HEXAMIDINE DIISETHIONATE

Synonyms

Hexamidine diisethionate; 2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1); 659-40-5; Desomedine; Hexomedine; Ophtamedine; Esomedina; UNII-023XA5Z50L; Hexamidine isethionate; 023XA5Z50L; 2-HYDROXYETHANESULPHONIC ACID, COMPOUND WITH 4,4'-[HEXANE-1,6-DIYLBIS(OXY)]BIS[BENZENECARBOXAMIDINE] (2:1); 2535 RP; RP 2535; 2535 R. P.; Desmedine; 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; 2-hydroxyethanesulfonic acid; Hexamidin 2-hydroxyethansulfonat; 2-Hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1) ;EINECS 211-533-5; 4,4'-(Hexane-1,6-diylbis(oxy))dibenzimidamide bis(2-hydroxyethanesulfonate); Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI); Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI); hekzamidin diizetionat; hekzamidin di izetionat;  hekzamidin dietionat; hekzamidin di etionat; hegzamidin diizetionat; hegzamidin di izetionat;  hegzamidin dietionat; hegzamidin di etionat; heksamidin diizetionat; heksamidin di izetionat;  heksamidin dietionat; heksamidin di etionate ;hekzamidin diizetionate; hekzamidin di izetionate;  hekzamidin dietionate; hekzamidin di etionate ; hekzamidin diizotiyonat; hekzamidin di izotiyonat ; hekzamidin diizotiyonate; hekzamidin di izotiyonate

HEXAMIDINE DIISETHIONATE

CAS Number:    659-40-5
Hexamidine Diisethionate

What Is Hexamidine Diisethionate?
In cosmetics and personal-care products, Hexamidine and Hexamidine Diisethionate function as a preservatives and are used in the formulation of hair, nail, and skin-care products, as well as eye makeup and baby products.

Why is Hexamidine Diisethionate used in cosmetics and personal care products?
Hexamidine Diisethionate helps cleanse the skin or prevent odor by destroying or inhibiting the growth of microorganisms.

Scientific Facts: 
Hexamidine Diisethionate is an organic salt of Hexamidine. Hexamidine is soluble in water and insoluble in organic solvents. These ingredients function as preservatives, which help cleanse the skin or prevent odor by inhibiting the growth of or destroying microorganisms, such as bacteria, fungi and yeast.

HEXAMIDINE DIISETHIONATE
HEXAMIDINE DIISETHIONATE is classified as :
Antifoaming
Emollient
Preservative
Skin conditioning
CAS Number    659-40-5
EINECS/ELINCS No:    211-533-5
Restriction (applies to EU only):    VI/47
COSING REF No:    34260
Chem/IUPAC Name:    2-Hydroxyethanesulphonic acid, compound with 4,4'-[hexane-1,6-diylbis(oxy)]bis[benzenecarboxamidine] (2:1)

Hexamidine

Hexamidine
Skeletal formula of hexamidine
Ball-and-stick model
Names
IUPAC name
4,4'-[hexane-1,6-diylbis(oxy)]dibenzenecarboximidamide
Other names
4-[6-(4-carbamimidoylphenoxy)hexoxy]benzamidine
Identifiers
CAS Number    
3811-75-4 check
3D model (JSmol)    
Interactive image
ChEBI    
CHEBI:87184 ☒
ChEMBL    
ChEMBL25105 check
ChemSpider    
58639 check
DrugBank    
DB03808 check
PubChem CID    
65130
UNII    
3483C2H13H check
CompTox Dashboard (EPA)    
DTXSID60191524 
InChI[show]
SMILES[show]
Properties
Chemical formula    C20H26N4O2
Molar mass    354.446
Pharmacology
ATC code    D08AC04 (WHO) R01AX07 (WHO) R02AA18 (WHO) S01AX08 (WHO) S03AA05 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Hexamidine is an antiseptic and disinfectant. Hexomedine is the trade name of a diisethionate solution (1/1.000) of hexamidine.[1] Hexamidine is used primarily as its diisethionate salt, which is more water-soluble than the dihydrochloride. The dihydrochloride was first synthesized and patented as a trypanocide for May & Baker in 1939. Its amoebicidal properties emerged in the 1990s. The exact mechanism of its biocidal action is unknown, but presumed similar to quaternary ammonium compounds, involving binding to the negatively charged lipid membranes of pathogens. Hexamidine and its shorter congener, propamidine, are used as antiseptics and preservatives in pharmaceuticals and cosmetics. They are particularly used for the topical treatment of acanthamoebiasis (Acanthamoeba keratitis)

Molecular Weight of Hexamidine Diisethionate    606.7 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Hydrogen Bond Donor Countt of Hexamidine Diisethionate    8    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Countt of Hexamidine Diisethionate    12    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Countt of Hexamidine Diisethionate    15    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Masst of Hexamidine Diisethionate    606.202936 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Masst of Hexamidine Diisethionate    606.202936 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Areat of Hexamidine Diisethionate    284 Ų    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Countt of Hexamidine Diisethionate    40    Computed by PubChem
Formal Charget of Hexamidine Diisethionate    0    Computed by PubChem
Complexityt of Hexamidine Diisethionate    505    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Countt of Hexamidine Diisethionate    0    Computed by PubChem
Defined Atom Stereocenter Countt of Hexamidine Diisethionate    0    Computed by PubChem
Undefined Atom Stereocenter Countt of Hexamidine Diisethionate    0    Computed by PubChem
Defined Bond Stereocenter Countt of Hexamidine Diisethionate    0    Computed by PubChem
Undefined Bond Stereocenter Countt of Hexamidine Diisethionate    0    Computed by PubChem
Covalently-Bonded Unit Countt of Hexamidine Diisethionate    3    Computed by PubChem
Compound of Hexamidine Diisethionate is Canonicalized    Yes

CAS number: 659-40-5
 "Satisfactory" in all categories.
Origin (s): Synthetic
INCI name: HEXAMIDINE DIISETHIONATE
EINECS / ELINCS number: 211-533-5
Classification: Regulated, Conservative
Restriction in Europe: The maximum authorized concentration in ready-to-use cosmetic preparations is 0.1%.
Its functions (INCI)
Anti-foaming: Suppresses foam during manufacturing / reduces foaming in liquid end products
Emollient: Softens and softens the skin
Preservative: Inhibits the development of microorganisms in cosmetic products.
Skin care agent: Keeps the skin in good condition
Anti-Dandruff: Helps fight dandruff
Antimicrobial: Helps slow the growth of microorganisms on the skin and inhibits the growth of microbes
This ingredient is present in 0.06% of cosmetics.

HEXAMIDINE (DIISETHIONATE)
Each drug has one or more active principle (s) which gives it (s) a particular therapeutic effect. An active principle can be a set of chemical compounds or a natural plant, mineral or animal substance. Find in this section a medicine according to its active principle, also called active substance.
Hexamidine can cause contact dermatitis. It is considered non-toxic in cosmetics for concentrations of 0.03% to 0.1%.

HEXAMIDINE: MECHANISM OF ACTION
Hexamidine (belonging to the family of diamidines) is a cationic antibacterial agent and exhibits surfactant properties.

In vitro, its activity is exerted on Gram + bacteria and is not inhibited by pus, serum or organic debris.

HEXAMIDINE: USE CASE
Ophthalmically, hexamidine is used in the management of:

bacterial blepharitis,
bacterial conjunctivitis,
dacryocystitis,
bacterial keratoconjunctivitis.
By the nasal route, hexamidine is used in the management of acute nasopharyngitis.

Dermally, hexamidine is used in the management of bacterial skin conditions.

By the ear, in combination with lidocaine, hexamidine is used in the management of otitis externa.

By local route, in combination with lidocaine or tetracaine, hexamidine is used in the management of oral disorders.