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CAS NO:643-79-8
EC NO:211-402-2
Phthalaldehyde (sometimes also o-phthalaldehyde or ortho-phthalaldehyde, OPA) is the chemical compound with the formula C6H4(CHO)2.
Phthalaldehyde is one of three isomers of benzene dicarbaldehyde, related to phthalic acid. This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids. OPA dissolves in water solution at pH < 11.5. Its solutions degrade upon UV illumination and exposure to air.
Properties:
Chemical formula: C8H6O2
Molar mass: 134.134 g·mol−1
Appearance: Yellow solid
Density: 1.19 g/mL
Melting point: 55.5 to 56 °C (131.9 to 132.8 °F; 328.6 to 329.1 K)[2]
Boiling point: 266.1 °C (511.0 °F; 539.2 K)
Solubility in water: Low
Phthalaldehyde is a dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.
Phthalaldehyde has a role as an epitope.
Phthalaldehyde is a dialdehyde and a member of benzaldehydes.
A reagent that forms fluorescent conjugation products with primary amines.
Phthalaldehyde is used for the detection of many biogenic amines, peptides, and proteins in nanogram quantities in body fluids.
-Used as a disinfectant and in the fluorometric determination of primary amines and thiols;
-Used to sterilize medical and dental equipment, as an enzyme inhibitor, indicator, chemical intermediate, diagnostic agent, tanning agent for leather, in water treatment, pulp and paper manufacturing, oil field water flooding, hair colorings, wood treatment, and antifouling paints.
Physicochemical Information:
Boiling point: 83 - 84 °C (1 hPa)
Density: 1.13 g/cm3 (20 °C)
Flash point: 132 °C
Ignition temperature: 480 °C
Melting Point: 55 - 56 °C
pH value: 7 (53 g/l, H₂O, 20 °C)
Vapor pressure: 0.33 Pa (20 °C)
Bulk density: 530 kg/m3
Solubility: 53 g/l
Phthaldialdehyde is used as a fluorescent reagent for checking the assay of amines present in proteins, peptides by capillary electrophoresis and chromatography.
Phthaldialdehyde is also used for cholesterol assay in the picomole range as well as for fluorometric determination of histamine, histidine and other amino acids.
Phthaldialdehyde is used as a fluorescent reagent for checking the assay of amines present in proteins, peptides by capillary electrophoresis and chromatography.
Phthaldialdehyde is also used for cholesterol assay in the picomole range as well as for fluorometric determination of histamine, histidine and other amino acids.
Phthaldialdehyde is obtained by the polymerization reaction which is used to make a photoresist. The nitrogen by o-phthaldialdehyde assay (NOPA) is a method used in winemaking process to measure the completion of fermentation.
General description
Phthaldialdehyde, also known as o-Phthalaldehyde or OPA, is a pre-column (HPLC) derivatization reagent. OPA reacts with primary amino acids (AA) except cystine to form highly fluorescent adducts. The fluorescence of the derivatives is monitored at excitation and emission wavelengths of 345nm and 455nm, respectively. The HPLC technique efficiently separates the OPA-AA derivatives.
Application
Phthaldialdehyde or OPA determines amino acids in proteins from animal tissue and food samples. Quantification of amino acids adducts of tyramine and phenylethylamine produced by lactic acid bacteria used OPA as the pre-column derivative reagent for HPLC. Intracellular forms of glutathione (GSH/GSSG) are investigated using o-Phthalaldehyde as the pre-column fluorescent agent.
Uses
1. Phthaldialdehyde is a pharmaceutical intermediate.
Phthaldialdehyde is the latest external efficient and safe antibacterial disinfectant.
Phthaldialdehyde is used as a disinfection and sterilization of endoscopic surgical instruments in hospitals.
Phthaldialdehyde can be used to synthesize a new anti-platelet aggregation drug indolebofen.
Phthaldialdehyde is also an analytical reagent in the chemical field.
3, yellow needle crystal, mainly used in medicine, dyes, etc. Amino acid derivative reagent, fluorescence detection, the reaction can be completed in one minute, but the product is unstable and needs to be detected immediately.
4, mainly used in medicine, dyes, amino acid derivative reagents, etc.
5, amine alkaloid reagents, used for fluorescence determination of primary amines and peptide bond decomposition products. Organic synthesis.?
6. Reagents for amine alkaloids, used for fluorescence determination of primary amines and peptide bond decomposers; suitable for pre-column derivatization of amino acids in high performance liquid chromatography separation; used for measurement of protein sulfhydryl by flow cytometry
7, 1 chemical field analysis reagent: as an amine alkaloid reagent, used for fluorescence determination of primary amines and peptide bond decomposition products. 2. Organic synthesis: It is also a pharmaceutical intermediate 3. Fluorescent reagent, used for pre-column HPLC separation of amino acid derivatives, flow cytometry to measure the thiol groups of proteins.
8, for medical inspection
Phthalaldehyde is a compound that reacts with primary amines to produce a product that emits a highly fluorescent blue colour.
Phthalaldehyde is used for the quick visualization of histamine, characterized by the appearance of a yellow stain.
Chemical Properties
Phthaldialdehyde is a pale yellow crystalline solid.
Phthaldialdehyde is mainly used as a high-level disinfectant (a low-temperature chemical method) for heat-sensitive medical and dental equipment such as endoscopes and thermometers; in recent years, it has gained popularity as a safe and better alternative to glutaraldehyde.
There are some researches show, pH7.5 contains the sterilizing agent of o-phthalaldehyde 0.5%, and its sterilizing power, sterilization speed, stability and toxicity all are better than glutaraldehyde, can kill mycobacterium in the 5min, the bacterium number reduces by 5 logarithmic value, and o-phthalaldehyde is very stable, tasteless in pH3～9 scopes, non-stimulated to human nose, eye mucosa, and need not activate before using, various materials are had good consistency, have tangible microbiocidal activity.
Uses
Phthaldialdehyde can be widely used for precolumn derivatization of amino acids in HPLC separation or Capillary electrophoresis. For flow cytometric measurements of protein thiol groups.
Uses
Phthaldialdehyde can be used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups.
Uses
Precolumn derivatization reagent for primary amines and amino acids. The fluorescent derivative can be detected by reverse-phase HPLC. The reaction requires OPA, primary amine and a sulfhydryl. In the presence of excess sulfhydryl, amines can be quantitated. In the presence of excess amine, sulfhydryls can be quantitated.
Uses
Disinfectant. Reagent in fluorometric determination of primary amines and thiols.
Preparation
Phthaldialdehyde is a high-level chemical disinfectant that is commonly used for disinfection of dental and medical instruments as an alternative to glutaraldehyde, which is a known skin and respiratory sensitizer.
A variety of processes for manufacturing o-phthalaldehyde have been reported in the literature.
Phthaldialdehyde is produced by heating pure benzaldehyde and chloroform with potassium hydroxide solution. The resulting solution is further acidified with hydrochloric acid and cooled to yield a colorless powder of o-phthalaldehyde.
Phthaldialdehyde is also produced by ozonization of naphthalene in alcohol followed by catalytic hydrogenation.
Catalytic oxidation of various chemicals is also used in manufacturing o-phthalaldehyde. o-Phthalaldehyde can be manufactured by oxidation of phthalan by nitrogen monoxide in acetonitrile with N-hydroxyphthalimide as the catalyst to yield 80% to 90%.
Definition
ChEBI: A dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.
About Phthaldialdehyde
Helpful information
Phthaldialdehyde is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.
Phthaldialdehyde is used by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which Phthaldialdehyde is most likely to be released to the environment.
Article service life
ECHA has no public registered data on the routes by which Phthaldialdehyde is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
Phthaldialdehyde is used in the following products: biocides (e.g. disinfectants, pest control products).
Phthaldialdehyde is used in the following areas: health services.
Other release to the environment of Phthaldialdehyde is likely to occur from: indoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Formulation or re-packing
Phthaldialdehyde is used in the following products: biocides (e.g. disinfectants, pest control products), laboratory chemicals and washing & cleaning products. Release to the environment of Phthaldialdehyde can occur from industrial use: formulation of mixtures.
Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Phthaldialdehyde is used for the manufacture of: chemicals.
ECHA has no public registered data on the routes by which Phthaldialdehyde is most likely to be released to the environment.
Manufacture
Release to the environment of Phthaldialdehyde can occur from industrial use: manufacturing of the substance.
Phthalaldehyde, also o-phthalaldehyde or ortho-phthalaldehyde or OPA, is the chemical compound with the formula C6H4(CHO)2.
Phthalaldehyde is one of three isomers of benzene dicarbaldehyde.
Phthalaldehyde is commonly used as a high-level disinfectant for medical instruments, as a polymerizer as well as in certain methods of wine making.
Phthalaldehyde is the chemical compound with the formula C6H4(CHO)2. Often abbreviated OPA, the molecule is a dialdehyde, consisting of two formyl (CHO) groups attached to adjacent carbon centres on a benzene ring. This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids.
Phthalaldehyde or ortho-phthalaldehyde is the chemical compound with the formula C₆H₄(CHO)₂. Often abbreviated OPA, the molecule is a dialdehyde, consisting of two formyl groups attached to adjacent carbon centres on a benzene ring.
Mainly used in medicine, dyestuff and so on.
Phthalaldehyde is a pharmaceutical intermediates, the latest topical efficient and safe anti-bacterial disinfectant, as an endoscopic surgical instruments used in hospital sterilization, can be used for the synthesis of new anti-platelet aggregation drugs indole Bofen, but also the field of chemistry analysis reagents.
IUPAC names:
1,2-Benzenedicarboxaldehyde
Aldehyde, ortho-Phthalico Phthalaldehydeo Phthaldialdehydeo-Phthalaldehydeo-Phthaldialdehydeortho Phthalaldehydeortho Phthalic Aldehydeortho-Phthalaldehydeortho-Phthalic AldehydeOrthophthaldialdehyde
benzene-1,2-dicarbaldehyde
o-Phthalaldehyde
o-Phthalaldehyde [for HPLC Labeling]
Phthalaldehyde
phthalaldehyde
Phthaldialdehyd
SYNONYMS:
ortho-Phthalaldehyde
1,2-Benzenedicarboxaldehyde [ACD/Index Name]
211-402-2 [EINECS]
4-07-00-02138 (Beilstein Handbook Reference) [Beilstein]
643-79-8 [RN]
Benzene-1,2-dicarbaldehyde [ACD/IUPAC Name]
Benzene-1,2-dicarboxaldehyde [ACD/IUPAC Name]
Benzol-1,2-dicarbaldehyd [German]
o-Phthalaldehyde
o-Phthaldialdehyde
Phtalaldéhyde [French] [ACD/IUPAC Name]
Phthalaldehyd [German] [ACD/IUPAC Name]
Phthalaldehyde [ACD/IUPAC Name]
Phthaldialdehyde
VHR BVH [WLN]
[643-79-8] [RN]
o-phthalaldehyde
o-phthaldialdehyde
o-phthalicdicarboxaldehyde
1, 2-Phthalic dicarboxaldehyde
1,2-Diformylbenzene
25750-62-3 [RN]
phthalaldehyde
o-Phthalic dicarboxaldehyde
o-Phthaldialdehyde OPD
o-Phthalaldehyde (1.11452)
Phthaldialdehyde
o-Phthaldialdehyde
O-PHTHALALDEHYDE
O-PHTALALDEHYDE
o-phthaladehyde
Benzene-1,2-dicarboxaldehyde
OPA
benzene-1,2-dicarbaldehyde
1,2-Benzenedialdehyde
