ETHANESULFONIC ACID SODIUM SALT

Ethanesulfonic acid sodium salt is a chemical compound that results from the reaction between ethanesulfonic acid and sodium hydroxide, producing a neutral sodium salt. 
Ethanesulfonic acid sodium salt belongs to the class of compounds known as organosulfonates, which are organic molecules containing a sulfonic acid group (–SO₃H) bonded to an alkyl or aryl group.
Ethanesulfonic acid sodium salt is an inorganic compound formed by the neutralization of ethanesulfonic acid with sodium hydroxide. 

CAS Number: 5324-47-0
Molecular Formula: C2H7NaO3S
Molecular Weight: 134.12
EINECS Number: 226-194-9

Synonyms: 5324-47-0, Sodium ethanesulphonate, EINECS 226-194-9, DTXSID20201335, NSC 2695, DTXCID20123826, 226-194-9, Sodium Ethanesulfonate, Ethanesulfonic Acid Sodium Salt, sodium;ethanesulfonate, ETHANESULFONIC ACID, SODIUM SALT, ethane sulfonic acid sodium salt, Sodium ethylsulfonate, MFCD00066498, SODIUM ESYLATE, sodium ethane sulfonate, SCHEMBL124278, Ethylsulfonic Acid Sodium Salt, KQFAFFYKLIBKDE-UHFFFAOYSA-M, AKOS027327434, AS-57759, CS-0206836, E0256, NS00081491, D78206, Ethanesulfonic acid sodium salt, 98%, may cont. ca 2% water, SODIUM ETHANESULFONATE;ETHYLSULFONIC ACID SODIUM SALT;ETHANESULFONIC ACID SODIUM SALT;sodium ethanesulphonate, Ethanesulfonicacidsodiumsalt,99%, Ethanesulfonic acid sodium salt, 98%, may cont. ca 2% water, Ethylsulfonic Acid Sodium Salt Ethanesulfonic Acid Sodium Salt, Sodium ethylsulfonate

Ethanesulfonic acid sodium salt is the hydrated sodium salt of ethanesulfonic acid.
The structure consists of a sulfonic acid group (-SO₃H) attached to an ethyl chain, where the acidic hydrogen is replaced by a sodium ion (Na⁺), making it a salt. 
This substitution makes the compound more water-soluble and often more chemically stable, which is important in laboratory and pharmaceutical applications.

Ethanesulfonic acid sodium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Ethanesulfonic acid sodium salt, also known as sodium ethanesulfonate, is the sodium salt form of ethanesulfonic acid, a small organosulfonic acid. 
Ethanesulfonic acid sodium salt is commonly used in pharmaceutical research and chemical synthesis as a reagent or intermediate.

It is commonly used as a buffering agent, counterion, or intermediate in organic synthesis and drug formulation. 
In some cases, it is used to form salts of pharmaceutical drugs, improving their solubility or stability in aqueous solutions. 
Although not a widely known household chemical, it plays a vital role in specialized chemical environments, particularly in analytical chemistry and chemical manufacturing.

In the case of ethanesulfonic acid sodium salt, the molecule consists of a two-carbon alkyl chain (ethane) attached to a sulfonic acid group, which has been neutralized by replacing the hydrogen ion (H⁺) with a sodium ion (Na⁺). 
This gives it improved solubility in water and polar solvents, making it a useful additive or reagent in various chemical processes.
Ethanesulfonic acid sodium salt is commonly used in laboratory chemistry, pharmaceutical development, and analytical testing. 

In pharmaceutical research, it is sometimes used to form drug salts, where the active pharmaceutical ingredient (API) is converted into a sodium ethanesulfonate salt to enhance its bioavailability, solubility, or stability. 
Salt formation is a common strategy in drug formulation, especially when a compound needs to dissolve quickly in the body or remain stable over time.
Ethanesulfonic acid sodium salt, also referred to by names like sodium ethanesulfonate or sodium ethylsulfonate, has the molecular formula C₂H₅NaO₃S. 

Ethanesulfonic acid sodium salt consists of a two-carbon alkyl chain (ethane) bonded to a sulfonic acid group (–SO₃H), where the hydrogen ion has been replaced by a sodium ion (Na⁺). 
The presence of the sulfonic acid group makes this molecule a strong acid in its original form (ethanesulfonic acid), but when converted into a sodium salt, it becomes non-acidic, making it suitable for different chemical environments.
Due to the ionic nature of the sulfonate group and the presence of the sodium ion, the compound is highly soluble in water and other polar solvents. 

This property is particularly important in chemical reactions and drug formulations that require water-soluble components.
In pharmaceutical development, ethanesulfonic acid sodium salt is often used to form salt versions of drug molecules.
Many drugs are originally synthesized as free acids or bases, which may not have ideal properties for absorption in the body. 

By converting these drugs into sodium ethanesulfonate salts, scientists can improve their solubility, stability, and absorption (bioavailability).
For example, a poorly soluble drug might be difficult for the body to absorb. 
By creating a salt with ethanesulfonic acid (which is highly soluble), the drug can be more easily dissolved in the bloodstream, leading to better therapeutic effects. 

This process is known as salt screening and is a standard method used during the early stages of drug formulation.
Additionally, ethanesulfonic acid sodium salt may be used as a counterion to balance the charge of ionizable drugs or molecules in injectable or oral formulations, helping to ensure compatibility with bodily fluids or other formulation ingredients.

Melting point: 267-270°C (dec.)
form: Powder
color: White
Sensitive: Hygroscopic

Ethanesulfonic acid sodium salt, is a zwitterionic buffer commonly used in biological and biochemical research.
In the life science field, Ethanesulfonic acid sodium salt is primarily utilized as a buffering agent to maintain a stable pH in various experimental procedures. 
Ethanesulfonic acid sodium salt is particularly effective in the pH range of 5.5 to 6.7, making it suitable for applications requiring slightly acidic to neutral pH conditions. 

Ethanesulfonic acid sodium salt is commonly used in protein purification, enzyme assays, and electrophoresis techniques where a specific pH range needs to be maintained. 
Its buffering capacity and stability within the desired pH range make it valuable in these applications. 
One of the significant advantages of Ethanesulfonic acid sodium salt is its compatibility with biological systems and enzymes. 

Ethanesulfonic acid sodium salt exhibits minimal interference with enzymatic activity and other biological processes, ensuring reliable and accurate results. 
In addition, Ethanesulfonic acid sodium salt can serve as a buffer component or a reactant in organic synthesis. 
It helps maintain pH levels in chemical reactions and may act as a source of the ethanesulfonate group, which can be incorporated into other molecules for research or industrial applications.

From a chemical perspective, it is considered non-volatile, stable, and relatively non-reactive under normal laboratory conditions. 
These properties make it a convenient and safe compound to handle in standard chemical environments.
In analytical chemistry, Ethanesulfonic acid sodium salt is used as a buffering agent in certain applications, particularly where strong acid or strong base behavior is required in a controlled manner. 

Ethanesulfonic acid sodium salts predictable dissociation and pKa value make it suitable for maintaining pH stability in some chemical reactions or tests.
In organic synthesis, it may be used as a source of sulfonate groups for the modification of other organic molecules. 
The ethanesulfonyl group can be introduced into target molecules to enhance water solubility, add reactivity, or alter chemical behavior in a desired way.

Ethanesulfonic acid sodium salt is typically considered chemically stable, non-volatile, and low in toxicity when handled properly. 
Its stability means it can be stored for extended periods without significant decomposition, and it poses low flammability risk. 

Ethanesulfonic acid sodium salt does not easily react with other common laboratory chemicals under normal conditions.
However, as with any chemical compound, appropriate handling precautions should be observed, including the use of gloves, eye protection, and adequate ventilation when working with it in powdered or concentrated solution form.

Uses:
Ethanesulfonic acid sodium salt is used in preparation of pyridazinone derivatives in the treatment of disease.
One of the most important uses of Ethanesulfonic acid sodium salt is in the pharmaceutical industry, where it is employed to create pharmaceutically acceptable salt forms of active pharmaceutical ingredients (APIs). 
Many drug molecules in their original, free-base or free-acid forms may suffer from poor solubility, low stability, or limited bioavailability, which can hinder their effectiveness inside the body. 

By reacting these drugs with ethanesulfonic acid to form ethanesulfonate salts (also known as esylates), pharmaceutical scientists can improve the drug’s solubility in water, allowing it to dissolve more easily in bodily fluids, which in turn enhances absorption into the bloodstream.
Ethanesulfonic acid sodium salt is especially favored when a non-volatile, strong acidic component is needed to balance a basic drug, and it is often used during the salt screening process, where different acid or base pairs are tested to optimize a drug’s physical and chemical properties. 
Additionally, ethanesulfonic acid sodium salt can contribute to greater shelf stability, ensuring that drugs maintain their potency and effectiveness over time without breaking down under typical storage conditions.

In laboratory settings, ethanesulfonic acid sodium salt is sometimes used as a buffering agent, especially in chemical reactions that require tight control over pH levels.
Because the sulfonic acid group is a strong acid, its conjugate base (the sodium salt) provides a stable anionic species that does not easily interfere with many chemical or biological reactions. 
This makes it useful for maintaining pH balance in aqueous solutions, particularly in experiments that are sensitive to even slight changes in acidity or alkalinity.

Such buffering capacity can be valuable in protein purification, enzyme assays, and cell culture, where a stable pH is essential for the proper function of biological molecules or living cells.
In the field of organic synthesis, Ethanesulfonic acid sodium salt can be used as an intermediate or a reagent in the preparation of other sulfonated compounds. 
Ethanesulfonic acid sodium salt serves as a source of the ethanesulfonate group (–SO₃CH₂CH₃), which can be transferred to other molecules to introduce hydrophilic (water-attracting) functional groups. 

This modification is especially useful when designing compounds that need to be more soluble in water or more reactive under specific conditions, such as during catalytic reactions or polymer production.
Furthermore, it can be used to derivatize other chemicals, helping to change or control their reactivity, solubility, or polarity in synthetic pathways.
In analytical chemistry, ethanesulfonic acid sodium salt is sometimes used as a counterion in chromatography or spectroscopic methods. 

Ethanesulfonic acid sodium salt may help stabilize ionic species in solution, reduce background noise, or adjust ion strength for more precise measurements. 
Its well-characterized chemical behavior, non-volatility, and minimal UV absorbance make it suitable for sensitive techniques such as high-performance liquid chromatography (HPLC), where clean and stable baseline signals are essential for accurate analysis.
Although less common, ethanesulfonic acid sodium salt may find applications in electrochemical research or battery technologies, where sulfonic acid derivatives are used as conductive materials or ionic dopants. 

In industrial processes, sulfonates such as this one can be added to detergents, dyes, or lubricants to modify surface properties, enhance solubility, or improve chemical compatibility. 
However, in this context, simpler and more cost-effective sulfonates (like methanesulfonates or toluenesulfonates) are more commonly used.
In environmental testing, ethanesulfonic acid sodium salt may be utilized in buffer solutions and extraction protocols, especially when analyzing pollutants or toxins that require controlled pH levels for accurate detection. 

Ethanesulfonic acid sodium salt may also play a role in biochemical assays where sulfonate-based buffering systems are needed to preserve enzyme activity or maintain protein structure under experimental conditions. 
Its inertness and predictable dissociation behavior make it a useful tool in molecular biology, where even minor pH shifts can alter enzymatic reaction rates or DNA stability.
In drug development, the transformation of an active pharmaceutical ingredient (API) into a salt form using ethanesulfonic acid (as its sodium salt) is not merely about solubility; it is also a strategic decision that impacts the drug’s stability during manufacturing, its crystallinity (which affects formulation), and its rate of dissolution in biological environments. 

For example, when a drug is made into its ethanesulfonate (esylate) salt, it often acquires better thermal stability, allowing it to be processed at higher temperatures without degradation, and may exhibit favorable polymorphic behavior, meaning it can exist in a predictable and uniform crystal form, which is essential for consistent bioavailability and patent protection.
By altering the ionic form of a drug through the inclusion of ethanesulfonic acid sodium salt, pharmaceutical chemists can directly influence pharmacokinetic parameters, such as absorption rate, distribution in body tissues, and clearance from the body. 

The sodium ethanesulfonate form often creates an environmentally stable, ionized version of the drug that dissolves quickly in the gastrointestinal tract, leading to faster onset of action or more efficient drug delivery, especially for drugs that are otherwise poorly soluble in water or prone to degradation in acidic stomach conditions.
Due to its excellent aqueous solubility and low toxicity profile, ethanesulfonic acid sodium salt is also useful in the formulation of injectable drug products, where solubility, sterility, and pH compatibility are absolutely critical. 

In injectable formulations, every component must be biocompatible and free from irritation, and Ethanesulfonic acid sodium salt fits that need well, offering a stable counterion that does not interact negatively with the drug or the body. 
Ethanesulfonic acid sodium salt is also used in infusion solutions, where it helps maintain the stability of sensitive ingredients or balance the ionic strength of the solution.

Similar to its role in human medicine, ethanesulfonic acid sodium salt is sometimes employed in the formulation of veterinary drugs, particularly in animals where water-soluble medications are required for oral, injectable, or topical use. 
Since livestock and companion animals often receive medications via feed, water, or injection, formulations based on water-soluble salts like sodium ethanesulfonate offer practical advantages in terms of ease of administration and absorption.

Safety Profile:
Although Ethanesulfonic acid sodium salt is not highly toxic, direct exposure to its solid form or concentrated solutions can cause irritation to the skin, eyes, and respiratory tract. 
If the powder is inhaled—especially in large amounts or over prolonged periods—it may irritate the mucous membranes of the nose and throat, leading to symptoms such as coughing, sneezing, or mild respiratory discomfort.

In the event of skin contact, it may cause mild redness or dryness, especially with repeated or prolonged exposure. 
If the substance comes into contact with the eyes, it can cause stinging, watering, or temporary discomfort, so the use of eye protection is recommended when handling it in bulk.
Ingestion of the compound, though unlikely in controlled environments, could cause mild gastrointestinal upset due to the compound’s acidic nature and the presence of sodium ions. 

However, its acute oral toxicity is considered low, and accidental small exposures are generally not considered life-threatening.
Ethanesulfonic acid sodium salt is not known to be acutely toxic to aquatic life, but like many sodium salts, if released in large quantities, it could disrupt the ionic balance of water ecosystems, especially in small or closed aquatic environments. 
Ethanesulfonic acid sodium salt is generally not classified as environmentally hazardous, but proper disposal methods should still be followed to avoid accumulation in soil or water systems, particularly in areas where it could affect sensitive species.

Ethanesulfonic acid sodium salt is not flammable and does not support combustion. 
It is considered stable under normal storage and handling conditions, and it does not readily decompose or react with most other common laboratory reagents. 

However, heating it to decomposition (extremely high temperatures) may release sulfur oxides (SO₂, SO₃) and irritating fumes, which are harmful if inhaled.
Because it is a strongly ionic compound, it should not be mixed with strong oxidizing agents or strong acids, as this may produce heat or lead to decomposition reactions that generate hazardous gases.