexes, known as chelation complexes, which effectively sequester both divalent and trivalent ions (e.g., Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺), preventing these ions from catalyzing oxidation, precipitation, or biological reactions.
The substitution of two acidic protons with sodium ions (Na⁺) creates a more soluble and pH-compatible form of EDTA 2Na suitable for a wide range of aqueous formulations and biological environments.
Due to its ability to control metal ion activity, EDTA 2Na acts as a preservative synergist, antioxidation protector, and stability enhancer across cosmetic, pharmaceutical, food, and industrial systems.
In analytical chemistry, it functions as a standard chelating reagent in complexometric titrations, enabling precise quantification of metal concentrations in solutions such as water hardness testing.
Because many biological processes depend on metal cofactors, EDTA 2Na is used to moderate enzyme activity, inhibit clotting, and stabilize proteins and nucleic acids during laboratory procedures and sample storage.
Structurally, EDTA 2Na forms chelate rings around metal ions that greatly reduce their reactivity and mobility, a property central to its use in detergents, water treatment, and industrial scale prevention.
Melting point: 248 °C (dec.) (lit.)
Boiling point: >100 °C
Density: 1.01 g/mL (25 °C)
Vapor pressure: 0 Pa (25 °C)
Refractive index: n20/D 1.363
Storage temperature: 2–8 °C
Solubility: H₂O: clear, colorless
Form: Solution
Color: ≤5 APHA (0.5 M)
pH: 8.0 ± 0.2
Odor: Odorless (at 100 %)
Water solubility: Miscible with water
BRN: 3822669
Stability: Hygroscopic
LogP: −4.3 (25 °C)
EDTA 2Na is incorporated in personal care products to chelate and sequester metal ions, in an effort to increase shelf life and enhance the products foaming properties.
EDTA 2Na is used in shampoo, dyes, lotion, gel, cosmetics.
EDTA 2Na has the ability to block the binding of vasoactive intestinal peptide to macrophage membranes.
It is mainly used in the purification of protein, to remove divalent cations and also to prevent protease activity.
Edetate salts are more stable than edetic acid (see also Edetic acid).
However, EDTA 2Na loses water of crystallization when heated to 120°C.
Aqueous solutions of EDTA 2Na may be sterilized by autoclaving, and should be stored in an alkali-free container.
EDTA 2Na is hygroscopic and is unstable when exposed to moisture.
It should be stored in a well-closed container in a cool, dry place.
EDTA 2Na behaves as a weak acid, displacing carbon dioxide from carbonates and reacting with metals to form hydrogen.
It is incompatible with strong oxidizing agents, strong bases, metal ions, and metal alloys.
EDTA 2Na is a hexadentate coordination ligand, meaning each molecule can occupy six coordination sites on a single metal ion, forming highly stable octahedral metal–ligand complexes that are resistant to dissociation once formed.
Its high formation constants (Kf) for transition metals make it exceptionally effective at neutralizing trace metal catalysts, thus preventing radical formation, oxidative degradation, and unwanted color changes in sensitive chemical and biological formulations.
In aqueous systems, EDTA 2Na exists mostly as a partially dissociated anion, and its chelation effectiveness increases as pH increases, where more carboxyl groups become deprotonated and available for metal binding.
Because metal ions play critical roles in enzymatic reactions, membrane integrity, and protein structures, EDTA 2Na is widely used to precisely regulate metalloproteins, disrupt biofilms, and inhibit metalloprotease activity in pharmaceutical and laboratory applications.
Its strong affinity with calcium and magnesium enables controlled interference in blood coagulation pathways, which is why it is commonly used in anticoagulant blood tubes and clinical sample stabilization.
In industrial processes, EDTA 2Na is key for water softening, preventing mineral scale formation, improving detergent performance, and extending the lifetime of pipelines and heat exchange systems.
Because of its capacity to maintain transparency and product integrity, EDTA 2Na is considered a formulation stabilizer of high strategic value in cosmetics, personal care, and high-purity chemical manufacturing.
uses Of EDTA 2Na:
EDTA 2Na is an aminopolycarboxylic acid and a hexadentate ligand.
It chelates with metal ions, especially with cations to form an octahedral complex.
EDTA 2Na is a blood anticoagulant and contributes to the pathogenesis of pseudothrombocytopenia.
EDTA 2Na chelates with calcium in the blood and inhibits clotting and is routinely used in haematological tests.
It enhances the antibacterial activity of lysozyme.
EDTA 2Na used in chelation therapy chelates with calcium and favors dilation of artery, solubilisation of atheromatous plaques in atherosclerotic vascular disease.
EDTA 2Na chelation therapy may also protect from oxidative damage during blood and lipid peroxidation in liver fibrosis.
EDTA 2Na is a sequestrant and chelating agent whose complete name is disodium ethylenediamine tetraacetate.
EDTA 2Na is a nonhygroscopic powder that is colorless, odorless, and tasteless at recommended use levels.
EDTA 2Na is used to control the reaction of trace metals to include calcium and magnesium with other organic and inorganic components in food to prevent deterioration of color, texture, and development of precipitates and to prevent oxidation.
Its function is comparable to that of disodium calcium edta.
Widely used in cosmetics and personal care products (shampoo, cream, cleanser) to stabilize formulas and prevent metal-driven oxidation.
Employed in pharmaceuticals to protect active ingredients and improve stability of injectable and oral formulations.
Applied in foods and beverages (where permitted) to preserve color, flavor, and clarity by preventing oxidation.
Used in laboratories for complexometric titration to determine metal ion concentrations.
Included in water treatment and detergents to soften water and reduce scale formation.
Utilized as an anticoagulant in blood collection and biochemical testing by binding calcium ions required for coagulation.
EDTA 2Na is widely used in textile industry. Usually applied to dissolve limescale.
EDTA 2Na is applied in textile industry, pulp and paper industry and also in chelation therapy.
In cosmetics, it acts as a sequestering agent.
EDTA 2Na acts as a corrosion inhibitor to carbon steel in the industries.
EDTA 2Na also acts as a food additive.
EDTA 2Na has been in seed germination trials of plant species and in protein extraction from Moss, Physcomitrella paten.
It has also been used in lysis and vacuole buffer for the isolation of vacuoles from Petunia petals.
Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.
EDTA 2Na is used as a chelating agent in a wide range of pharmaceutical preparations, including mouthwashes, ophthalmic preparations, and topical preparations, typically at concentrations between 0.005 and 0.1% w/v.
EDTA 2Na forms stable water-soluble complexes (chelates) with alkaline earth and heavy-metal ions.
The chelated form has few of the properties of the free ion, and for this reason chelating agents are often described as ‘removing’ ions from solution, a process known as sequestering.
The stability of the metal–edetate complex is dependent on the metal ion involved and the pH.
EDTA 2Na is also used as a water softener as it will chelate calcium and magnesium ions present in hard water.
It is also used therapeutically as an anticoagulant as it will chelate calcium and prevent the coagulation of blood in vitro.
Used in cosmetics and personal care products (shampoos, creams, soaps, sunscreens) to stabilize formulations, prevent oxidation, and maintain clarity by binding trace metals.
Employed in pharmaceutical formulations as a stabilizer for biologics, ophthalmic solutions, and injectables, protecting active ingredients from metal-induced degradation.
Applied in foods and beverages (where approved) to preserve flavor, color, and freshness by inhibiting metal-catalyzed oxidation of fats, vitamins, and aromatic compounds.
Essential in complexometric titrations in analytical chemistry for accurate measurement of metal concentrations (e.g., water hardness testing).
Utilized in water treatment and detergent formulations to soften water, prevent scale buildup, and improve cleaning efficiency by reducing calcium and magnesium interference.
Included in anticoagulant blood collection tubes to bind calcium ions and prevent blood coagulation for hematological analysis.
Used in textile and paper manufacturing to remove metal impurities that disrupt dyeing, bleaching, and pulping processes.
Employed in industrial cleaning to dissolve mineral deposits and prevent re-precipitation during maintenance of boilers, pipelines, and heat exchangers.
Plays a role in environmental remediation for controlled removal of heavy metals from soils and wastewater streams through metal chelation.
EDTA 2Na is used in molecular biology & biochemistry to protect proteins and DNA by inhibiting metal-dependent enzymatic degradation.
Safety Profile Of EDTA 2Na:
Poison by intraperitoneal and intravenous routes.
Moderately toxic by ingestion experimental teratogenic and reproductive effects.
Mutation data reported, the calcium disodium salt of EDTA 2Na is used as a chelating agent in treating lead poisoning.
When heated to decomposition it emits toxic fumes of NOx and NasO.
Low toxicity overall but may cause skin, eye, or respiratory irritation upon direct contact or inhalation of dust.
Excessive ingestion may lead to electrolyte imbalance by chelating essential ions like calcium and magnesium.
Persistent in the environment and may mobilize heavy metals if improperly released, requiring controlled disposal practices.
EDTA 2Na is used widely in topical, oral, and parenteral pharmaceutical formulations; it is used extensively in cosmetic and food products.
EDTA 2Na and edetate calcium disodium are used in a greater number and variety of pharmaceutical formulations than is edetic acid.
Both disodium edetate and edetate calcium disodium are poorly absorbed from the gastrointestinal tract and are associated with few adverse effects when used as excipients in pharmaceutical formulations.
Disodium edetate, trisodium edetate, and edetic acid readily chelate calcium and can, in large doses, cause calcium depletion (hypocalcemia) if used over an extended period of time, or if administered too rapidly by intravenous infusion.
If used in preparations for the mouth, they can also leach calcium from the teeth. However, edetate calcium disodium does not chelate calcium.
EDTA 2Na should be used with caution in patients with renal impairment, tuberculosis, and impaired cardiac function.
Although EDTA 2Na is generally considered safe, there have been reports of disodium edetate toxicity in patients receiving chelation therapy.
Nasal formulations containing benzalkonium chloride and disodium edetate, both known to be local irritants, were shown to produce an inflammatory reaction, and microscopic examination showed an extended infiltration of the mucosa by eosinophils, and pronounced atrophy and disorganization of the epithelium, although these effects were subsequently shown to be reversible.
