(ii) RIBOFLAVIN-5'-PHOSPHATE

(ii) Riboflavin-5'-phosphate is widely utilized across pharmaceutical, nutritional, and biochemical fields due to its high bioavailability and essential role in cellular metabolism.
In pharmaceutical applications, (ii) Riboflavin-5'-phosphate is commonly used as a vitamin B2 supplement, particularly in injectable formulations where rapid absorption is required.

CAS Number: 130-40-5
EC Number (EINECS): 204-988-6
Molecular Formula: C₁₇H₂₁N₄O₉P
Molecular Weight: 456.34 g/mol

SYNONYMS:
Riboflavin-5′-phosphate, Flavin mononucleotide, FMN, Riboflavin monophosphate, Riboflavin phosphate sodium (when in salt form), Lactoflavin phosphate, Vitamin B2 phosphate, Flavine mononucleotide

(ii) Riboflavin-5'-phosphate’s a flexible way to support energy-yielding metabolism, reduction of fatigue and maintenance of normal skin and vision when you prefer liquids to capsules.
(ii) Riboflavin-5'-phosphate (R5P), or flavin mononucleotide (FMN), is a highly bioavailable, metabolically active coenzyme form of Vitamin.

(ii) Riboflavin-5'-phosphate, also known as flavin mononucleotide (FMN), is a biologically active derivative of vitamin B2.
(ii) Riboflavin-5'-phosphate plays a crucial role as a cofactor in various oxidative enzymes involved in cellular metabolism.
(ii) Riboflavin-5'-phosphate is essential for redox reactions, particularly in the electron transport chain where it contributes to energy production.

(ii) Riboflavin-5'-phosphate is more water-soluble than riboflavin, making it readily absorbed and utilized in biological systems.
(ii) Riboflavin-5'-phosphate is commonly used in food fortification and pharmaceutical formulations due to its stability and bioavailability.
Additionally, (ii) Riboflavin-5'-phosphate participates in enzymatic processes that support cellular growth, development, and overall metabolic function.

USES and APPLICATIONS of (ii) RIBOFLAVIN-5'-PHOSPHATE:
(ii) Riboflavin-5'-phosphate, also known as flavin mononucleotide (FMN), is widely utilized across pharmaceutical, nutritional, and biochemical fields due to its high bioavailability and essential role in cellular metabolism.
In pharmaceutical applications, (ii) Riboflavin-5'-phosphate is commonly used as a vitamin B2 supplement, particularly in injectable formulations where rapid absorption is required.

(ii) Riboflavin-5'-phosphate is administered in the prevention and treatment of riboflavin deficiency and related metabolic disorders, and it is often included in multivitamin preparations and clinical nutrition products.
In the food and beverage industry, (ii) Riboflavin-5'-phosphate is used as a fortifying agent to enhance the nutritional value of products, especially in cereals, infant formulas, and dietary supplements.

(ii) Riboflavin-5'-phosphate's natural yellow color also allows it to function as a coloring agent in certain formulations.
In biotechnology and laboratory settings, (ii) Riboflavin-5'-phosphate serves as an essential cofactor in enzymatic reactions, particularly those involving oxidation–reduction processes.
(ii) Riboflavin-5'-phosphate is frequently used in research involving electron transport chains, flavoproteins, and metabolic pathway analysis.

From a functional perspective, (ii) Riboflavin-5'-phosphate provides significant biological benefits due to its role in energy production.
(ii) Riboflavin-5'-phosphate participates in redox reactions by cycling between oxidized and reduced forms, thereby supporting mitochondrial function and ATP generation.
(ii) Riboflavin-5'-phosphate is also involved in the metabolism of carbohydrates, fats, and proteins, making it critical for maintaining overall metabolic efficiency.

Additionally, (ii) Riboflavin-5'-phosphate contributes to the maintenance of healthy skin, eyes, and nervous system function, and plays a role in antioxidant defense mechanisms by supporting the activity of glutathione reductase.
In terms of characteristics, (ii) Riboflavin-5'-phosphate is distinguished by its high water solubility compared to riboflavin, which enhances its absorption and usability in aqueous systems.

(ii) Riboflavin-5'-phosphate exhibits strong fluorescence under ultraviolet light and is sensitive to light exposure, requiring careful handling and storage conditions.
Chemically, (ii) Riboflavin-5'-phosphate is a phosphorylated derivative of riboflavin, which allows it to act directly as a coenzyme or be further converted into flavin adenine dinucleotide (FAD) in biological systems.

Its stability is generally maintained under acidic to neutral conditions, although (ii) Riboflavin-5'-phosphate may degrade in alkaline environments or upon prolonged exposure to light.
These combined properties make (ii) Riboflavin-5'-phosphate a highly versatile and biologically important compound in both industrial and physiological contexts.
(ii) Riboflavin-5'-phosphate is widely used in the pharmaceutical, food, and biotechnology industries.

In pharmaceuticals, (ii) Riboflavin-5'-phosphate is used as a vitamin supplement, especially in injectable formulations due to its superior bioavailability.
(ii) Riboflavin-5'-phosphate is used in treating riboflavin deficiency and associated disorders such as ariboflavinosis.
In the food industry, (ii) Riboflavin-5'-phosphate is used as a food additive and fortification agent to enrich foods with vitamin B2.

(ii) Riboflavin-5'-phosphate also acts as a natural colorant due to its bright yellow color.
In biotechnology and research, (ii) Riboflavin-5'-phosphate is used as a cofactor in enzymatic reactions and biochemical assays.
(ii) Riboflavin-5'-phosphate plays a role in studying electron transport chains and oxidative enzymes.

(ii) Riboflavin-5'-phosphate acts as a necessary cofactor for energy metabolism, cellular function, and tissue maintenance, often used in supplements and as a food colorant (E101ii).
FMN is also used in ophthalmic preparations for corneal collagen cross-linking.
(ii) Riboflavin-5'-phosphate is generally regarded as safe (GRAS) when used in food and supplements at recommended levels.
(ii) Riboflavin-5'-phosphate is a key intermediate in biological systems and is essential for the function of flavoproteins.

(ii) Riboflavin-5'-phosphate plays a role in mitochondrial energy production and is critical for maintaining cellular oxidative balance.
(ii) Riboflavin-5'-phosphate's sodium salt form is often used commercially due to improved stability and solubility.
(ii) Riboflavin-5'-phosphate is also used in photochemical and photobiological studies because of its light sensitivity and fluorescence properties.

CHARACTERISTICS of (ii) RIBOFLAVIN-5'-PHOSPHATE:
(ii) Riboflavin-5'-phosphate is a biologically active coenzyme precursor that is readily converted into flavin adenine dinucleotide (FAD).
(ii) Riboflavin-5'-phosphate acts as a prosthetic group in various flavoproteins and enzymes.
(ii) Riboflavin-5'-phosphate is essential for metabolic pathways such as fatty acid oxidation, the citric acid cycle, and amino acid metabolism.
(ii) Riboflavin-5'-phosphate's enhanced solubility compared to riboflavin makes it more suitable for pharmaceutical and nutritional formulations.
(ii) Riboflavin-5'-phosphate is also photosensitive, requiring protection from light during storage and handling.

KEY DETAILS of (ii) RIBOFLAVIN-5'-PHOSPHATE:
Active Form: 
Unlike standard riboflavin, (ii) Riboflavin-5'-phosphate is the coenzymated form, allowing the body to use it directly without requiring further conversion, increasing its effectiveness.

Biological Function: 
(ii) Riboflavin-5'-phosphate serves as a coenzyme for flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are critical for metabolizing fats, proteins, and carbohydrates.

Supplementation: 
(ii) Riboflavin-5'-phosphate is commonly used in supplements to support energy and cellular health.

Other Uses of (ii) Riboflavin-5'-phosphate: 
Authorized in the EU as a food colorant (E101ii) and in topical ophthalmology to treat eye conditions like corneal ectasia.

(ii) Riboflavin-5'-phosphate is the biologically active phosphorylated derivative of riboflavin (vitamin B2).
(ii) Riboflavin-5'-phosphate functions as a key coenzyme in cellular redox reactions, particularly in energy metabolism.
(ii) Riboflavin-5'-phosphate is naturally present in living organisms and plays a critical role in oxidative phosphorylation and electron transport systems.

BENEFITS of (ii) RIBOFLAVIN-5'-PHOSPHATE:
(ii) Riboflavin-5'-phosphate supports cellular energy production by participating in redox reactions.
(ii) Riboflavin-5'-phosphate contributes to maintaining healthy skin, eyes, and nervous system function.
(ii) Riboflavin-5'-phosphate also helps in the metabolism of carbohydrates, fats, and proteins.
(ii) Riboflavin-5'-phosphate's phosphorylated form allows for faster absorption and utilization in the body compared to riboflavin.
(ii) Riboflavin-5'-phosphate also has antioxidant properties through its role in redox cycling.

PHYSICAL AND CHEMICAL PROPERTIES of (ii) RIBOFLAVIN-5'-PHOSPHATE:
(ii) Riboflavin-5'-phosphate typically appears as a yellow to orange crystalline powder with high water solubility compared to riboflavin itself.
(ii) Riboflavin-5'-phosphate is hygroscopic and sensitive to light, especially ultraviolet radiation, which can lead to degradation.
Chemically, (ii) Riboflavin-5'-phosphate contains an isoalloxazine ring system linked to a ribitol moiety, with a phosphate group attached at the 5′ position.
This phosphate group increases (ii) Riboflavin-5'-phosphate's polarity and solubility in aqueous environments.

(ii) Riboflavin-5'-phosphate has:
*Strong fluorescence under UV light
*Stability in acidic to neutral pH, but degradation in alkaline conditions
*Limited solubility in organic solvents
*A characteristic yellow coloration due to its conjugated ring system
(ii) Riboflavin-5'-phosphate participates in reversible redox reactions, alternating between oxidized (FMN) and reduced (FMNH₂) forms, making it essential in biochemical electron transfer.

PHYSICAL and CHEMICAL PROPERTIES of (ii) RIBOFLAVIN-5'-PHOSPHATE:
CAS Number: 130-40-5
EC Number (EINECS): 204-988-6
Molecular Formula: C₁₇H₂₁N₄O₉P
Molecular Weight: 456.34 g/mol
Appearance: Yellow to orange crystalline powder
Color: Bright yellow (characteristic of flavins)
Odor: Odorless or faint characteristic odor
Solubility:
Freely soluble in water
Practically insoluble in organic solvents (e.g., ethanol, chloroform)

Hygroscopicity: Slightly hygroscopic
Fluorescence: Strong yellow-green fluorescence under UV light
Melting Point: Decomposes before melting (no sharp melting point)
Taste: Slightly bitter (in solution)
Molecular Formula: C₁₇H₂₁N₄O₉P
Molecular Weight: 456.34 g/mol
Chemical Structure: Isoalloxazine ring system linked to ribitol with a phosphate group at the 5′ position
pH Stability:

Stable in acidic to neutral conditions
Unstable in alkaline (basic) conditions
Light Sensitivity:
Highly sensitive to light (especially UV)
Undergoes photodegradation
Redox Behavior:
Participates in reversible oxidation-reduction reactions
Exists in oxidized (FMN) and reduced (FMNH₂) forms
Thermal Stability:
Relatively stable at moderate temperatures
Decomposes upon prolonged heating

Ionization: Contains ionizable phosphate group (acidic character)
Polarity: High polarity due to phosphate group
Chemical Reactivity:
Acts as a coenzyme in oxidation-reduction reactions
Can form complexes with proteins (flavoproteins)
Photosensitivity: Requires protection from light during storage
Oxidative Behavior: Can be degraded by strong oxidizing or reducing agents
Salt Formation: Commonly used as sodium salt (riboflavin-5′-phosphate sodium) for improved stability and solubility

FIRST AID MEASURES of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of (ii) RIBOFLAVIN-5'-PHOSPHATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available