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GLUTARALDEHYDE 35%

synonyms: 1,5-Pentanedial; Glutaraldehyde; Pentane-1,5-dial; Glutaric acid dialdehyde, Glutaric aldehyde; Aldesan; Aldesen; Alhydex; Aqucar; Bactron K31; Cidex; Cidex 7; Coldcide-25 microbiocide; Dioxopentane; Diswart

Glutaraldehyde is used to sterilize surgical instruments and other areas of hospitals. As a medication, it is used to treat warts on the bottom of the feet. Glutaraldehyde is applied as a liquid.

CAS No: 111-30-8

synonyms:
 1,5-Pentanedial; Glutaraldehyde; Pentane-1,5-dial; Glutaric acid dialdehyde, Glutaric aldehyde, Glutaric dialdehydeCas No: 111-30-8Bioglan Brand of GlutaralBode Brand of GlutaralCahill May Roberts Brand of GlutaralCidexDermal Brand of GlutaralDermatech Brand of GlutaralDiswartEcolab Brand of Glutaral; Gludesin; Glutaral; Glutaraldehyde; Glutardialdehyde; Glutarol; Johnson and Johnson Brand of Glutaral; Korsolex; Novaruca; Sekumatic; Sonacide; Sporicidin; glutaraldehyde; Pentanedial; Glutaral; 111-30-8; Glutaric dialdehyde; Cidex; Glutardialdehyde;1,5 Pentanedial ;Glutarol; Sonacide; Glutaric aldehyde; 1,5-Pentanedione;Glutaric acid dialdehyde;Glutaraldehyd ;Glutaralum ;Ucarcide ;Aldesan; Alhydex ;Hospex; Pentane-1,5-dial; 1,3-Diformylpropane; Gluteraldehyde; Glutaraldehyde solution; Aldesen; NCI-C55425;component of Cidex;Caswell No. 468;Glutaraldehyd [Czech];1,3-Diformyl propane
;Glutaralum [INN-Latin];Glutaraldehyde; Pentanedial; Glutaral; 111-30-8; Glutaric dialdehyde; Cidex; Bioglan Brand of Glutaral Bode Brand of Glutaral; Cahill May Roberts Brand of Glutaral; Cidex; Dermal Brand of Glutaral; Dermatech Brand of Glutaral; Diswart; Gludesin; Glutaral; Glutaraldehyde; Glutardialdehyde; Glutarol; Korsolex; Novaruca; Sekumatic; Sonacide; Sporicidin; 111-30-8; glutaral; Glutaraldehyd; Glutaraldehyde; Glutaraldéhyde; glutaralum; Glutardialdehyde; Glutaric acid dialdehyde; Glutaric aldehyde; glutaric dialdehyde; Gluteraldehyde; PENTANE-1,5-DIAL; Pentanedial; [111-30-8]; 1,3-Diformyl propane; 1,3-Diformylpropane; 1,5-Pentanedial; 203-856-5; 4-01-00-03659; 5-Pentanedial; Aldehyd glutarowy; Aldehyd glutarowy; Aldesan; Aldesen; Alhydex; Aqucar; Bactron K31; Cidex; Cidex 7; Coldcide-25 microbiocide; Dioxopentane; Diswart; EINECS 203-856-5; Gludesin; Glutaclean; Glutaral; Glutaraldehyd; Glutaraldehyde solution; Glutaraldehyde solution, 25% in water; Glutaralum; Glutaralum; Glutarex 28; Glutaric dialdehyde solution, 35 wt. % in H2O; Glutaricdialdehyde; Glutarol; Glutarol-1,5-pentanedial; Glutural; Hospex; MA2435000; MFCD00007025; Novaruca; Pentanedial, 35 % aqueous solution; PTD; Relugan GT; Relugan GT 35; Relugan GTW; Sonacide; Sporicidin; Sterihyde; Sterihyde L; Ucarcide; Ucarcide 225; Ucarcide 235; Ucarset; UNII-T3C89M417N; Verucasep; Veruca-sep; Virsal; Glutaric acid dialdehyde; Glutardialdehyde; Glutaral;
1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Glutaric aldehyde; Glutarol; Gluteraldehyde; Pentanedial; Sonacide; Aldehyd glutarowy; Aldesan; Ucarcide; Other RN: 37245-61-7, 79215-57-9, 107935-89-0;Glutaric acid dialdehyde; Glutardialdehyde; Glutaral;
1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Glutaric aldehyde; Glutarol; Gluteraldehyde; Pentanedial; Sonacide; Aldehyd glutarowy; Aldesan; Ucarcide; Other RN: 37245-61-7, 79215-57-9, 107935-89-0;1,5-PENTANEDIAL;FIXATIVE 15960;FIXATIVE 15970;FIXATIVE 15980;GLUTARALDEHYDE;GLUTARDIALDEHYDE;GLUTARIC DIALDEHYDE;PANTHANEDIAL;PENTANE-1,5-DIAL;1,3-diformalpropane;1,3-Diformylpropane;1,5-Pentanedione;aldehydglutarowy;Aldesan;aldesen;Alhydex;Aqucar;Cidex;Cidex 7;Coldcide-25 microbiocide;;glutaraldehyde;Pentanedial;Glutaral;111-30-8;Glutaric dialdehyde;Cidex;Glutardialdehyde;1,5-Pentanedial;Sonacide;Glutarol;Glutaric aldehyde;Glutaraldehyd;Glutaralum;Aldesan;Alhydex;Ucarcide;1,5-Pentanedione;Hospex;Glutaric acid dialdehyde; Pentane-1,5-dial;1,3-Diformylpropane; Gluteraldehyde; Aldesen; NCI-C55425; Caswell No. 468; Glutaraldehyd [Czech];Glutaraldehyde solution;Glutaralum [INN-Latin];Aldehyd glutarowy [Polish];component of Cidex;NSC 13392;UNII-T3C89M417N;CCRIS 3800;HSDB 949;1,3-Diformyl propane;EINECS 203-856-5;Glutarol-1,5-pentanedial;EPA Pesticide Chemical Code 043901;BRN 0605390;CHEBI:64276;SXRSQZLOMIGNAQ-UHFFFAOYSA-N;MFCD00007025;Glutaraldehyde solution (35% or less);Glutaraldehyde solution, 25% in water;NCGC00091110-01;DSSTox_CID_5355;DSSTox_RID_77761;DSSTox_GSID_25355;Sporicidin;Novaruca;Aldehyd glutarowy;Polyglutaraldehyde;79215-57-9;CAS-111-30-8;PTD;Poly(glutaraldehyde);Glutaclean;Glutaral [USAN:INN:JAN];Sterihyde;Aqucar;Glutaraldehyde solution, for electron microscopy, ~25% in H2O;Glutardialdehydl;Veruca-sep;Glutaric aldehydl;Relugan GT;Relugan GTW;Glutaral [USAN:USP:INN:JAN];Glutaric dialdehydl;Glutarex 28;Sonacide (TN);Cidex 7;Ucarcide 235;Sterihyde L (TN);Relugan GT 35;Ginkgo biloba extract;Glutaraldehyde,solution;Glutaric acid dialdehydl;Pentanedial, homopolymer;ACMC-1BGTC;pentane-1,5-dialdehyde;AC1Q6QKG;Coldcide-25 microbiocide;SCHEMBL836;WLN: VH3VH;Glutaric dialdehyde solution;AC1L1G1H;Glutaral (JAN/USP/INN);4-01-00-03659 (Beilstein Handbook Reference); KSC175E5H;BIDD:ER0299; Potentiated acid glutaraldehyde;CHEMBL1235482;DTXSID6025355;CTK0H5253;GLUTARALDEHYDE, 25% SOLN;MolPort-001-781-859;Bio1_000462;Bio1_000951;Bio1_001440;T3C89M417N;NSC13392;ZINC1729593;Tox21_111083;Tox21_201742;Tox21_303295;ANW-43543;LS-529;NSC13392; STL281872;ZINC01729593;AKOS008967285;DB03266;MCULE-6802048757;NE10465;RL00461;RP18697;RTR-034054;Glutaric dialdehyde, 25%sol. In water;NCGC00091110-02;NCGC00091110-03;NCGC00257231-01;NCGC00259291-01;29257-65-6;AJ-31184;AK156425;AN-22657;CJ-29390;DR000111;I856;KB-52255;LP067495;SC-22641;Glutaraldehyde solution, 25 wt. % in H2O;Glutaraldehyde solution, 35 wt. % in H2O;TR-034054;FT-0626730;G0067;G0068;ST24047332;EN300-18037;C12518;D01120;Glutaraldehyde solution, for synthesis, 25.0%;49147-EP2270355A1;49147-EP2280274A2;49147-EP2282200A2;49147-EP2287152A2;49147-EP2287155A1;49147-EP2298312A1;49147-EP2301940A1;49147-EP2308848A1;49147-EP2311823A1;49147-EP2372017A1;49147-EP2377842A1;49147-EP2377845A1;Glutaraldehyde solution, Grade II, 25% in H2O;Glutaric dialdehyde solution, 35 wt. % in H2O;A802339;Glutaraldehyde solution, 35 wt. % in water 100g;Glutaraldehyde solution, for in vitro diagnostic use;I14-1782;Q-201162;Glutaric dialdehyde solution, 35 wt. % in H2O, FCC;I14-10112;F2191-0161;Glutaraldehyde solution, SAJ first grade, 20.0-26.0%;Glutaraldehyde solution, technical, ~25% in H2O (2.6 M);Glutaraldehyde solution, technical, ~35% in H2O (5.6 M);Glutaraldehyde solution, 1.2 % (w/v) glutaraldehyde in H2O;Glutaraldehyde solution, for electron microscopy, ~35% in H2O;Glutaraldehyde solution, for electron microscopy, ~8% in H2O;Glutaraldehyde solution, 35% in H2O, suitable for photographic applications;107935-89-0;37245-61-7;Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative; 1,5-Pentanedial; Glutaraldehyde; Pentane-1,5-dial; Glutaric acid dialdehyde, Glutaric aldehyde, Glutaric dialdehydeCas No: 111-30-8Bioglan Brand of GlutaralBode Brand of GlutaralCahill May Roberts Brand of GlutaralCidexDermal Brand of GlutaralDermatech Brand of GlutaralDiswartEcolab Brand of Glutaral;Gludesin;Glutaral;Glutaraldehyde;Glutardialdehyde;Glutarol;Johnson and Johnson Brand of Glutaral;Korsolex;Novaruca;Sekumatic;Sonacide;Sporicidin;glutaraldehyde;Pentanedial;Glutaral;111-30-8;Glutaric dialdehyde;Cidex;Glutardialdehyde;1,5-Pentanedial;Glutarol;Sonacide;Glutaric aldehyde;1,5-Pentanedione;Glutaric acid dialdehyde;Glutaraldehyd;Glutaralum;Ucarcide;Aldesan;Alhydex;Hospex;Pentane-1,5-dial;1,3-Diformylpropane;Gluteraldehyde;Glutaraldehyde solution;Aldesen;NCI-C55425;component of Cidex;Caswell No. 468;Glutaraldehyd [Czech];1,3-Diformyl propane
;Glutaralum [INN-Latin];Glutaraldehyde; Pentanedial; Glutaral; 111-30-8; Glutaric dialdehyde; Cidex; Bioglan Brand of Glutaral Bode Brand of Glutaral; Cahill May Roberts Brand of Glutaral; Cidex; Dermal Brand of Glutaral; Dermatech Brand of Glutaral; Diswart; Gludesin; Glutaral; Glutaraldehyde; Glutardialdehyde; Glutarol; Korsolex; Novaruca; Sekumatic; Sonacide; Sporicidin; 111-30-8; glutaral; Glutaraldehyd; Glutaraldehyde; Glutaraldéhyde; glutaralum; Glutardialdehyde; Glutaric acid dialdehyde; Glutaric aldehyde; glutaric dialdehyde; Gluteraldehyde; PENTANE-1,5-DIAL; Pentanedial; [111-30-8]; 1,3-Diformyl propane; 1,3-Diformylpropane; 1,5-Pentanedial; 203-856-5; 4-01-00-03659; 5-Pentanedial; Aldehyd glutarowy; Aldehyd glutarowy; Aldesan; Aldesen; Alhydex; Aqucar; Bactron K31; Cidex; Cidex 7; Coldcide-25 microbiocide; Dioxopentane; Diswart; EINECS 203-856-5; Gludesin; Glutaclean; Glutaral; Glutaraldehyd; Glutaraldehyde solution; Glutaraldehyde solution, 25% in water; Glutaralum; Glutaralum; Glutarex 28; Glutaric dialdehyde solution, 35 wt. % in H2O; Glutaricdialdehyde; Glutarol; Glutarol-1,5-pentanedial; Glutural; Hospex; MA2435000; MFCD00007025; Novaruca; Pentanedial, 35 % aqueous solution; PTD; Relugan GT; Relugan GT 35; Relugan GTW; Sonacide; Sporicidin; Sterihyde; Sterihyde L; Ucarcide; Ucarcide 225; Ucarcide 235; Ucarset; UNII-T3C89M417N; Verucasep; Veruca-sep; Virsal; Glutaric acid dialdehyde; Glutardialdehyde; Glutaral;
1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Glutaric aldehyde; Glutarol; Gluteraldehyde; Pentanedial; Sonacide; Aldehyd glutarowy; Aldesan; Ucarcide; Other RN: 37245-61-7, 79215-57-9, 107935-89-0;Glutaric acid dialdehyde; Glutardialdehyde; Glutaral;
1,3-Diformylpropane; 1,5-Pentanedial; 1,5-Pentanedione; Glutaric aldehyde; Glutarol; Gluteraldehyde; Pentanedial; Sonacide; Aldehyd glutarowy; Aldesan; Ucarcide; Other RN: 37245-61-7, 79215-57-9, 107935-89-0;1,5-PENTANEDIAL;FIXATIVE 15960;FIXATIVE 15970;FIXATIVE 15980;GLUTARALDEHYDE;GLUTARDIALDEHYDE;GLUTARIC DIALDEHYDE;PANTHANEDIAL;PENTANE-1,5-DIAL;1,3-diformalpropane;1,3-Diformylpropane;1,5-Pentanedione;aldehydglutarowy;Aldesan;aldesen;Alhydex;Aqucar;Cidex;Cidex 7;Coldcide-25 microbiocide;;glutaraldehyde;Pentanedial;Glutaral;111-30-8;Glutaric dialdehyde;Cidex;Glutardialdehyde;1,5-Pentanedial;Sonacide;Glutarol;Glutaric aldehyde;Glutaraldehyd;Glutaralum;Aldesan;Alhydex;Ucarcide;1,5-Pentanedione;Hospex;Glutaric acid dialdehyde;Pentane-1,5-dial;1,3-Diformylpropane;Gluteraldehyde;Aldesen;NCI-C55425;Caswell No. 468;Glutaraldehyd [Czech];Glutaraldehyde solution;Glutaralum [INN-Latin];Aldehyd glutarowy [Polish];component of Cidex;NSC 13392;UNII-T3C89M417N;CCRIS 3800;HSDB 949;1,3-Diformyl propane;EINECS 203-856-5;Glutarol-1,5-pentanedial;EPA Pesticide Chemical Code 043901;BRN 0605390;CHEBI:64276;SXRSQZLOMIGNAQ-UHFFFAOYSA-N;MFCD00007025;Glutaraldehyde solution (35% or less);Glutaraldehyde solution, 25% in water;NCGC00091110-01;DSSTox_CID_5355;DSSTox_RID_77761;DSSTox_GSID_25355;Sporicidin;Novaruca;Aldehyd glutarowy;Polyglutaraldehyde;79215-57-9;CAS-111-30-8;PTD;Poly(glutaraldehyde);Glutaclean;Glutaral [USAN:INN:JAN];Sterihyde;Aqucar;Glutaraldehyde solution, for electron microscopy, ~25% in H2O;Glutardialdehydl;Veruca-sep;Glutaric aldehydl;Relugan GT;Relugan GTW;Glutaral [USAN:USP:INN:JAN];Glutaric dialdehydl;Glutarex 28;Sonacide (TN);Cidex 7;Ucarcide 235;Sterihyde L (TN);Relugan GT 35;Ginkgo biloba extract;Glutaraldehyde,solution;Glutaric acid dialdehydl;Pentanedial, homopolymer;ACMC-1BGTC;pentane-1,5-dialdehyde;AC1Q6QKG;Coldcide-25 microbiocide;SCHEMBL836;WLN: VH3VH;Glutaric dialdehyde solution;AC1L1G1H;Glutaral (JAN/USP/INN);4-01-00-03659 (Beilstein Handbook Reference); KSC175E5H ;BIDD:ER0299; Potentiated acid glutaraldehyde; CHEMBL1235482; DTXSID6025355; CTK0H5253; GLUTARALDEHYDE, 25% SOLN;MolPort-001-781859;Bio1_000462;Bio1_000951;Bio1_001440;T3C89M417N;NSC13392;ZINC1729593;Tox21_111083;Tox21_201742;Tox21_303295;ANW-43543;LS-529; NSC 13392; STL281872; ZINC01729593; AKOS008967285; DB03266 ;MCULE-6802048757; NE10465; RL00461; RP18697;RTR-034054;Glutaric dialdehyde, 25%sol. In water;NCGC00091110-02;NCGC00091110-03;NCGC00257231-01;NCGC00259291-01;29257-65-6;AJ-31184;AK156425;AN-22657;CJ-29390;DR000111;I856;KB-52255;LP067495;SC-22641;Glutaraldehyde solution, 25 wt. % in H2O;Glutaraldehyde solution, 35 wt. % in H2O;TR-034054;FT-0626730;G0067;G0068;ST24047332;EN300-18037;C12518;D01120;Glutaraldehyde solution, for synthesis, 25.0%;49147-EP2270355A1;49147-EP2280274A2;49147-EP2282200A2;49147-EP2287152A2;49147-EP2287155A1;49147-EP2298312A1;49147-EP2301940A1;49147-EP2308848A1;49147-EP2311823A1;49147-EP2372017A1;49147-EP2377842A1;49147-EP2377845A1;Glutaraldehyde solution, Grade II, 25% in H2O;Glutaric dialdehyde solution, 35 wt. % in H2O;A802339;Glutaraldehyde solution, 35 wt. % in water 100g;Glutaraldehyde solution, for in vitro diagnostic use;I14-1782;Q-201162;Glutaric dialdehyde solution, 35 wt. % in H2O, FCC;I14-10112;F2191-0161;Glutaraldehyde solution, SAJ first grade, 20.0-26.0%;Glutaraldehyde solution, technical, ~25% in H2O (2.6 M);Glutaraldehyde solution, technical, ~35% in H2O (5.6 M);Glutaraldehyde solution, 1.2 % (w/v) glutaraldehyde in H2O;Glutaraldehyde solution, for electron microscopy, ~35% in H2O;Glutaraldehyde solution, for electron microscopy, ~8% in H2O;Glutaraldehyde solution, 35% in H2O, suitable for photographic applications;107935-89-0;37245-61-7;Glutaraldehyde solution, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative;Glutaraldehyde solution, Grade I, 35% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use;Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use;Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use ;GLUTRALDEHT; GLUTERALDEHİT ;GLUTERALDEHİT; GLUTERALDEHT; GLUTARALDEHT; GLUTER ALDEHİT; GLUTER ALDEHIT; gluteraldeht ;gluteraldehit ; gluteraldeht; glutaraldeht; gluter aldehit; gluter aldehıt; Glutaraldehyde solution, Grade I, 35% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use;Glutaraldehyde solution, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use;Glutaraldehyde solution, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticateduse;GLUTRALDEHT 35; GLUTERALDEHİT35;GLUTERALDEHİT 35; GLUTERALDEHT 35;GLUTARALDEHT 35;GLUTERALDEHİT 35;GLUTERALDEHIT 35;gluteraldeht 35; gluteraldehit; gluteraldeht; glutaraldeht; gluteraldehit 35; gluter aldehıt 35;  Glutaraldehit %35; Glutaraldehit 35%; Glutaraldehit ; Glutaraldehit35; Glutar aldehit; Glutar aldehit 35%; Glutar aldehit%35 Glutaraldehit35; Glutaraldehit35%; GLUTARALDEHİT; GLUTARALDEHIT; GLUTARALDEHITE; GLUTARALDEHIDE;GLUTAR ALDEHITE; GLUTAR ALDEHIDE

 


Glutaraldehyde 35%

Glutaraldehyde, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative. As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde is applied as a liquid.[3]

Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] Glutaraldehyde is a dialdehyde.[8] It works by a number of mechanisms.[7]

Glutaraldehyde came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines.[10] There are a number of other commercial uses such as leather tanning.[11]

Uses
Disinfection
Glutaraldehyde is used as a disinfectant and medication.[3][4][12]

Usually applied as a solution, it is used to sterilize surgical instruments and other areas.[3]

Fixative
Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[13] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed]

Another application for treatment of proteins with glutaraldehyde is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[14]

In a related application, glutaraldehyde is sometimes employed in the tanning of leather and in embalming.[citation needed]

Wart treatment
As a medication it is used to treat plantar warts.[4] For this purpose, a 10% w/v solution is used. It dries the skin, facilitating physical removal of the wart.[15] Trade names include Diswart Solution and Glutarol.[citation needed]

Safety
Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7]

As a strong sterilant, glutaraldehyde is toxic and a strong irritant.[16] There is no strong evidence of carcinogenic activity.[17] Some occupations that work with this chemical have an increased risk of some cancers.[17]

Mechanism of action
A number of mechanisms have been invoked to explain the biocidal properties of glutaraldehyde.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[18]

Production and reactions

Synthesis of glutaraldehyde via the Diels-Alder reaction.
Glutaraldehyde is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[19]

Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), glutaraldehyde converts in aqueous solution to various hydrates that in turn convert to other equilibrating species

General description
Glutaraldehyde solution is 35% solution of glutaraldehyde in water. Antibacterial action of 2% solution of alkaline glutaraldehyde against various atypical mycobacteria has been investigated.[8]
Related Categories    Aldehydes, Biochemicals and Reagents, Building Blocks, C1 to C6, Carbohydrates,
Carbohydrates A to Z, Carbohydrates G, Carbonyl Compounds, Chemical Synthesis, Core Bioreagents, Monosaccharide, Organic Building Blocks, Research Essentials

Quality Level      200
vapor density      1.05 (vs air)
vapor pressure      15 mmHg ( 20 °C)
concentration      35 wt. % in H2O
refractive index      n20/D 1.42
density      1.106 g/mL at 25 °C
SMILES string      [H]C(CCCC([H])=O)=O
InChI      1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
InChI key      SXRSQZLOMIGNAQ-UHFFFAOYSA-N
Application
Cross-linking agent for gelatin,[1][2] poly(vinyl alcohol),[3] and polyheptapeptides.[4]

Glutaraldehyde may be used in the following studies:
• To compose the fixative solution (Glutaraldehyde + Paraformaldehyde + NaPO4) for use in high-resolution light microscopy and electron microscopy studies.[5]
• To study the conjugation of goat anti-horseradish peroxidase with alkaline phosphatase by a reported method.[6]
• To compose the primary fixative, which is employed to protect the deterioration of cytoplasmic features of yeast cells during permanganate fixation.[7]
Packaging
1 L in glass bottle

25 mL in glass bottle
Glutaraldehyde

Skeletal formula of glutaraldehyde
Ball-and-stick model of the glutaraldehyde molecule
Names
Preferred IUPAC name
Pentanedial[1]
Other names
Glutaraldehyde
Glutardialdehyde
Glutaric acid dialdehyde
Glutaric aldehyde
Glutaric dialdehyde
1,5-Pentanedial
Identifiers
CAS Number
111-30-8 ☑
3D model (JSmol)
Interactive image
ChemSpider    
3365 ☑
DrugBank    
DB03266 ☑
ECHA InfoCard    100.003.356
KEGG    
D01120 ☑
PubChem CID
3485
UNII    
T3C89M417N ☑
CompTox Dashboard (EPA)
DTXSID6025355 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula
C5H8O2
Molar mass    100.117
Appearance    Clear liquid
Odor    pungent[2]
Density    1.06 g/mL
Melting point    −14 °C (7 °F; 259 K)
Boiling point    187 °C (369 °F; 460 K)
Solubility in water
Miscible, reacts
Vapor pressure    17 mmHg (20°C)[2]
Hazards
Safety data sheet    CAS 111-30-8
GHS pictograms    GHS05: CorrosiveGHS06: ToxicGHS08: Health hazardGHS09: Environmental hazard
GHS Signal word    Danger
GHS hazard statements
H302, H314, H317, H331, H334, H400
GHS precautionary statements
P260, P264, P270, P271, P272, P273, P280, P284, P301+312, P330, P302+352, P332+313, P304+340, P305+351+338, P311, P403+233, P405, P351
NFPA 704 (fire diamond)    
NFPA 704 four-colored diamond
220
Flash point    noncombustible[2]
Threshold limit value (TLV)
0.2 ppm (0.82 mg/m3) (TWA), 0.05 ppm (STEL)
Lethal dose or concentration (LD, LC):
LD35 (median dose)
134 mg/kg (rat, oral); 2,560 mg/kg (rabbit, dermal)
NIOSH (US health exposure limits):
REL (Recommended)
0.2 ppm (0.8 mg/m3)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Glutaraldehyde, sold under the brandname Cidex and Glutaral among others, is a disinfectant, medication, preservative, and fixative.[3][4][5][6] As a disinfectant, it is used to sterilize surgical instruments and other areas of hospitals.[3] As a medication, it is used to treat warts on the bottom of the feet.[4] Glutaraldehyde is applied as a liquid.[3]

Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7] Glutaraldehyde is a dialdehyde.[8] It works by a number of mechanisms.[7]

Glutaraldehyde came into medical use in the 1960s.[9] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] The wholesale cost in the developing world is about US$1.35–7.40 per liter of 2% solution.[11] There are a number of other commercial uses such as leather tanning.[12]

Uses
Disinfection
Glutaraldehyde is used as a disinfectant and medication.[3][4][13]

Usually applied as a solution, it is used to sterilize surgical instruments and other areas.[3]

Fixative
Glutaraldehyde is used in biochemistry applications as an amine-reactive homobifunctional crosslinker and fixative prior to SDS-PAGE, staining, or electron microscopy. It kills cells quickly by crosslinking their proteins. It is usually employed alone or mixed with formaldehyde[14] as the first of two fixative processes to stabilize specimens such as bacteria, plant material, and human cells. A second fixative procedure uses osmium tetroxide to crosslink and stabilize cell and organelle membrane lipids. Fixation is usually followed by dehydration of the tissue in ethanol or acetone, followed by embedding in an epoxy resin or acrylic resin.[citation needed]

Another application for treatment of proteins with glutaraldehyde is the inactivation of bacterial toxins to generate toxoid vaccines, e.g., the pertussis (whooping cough) toxoid component in the Boostrix Tdap vaccine produced by GlaxoSmithKline.[15]

In a related application, glutaraldehyde is sometimes employed in the tanning of leather and in embalming.[citation needed]

Wart treatment
As a medication it is used to treat warts on the bottom of the feet.[4] For this purpose, a 10% w/w solution is used. It dries the skin, facilitating physical removal of the wart.[16] Trade names include Diswart Solution and Glutarol.[citation needed]

Safety
Side effects include skin irritation.[4] If exposed to large amounts, nausea, headache, and shortness of breath may occur.[3] Protective equipment is recommended when used, especially in high concentrations.[3] Glutaraldehyde is effective against a range of microorganisms including spores.[3][7]

As a strong sterilant, glutaraldehyde is toxic and a strong irritant.[17] There is no strong evidence of carcinogenic activity.[18] Some occupations that work with this chemical have an increased risk of some cancers.[18]

Mechanism of action
A number of mechanisms have been invoked to explain the biocidal properties of glutaraldehyde.[7] Like many other aldehydes, it reacts with amines and thiol groups, which are common functional groups in proteins. Being bi-function, it is also a potential crosslinker.[19]

Production and reactions

Synthesis of glutaraldehyde via the Diels-Alder reaction.
Glutaraldehyde is produced industrially by the oxidation of cyclopentene. Alternatively it can be made by the Diels-Alder reaction of acrolein and vinyl ethers followed by hydrolysis.[20]

Like many other dialdehydes, (e.g., glyoxal) and simple aldehydes (e.g., formaldehyde), glutaraldehyde converts in aqueous solution to various hydrates that in turn convert to other equilibrating species.[clarification needed][21][20]

GlutaldehydeHydrateEquilibria.png
Monomeric glutaraldehyde polymerizes by aldol condensation reaction yielding alpha, beta-unsaturated poly-glutaraldehyde. This reaction usually occurs at alkaline pH values.[medical citation needed]

History and culture
Glutaraldehyde came into medical use in the 1960s.[22] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[10] The wholesale cost in the developing world is about US$1.35–7.40 per liter of 2% solution.[11] There are a number of other commercial uses such as leather tanning.[23]

A glutaraldehyde solution of 0.1% to 1.0% concentration may be used as a biocide for system disinfection and as a preservative for long-term storage. It is a sterilant, killing endospores in addition to many microorganisms and viruses.[24]

As a biocide, glutaraldehyde is a component of hydraulic fracturing ("fracking") fluid. It is included in the additive called Alpha 1427.[25] Bacterial growth impairs extraction of oil and gas from these wells. Glutaraldehyde is pumped as a component of the fracturing fluid to inhibit microbial growth.[medical citation needed]
Glutaraldehyde is a colorless, oily liquid with a sharp, pungent odor. Glutaraldehyde is used for industrial, laboratory, agricultural, medical, and some household purposes, primarily for disinfecting and sterilization of surfaces and equipment. For example, it is used in oil and gas recovery operations and pipelines, waste water treatment, x-ray processing, embalming fluid, leather tanning, paper industry, in fogging and cleaning of poultry houses, and as a chemical intermediate in the production of various materials. It may be used in select goods, such as paint and laundry detergent.

CDC-ATSDR Toxic Substances Portal
Glutaral is used as an antimicrobial agent in sugar mills and as a fixing agent in the immobilisation of glucose isomerase enzyme preparations for use in the manufacture of high fructose corn syrup A polymerized isomer of glutaraldehyde known as polycycloglutaracetal is a fertilizer for aquatic plants. It is claimed that it provides a bioavailable source of carbon for higher plants that is not available to algae. Though not marketed as such due to federal regulations, the biocidal effect of glutaraldehyde kills most algae at concentrations of 0. 5 - 5. 0 ppm. These levels are not harmful to most aquatic fauna and flora. Adverse reactions have been observed by some aquarists at these concentrations in some aquatic mosses, liverworts, and vascular plants. Glutaraldehyde is a colorless liquid with a pungent odor used to disinfect medical and dental equipment. It is also used for industrial water treatment and as a chemical preservative. Glutaraldehyde is an oily liquid at room temperature (density 1. 06 g/mL), and miscible with water, alcohol, and benzene. It is used as a tissue fixative in electron microscopy. It is employed as an embalming fluid, is a component of leather tanning solutions, and occurs as an intermediate in the production of certain industrial chemicals. Glutaraldehyde is frequently used in biochemistry applications as an amine-reactive homobifunctional crosslinker. The oligomeric state of proteins can be examined through this application. However, it is toxic, causing severe eye, nose, throat and lung irritation, along with headaches, drowsiness and dizziness. It is a main source of occupational asthma among health care providers.

Human Metabolome Database (HMDB)
Glutaraldehyde is a dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5. It has a role as a cross-linking reagent, a disinfectant and a fixative.
Glutaraldehyde
Glutaraldehyde is a commonly used chemical cross-linking agent that forms cross-links between the aldehyde and the e-amine groups of lysine or hydroxylysine in collagen.

From: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 2018

Related terms:
ResinAntibodyProteinFormaldehydeCacodylic AcidElectron MicroscopyParaformaldehydeUranyl Acetate
ChEBI
EC NUMBER: 203-856-5

Names and Identifiers of GLUTARALDEHYDE

Computed Descriptors of GLUTARALDEHYDE

IUPAC Name of GLUTARALDEHYDE
pentanedial

Molecular Formula Molecular Formula
C5H8O2

PHYSICAL AND CHEMICAL PROPERTIES of GLUTARALDEHYDE

PHYSICAL STATE: Clear to yellowish liquid
MELTING POINT: -14 C
BOILING POINT: 187 C     
SOLUBILITY IN WATER: soluble
SOLVENT SOLUBILITY: Soluble in alcohol
pH: 3.2 - 4.2
log P: -0.18 
VAPOR PRESSURE: 0.6 (mmHg at 25 C)


Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2. A pungent colorless oily liquid, glutaraldehyde is used to sterilise medical and dental equipment. It is also used for industrial water treatment and as a preservative. It is mainly available as an aqueous solution, and in these solutions the aldehyde groups are hydrated. Glutaraldehyde is a chemical frequently used as a disinfectant and sterilizing agent against bacteria and viruses (2% solution), an embalming fluid and tissue fixative, a component of leather tanning solutions, and an intermediate in the production of certain sealants, resins, dyes, and electrical products (HSDB, 1996). For commercial purposes, solutions of 99%, 35%, and 20% are available. Glutaraldehyde is also an atmospheric reaction product of cyclohexene. The annual statewide industrial emissions from facilities reporting under the Air Toxics Hot Spots Act in California based on the most recent inventory were estimated to be 29,603 pounds of glutaraldehyde
Glutaraldehyde can help to eliminate microbial contamination problems. Based on the powerful and unparalleled antimicrobial action of glutaraldehyde, these high-performance antimicrobials provide excellent control over a wide variety of microorganisms. It has antimicrobial efficacy against bacteria, mold, and yeast at low use concentrations (0.01-0.1% active ingredient). It shows excellent compatibility with anionic, nonionic, and cationic surfactants and biocidal activity over a broad pH and temperature range.
Glutaraldehyde containing two aldehyde groups, is used as a disinfectant. It is used in sterilizing medical and dental equipment which cannot be heat sterilized. It is used as a fixative for biological tissues and for leather tanning. It is used as a chemical intermediate to produce other compounds.

Glutaraldehyde is a colorless, oily, liquid-chemical with a pungent odor. It is used for a number of applications such as the following:

-A cold sterilant in the health care industry
-A cross-linking and tanning agent
-A biocide in metalworking fluids and in oil and gas pipelines
-An antimicrobial in water-treatment systems
-A slimicide in paper manufacturing
-A preservative in cosmetics
-A disinfectant in animal housing
-A tissue fixative in histology and pathology labs
-A hardening agent in the development of X-rays
-In embalming solutions
-In the preparation of grafts and bioprostheses
-In various clinical applications
-In the health care industry, glutaraldehyde is most often used to disinfect equipment that cannot be heat sterilized such as dialysis instruments, surgical instruments, suction bottles, bronchoscopes, endoscopes, and ear, nose, and throat instruments.
 

EC NUMBER: 203-856-5

Names and Identifiers of GLUTARALDEHYDE

Computed Descriptors of GLUTARALDEHYDE

IUPAC Name of GLUTARALDEHYDE
pentanedial

Molecular Formula Molecular Formula
C5H8O2

PHYSICAL AND CHEMICAL PROPERTIES of GLUTARALDEHYDE

PHYSICAL STATE: Clear to yellowish liquid
MELTING POINT: -14 C
BOILING POINT: 187 C     
SOLUBILITY IN WATER: soluble
SOLVENT SOLUBILITY: Soluble in alcohol
pH: 3.2 - 4.2
log P: -0.18 
VAPOR PRESSURE: 0.6 (mmHg at 25 C)


Glutaraldehyde is an organic compound with the formula CH2(CH2CHO)2. A pungent colorless oily liquid, glutaraldehyde is used to sterilise medical and dental equipment. It is also used for industrial water treatment and as a preservative. It is mainly available as an aqueous solution, and in these solutions the aldehyde groups are hydrated. Glutaraldehyde is a chemical frequently used as a disinfectant and sterilizing agent against bacteria and viruses (2% solution), an embalming fluid and tissue fixative, a component of leather tanning solutions, and an intermediate in the production of certain sealants, resins, dyes, and electrical products (HSDB, 1996). For commercial purposes, solutions of 99%, 35%, and 20% are available. Glutaraldehyde is also an atmospheric reaction product of cyclohexene. The annual statewide industrial emissions from facilities reporting under the Air Toxics Hot Spots Act in California based on the most recent inventory were estimated to be 29,603 pounds of glutaraldehyde
Glutaraldehyde can help to eliminate microbial contamination problems. Based on the powerful and unparalleled antimicrobial action of glutaraldehyde, these high-performance antimicrobials provide excellent control over a wide variety of microorganisms. It has antimicrobial efficacy against bacteria, mold, and yeast at low use concentrations (0.01-0.1% active ingredient). It shows excellent compatibility with anionic, nonionic, and cationic surfactants and biocidal activity over a broad pH and temperature range.
Glutaraldehyde containing two aldehyde groups, is used as a disinfectant. It is used in sterilizing medical and dental equipment which cannot be heat sterilized. It is used as a fixative for biological tissues and for leather tanning. It is used as a chemical intermediate to produce other compounds.

Glutaraldehyde is a colorless, oily, liquid-chemical with a pungent odor.

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