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Hexadecyl hexadecanoate (Cetyl Palmitate), also known as cetyl palmitate, is the ester derived from hexadecanoic acid and 1-hexadecanol.
Hexadecyl hexadecanoate (Cetyl Palmitate) is the primary constituent of spermaceti, the once highly prized wax found in the skull of sperm whales.
Hexadecyl hexadecanoate (Cetyl Palmitate) is a component of some solid lipid nanoparticles.
CAS: 540-10-3
MF: C32H64O2
MW: 480.85
EINECS: 208-736-6
Synonyms
SPERMACETI;PALMATIC ACID N-HEXADECYL ESTER;Cetyl Palmitate (50 mg);n-Hexadecyl palMitate, 98% 25GR;n-Hexadecyl palMitate, 98% 5GR;SperMwax;Cetyl Palmitate Palmitic Acid Hexadecyl Ester;PalMityl palMitate, 95+%;
Hexadecanoic acid,hexadecyl ester;Palmitic acid,hexadecyl ester;Palmitic acid,cetyl ester;1-Hexadecanol,palmitate;Cetin;Cetyl palmitate;Hexadecyl palmitate;n-Hexadecyl hexadecanoate;Palmityl palmitate;Hexadecyl hexadecanoate;Standamul 1616;Starfol Wax CG;n-Hexadecyl n-hexadecanoate;Precifac;Cutina CP;Stepan 653;Stepantex 653;N-SP;Kessco 653;Palmitic acid palmityl ester;Cutina CPA;Estol 3694;Nikkol N-SP;Precifac ATO;S 653;Radia 7500;Nikkol N-SPV;Cutina CP-PH;Kollicream CP 15;Amleps PC;Monecol PC;Amreps PC;Crodamol CP
Stony corals, which build the coral reefs, contain large amounts of cetyl palmitate wax in their tissues, which may function in part as an antifeedant.
A palmitate ester resulting from the formal condensation of palmitic acid with palmityl alcohol.
Hexadecyl hexadecanoate (Cetyl Palmitate)It is used as a thickener and emollient in cosmetics.
Hexadecyl hexadecanoate (Cetyl Palmitate) is an ester of palmitic acid, obtained via the reaction of cetyl alcohol and palmitic acid.
Hexadecyl hexadecanoate (Cetyl Palmitate) is an ingredient of many cosmetic preparations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hexadecyl hexadecanoate (Cetyl Palmitate) is a cosmetic ingredient widely used as an emollient, emulsifier, and thickening agent in skincare and personal care products.
In its raw form, Hexadecyl hexadecanoate (Cetyl Palmitate) appears as a white, waxy solid.
Hexadecyl hexadecanoate (Cetyl Palmitate) enhances the texture of creams and lotions, imparting a smooth and silky feel to the skin while also helping to stabilize formulations.
Hexadecyl hexadecanoate (Cetyl Palmitate)'s emollient properties contribute to skin hydration by forming a protective barrier that reduces moisture loss.
Additionally, Hexadecyl hexadecanoate (Cetyl Palmitate) improves the spreadability of products, ensuring even application.
The chemical formula of Hexadecyl hexadecanoate (Cetyl Palmitate) is C32H64O2.
Hexadecyl hexadecanoate (Cetyl Palmitate), also known as hexadecyl hexadecanoate, is a naturally occurring waxy lipid used to formulate solid lipid nanoparticles (SLNs).
Hexadecyl hexadecanoate (Cetyl Palmitate)'s are nano-sized particles composed of certain lipids, like waxes, that are solid at room and body temperature.
Hexadecyl hexadecanoate (Cetyl Palmitate)'s are advantageous over other drug delivery systems due to the inherent biocompatibility of the materials used for formulation.
Hexadecyl hexadecanoate (Cetyl Palmitate), in combination with other two-tailed lipids, has been effectively utilized for transfection as well as other types of drug delivery in a variety of cell lines.
Hexadecyl hexadecanoate (Cetyl Palmitate) Chemical Properties
Melting point: 55-56 °C(lit.)
Boiling point: 360 °C
Density: d20 0.989
Refractive index: 1.4429 (589.3 nm 60℃)
Storage temp.: 2-8°C
Solubility: Soluble in hot acetone.
Form: Crystalline Powder
Color: White to almost white
Biological source: synthetic (organic)
Merck: 14,2031
Dielectric constant: 2.2（Ambient）
Cosmetics Ingredients Functions FRAGRANCE
SKIN CONDITIONING
SKIN CONDITIONING - EMOLLIENT
InChI: InChI=1S/C32H64O2/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-34-32(33)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-31H2,1-2H3
InChIKey: PXDJXZJSCPSGGI-UHFFFAOYSA-N
LogP: 15.051 (est)
CAS DataBase Reference: 540-10-3(CAS DataBase Reference)
EPA Substance Registry System: Hexadecyl hexadecanoate (Cetyl Palmitate) (540-10-3)
Uses
Hexadecyl hexadecanoate (Cetyl Palmitate) is a wax ester of palmitic acid used in cosmetic and personal care products.
The chemical structure of cetyl palmitate (synthetic spermaceti) is the same as whale spermaceti.
Hexadecyl hexadecanoate (Cetyl Palmitate) may be used to thicken, produce viscose emulsions, give stability, and add texture to emulsions.
Hexadecyl hexadecanoate (Cetyl Palmitate) is similar to cetearyl palmitate.
Hexadecyl hexadecanoate (Cetyl Palmitate) is used as emollients, masking agents and skin conditioning and a glosser and thickener for creams.
Hexadecyl hexadecanoate (Cetyl Palmitate) improves emulsion texture and stability and gives structure to cosmetic sticks.
Used in skin and hair applications.
Hexadecyl hexadecanoate (Cetyl Palmitate) is used in cosmetics as a thickener and emulsifier.
Hexadecyl hexadecanoate (Cetyl Palmitate) is a wax ester of palmitic acid used in cosmetic and personal care products.
The chemical structure of Hexadecyl hexadecanoate (Cetyl Palmitate) is the same as whale spermaceti.
Hexadecyl hexadecanoate (Cetyl Palmitate) may be used to thicken, produce viscose emulsions, give stability, and add texture to emulsions.
Hexadecyl hexadecanoate (Cetyl Palmitate)It is similar to cetearyl palmitate.
Synthesis
GENERAL METHOD: 1.0 g (7.69 mmol) of 1-hexadecanol was added to a 50 mL round-bottomed flask, followed by 0.523 g (0.66 eq.) of NaBr and 0.383 g (0.33 eq.) of NaBrO3, and 10 mL of H2O.
The reaction mixture was stirred vigorously to ensure complete dissolution of the contents.
An aqueous solution of H2SO4 (0.5 equiv, prepared from 0.21 mL of 98% H2SO4 with 1 mL of water) was slowly added to the above reaction mixture at room temperature with continuous stirring for 2.5 hours.
The reaction mixture was continued to be stirred for up to 24 hours.
Upon completion of the reaction, the product was extracted with CH2Cl2 (3 x 15 mL) and the organic layer was dried with Na2SO4, followed by removal of the solvent to afford hexadecanoic acid hexadecyl ester in 98% yield (0.953 g) as a colorless liquid.
The structure of the product was confirmed by GC-MS and NMR.
