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Glyceryl Trioctanoate is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions.
Dietary administration of Glyceryl Trioctanoate increases hepatic and adipose tissue glucose-6-phosphate dehydrogenase (G6PDH), citrate cleavage enzyme (CCE), and malic enzyme activities in rats.
Glyceryl Trioctanoate induces nuclear edema and cytolysis in tumor cells, but not normal hepatic cells, in a murine hepatic carcinoma model.
CAS: 538-23-8
MF: C27H50O6
MW: 470.68
EINECS: 208-686-5
Synonyms
1,2,3-tris-(octanoyloxy)-propane;2,3-Bis(octanoyloxy)propyl octanoate;Caprylic triglyceride;Captex 8000;Glycerol trioctanoate;Glyceroltrioctanoate;Glyceryl tricaprylate-caprate;Maceight
A triglyceride obtained by acylation of the three hydroxy groups of glycerol by octanoic acid.
Used as an alternative energy source to glucose for patients with mild to moderate Alzheimer's disease.
Odorless viscous clear colorless to amber-brown liquid.
Glyceryl Trioctanoate is a triester of glycerin and caprylic acid, which is a medium-chain fatty acid derived from coconut oil.
Glyceryl Trioctanoate has been used as a molecular tool for various biochemical applications.
Glyceryl Trioctanoate has also been used in a wide array of other chemical and immunological applications.
Custom bulk amounts of this product are available upon request.
Glyceryl Trioctanoate Chemical Properties
Melting point: 9-10 °C
Boiling point: 233 °C/1 mmHg (lit.)
Density: 0.956 g/mL at 20 °C (lit.)
Vapor pressure: 0Pa at 25℃
Refractive index: n20/D 1.448
Fp: 225 °C
Storage temp.: -20°C
Solubility: Miscible with most organic solvents including ethanol (95%). Captex 8000 is insoluble in water.
Form: Liquid
Color: Colourless
Odor: at 100.00?%. odorless
Biological source: vegetable oil ( (coconut and palm kernel oils))
Water Solubility: 65mg/L at 20℃
BRN: 1717202
LogP: 9.2 at 20℃
CAS DataBase Reference: 538-23-8(CAS DataBase Reference)
EPA Substance Registry System: Glyceryl Trioctanoate (538-23-8)
Glyceryl Trioctanoate occurs as a clear, colorless to pale-yellow liquid.
Glyceryl Trioctanoate forms crystals from acetone/ethanol (95%).
Glyceryl Trioctanoate is odorless.
Uses
Glyceryl Trioctanoate is a low viscosity polyol ester suggested for use as a synthetic fiber lubricant.
Glyceryl Trioctanoate offers a balance of moderate volatility and low varnishing behavior.
For low to moderate denier polyester and nylon filament and staple yarn applications.
Glyceryl Trioctanoate is an emollient with skin-softening abilities.
Production Methods
Glyceryl Trioctanoate is a triglyceride manufactured by esterification of caprylic acid and glycerin.
Reactivity Profile
Glyceryl Trioctanoate is an ester.
Esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Glyceryl Trioctanoate is incompatible with strong oxidizers.
Pharmaceutical Applications
Glyceryl Trioctanoate is used in pharmaceutical preparations as a neutral carrier, absorption promoter, and solubilizer for active drugs.
Glyceryl Trioctanoate has been used as an oily phase to prepare water-in-oil-in-water multiple emulsions for incorporating water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine, and also for obtaining stable microcapsules.
Glyceryl Trioctanoate acts as a vehicle for topical creams and lotions, and cosmetic preparations.
Glyceryl Trioctanoate is used as a penetration-enhancing lipid base with excellent emollient and skin-smoothing properties.
Owing to its non-greasy components and low viscosity, Glyceryl Trioctanoate has very good spreadability.
In spite of being skin-permeable, Glyceryl Trioctanoate does not obstruct natural skin respiration, and hence it is used in baby oils, massage oils, and face masks.
Glyceryl Trioctanoate is an excellent dispersant, and acts as a solubilizer, wetting agent and binder in color cosmetics.
Being readily miscible with natural oils and surfactants, Glyceryl Trioctanoate is used as the fat component in two-phase foam baths.
Glyceryl Trioctanoate is used in sunscreen creams and oils because of its compatibility with organic and inorganic filter agents.
Glyceryl Trioctanoate is also used as a fixative for perfumes/fragrances.
Biochem/physiol Actions
Glyceryl Trioctanoate might serve as a skin softening agent.
Glyceryl Trioctanoate possesses caprylic acid as the aliphatic chain.
