PRODUCTS

GALACTOMANNAN POLYSACCHARIDE (GUAR GUM)

CAS Number: 11078-30-1
EC Number: 234-299-6
Chemical Formula: C18H32O16

Other names: D-Galacto-d-mannan, d-Galacto-d-mannan, 11078-30-1, Galactomannan, Galactomannoglycan, CAROB GALACTOMANNAN, (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol, 11078-30-1, C00883, AC1L975N, D-Galacto-D-mannane, SCHEMBL19799345, CHEBI:27680, ZINC8216558, W-200825, 6-O-alpha-D-Galactopyranosyl-4-O-beta-D-mannopyranosyl-beta-D-mannopyranose, WURCS=2.0/2,3,2/[a1122h-1b_1-5][a2112h-1a_1-5]/1-1-2/a4-b1_a6-c1, (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]methoxy]tetrahydropyran-3,4,5-triol, α-D-Galactopyranosyl-(1->6)-[β-D-mannopyranosyl-(1->4)]-β-D-mannopyranose [German] [ACD/IUPAC Name], α-D-Galactopyranosyl-(1->6)-[β-D-mannopyranosyl-(1->4)]-β-D-mannopyranose [ACD/IUPAC Name], α-D-Galactopyranosyl-(1->6)-[β-D-mannopyranosyl-(1->4)]-β-D-mannopyranose [French] [ACD/IUPAC Name], β-D-Mannopyranose, O-α-D-galactopyranosyl-(1->6)-O-[β-D-mannopyranosyl-(1->4)]- [ACD/Index Name], (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-{[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]methoxy}oxane-3,4,5-triol, ?-D-GALACTOPYRANOSYL-(1->6)-[?-D-MANNOPYRANOSYL-(1->4)]-?-D-MANNOPYRANOSE, [11078-30-1] [RN], 11078-30-1 [RN], 234-299-6 [EINECS], Carob galactomannan, Carobgalactomannan, D-Galacto-D-mannane, Galactomannan [Wiki], Galactomannoglycan, MFCD00146683, C00883 [DBID]

Galactomannan polysaccharide (guar gum) is a heteroglycan consisting of a mannan backbone with galactose side groups.
Galactomannan polysaccharide (guar gum) is a natural product found in Astragalus lehmannianus, Umbilicaria esculenta, and other organisms with data available.
Galactomannan polysaccharide (guar gum) are polysaccharides consisting of a mannose backbone with galactose side groups, more specifically, a (1-4)-linked beta-D-mannopyranose backbone with branchpoints from their 6-positions linked to alpha-D-galactose, (i.e. 1-6-linked alpha-D-galactopyranose).

Food use of Galactomannan polysaccharide (guar gum)
Galactomannan polysaccharide (guar gum) are used in foods as stabilisers.
Galactomannan polysaccharide (guar gum) are commonly used in ice cream to improve texture and reduce ice cream meltdown.
Galactomannan polysaccharide (guar gum) is also used extensively in cream cheese,fruit preparations and salad dressings. Tara gum is seeing growing acceptability as a food ingredient but is still used to a much lesser extent than guar or Galactomannan polysaccharide (guar gum).
Galactomannan polysaccharide (guar gum) has the highest usage in foods, largely due to its low and stable price.

Clinical use of Galactomannan polysaccharide (guar gum)
Galactomannan polysaccharide (guar gum) is a component of the cell wall of the mold Aspergillus and is released during growth.
Detection of Galactomannan polysaccharide (guar gum) in blood is used to diagnose invasive aspergillosis infections in humans.

This is performed with monoclonal antibodies in a double-sandwich ELISA; this assay from Bio-Rad Laboratories was approved by the FDA in 2003 and is of moderate accuracy.
The assay is most useful in patients who have had hemopoetic cell transplants (stem cell transplants).
False positive Galactomannan polysaccharide (guar gum) test have been found in patients on intravenous treatment with some antibiotics or fluids containing gluconate or citric acid such as some transfusion platelets, parenteral nutrition or PlasmaLyte.

The pharmaceutical use of Galactomannan polysaccharide (guar gum) from different sources, commercial and noncommercial, has been extensively studied over the past decade.
Galactomannan polysaccharide (guar gum) show potential in the global trend towards the use of more plant-based products for ecological motives, and their production and application do not cause pollution or disturb the ecosystem.

There is a variety of Galactomannan polysaccharide (guar gum) sources and various pharmaceutical forms of application, such as tablets or capsules, hydrogels and films.
Besides the simple use as inert excipient this polysaccharides play role in the modification of drug release, especially in colonic environmental, as a matrix or coating material.

Galactomannan polysaccharide (guar gum) are versatile macromolecules with broad industrial potential.
The influence of changes in the chemical structures and respective bioactivities of these polysaccharides have been extensively studied.
The derivatives obtained by sulfation, complexation, and phosphorylation are the most studied biological properties in Galactomannan polysaccharide (guar gum).
The derivatives obtained have shown several pharmacological activities such as antiviral, antimicrobial, anticoagulant, fibrinolytic, chemopreventive, anticancer, antioxidant, chondroprotective, analgesic, immunomodulatory, and antileishmanial.

Considering the relevance of these studies, we aim to provide an overview of studies that apply Galactomannan polysaccharide (guar gum) modification or derivatization strategies to improve their properties for applications in the biomedical area.
However, some studies found loss of bioactivity of the original polysaccharide after chemical changes to its original structures.

Galactomannan polysaccharide (guar gum) is a molecule found in the cell wall of some fungi such as Aspergillus species.
Testing for the presence of Galactomannan polysaccharide (guar gum) in the serum and/or bronchoalveolar lavage fluid may be aid the diagnosis of invasive fungal.

Hazard classification & labelling of Galactomannan polysaccharide (guar gum)
Warning! According to the classification provided by companies to ECHA in CLP notifications this substance may cause an allergic skin reaction.

Galactomannan polysaccharide (guar gum) indicated, in 2009, as being intended to be registered by at least one company in the EEA.
Galactomannan polysaccharide (guar gum) for which classification and labeling data have been submitted to ECHA in a registration under REACH or notified by manufacturers or importers under CLP. Such notifications are required for hazardous substances, as such or in mixtures, as well as for all substances subject to registration, regardless of their hazard.
Galactomannan polysaccharide (guar gum) listed in the EINECS, ELINCS, or NLP inventories.