PRODUCTS

ELLAGIC ACID

EC / List no.: 207-508-3
CAS no.: 476-66-4
Mol. formula: C14H6O8

Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables.
Ellagic acid is the dilactone of hexahydroxydiphenic acid.
There is no scientific evidence that consuming ellagic acid has any beneficial effect on human health or prevents diseases.

Name
The name comes from the French term acide ellagique, from the word galle spelled backwards because it can be obtained from noix de galle (galls), and to distinguish it from acide gallique (gallic acid).
The molecule structure resembles to that of two gallic acid molecules being assembled "head to tail" and bound together by a C–C bond (as in biphenyl, or in diphenic acid) and two lactone links (cyclic carboxylic esters).

Metabolism
Biosynthesis
Plants produce ellagic acid from hydrolysis of tannins such as ellagitannin and geraniin.

Biodegradation
Urolithins are gut flora human metabolites of dietary ellagic acid derivatives.
Ellagic acid has low bioavailability, with 90% remaining unabsorbed from the intestines until metabolized by microflora to the more bioavailable urolintins.

History
Ellagic acid was first discovered by chemist Henri Braconnot in 1831.
Maximilian Nierenstein prepared this substance from algarobilla, dividivi, oak bark, pomegranate, myrabolams, and valonea in 1905.
He also suggested its formation from galloyl-glycine by Penicillium in 1915.
Julius Löwe was the first person to synthesize ellagic acid by heating gallic acid with arsenic acid or silver oxide.

Natural occurrences
Ellagic acid is found in oak species such as the North American white oak (Quercus alba) and European red oak (Quercus robur).

The macrophyte Myriophyllum spicatum produces ellagic acid.

Ellagic acid can be found in the medicinal mushroom Phellinus linteus.

In food
The highest levels of ellagic acid are found in raw chestnuts, walnuts, pecans, cranberries, raspberries, strawberries, and grapes, as well as distilled beverages.
Ellagic acid is also found in peaches and pomegranates.

Chemical Properties
Ellagic acid is cream to light yellow crystalline solid

Uses
hemostatic, antineoplastic, antimutagenic

Ellagic Acid is a phenol antioxidant found naturally in various fruits and vegetables.
Ellagic Acid was shown to exhibit high levels of antiproliferative and antioxidant properties in studies, which s uggests its potential health benefits following ellagic acid consumption.

Definition
ChEBI: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl.
Ellagic acid is found in many fruits and vegetables, ncluding raspberries, strawberries, cranberries, and pomegranates.

General Description
Cream-colored needles (from pyridine) or yellow powder. Odorless.

Air & Water Reactions
Insoluble in water.

Reactivity Profile
Ellagic acid reacts as a weak acid.
Incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides.
Flammable gas (H2) is often generated.
Heat is also generated by the acid-base reaction between phenols and bases.
May be sulfonated exothermically very readily (for example, by concentrated sulfuric acid at room temperature).
May be nitrated very rapidly, even by dilute nitric acid.

Fire Hazard
Flash point data for Ellagic acid are not available; however, Ellagic acid is probably combustible.

Biological Activity
Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC 50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk? and FGR respectively).
Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.

Anticancer Research
Ellagic acid is a naturally occurring phenolic constituent present in natural productsand nuts, most elevated amounts of which are found in raspberries (Daniel et al.1990).
Ellagic acid is considered as a potent anticarcinogenic and antimutagenic compound.
Ellagic acid shows anti-angiogenic property by repressing PDGF-R movement and phosphorylationof its substrate.
Ellagic acid can intrude with endothelial cell-associated VEGR-2phosphorylation bringing about the restraint of the downstream signaling activatedby this receptor and in the hindrance of two key events fundamental in angiogenesis,i.e., EC movement and morphogenic separation into capillary-like structure.
In parallel,Ellagic acid indicated robust inhibitory activity against perivascular cells through itsrestraint of PDGF-R action and signaling prompting hindrance of VSMC relocation(Labrecque et al. 2005).
Ellagic acid is a phenolic compound extracted from pomegranate.
Ellagic acid is an antiproliferative andantioxidant compound (Murakami et al. 1996).
Ellagic acid induces apoptosis in cancer cellsof the prostate and breast and prevents the process of metastasis in different cancers(Singh et al. 2016b).

Purification Methods
This antioxidant crystallises from pyridine.
Ellagic acid forms a dark green solution in aqueous N NaOH. The tetraactetate dilactone crystallises from Ac2O, with m 340o.

Ellagic acid is an organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl.
Ellagic acid is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Ellagic acid has a role as an antioxidant, a food additive, a plant metabolite, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, an EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor, an EC 2.4.1.1 (glycogen phosphorylase) inhibitor, an EC 2.5.1.18 (glutathione transferase) inhibitor, an EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor, an EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor, an EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor, a skin lightening agent, a fungal metabolite and an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor.
Ellagic acid is an organic heterotetracyclic compound, a cyclic ketone, a lactone, a member of catechols and a polyphenol.
Ellagic acid derives from a gallic acid.

Ellagic acid appears as cream-colored needles (from pyridine) or yellow powder. Odorless.

Ellagic acid is present in several fruits such as cranberries, strawberries, raspberries, and pomegranates.
In pomegranates, there are several therapeutic compounds but ellagic acid is the most active and abundant.
Ellagic acid is also present in vegetables.
Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines.
Ellagic acid's therapeutic action mostly involves antioxidant and anti-proliferative effects.

Therapeutic Uses
Italian researchers found that ellagic acid seemed to reduce the side effects of chemotherapy in men with advanced prostate cancer, although it did not help slow disease progression or improve survival.

Ellagic acid seems to have some anti-cancer properties.
Ellagic acid can act as an antioxidant, and has been found to cause apoptosis (cell death) in cancer cells in the lab.
In other lab studies, ellagic acid seems to reduce the effect of estrogen in promoting growth of breast cancer cells in tissue cultures.
There are also reports that it may help the liver to break down or remove some cancer-causing substances from the blood.
Some supporters have claimed these results mean that ellagic acid can prevent or treat cancer in humans.
This has not been proven.
The available scientific research does not support these claims at this time.

Ellagic acid is a naturally occurring substance.
The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, cherries, and walnuts.

Ellagic acid is used for cancer, dark skin patches on the face (melasma), memory and thinking skills (cognitive function), and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?
Ellagic acid may bind to chemicals that cause cancer.
Ellagic acid may also prevent the growth of cancer cells and improve the safety and efficacy of some cancer drugs.
However, ellagic acid is poorly absorbed and is also eliminated quickly from the body.
These characteristics may limit its usefulness as a medicine.

Ellagic acid may not be a household name, yet this powerful polyphenol has been associated with a long list of impressive health benefits.

In particular, studies show that ellagic acid may decrease cancer cell growth, alleviate inflammation, and protect brain function.

Plus, it’s found in many food sources and often featured in your supplements and skin care products.

What is ellagic acid?
Ellagic acid is an antioxidant found naturally in many of your favorite foods, including many fruits and vegetables.

Some foods also contain a compound called ellagitannin, which your body converts into ellagic acid.

Ellagic acid has been studied for its beneficial health effects. In fact, research shows that it may boast powerful anti-inflammatory, cancer-fighting properties

What’s more, some animal and human studies suggest that it may be useful for the treatment and prevention of conditions like type 2 diabetes, cancer, and brain diseases like Alzheimer’s.

In addition to food sources, ellagic acid is widely available in supplement form.
You can also find it in many skin care products, thanks to its ability to reduce hyperpigmentation.

Ellagic acid is an antioxidant found in many food sources, supplements, and skin care products.
Ellagic acid has been studied for its anti-inflammatory, cancer-fighting properties and may be beneficial for a variety of chronic health conditions.

How does ellagic acid work?
Ellagic acid acts as an antioxidant, meaning that it can neutralize harmful compounds known as free radicals to protect your cells from damage and oxidative stress.

Ellagic acid may also help regulate your immune function and decrease several specific markers of inflammation, including prostaglandin E2 and interleukin 6.

Sustaining high levels of inflammation long-term may contribute to a number of chronic conditions, including cancer, heart disease, and autoimmune disorders.

Test-tube and animal studies have also found that ellagic acid may help preserve brain function and decrease cancer cell growth thanks to its potent antioxidant properties.

What’s more, some research shows that it can lighten your skin by blocking the activity of a specific enzyme involved in the production of melanin, a type of skin pigment.

Ellagic acid acts as an antioxidant and can decrease levels of inflammation to protect against disease.
Ellagic acid may also help lighten your skin by blocking the activity of an enzyme involved in melanin production.

Does ellagic acid fight cancer?
Multiple studies show that ellagic acid may have powerful cancer-fighting properties.

According to one review of in vitro and in vivo evidence, ellagic acid may inhibit the growth and spread of tumors while killing cancer cells.

Additionally, it may increase tumors’ sensitivity to chemotherapy and radiation, enhancing the effectiveness of these cancer treatments.

In particular, test-tube studies show that ellagic acid may help protect against several types of cancer, including breast, bladder, prostate, colorectal, and lung cancer.

However, keep in mind that most research on the effects of ellagic acid specifically have been conducted in test-tubes or animals and use very high doses of ellagic acid.

While some studies in humans also suggest that pomegranate juice or extract, which is rich in ellagic acid, may be beneficial against prostate and colorectal cancer, it’s unclear whether other compounds found in pomegranate may also play a role.

Ellagic acid may slow the growth and spread of certain types of cancer cells, but more research in humans is needed.

Dosage and supplement info
You can buy ellagic acid supplements at local natural health stores and via online retailers.
Health stores often market ellagic acid as a natural remedy for cancer and bacterial or viral infections.

Ellagic acid is also commonly found in supplements like pomegranate extract, which typically contains 250–500 mg of ellagic acid per serving.

Although there are no official dosage recommendations for ellagic acid, some studies estimate that ellagic acid may be most effective at doses ranging from 30–850 mg.

However, some research suggests that your body may not absorb ellagic acid from supplements as effectively as it absorbs ellagic acid from food sources.
This may limit ellagic acid supplements’ potential health benefits (24Trusted Source).

Additionally, if you’re taking any other medications or have any underlying health conditions, it’s best to talk with your doctor before starting these supplements, as ellagic acid may not be suitable for everyone.

SUMMARY
Ellagic acid supplements are widely available.
Studies suggest that ellagic acid may be most effective in doses ranging from 30-850 mg, but it may not be well absorbed by the body via supplement form, which could limit its effectiveness.

Food sources of ellagic acid
You can find ellagic acid naturally in a variety of food sources, including certain types of fruits and tree nuts.

Some of the richest food sources of ellagic acid include:
pomegranates
apples
grapes
strawberries
raspberries
cranberries
cloudberries
walnuts
pistachios
cashews
pecans

Keep in mind that you would have to eat very high amounts of these foods to obtain the amount of ellagic acid found in supplements.

According to one older study, the average daily intake of ellagic acid was 44 mg and 55 mg for men and women, respectively, among American adults meeting the recommendations for daily fruit and vegetable consumption.

Ellagic acid is found in many types of fruits and tree nuts.

Ellagic acid, a polyphenol found in fruits and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, wolfberry, and other plant foods, is one of the well-studied phytochemical.
Ellagic acid possesses antioxidant, antimutagenic, and anticancer properties.
Administering ellagic acid to rats with ethanol-induced hepatotoxicity was shown to ameliorate the increased serum levels of aminotransferases, lipid peroxides, and hydroperoxides and also to reduce the elevated hepatic contents of cholesterol, free fatty acids, triglycerides, and phospholipids.
Ellagic acid mitigated the alcohol-induced toxicity in rats by improving the body weight, restoring antioxidant status, modulating micronutrients, and attenuating the lipid levels in blood.
Studies have also shown ellagic acid decreases ethanol-induced hepatotoxicity by modulating the ethanol-induced alterations in the expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases.
Additionally, ellagic acid is also reported to possess antifibrotic effects and thus be of benefit in preventing alcoholic liver disease.
Studies with HepG2 cells have also shown that treatment with ellagic acid (1, 10, and 100 μM) reduced the levels of ethanol-induced production of NO, TGF-β1, and scavenger receptor class B type I (SR-B1).
Recent studies have shown that in liver and steroidogenic tissues, SR-B1 plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester and that ellagic acid modulated this to promote cholesterol efflux.

Ellagic acid (EA) is a naturally occurring polyphenol found in some fruits and nuts, including berries, pomegranates, grapes, and walnuts.
Ellagic acid has been investigated extensively because of its antiproliferative action in some cancers, along with its anti-inflammatory effects.
A growing body of evidence suggests that the intake of Ellagic acid is effective in attenuating obesity and ameliorating obesity-mediated metabolic complications, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis.
In this review, we summarize how intake of Ellagic acid regulates lipid metabolism in vitro and in vivo, and delineate the potential mechanisms of action of Ellagic acid on obesity-mediated metabolic complications.
We also discuss Ellagic acid as an epigenetic effector, as well as a modulator of the gut microbiome, suggesting that Ellagic acid may exert a broader spectrum of health benefits than has been demonstrated to date.
Therefore, this review aims to suggest the potential metabolic benefits of consumption of EA-containing fruits and nuts against obesity-associated health conditions.

General description
Ellagic acid is a dimeric derivative of gallic acid.
Ellagic acid is a plant polyphenol which has properties like antioxident, anti-inflammatory, anticancer and antiatherosclerosis.

Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ellagic acid was used in TLC and RP-HPLC analysis for determination of phytoconstituents content in Root Bark of Oroxylum indicum.

Biochem/physiol Actions
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.
Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Ellagic acid is a naturally occurring substance. The best sources of ellagic acid in the diet are strawberries, raspberries, blackberries, and walnuts.

Medicinally, ellagic acid is used to prevent cancer and treat viral and bacterial infections.

How does Ellagic acid work?
Ellagic acid may bind to chemicals that cause cancer, and it may also prevent the growth of cancer cells.
However, ellagic acid is poorly absorbed and is also eliminated quickly from the body.
These characteristics may limit its usefulness as a medicine.

USES & EFFECTIVENESS
Insufficient Evidence to Rate Effectiveness for...
Preventing cancer.
Treating viral infections.
Treating bacterial infections.
Other conditions.

Antioxidants, including ellagic acid, play a significant role in promoting health and guarding against disease.
You’re already reaping the antioxidant benefits of ellagic acid if you follow a nutritious diet that incorporates a variety of fruits and nuts.
That’s because grapes, strawberries, raspberries, cranberries, pomegranates, walnuts, pecans and green tea contain rich amounts of this nutrient.
The primary focus of research into ellagic acid revolves around its antioxidant properties.

The Importance of Antioxidants
Without oxygen you’d die within a few minutes.
Every cell in your body needs oxygen to produce energy, but there’s a down side to oxygen called free radicals.
If you remember biology class, you know that free radicals are a natural byproduct of oxygen usage.
They’re highly unstable molecules that react negatively with healthy cells and tissues, causing damage.
To combat this, your body possesses a powerful antioxidant system to neutralize free radicals so that you remain healthy.

Some antioxidants in your diet are much more powerful than others.
Researchers tend to hone in on these more powerful antioxidants, and they believe ellagic acid is one of them.

What It’s Got to Do with Disease
When there aren’t enough antioxidants to keep free radicals in check, an imbalanced state known as oxidative stress occurs.
This is where free radicals go around unchecked causing damaging chemical reactions in your body.
Inflammation, tissue damage and DNA damage are hallmarks of oxidative stress, which is linked to obesity, heart disease, type 2 diabetes and other chronic diseases.

An antioxidant-rich diet high in fruits and vegetables can reduce your risk for chronic diseases.
That's why scientists focus on antioxidants like ellagic acid for their potential health benefits.

Ellagic Acid Protects Against Oxidative Stress
Scientists hope that studying antioxidants like ellagic acid will lead to news ways of protecting against disease.
They theorize that reducing oxidative stress will improve common disease states, and their theory has yielded positive research results.
In one such laboratory finding, ellagic acid showed a powerful ability to scavenge free radicals, neutralizing them continuously in a virtual cascade, reported the journal Chemical Research in Toxicology in April 2014.
The researchers deemed ellagic acid a novel and versatile protector against free radicals.

Ellagic acid caused breast cancer cells to self-destruct and stopped them from spreading, in a separate study reported in the April 2015 issue of the International Journal of Oncology.

This doesn’t mean that you should run out and purchase ellagic acid supplements. Scientists are far from proving the safety and effectiveness of the therapeutic use of ellagic acid on its own. But eating foods rich in the ellagic acid and other antioxidants is a healthful choice.

Focusing on What Matters
Avoid thinking of your diet in terms of single nutrients and focus on your entire eating pattern as the bigger picture.
Hundreds of nutrients, be they vitamins, minerals, or antioxidants work together to keep you healthy.
The only way to ensure that you get enough of these vital constituents is to eat a varied diet filled with whole foods.

The bad news is that most Americans fail to eat enough fruits and vegetables, which means you could be missing out on vital antioxidants, including ellagic acid, and other key nutrients.
Try adding more fruits and veggies to your plate to replace foods you may be getting too much of, such as processed foods.

Getting More Ellagic Acid From Foods
Think of new ways to enjoy foods and beverages that are high in ellagic acid. Drink green tea or pomegranate juice.
Add raspberries to homemade fruit smoothies or mix pecans into your morning yogurt.
Try taking a bunch of grapes or some walnuts and dried cranberries in a container for a snack to eat at work.
Or top a grilled chicken salad with strawberries at dinnertime.

Ellagic acid is found in many foods that are part of a healthy diet, but there is no evidence to support its use for cancer treatment.

Ellagic acid is a naturally occurring compound called a tannin, found in red raspberries, strawberries, pomegranates, and walnuts.
In laboratory studies, ellagic acid showed antiviral, antibacterial and antioxidant and cancer-preventive properties.

Small clinical studies have shown that ellagic acid may lower cholesterol and decrease lipid peroxidation in patients with metabolic syndrome; and may help restore cognitive performance associated with mild age-related decline.
Consuming red raspberries may help improve endothelial function.

Purported Uses
To lower cholesterol
One study found that consumption of a drink made with freeze-dried strawberry powder for 4 weeks lowered total cholesterol and LDL levels in obese women with metabolic syndrome.
Further research is needed to confirm this effect.

For Healthcare Professionals
Clinical Summary
A phenolic compound derived from ellagitannins commonly found in red raspberries, strawberries, pomegranates, and walnuts, ellagic acid has antiviral, antibacterial and antioxidant properties.
Small clinical studies have shown that it may lower cholesterol and decrease lipid peroxidation in patients with metabolic syndrome; and may help restore cognitive performance associated with mild age-related decline.
In addition, consumption of red raspberries was associated with improvements in endothelial function and a pomegranate extract may have beneficial effects by inducing ellagitanin metabolite formation and changing microbiota.

Pre-clinical studies indicate anticarcinogenic effects of ellagic acid against liver, esophageal, prostate, and colorectal cancer cell lines.
Ellagic acid was also shown to induce apoptosis and potentiate all-trans retinoic acid myeloid differentiation therapy in human leukemia HL-60 cells.
In another study, pomegranate-derived ellagitannins exhibited anti-aromatase activity and suppressed testosterone-induced breast cancer cell proliferation, but ellagic acid did not have such effects.
In an exploratory study of patients with biochemically recurrent prostate cancer, grape skin comprising ellagic acid, quercetin, and resveratrol was reported to be safe and to affect a non-significant increase in prostate-specific antigen doubling time.
Further research is needed to assess the anticancer potential of ellagic acid.

Food Sources
Red raspberries, strawberries, pomegranates, walnuts

Purported Uses
Hypercholesterolemia
Mechanism of Action
Ellagic acid appears to inhibit chemical-induced esophageal carcinogenesis in animals.
Ellagic acid down-regulates insulin-like growth factor IGF-II and activates p53/p21 expression, leading to cell cycle arrest at the G1/S phase and apoptosis.
In vitro studies report that ellagic acid protects cells from oxidative DNA damage caused by hydrogen peroxide and bleomycin.
Ellagic acid’s ability to induce detoxification enzymes NADPH and quinone reductase contribute to some of its chemopreventive activities.
Conversely, certain cytochrome P450 enzymes are inhibited by ellagic acid, preventing other carcinogens from being metabolized into more mutagenic forms.

General description
Ellagic acid is a naturally occurring phenolic acid in many fruits and vegetables, as a secondary plant metabolite.
Ellagic acid is commonly found in green tea, pomegranate, strawberries, blackberries, raspberries, and walnuts.
Application
Ellagic acid has been used:
to study the metabolism of dietary phenolic acids by Lactobacillus plantarum CECT 748T
as a potential substrate for the high production of Lactobacillus plantarum tannase
as a standard in the study to examine the phenolic components and anti-oxidant activity of nettle
to study the links between dietary ellagic acid and epigenetic modulation of adipogenesis

Biochem/physiol Actions
Ellagic acid has been found to exhibit antioxidant activity by virtue of having an inhibitory effect on the oxidation of low-density lipoproteins.
This makes them have a cardioprotective effect on humans.
In addition, it shows anticarcinogenic, antifibrotic, antiplasmodial, apoptotic, and chemopreventive activities as well.
Commonly occurring plant polyphenol, inhibitor of glutathione S-transferase.
Used for the assay of factor XIIa in plasma. Contact activation in blood coagulation.

Ellagic acid is something you likely consumealready.

What is Ellagic acid?
Ellagic acid is a plant chemical shown by scientific research to possess impressive antioxidant, anti-mutagenic and anticancer properties.

Research to date suggests that the consumption of this acid may not only lower inflammation and fight off cancer, but also reduce obesity and improve complications related to obesity, including atherosclerosis, nonalcoholic fatty liver disease, insulin resistance and type 2 diabetes.

If you’re looking to start an ellagic acid diet plan, what kinds of foods should you eat?
Foods high in ellagic acid include things like berries and nuts.

Are there beverages rich in this plant-based acid? Green tea is one option.

Eucalyptus essential oil can also thank its content of this acid for some of its impressive health benefits.
Ready to learn more about the many potential ellagic acid benefits? Read on.

What Is Ellagic Acid?
Ellagic acid (EA) was first discovered by chemist Henri Braconnot in 1831.

Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables.
Ellagic acid can also be described as a type of plant-derived polyphenol (along with flavonoids, chalcones and resveratrol).

Plants produce the acid from hydrolysis of tannins.

How is ellagic acid related to gallic acid?
Ellagic acid is a dimeric derivative of gallic acid, which is often a part of tannins.

What foods contain beneficial polyphenols and ellagic acid? Fruit is a food group that commonly contains both.

There are many high ellagic acid foods you can add to your diet starting today.

Ellagic Acid Foods and Sources
Wondering what an ellagic acid weight loss menu might look like?
Ellagic acid would certainly include berries and certain nuts.

What foods are high in ellagic acid? Top ellagic acid sources include:
raspberries
cloudberries
blackberries
strawberries
cranberries
darkly colored grapes (like muscadine)
walnuts
pecans
chestnuts
green tea
pomegranate juice
red wine aged in oak barrels
Do blueberries contain ellagic acid?
Yes, there is Ellagic acid in blueberries, but other berries like raspberries are even higher sources.

You can obtain both ellagic acid and resveratrol by consuming things like dark berries, red grapes and organic wine.

Which red wine has the most ellagic acid?
The specific amount of ellagic acid in red wine varieties is not well-known.

However, according to Wine Spectator:

Muscadine, a native North American grape variety, has been found to be particularly high in polyphenols, including both ellagic acid and resveratrol, but you’re unlikely to find many Muscadines on the shelves of your local wine shop.

Obtaining this beneficial acid via whiskey consumption has made the news in recent years, but this has yet to be backed up by research (and the doctor promoting it was a known consultant to the drinks industry).

Potential Benefits and Uses
1. Cancer
There are strong links between ellagic acid and cancer prevention.

According to a 2014 scientific article, this acid has “potent preventive and therapeutic effects against several types of cancers, including colon cancer, breast cancer, prostate cancer, skin cancer, esophageal cancer, and osteogenic sarcoma.”

2. Obesity
According to a 2015 study, moderate consumption of red grapes, red grape juice or red wine may help boost the health status of overweight people by helping them to burn fat more efficiently and avoid obesity-related complications.

The researchers found that the ellagic acid found in grapes dramatically slowed down the growth of existing fat cells as well as the formation of fat cells.
Ellagic acid also improved the metabolism of fatty acids in liver cells.

In general, clinical studies have shown a link between a diet rich in polyphenols (Ellagic acid is one of several) and beneficial effects on metabolic syndrome, which includes major health concerns like obesity, high blood pressure, high cholesterol and high blood sugar.

Why is this significant?
Research reveals that human resistin may link insulin resistance to inflammatory diseases, such as obesity, type 2 diabetes and atherosclerosis.
Overall, the study results suggest that the Ellagic acid in pomegranate is able to suppress the secretion of resistin.

3. DNA Damage
A research study published in the International Journal of Molecular Sciences finds that berries rich in ellagic acid were able to protect against oxidative stress and reduce DNA damage in the livers of animal subjects.

4. Wrinkles and Inflammation
A study published in 2010 in the journal Experimental Dermatology found that topical application of Ellagic acid was able to prevent the breakdown of collagen in both human skin cells and hairless mice.

In the animal subjects, non-toxic Ellagic acid also helped prevent wrinkles and skin thickening as a result of UV-B exposure.

Overall, the study results show how Ellagic acid can prevent collagen destruction, inflammatory responses and signs of aging caused by UV exposure.

5. Viral Infections
Some people take Ellagic acid for viral infections.

A research study published in 2018 in the journal Biomedicine & Pharmacotherapy points toward the ability of Ellagic acid to help fight viral infections like influenza.

A small study has also shown that the acid may be able to help fight the human papilloma virus (HPV) in women.

Supplements and Dosage Info
It’s not hard to consume ellagic acid food sources, but some people opt to take ellagic acid supplements. You can choose between options like ellagic acid powder or capsules.

The appropriate dose of an Ellagic acid supplement depends on several factors, including the age and health of the user.
Currently, there are no standard dosing recommendations for EA.

Before taking an ellagic acid supplement for weight loss or any other health concern, talk to your health care provider first.

Ellagic acid has been described as an inhibitor of tyrosinase or polyphenol oxidase and, therefore, of melanogenesis. ,
In this work, we demonstrate that ellagic acid is not an inhibitor, but a substrate of mushroom polyphenol oxidase, an enzyme which oxidizes ellagic acid, generating its o-quinone.
Because o-quinones are very unstable, we used an oxymetric method to characterize the kinetics of this substrate, based on measurements of the oxygen consumed in the tyrosinase reaction.
The catalytic constant is very low at both pH values used in this work (4.5 and 7.0), which means that the Michaelis constant for the oxygen is low.
The affinity of the enzyme for the substrate is high, showing the double possibility of binding the substrate.
Moreover, a new enzymatic method is applied for determining the antioxidant activity.
Ellagic acid shows high antioxidant activity, probably because of the greater number of hydroxyl groups in its structure capable of sequestering and neutralizing free radicals

Biological Activity for Ellagic acid
Ellagic acid is a selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk and FGR respectively).
Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutathione S-transferase.

10 Foods That Contain Ellagic Acid in Significant Amounts

When we think of foods rich in ellagic acid, we typically think of berries such as raspberries, strawberries, and blackberries.
But are there also other good dietary sources of this powerful phenolic compound that has been shown to exert strong anti-cancer and antioxidant activity in test tube and animal studies?
Turns out, also several exotic fruits (such as pomegranate), a few nuts (such as walnuts), and even the Fistulina hepatica mushroom contain high levels of ellagic acid (or ellagitannins which can be hydrolyzed into ellagic acid).

Here's a list of 10 good, if not the best, sources of ellagic acid Mother Nature has blessed us with:

1. Wild Strawberries
Wild strawberries, also known by their scientific name Fragaria vesca, might well be the best natural source of ellagic acid there is.
They have been shown to contain about ten times as much ellagic acid as raspberries, the next food on our list.
Also wild strawberry leaf tea as well as cultivated strawberries are good sources, even though they contain much less ellagic acid than wild strawberries, raspberries, or blackberries.

2. Raspberries
Raspberries are known for their health benefits, many of which are linked to their high concentration of ellagic acid.
In fact, when it comes to foods that are rich in ellagic acid, it is hard to beat raspberries.
On a dry weight basis, raspberries have been shown to contain more than twice the amount of ellagic acid found in cultivated strawberries, almost three times the amount found in walnuts, and almost five times the amount found in pecans.
Nearly 90% of the ellagic acid in the raspberry fruit is contained in its tiny seeds.

3. Blackberries
Also blackberries are right there on top of the list of foods that contain ellagic acid.
A study published in the Journal of Food Composition and Analysis found that the blackberry fruit contains about as much ellagic acid as its close relative, the raspberry.
For more on blackberries, check out our in-depth article Health Benefits of Blackberries.

4. Cloudberries
Both raspberries and blackberries are members of the Rubus genus of fruit bearing plants.
But they are hardly the only Rubus berries that have been shown to contain significant levels of ellagic acid.
Cloudberries, also known by their scientific name Rubus chamaemorus, are packed with ellagic acid.
These beautiful orange berries grow wild in bogs, marshes and wet meadows in Scandinavia, northern Canada, and Alaska.

5. Exotic Fruits in the Myrtaceae Family
A Brazilian study published in the Journal of the Science of Food and Agriculture detected significant levels of ellagic acid in exotic fruits in the Myrtaceae family of plants.
The total ellagic acid levels in most of the tested Myrtaceae fruits were even higher than the levels found in cultivated strawberries (which are considered one of the best natural sources of ellagic acid in the US and UK).
The Myrtaceae fruits that had the highest levels included jabuticaba, cambuci, and Surinam cherries (regular cherries, which belong to the Rosaceae family, did not have detectable levels).
Myrtaceae fruits with somewhat lower levels included camu-camu, red guava, and white guava.

6. Pomegranate Fruit
Next up on our list of foods rich in ellagic acid is the pomegranate.
Although the amounts of free ellagic acid in the pomegranate fruit are relatively low compared with fruits like cultivated strawberries or blackberries, this gorgeous red fruit has high levels of total ellagic acid thanks to the high amounts of ellagitannins it contains.

7. Walnuts
Most of the world's best sources of ellagic acid are fruits and berries, but there are also a few nuts that contain this phenolic acid.
Walnuts, for example, have been shown to contain almost as much ellagic acid as cultivated strawberries (on a dry weight basis).
As an added bonus, walnuts are a very good source of omega-3 fatty acids for vegans and other people who don't eat fish.
To learn more about the nutritional benefits of walnuts, check out the article Walnut - An Antioxidant-Rich Superfood with Many Health Benefits.

8. Pecans
Pecans, which belong to the same Juglandaceae family as walnuts, have also been shown to contain ellagic acid.
However, they contain only slightly more than half of the ellagic acid found in walnuts.
You should also note that apart from walnuts and pecans, nuts are not considered a good source of ellagic acid (cashew nuts, pistachios, hazelnuts, Brazil nuts, macadamia nuts, and almonds – for example – have not been shown to contain detectable levels of this polyphenol).

9. Beefsteak Fungus (Ox Tongue Mushroom)
When it comes to the most unexpected natural sources of ellagic acid, beefsteak fungus (Fistulina hepatica) is right there on top of the list.
Also known as the ox tongue mushroom, this meaty mushroom has been used as a meat substitute in the past.
This reddish-brown mushroom is commonly found growing on oaks and chestnut trees in Britain, but it can be found in the rest of Europe, North America, and Australia.

10. Cranberries
Protection against urinary tract infections is probably the most famous health benefit of the superfood cranberry, but cranberry extracts have also been shown to inhibit the growth of human oral, prostate, colon, and breast tumor cell lines in test tubes.
Not surprising, considering that cranberries contain a wide range of phenolic compounds, including some ellagic acid.

Ellagic acid is a potent CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.
Ellagic acid also blocks other kinases such as LYN, PKA, SYK, GSK3, FGR and CK1, with IC50s of 2.9, 3.5, 4.3, 7.5, 9.4 and 13.0 μM, respectively, and shows no obvious effects on DYRK1a, CSK, NPM-ALK, RET and FLT3 (IC50s > 40 μM).
Ellagic acid (5-100 μM) shows inhibitory activities against Karpas299, SUDHL1, SR786, and FE-PD cell lines.
Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation.
Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments.
Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells.

Ellagic acid is a crystalline phenolic compound C14H6O8 with two lactone groupings that is obtained especially from oak galls and some tannins and is used medicinally as a hemostatic

Ellagic acid (EA4) is a naturally-occurring phenolic compound found in certain oak species, medicinal mushroom Phellinus linteus, and macrophyte Myriophyllum spicatum.
Ellagic acid is also richly contained in some human food sources (4–12).
High levels of Ellagic acid are found in Longan (also known as Dimocarpus longan), Litchi (Litchi chinensis), walnuts, pecans, cranberries, raspberries, strawberries, grapes, and peach (4–12).
Ellagic acid has been reported to have a number of biological activities, including antioxidant and antiproliferative properties as observed in some of the in vitro and animal models (10,13–16).
As with other polyphenol antioxidants, it has been suggested that Ellagic acid may have a chemoprotective effect in cellular models by inhibiting reactive chemical carcinogens from covalently modifying DNA (17–19).
Ellagic acid is noteworthy that in recent years, Ellagic acid has been controversially marketed as a dietary supplement with a number of assumed benefits against cancer, heart disease, as well as other medical issues, and these claims have received warnings from the US Food and Drug Administration (FDA).

Ellagic acid is a dilactone of hexahydroxydiphenic acid, that found in numerous fruits and vegetables.
Ellagic acid was first discovered by chemist Henri Braconnot in 1831.
Ellagic acid is found in oaks species like the North American white oak (Quercus alba) and European red oak (Quercus robur).
The highest levels of ellagic acid are found in walnuts, pecans, cranberries, raspberries, strawberries, and grapes, as well as distilled beverages.
Ellagic acid is also found in peach, and other plant foods.
Ellagic acid has antiproliferative and antioxidant properties in a number of in vitro and small-animal models.
The antiproliferative properties of ellagic acid may be due to its ability to directly inhibit the DNA binding of certain carcinogens, including nitrosamines and polycyclic aromatic hydrocarbons.
As with other polyphenol antioxidants, ellagic acid has a chemoprotective effect in cellular models by reducing oxidative stress.
Ellagic acid is an investigational drug studied for treatment of Follicular Lymphoma (phase 2 trial), protection from brain injury of intrauterine growth restricted babies (phase 1 and 2 trial), improvement of cardiovascular function in adolescents who are obese (phase 2 trial), and topical treatment of solar lentigines.
Ellagic acid has been marketed as a dietary supplement with a range of claimed benefits against cancer, heart disease, and other medical problems. Ellagic acid has been identified by the U.S. Food and Drug Administration as a "fake cancer 'cure' consumers should avoid".

Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables.
The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.

What is Ellagic Acid?
Ellagic acid is a fused four-ring polyphenol.
Pure ellagic acid is a cream to light yellow crystalline solid.
Distribution
Ellagic acid is present in many red fruits and berries, including raspberries, strawberries, blackberries, cranberries, pomegranate and some nuts including pecans and walnuts.
The highest levels of ellagic acid are found in raspberries.
In plants ellagic acid is present in the form of ellagitannin, which is ellagic acid bound to a sugar molecule.

Health Benefits of Ellagic Acid
Ellagic acid has antioxidant, anti-mutagen and anti-cancer properties.
Studies have shown the anti-cancer activity on cancer cells of the breast, oesophagus, skin, colon, prostate and pancreas.
More specifically, ellagic acid prevents the destruction of P53 gene by cancer cells.
Ellagic acid can bind with cancer causing molecules, thereby making them inactive.
In their studie The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes.
Ahn D et al showed that ellagic acid causes a decrease in total hepatic mucosal cytochromes and an increase in some hepatic phase II enzyme activities, thereby enhancing the ability of the target tissues to detoxify the reactive intermediates.
Ellagic acid showed also a chemoprotective effect against various chemically induced cancers.

Ellagic acid has also antiviral and antibacterial activities.
Facts about Ellagic Acid
Plants produce ellagic acid to protect themselves from microbiological infection and pests.

Ellagic Acid (ellagic acid) is a phytochemical, a phytochemical substance that is naturally produced by plants that use this substance to prevent infections and damage caused by fungi and vermin.
Ellagic Acid has a strong cell protective effect.

Ellagic Acid in capsule form is extracted from the more than 100 phytochemicals (organic acids) from the pomegranate.

Ellagic Acid Sources
So how can you boost your ellagic acid intake? Here’s a guide to some of the most densely packed foods.

Pomegranates:
Thanks to its deep ellagic acid reservoirs, pomegranate extracts have been shown to slow breast, colon, and lung cancers, and some research indicates pomegranate juice slows prostate growth, too.
Incorporating pomegranates in any form (juice, whole fruit, seed oil, or extract) will be a worthy addition to any food plan.

Strawberries:
EA accounts for 50% of all the phenolic acids in the berry, and it’s found in the stem and leaves, too, so blending whole strawberries will maximize EA quantities.

Raspberries:
When weighed dry, raspberries contain twice as much EA as strawberries and three times as much as walnuts.
A recent study at Ohio State University showed that black raspberries are particularly effective at stopping cervical cancer growth.

Blackberries: These contain nearly as much EA as raspberries, plus they house another important polyphenol, anthocyanin, which carries its own antitumor properties

Walnuts:
EA isn’t just relegated to the fruit world. Walnuts (and to a lesser degree pecans) still deliver the goods, plus they contribute omega-3 fatty acids, which can be important cancer deterrents in their own right.

Antioxidants are important substances that we need.

These substances help to fight against certain toxins in the body. These toxins are free radicals. They cause damage to several parts of the body.

Free radicals link to severe diseases. The presence of free radicals causes inflammatory triggers in the body. Studies have also linked free radicals to cancer1.

Many substances have been researched for their antioxidant activity. One particularly potent option is ellagic acid. This natural chemical is in many foods – including some that we use in dishes daily.

In this post, we look at what ellagic acid is. We will also consider how it helps and what the health benefits of this antioxidant are.

The post will also provide an overview of the best foods to eat to increase the consumption of ellagic acid.

What Is Ellagic Acid?
Ellagic acid is a natural chemical in certain foods.
It is also classified as a phenolic compound. Sometimes, it is rather referred to as a polyphenol antioxidant.

It is also a micronutrient that plays a few essential roles in the human body. There are many other types of phenolic compounds too.
Gallic acid is one example – which also plays a role as an antioxidant in the body. The antioxidant capacity of ellagic acid is generally impressive.

There is an alternative form of ellagic acid.
This is a more complex version of the compound and called ellagitannin.
When a person eats foods with ellagitannin, their body will convert it into the acid.

The main benefit of this substance relates to its antioxidant properties.
The antioxidant properties of ellagic acid help to protect the body against free radicals.
This helps to minimize oxidation in cells. We know free radicals can cause cellular damage.
These compounds also link to a risk of DNA damage.

With this in mind, the primary role of ellagic acid is to protect normal cells and DNA against damage caused by these free radicals.
This is an essential antioxidant activity that ellagic acid consumption may contribute to.

Certain plants produce ellagic acid to protect themselves.
It is a natural defensive mechanism for these plants. The production of ellagic acid helps to protect the plants against pests, as well as insects.

When these plants produce ellagic acid, people can consume them to gain the benefits of this potent antioxidant.

There are quite a few studies on the subject.
Ellagic acid links to a large number of potential benefits.
In addition to helping protect against free radicals, there are other benefits that the plant-based compound may bring to the body.

At the moment, we do not know the safety profile of ellagic acid.
We need more scientific studies to help medical experts understand if it can be used over a long time without any serious side effects.
While there are some dosage recommendations available, we need more research to provide more data on the safest long-term dose for the compound.

What Foods Contain Ellagic Acid?
There are a few ways to add ellagic acid to a person’s diet.
One of the most preferred methods is through diet. This makes it possible to obtain it through a more natural state.

Many of these foods contain a complicated version of ellagic acid.
In such a case, the body needs to convert it into the acid first. The concentration absorbed by the body may not be as great.
Still, it is useful to add a combination of these foods to a person’s daily diet.

Below is a list of foods containing high amounts of dietary ellagic acid.
This makes them the best option for people who want to add more of this natural compound to their diet.

Cranberries
Grapes
Strawberries
Guava
Raspberries
Blackberries
Pecan nuts
Walnuts
Beefsteak fungus
Pomegranate (and pomegranate juice)

Wolfberry
A great thing about including these foods in a diet is that they will not only contribute to increasing the consumption of ellagic acid.
These foods contain other nutrients and natural compounds too.
This means a person can benefit from the additional plant chemicals, vitamins, minerals, and other compounds found in these plant foods.

Ellagic Acid Benefits
In this section, we take a closer look at the potential benefits of ellagic acid. We also consider what research papers say about these benefits.

Prostate Cancer
Cancer is a prevalent disease.
It places a significant burden on the public health system.
Cancer also claims the lives of many people every year.
Different types of cancers can develop.
Among men, one of the most common types of disease is prostate cancer.
This happens when tumor cells develop in the prostate gland.
It also causes problems with the standard cell cycle.

The prostate gland is a small, walnut-sized part of the reproductive system.
It is responsible for producing a fluid mixed with sperm.
This, in turn, creates semen – which expels from the penis during sex.

There is a strong link between oxidative damage in the body and cancer.
Free radicals cause oxidative to cells.
This includes the cells in the prostate.
The damage happens gradually, but can eventually cause cells to become abnormal. When this happens, a person becomes at risk of developing cancer.

In the United States, more than 190,000 men are diagnosed with prostate cancer annually.
There are also over 30,000 deaths associated with prostate cancer in the country each year.
Research also suggests that more than 10% of all men will develop prostate cancer at some point in their life. Most men diagnosed with prostate cancer are over the age of 65.
This gives men a good idea of who may be at a higher risk for this type of cancer.

Several strategies have linked the use of antioxidant compounds to a lower risk of prostate cancer.
Antioxidant compounds work against the free radicals involved in the formation of prostate cancer cells.
These antioxidants also play a role in reducing the risk of other cancers in the body.

What The Studies Show
A few studies show that ellagic acid, in particular, may be effective at helping with the fight against cancer.
The organic compounds may help to slow the growth of cancer cells.
It is also a potent inhibitor of certain actions, reducing cancer risk at the same time.

There are two studies at the moment that show the compound may have anticarcinogenic properties.

One study was in 2014.
The study specifically focused on providing data on the anticarcinogenic properties that this acid possesses.
The researchers note that ellagic acid as in vivo and in vitro actions that provide a cancer chemopreventive function.
It is also worth noting that this is still a relatively new research subject.
While studies show it can provide certain anti-cancer effects in the body, we still need further research.

At the moment, studies show ellagic acid reduces proliferation associated with cancer.
This helps to reduce the degradation of chromosomal DNA.
It also seems to induce an apoptosis effect in the human osteogenic sarcoma.

Another study showed the potential anti-cancer properties of ellagic acid in a group of laboratory mice. The study focused on ellagic acid from pomegranate extract.
While the study was conducted on mice, it still showed promising results.
Scientists in the study report that they have found potential when using this acid as a compound in the treatment against cancer.

Ellagic acid may assist in reducing a man’s risk of developing prostate cancer.
In women, the risk of breast cancer could potentially reduce too.
Colon cancer is also common.
The effects might be effective here, as well.

Inflammation
Another key benefit of ellagic acid lies in its ability to reduce inflammation in the boy, possibly. There is a significant concern regarding inflammation in the general population.

Research studies have already shown that inflammation plays a role in the development of most chronic diseases.
Many people suffer low-grade inflammation.
Most people do not realize they have lower grade inflammation.
Yet, the inflammation continues to cause gradual damage to the body.

There are a few studies that have looked at the anti-inflammatory properties of ellagic acid.

The antioxidant activity of this substance is the main reason why the compound seems to be effective against inflammation in the body.
Free radical damage does not only cause cancer.
It also leads to inflammatory triggers.

By reducing the effects of free radicals, ellagic acid may help to reduce inflammatory responses.

In one study, the research looks at how the use of ellagic acid may be useful for inflammation affecting the skin.
Human skin cells and mice were considered in the study.
The researchers looked at more than just the anti-inflammatory potential of ellagic acid.
They also examined the effects of the compound on collagen production.

Collagen is an important compound in the body.
It helps to keep the skin tight and supple.

A topical solution containing ellagic acid was used in the study.
Hairless mice were administered with a topical solution and they were then exposed to UV light.
The study lasted for a period of eight weeks.

Inflammation was effectively prevented in the mice exposed to the UV light.
There was also a reduced breakdown of collagen compounds.
This shows that this acid may provide a way of reducing the risk of inflammation too.
Furthermore, when used as a topical product, it may also slow down the aging process effectively.

Obesity
It also seems like ellagic acid may be a good option for people with obesity.
Some research has suggested that the compound might help with the weight loss process.
In turn, it poses as a potential natural anti-obesity treatment.

A majority of the American population is already either overweight or obese.
This poses a significant range of health risks to these individuals.
People who are obese have a much higher risk of developing diabetes, heart disease, and even cancer.

At the moment, research related to the anti-obesity properties of ellagic acid is limited to animal studies.
They do, however, show that the compound has potential.
Further studies are also being conducted to determine if the same effects will be present in human subjects.

Some studies also show this acid might reduce the level of resistin.
These studies were on mice subjects.
Resistin is a type of hormone that holds a link to obesity.
It also links to diabetes and insulin resistance.
By reducing the production of resistin, people may find that they can lose weight more effectively.
The risk of developing insulin resistance, which can turn into diabetes, greatly reduces with the use of this acid.

IUPAC NAMES:
4,4 ′ ,5,5 ′ ,6,6 ′ - Hexahydroxydiphenic acid 2,6,2 ′ ,6 ′ - dilactone
4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone
6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione
[1,1'-Biphenyl]-2,2'-dicarboxylic acid, 4,4',5,5',6,6'-hexahydroxy-, di-d-lactone[1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione,1,2-dihydro-2,3,7,8-tetrahydroxy-[1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
ELLAGIC ACID
Ellagic acid
ellagic acid
Ellagic Acid Dihydrate

SYNONYMS:
eleagicacid
gallogen(astringent)
lagistase
TIMTEC-BB SBB006501
2,3,7,8-tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione
ELLAGIC ACID
BENZOARIC ACID
AKOS NCG1-0028
4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID 2,6,2',6'-DILACTONE
4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID DILACTONE
Ellagic acid hydrate technical grade
Ellagic acid, >=98%
TBBD
4,3-cde)(1)benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-(1)benzopyrano(
4,3-cde][1]benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-[1]-Benzopyrano[5
alizarineyellow
c.i.55005
c.i.75270
elagostasine
Ellagic acid 476-66-4
4,4,5,5-tetrahydroxybiphenyl-2,6:2,6-biscarbolactone
ellagic acid from chestnut bark
EllagicAcidDihydrate97%
EllagicAcid(NutgallPe)95%ByHplc
EllagicAcid99%
2,3,7,8-TETRAHYDROXY-CHROMENO[5,4,3-CDE]CHROMENE-5,10-DIONE
Ellagic
ELLAGICACID,95%(BULK
ELLAGIC ACID(RG)
2,3,7,8-Tetrahydroxy[1]benzopyrano[5,4,3-cde][1] benzopyran-5,7-dione
Ellagic acid 4,4’,5,5’,6,6’-Hexahydroxydiphenic acid 1,6,1’,6’-dilactone
ELLAGIC ACID 95%
ELLAGIC ACID anhydrous
[1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
Pomegranate fruit extract powder
Ellagic acid hydrate, 97%, may cont. up to 12% water
2,6,2′,6′-dilactone Ellagic acid hydrate
4,4′,5,5′,6,6′-Hexahydroxydiphenic acid
Ellagic Acid Hydrate, May Cont. up to 12% Water
Elllagic Acid
Punica Granatum Pericarp Extract
Ellagic Acid, Dihydrate - CAS 476-66-4 - Calbiochem
Ellagic Acid (TBBD)
Ellagic Acid Standard
Liposomal Ellagic Acid, Water-Soluble Ellagic Acid
ic acid hydrate
Gallogen fandachem
agic acid hydrate
ellagic acid
476-66-4
Benzoaric acid
Elagostasine
Lagistase
2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione
Eleagic acid
Alizarine Yellow
Gallogen
Llagic acid
Acide ellagique
Acido elagico
Acidum ellagicum
C.I. 55005
C.I. 75270
Ellagicacid
Ellagate
Gallogen, astringent
4,4',5,5',6,6'-hexahydroxydiphenic acid 2,6,2',6'-dilactone
2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione
tetrahydroxy[?]dione
Ellagic acid, 97%
NCGC00017245-02
DSSTox_CID_557
Ellagic acid hydrate
(1)Benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
DSSTox_RID_75657
DSSTox_GSID_20557
Gallogen (VAN)
Gallogen (astringent)
ellagic-acid
Pomegranate juice
[1]Benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
Ellagic acid [INN:DCF]
CAS-476-66-4
Acido elagico [INN-Spanish]
CCRIS 774
Acide ellagique [INN-French]
Acidum ellagicum [INN-Latin]
MFCD00149494
SR-01000721925
EINECS 207-508-3
Benzoarate
Ellagsaeure
Polyphenolic
Eleagate
Ellagic
Llagate
Elagic Acid
Ellagic acid, 96%
4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate
Spectrum_001194
Diphenic acid, 4,4',5,5',6,6'-hexahydroxy-, di-delta-lactone
Ellagic acid, >=96.0% (HPCE)
2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)-(1)benzopyran-5,10-dione
E0375
Ellagic Acid, Dihydrate - CAS 476-66-4
FT-0603405
H2736
C10788
MLS-0066664.0001
AB00052292_11
AB00052292_12
Q422044
SR-01000721925-3
SR-01000721925-4
SR-01000721925-5
SR-01000721925-6
SR-01000721925-7
W-202834
BRD-K30466858-001-05-4
Ellagic acid, primary pharmaceutical reference standard
Ellagic acid, >=95% (HPLC), powder, from tree bark
Diphenic acid,4',5,5',6,6'-hexahydroxy-, di-.delta.-lactone
2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione #
Diphenic acid, 4,4',5,5',6,6'-hexahydroxy-, di-.delta.-lactone
[1]Benzopyrano[5,3-cde][1]benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
2,3,7,8-Tetrahydroxy[1]benzopyrano-[5,4,3-cde][1]benzopyran-5,10-dione
[1,2'-dicarboxylic acid, 4,4',5,5',6,6'-hexahydroxy-, di-.delta.-lactone
(1,1'-Biphenyl)-2,2'-dicarboxylic acid, 4,4',5,5',6,6'-hexahydroxy-, di-.delta.-lactone
122328-15-8
6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione
6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),4,6,8(16),11,13-hexaene-3,10-dione