Quick Search



Linear Formula: HOC6H4CO2C2H5
CAS Number: 120-47-8
Molecular Weight:1 66.17
Beilstein: 1101972
EC Number: 204-399-4
MDL number: MFCD00002353
Formula: C9H10O3

Ethylparaben is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol.
Ethylparaben has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen. 
Ethylparaben is a paraben and an ethyl ester.
Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
Ethylparaben is a natural product found in Ulva australis, Andrographis paniculata, and other organisms with data available.

Ethylparaben is the ethyl ester of p-hydroxybenzoic acid. 
Ethylparaben's formula is HO-C6H4-CO-O-CH2CH3. 
Ethylparaben is a member of the class of compounds known as parabens.

Ethylparaben is used as an antifungal preservative. As a food additive, it has E number E214.
Sodium ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215.
Ethyl paraben is an ethyl ester. 
Ethylparaben has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen.

Description of Ethylparaben
Ethylparaben is produced naturally and found in several fruits and insects, where it acts as an antimicrobial agent. 
Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine (E number E214). 
Ethylparaben is also can be used as feed preservatives and antiseptic for bacteria. 
Ethylparaben is readily absorbed from the gastrointestinal tract or through the skin. 
Ethylparaben is hydrolyzed to p-hydroxybenzoic acid and rapidly excreted in urine without accumulating in the body. 
Under the Federal Food, Drug, and Cosmetic Act (FD&C Act), cosmetic products and ingredients, other than color additives, do not need FDA approval before they go on the market. 
Broad concentration ranges reported in each product category in 1981 were < 0.1% and > 0.1% to 1%. Studies show the in vivo estrogenicity of MP and EP at human exposure levels, and indicate that populations exposed to large amounts of MP and EP may have a high burden of estrogenicity-related diseases.
Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive

USES & APPLICATIONS of Ethylparaben
Antimicrobial commonly used in toothpasteCosmetics: 
Antimicrobial used in mascara, eye liner and eye shadow
At-a-Glance Acme-Hardesty ethylparaben is prized for its antimicrobial properties. 
Ethylparaben is most commonly used in the manufacture of personal care products and cosmetics, in which it prevents the buildup of yeast and fungus, extending the shelf life of volatile products.
To support these and other applications, Acme-Hardesty ethyl paraben is available in NF-grade classification. 
Our product is non-irritating and has a low toxicity level. 
As a result, Ethylparaben can be used in a wide range of commercial products where, in low concentrations, Ethylparaben is an effective preventer of bacteria and fungus.

Molecular Weight: 166.17
Formula    : C9H10O3
CAS No.: 120-47-8

Properties of Ethylparaben
Chemical formula: C9H10O3
Molar mass: 166.176 g·mol−1
Melting point: 115 to 118 °C (239 to 244 °F; 388 to 391 K)
Boiling point: 297 to 298 °C (567 to 568 °F; 570 to 571 K)

Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative and food additive. 
Ethylparaben is a standardized chemical allergen. 
The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.
Ethylparaben has weak estrogenic and weak anti-androgenic effects in vitro.

In vivo    In vivo studies indicate that ethylparaben has estrogenic effects in vivo in immature and ovariotectomized mice. 
A study on fetal exposure to ethylparaben revealed no changes in male anogenital distance and no changes of fetal testosterone production, but changes in gene expression levels pointed to subtle endocrine disrupting effects. 
A limited study in young male rats found no adverse effects, although tendencies to lower sperm counts are seen. Ethylparaben causes vitellogenin induction in fish.

Chemical Information of Ethylparaben
Molecular Weight: 166.17
Formula    : C9H10O3

CAS No.: 120-47-8
3 years    -20°C    powder
2 years    -80°C    in solvent

What Are The Functions Of Ethylparaben?
Ethylparaben functions as a preservative in cosmetics and skincare products. 
In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%. 
The use of preservatives is necessary to prevent microbial contamination, as well as to prevent the product from degrading or going rancid. 
Preservatives like ethylparaben are vital to the safety of a formulation. 

Skincare are highly susceptible to microbial contamination and growth. 
The most susceptible products are creams and lotions that are packaged in jars, opened frequently, and applied to the skin with the fingers. 
Further, by limiting the growth of bacteria and fungi, preservatives like isobutylparaben help keep us safe from infection and other diseases. 
It’s true that skin already acts as a barrier, but if contaminated creams are applied to the skin, an inflammatory response can be elicited, and lead to skin damage in the long term. 
In addition, bacteria can easily invade our bodies if contaminated product is applied to broken skin, or if small amounts of contaminated lipstick or lip balm are accidentally ingested through the mouth.

Increased shelf-life 
Parabens help to stabilize the formulation of a product, increasing its shelf-life. 
Without preservatives, most skincare or cosmetic products would only last 2-4 weeks before going rancid. 

In many ways, the inclusion of such preservatives is indispensable in our day and age. We often take for granted how cheaply some skin care products can be purchased, and the fact that we don’t have to waste money throwing away too many expired products in the trash. 
In many ways, this is achieved through the use of parabens and other preservatives.

Description of Ethylparaben
Ethyl paraben (ethyl para hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid. 
Ethylparaben's formula is HO-C6H4-CO-O-CH2CH3. It is a member of the class of compounds known as parabens.

Ethylparaben is used as an antifungal preservative. 
As a food additive, Ethylparaben has E number E214.

Product Description of Ethylparaben
Ethyl Paraben (120-47-8) is white crystalline. 
Ethylparaben is also known as Ethyl 4-hydroxybenzoate, Ethyl parahydroxybenzoate;, Ethyl para-hydroxybenzoate and 4-Hydroxybenzoic acid ethyl ester.

Keep container tightly closed. 
Keep container in a cool, well-ventilated area.

Waste Disposal: 
Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Accidental Release Measures: 
Eliminate all ignition sources (if Flammable). 
Dispose of according to local and regional authority requirements.

Product Description of Ethylparaben
Catalogue Number: E925478
Chemical Name:Ethyl Paraben-d4
CAS Number: 1219795-53-5
Molecular Formula: C9H6D4O3
Appearance: White to Off-White Solid
Melting Point: 115-117°C
Molecular Weigh: t170.2
Storage: Refrigerator
Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
Category: Building Blocks; Isotopic Labeled Analogues; Miscellaneous;
Applications: Ethyl Paraben-d4 is the labeled analogue of Ethyl Paraben (E925475), an antimicrobial agent used in cosmetic products.

Computed Propertie of Ethylparaben
Molecular Weight: 166.17    
XLogP3: 2.5    
Hydrogen Bond Donor Count: 1    
Hydrogen Bond Acceptor Count: 3    
Rotatable Bond Count: 3    
Exact Mass: 166.062994177    
Monoisotopic Mass: 166.062994177    
Topological Polar Surface Area: 46.5 Ų    
Heavy Atom Count: 12    
Formal Charge: 0    
Complexity: 148    
Isotope Atom Count: 0    
Defined Atom Stereocenter Count: 0    
Undefined Atom Stereocenter Count: 0    
Defined Bond Stereocenter Count: 0    
Undefined Bond Stereocenter Count: 0    
Covalently-Bonded Unit Count: 1    
Compound Is Canonicalized: Yes    

Product Information
Name:Ethyl Paraben
Applications An antimicrobial agent used in cosmetic products.
Long term storage:Refrigerator

Chemical properties of Ethylparaben
Molecular weight:166.17
Color/Form: White to Off-White Solid
InChI key:
Melting point: 105-107°C
HS code: 2918.29.7500
Hazard Info
H Statements:
H219: H219
H303: May be harmful if swallowed.
H401: Toxic to aquatic life.

Technical Information of Ethylparaben
Safety Information    
SDS & Certificate of Analysis
Physical State :Solid
Solubility :Soluble in chloroform.
Storage :Store at 4° C
Melting Point :116-118° C
Boiling Point :~297.5° C at 760 mmHg (Predicted)
Density :1.291 g/cm3
Refractive Index :n20D 1.54 (Predicted)

Ethylparaben Description
Parabens are a group of controversial preservatives that include butylparaben, isobutylparaben, propylparaben, methylparaben, and ethylparaben. 
All of these were at one time the most widely used group of preservatives used in cosmetics. 
Parabens were so popular because of their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives but also because they were derived naturally from plants, a rare phenomenon for a preservative. 
Parabens are found in plants in the form of p-hydroxybenzoic acid (PHBA), a chemical that breaks down to become parabens for a plants own protection.
Over the past 10 years parabens have become criticized and condemned for use in cosmetics due to their alleged relation to health concerns affecting women and men. 
The research about parabens is conflicting and polarizing. Some research indicates they are safe as used in cosmetics and are preferred over other preservatives to keep a formula stable. 
These studies also showed parabens did not have any effect when compared to natural hormones in the body.

What Is Ethylparaben?
Ethylparaben is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
Ethylparaben is the ethyl ester of p-hydroxybenzoic acid. 
Ethylparaben is a member of the class of compounds known as parabens. Other common parabens include methylparaben, butylparaben, isobutylparaben, and propylparaben. 
Ethylparaben is used to extend the shelf-life of a product life by preventing microbial contamination. 
Microbial contamination can occur from exposure to bacteria and molds in the air and general use of the product from your hands.
Preservatives like parabens are designed to reduce the likelihood that bacteria and molds can grow in your product. 
This is important for ensuring the safety of a product. 
At one time, parabens were the most widely used group of preservatives in cosmetic products. 
The reason why parabens were so popular is due to their gentle, non-sensitizing, and highly effective profile in comparison to other preservatives. 
However, more recently they have been the topic of some controversy over claims that they can disrupt your hormones. 
While this claim isn’t backed by the research it has scarred the reputation of parabens. 

An ethyl ester of p-hydroxybenzoic acid, ethylparaben is primarily used as an antifungal preservative in food and other applications. 
Ethylparaben is also used extensively in the cosmetics industry as a preservative in everything from body lotion and skin cream to deodorant and antiperspirant. 
Ethylparaben is also added to essential oils to provide additional stability, and it is rare to find cosmetics that do not contain some form of ethylparaben as a means of preserving their contents over time and preventing the growth of fungus and bacteria. 
In terms of toxicity, there has been a considerable amount of debate in the cosmetics industry and the medical industry as to the carcinogenic nature of ethylparaben, though independent experts and the US FDA have both determined through extensive research that the levels of ethylparaben in cosmetics present an extremely low risk of being carcinogenic. 
To date, no strong evidence has been found that demonstrates that ethylparaben causes cancer in human beings.

Uses & Benefits of Ethylparaben
Parabens have been safely used for almost 100 years as preservatives in the food, drug and personal care and cosmetic industries.
Parabens (including methylparaben, ethylparaben, propylparaben, butylparaben, isopropylparaben, and isobutylparaben) may be used in products such as makeup, moisturizers, and hair care and shaving products. 
Contrary to some reports, most major brands of deodorants and antiperspirants no longer contain parabens.

Preservatives like parabens may be used in cosmetics to protect against microbial (e.g., bacteria, fungus) growth, both to protect consumers and to maintain product integrity.
In the food industry, parabens have been used for more than 50 years as preservatives and anti-microbial agents. Some fruits, such as blueberries, contain parabens as a naturally occurring preservative. 
Parabens are widely used in confectioneries, cereal-based snacks, dried meats, and much more.

PROPERTIES of Ethylparaben
Predicted Properties
Water Solubility: 2.49 mg/mL    ALOGPS
logP: 2.76    
logP: 2.03    
logS: -1.8    
pKa (Strongest Acidic): 8.5    
pKa (Strongest Basic): -6.1    
Physiological Charge: 0
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1    
Polar Surface Area: 46.53 Å2    
Rotatable Bond Count: 3    
Refractivity: 44.81 m3·mol-1    
Polarizability: 17.23 Å3    
Number of Rings: 1    
Bioavailability: 1    
Rule of Five: Yes    
Ghose Filter: Yes    
Veber's Rule: No    
MDDR-like Rule: No    

Ethyl-4-hydroxybenzoate (ethyl paraben) along with the other esters of p-hydroxybenzoate (parabens) are the most widely used preservatives in food, drugs, and cosmetics.

Catalogue number:PA PST 006470
Chemical name:    Ethyl paraben
CAS Number:
Molecular form:    C9H10O3
Appearance: Off-White Solid
Mol. Weight: 166.17
Storage: 2-8°C Refrigerator
Shipping Conditions: Ambient
Applications: NA

Product description
Preservative for the cosmetic industry. It is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries and topical pharmaceuticals. 
Ethylparaben remains fully stable over a wide pH range from 4- 8. 
In general the lower the pH of the formula-tion, the more active it is. That can result in a lower use concentration when the pH of the formulation is more acidic.
Fully stable over a wide pH range from 4- 8. In general the lower the pH of the formula-tion, the more active it is. 
That can result in a lower use concentration when the pH of the formulation is more acidic.

Ethyl 4-hydroxybenzoate (ethylparaben) was used to study the in-situderivatisation solid-phase microextraction procedure for determining parabens, related chlorophenols and triclosan in water. 
Ethylparaben is a novel sorbent for solid-phase extraction, was used to study its retention property. It has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding.

Common Name: Ethylparaben
Class: Small Molecule
Ethylparaben is found in alcoholic beverages. Ethylparaben is an antimicrobial agent, preservative. 
Ethylparaben is present in red wine, white wine and sake. Ethylparaben belongs to the family of Hydroxybenzoic Acid Derivatives. 
These are compounds containing an hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxylic acid.
Compound Type    
Food Toxin
Household Toxin
Industrial/Workplace Toxin
Organic Compound
Synthetic Compound

ClassyFire Taxonomy
Ethylparaben belongs to the class of organic compounds known as p-hydroxybenzoic acid alkyl esters. 
These are aromatic compounds containing a benzoic acid, which is esterified with an alkyl group and para-substituted with a hydroxyl group.
Kingdom    Organic: compounds
Super Class: Benzenoids
Class: Benzene and substituted derivatives
Sub Class: Benzoic acids and derivatives
Direct Parent: p-Hydroxybenzoic acid alkyl esters
Alternative Parents    
Benzoyl derivatives
1-hydroxy-2-unsubstituted benzenoids
Carboxylic acid esters
Monocarboxylic acids and derivatives
Organooxygen compounds
Organic oxides
Hydrocarbon derivatives

What is Ethylparaben?
Ethylparaben is an ethyl ester of Para-hydroxy benzoic acid. It comes as small colorless crystals or powder.

Use & Benefits of Ethylparaben: 
Parabens are the class of drug, used for many years in cosmetics as a preservative. 
Ethylparaben prevents the growth of bacteria and fungi. 
Usually, when product encounters unfavorable conditions like humidity, temperature, and/or sunlight, there are chances product may get decompose or separated or fungi or bacteria can develop. 
So, the preservatives are crucial for maintaining the product with the exact same quality throughout the shelf life. 
In the lower dose, the parabens are considered safe to use and non-irritant. 
Ethylparaben is used as a preservative in not only in cosmetics, adhesives, and pharmaceuticals.

Chemical Properties of Ethylparaben
Appearance: White crystalline powder
Boiling Point: 297–298 °C
CAS Number: 120-47-8
HS Code    29182930
IUPAC Name: Ethyl 4-Hydroxybenzoate
InChI: 1S/C9H10O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6,10H,2H2,1H3
Melting Point: 115–118 °C
Molar Mass: 166.17 g/mol
Molecular Formula: C9H10O3
RTECS Number: DH2190000
Related Compounds: Paraben;Butylparaben;Methylparaben;Propylparaben

Ethylparaben Biological Activity
Description: Ethylparaben is the ethyl ester of p-hydroxybenzoic acid, used as an antifungal preservative. and food additive
Related Catalog    
Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Others
1 mM    6.0179 mL    30.0897 mL    60.1793 mL
5 mM    1.2036 mL    6.0179 mL    12.0359 mL
10 mM    0.6018 mL    3.0090 mL    6.0179 mL

Powder    -20°C    3 years

Related Molecules    
Puromycin dihydrochloride 
Hygromycin B 
Avibactam sodium 
Neomycin sulfate 
Methicillin SodiuM 
Carbenicillin disodium 
Eravacycline dihydrochloride 
cefotaxime sodium
Chemical & Physical Properties
Density    1.2±0.1 g/cm3
Boiling Point: 297.5±0.0 °C at 760 mmHg
Melting Point: 114-117 °C(lit.)
Molecular Formula: C9H10O3
Molecular Weight: 166.174
Flash Point: 120.3±12.6 °C
Exact Mass: 166.062988
PSA: 46.53000
Vapour Pressure    0.0±0.6 mmHg at 25°C
Index of Refraction    1.539
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases

Synonyms of Ethylparaben    
Ethyl paraben
Ethyl p-hydroxybenzoate
4-Hydroxybenzoic acid ethyl ester
Ethyl parasept
Tegosept E
Nipagin A
Ethyl parahydroxybenzoate
Ethyl butex
p-Hydroxybenzoic acid ethyl ester
Aseptoform E
Napagin A
Nipazin A
Solbrol A
Sobrol A
Ethyl p-oxybenzoate
Benzoic acid, 4-hydroxy-, ethyl ester
Mekkings E
Aseptin A
Bonomold OE
Ethyl para-hydroxybenzoate
4-Hydroxy-benzoic acid ethyl ester
NSC 23514
p-Hydroxybenzoate ethyl ester
Ethylparaben [NF]
4-Hydroxybenzoic acid, ethyl ester
Para-hydroxybenzoic acid ethyl ester
Ethylester kyseliny p-hydroxybenzoove
Ester etylowykwasu p-hydroksybenzoesowego
Ethylparaben (NF)
Caswell No. 447
p-Hydroxybenzoic acid, ethyl ester
HSDB 938
EINECS 204-399-4
p-Oxybenzoesaeureaethylester [German]
EPA Pesticide Chemical Code 061202
BRN 1101972
Ethyl chemosept
Aseptine a
Nipagina A
Ethylester kyseliny p-hydroxybenzoove [Czech]
Ester etylowykwasu p-hydroksybenzoesowego [Polish]
Ethylis hydroxybenzoas
Ins no.214
Ethyl 4-hydroxy-benzoate
Ethyl 4-hydroxyl-benzoate
Ethylparaben, INN, USAN
EC 204-399-4
p-Hydroxybenzoic ethyl ester
4-10-00-00367 (Beilstein Handbook Reference)
Ethyl 4-Hydroxybenzoate,(S)
Ethyl parahydroxybenzoate (TN)
Ethyl parahydroxybenzoate e214
ethyl 4-hydroxybenzenecarboxylate
4-hydroxybenzoic acid-ethyl ester
Ethyl parahydroxybenzoate (JP17)
Parahydroxybenzoic acid ethyl ester
4-hydroxy benzoic acid ethyl ester
Ethyl 4-hydroxybenzoate, ReagentPlus(R), 99%

  • Share !