HOMOSALATE

Homosalate is an organic compound used in some sunscreens. 
Homosalate is made by the Fischer–Speier esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, the latter being a hydrogenated derivative of isophorone. 
Contained in 45% of U.S. sunscreens, Homosalate is used as a chemical UV filter.

CAS:    118-56-9
MF:    C16H22O3
MW:    262.34
EINECS:    204-260-8

Synonyms
Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester;Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester;component of Coppertone;Coppertone;Filtersol ''A'';Filtrosol A;Heliopan;Homosalat;Homosalate;118-56-9;Homomenthyl salicylate;Coppertone;3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE;Heliopan;Heliophan;Filtersol ''A'';3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate;m-Homomenthyl salicylate;Homosalato;Homosalatum;(3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate;Caswell No. 482B;52253-93-7;Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester;CCRIS 4885;NSC 164918;Metahomomenthyl salicylate;Homosalatum [INN-Latin];Homosalato [INN-Spanish];Salicylic acid, m-homomenthyl ester;EINECS 204-260-8;2-Hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester;UNII-V06SV4M95S;MFCD00019377;Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester;EPA Pesticide Chemical Code 076603;NSC-164918;V06SV4M95S;Homosalate [USAN:USP:INN];DTXSID1026241;EC 204-260-8;Salicylic acid, 3,3,5-trimethylcyclohexyl ester;NCGC00091888-01;Homosalatum (INN-Latin);Homosalato (INN-Spanish);HOMOSALATE (MART.);HOMOSALATE [MART.];HOMOSALATE (USP-RS);HOMOSALATE [USP-RS];Homosalate (USAN:USP:INN);DTXCID606241;Salicylic acid, 3,3,5-trimethylcyclohexyl ester (8CI);HOMOSALATE (USP IMPURITY);HOMOSALATE [USP IMPURITY];HOMOSALATE (USP MONOGRAPH);HOMOSALATE [USP MONOGRAPH];Filtrosol A;component of Coppertone;SR-05000001884;Homosalat;Kemester HMS;CAS-118-56-9;Homosalate; Salicylic acid 3,3,5-trimethylcyclohexyl ester; 3,3,5-Trimethylcyclohexyl salicylate;Filtersol''A'';Homosalate (Standard);HOMOSALATE [MI];Homosalate (USP/INN);HOMOSALATE [INN];Prestwick1_001090;Prestwick2_001090;Prestwick3_001090;HOMOSALATE [USAN];HOMOSALATE [WHO-DD];SCHEMBL16207;BSPBio_001140;SPECTRUM1505020;SPBio_003030;BPBio1_001254;Sun Protection Facial SPF 50;CHEMBL1377575;CHEBI:91642;HY-B0928R;MSK3404;3,5-Trimethylcyclohexyl salicylate;HMS1571I22;HMS2093G22;HMS2098I22;HMS3715I22;Pharmakon1600-01505020;component of Coppertone (Salt/Mix);HY-B0928;3,3,5-Trimethylcyclohexylsalicylate;Tox21_111174;Tox21_202109;Tox21_303082;Homosalate(mixture of cis and trans);NSC164918;NSC758908;s4572;AKOS015904082;Tox21_111174_1;CCG-213330;DB11064;NSC-758908;NCGC00091888-02;NCGC00091888-03;NCGC00091888-04;NCGC00091888-05;NCGC00091888-06;NCGC00091888-09;NCGC00257063-01;NCGC00259658-01;AS-10409;DA-54062;SY051923;SBI-0206787.P001;AB00514041;NS00009551;Salicylic acid,3,5-trimethylcyclohexyl ester;T2278;Benzoic acid, 3,3,5-trimethylcyclohexyl ester;D04450;E78223;AB00514041_02;EN300-7381967;Q2260189;SR-05000001884-1;SR-05000001884-2;BRD-A34751532-001-03-6;BRD-A34751532-001-04-4;BRD-A34751532-001-06-9;2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester;Homosalate, United States Pharmacopeia (USP) Reference Standard;Homosalate, Pharmaceutical Secondary Standard; Certified Reference Material;204-260-8

The salicylic acid portion of the molecule absorbs ultraviolet rays with a wavelength from 295 nm to 315 nm, protecting the skin from sun damage. 
The hydrophobic trimethyl cyclohexyl group provides greasiness that prevents Homosalate from dissolving in water.
Homosalate is an organic compound that belongs to a class of chemicals called salicylates. 
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. 
Homosalate specifically absorbs short-wave UVB rays, associated with DNA damage and an increased risk of skin cancer. 
Homosalate is a widely used chemical in sunscreens and skin care products with SPF. 
However, Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones. 
In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body.

Homosalate is a widely used chemical in sunscreens and skin care products with SPF. 
Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones. 
In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body.
Homosalate is an organic compound that belongs to a class of chemicals called salicylates. 
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light.
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.
Homosalate is a chemical compound commonly used in cosmetics and sunscreens as an ultraviolet (UV) filter, offering protection against sun-induced skin damage. 
Apart from this, it enhances the overall stability of sunscreen formulations. 

Homosalate is versatile and popular for its light, non-greasy texture, making it a preferred choice in various skincare products. 
While effective in UVB protection, it is important to note that Homosalate primarily addresses shorter-wavelength UV rays, necessitating the combination with other sunscreen agents for broad-spectrum coverage against both UVA and UVB rays. 
Additionally, Homosalate also goes by the name homomenthylsalicylate and has the chemical formula C16H22O3.
Homosalate is a liquid oil soluble UVB sunscreen. 
Homosalate (other name is homomenthylsalicylate) is an organic compound, an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol Sunscreen agent for mainly UVB protection. 
Can be combined with other sunscreens. 
Excellent dissolving properties for solid sunscreens.3,3,5-trimethylcyclohexylsalicylate appears as viscous or light yellow to slightly tan liquid or oil. 

Homosalate appears as viscous or light yellow to slightly tan liquid or oil. 
(NTP, 1992)|2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester is a benzoate ester and a member of phenols. 
Homosalate derives from a salicylic acid.|Homosalate is an organic compound that belongs to salicylates. 
Homosalate is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. 
Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. 
Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer. 
Homosalate is a common ingredient in many commercially available sunscreens. 
There are no reported adverse effects from homosalate.

Homosalate Chemical Properties
Boiling point: 161-165°C (12 torr)
Density: 1.05
Vapor pressure: 0.015Pa at 25℃
Refractive index: n20 1.516 to 1.518
Fp: 169 - 173℃
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Chloroform (Slightly), DMSO (Slightly)
Pka: 8.10±0.30(Predicted)
Form: Liquid
Color: Colourless
Odor: at 100.00?%. mild menthol
Water Solubility: <0.1 g/100 mL at 26 ºC
BRN: 2731604
LogP: 6.27 at 25℃
CAS DataBase Reference: 118-56-9(CAS DataBase Reference)
NIST Chemistry Reference: Homosalate(118-56-9)
EPA Substance Registry System: Homosalate (118-56-9)

Uses    
Homosalate used as a UV filter in various personal skin care formulations and cosmetics.
homosalate is a chemical uVB absorber included in the FDA’s Category I Sunscreen Chemical list. 
Homosalate's approved usage level is 4 to 15 percent by the FDA and 10 percent by the european union’s Cosmetic Directive.
Homosalate serves sunscreens and cosmetics primarily as a chemical UV filter. 
Homosalate absorbs the UV rays, specifically UVB rays, that are known to cause sunburn and contribute to sun damage. 
These harmful rays can also cause the skin to tan and sometimes lead to skin cancer. 
Homosalate is a stable ingredient that works its magic against UV rays for longer durations. 
Indirectly, Homosalate also acts as an anti-aging compound for the skin - maintaining its health and keeping it youthful. 
However, Homosalate is not strong enough to be used independently and is often combined with other ingredients to maximize protection.

Reactivity Profile    
An ester and a phenol. 
Esters react with acids to liberate heat along with alcohols and acids. 
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. 
Heat is also generated by the interaction of esters with caustic solutions. 
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Side effects    
Similar to oxybenzone, homosalate affects hormone activity once absorbed. 
Skin rashes, acne and skin irritation are rare side effects of the toxic chemical. 
Estrogen, androgen and progesterone have all been found to be disrupted when the body is exposed to homosalate.