IMIDAZOLIDINE

Imidazolidine can be used in imidzaole antifungal, econazole, clotrimazole. 
Imidazolidine is also the intermediate of ardiovascular ,ingredient of perservative and curing agent of epoxy resin.

CAS Number: 504-74-5 
EC Number: 206-019-2
Chemical formula: C3H8N2

SYNONYMS:
Imidazolidine, 1,3-Diazacyclopentane, Tetrahydroimidazole, 1,3-Diazolidine, Imidazolidine, 504-74-5, AEE9PL2D22, C3H8N2, Imidazolidines, an imidazolidine, 1,3-diazacyclopentane, Imidazole, tetrahydro-, Dihydroimidazol-2-ylidene, UNII-AEE9PL2D22, Imidazolidine, 90% in water, DTXSID2073192, CHEBI:33137, MFCD19216513, AKOS006352062, DB-230536, CS-0155210, Q3131185, Q5276431, 1,3-Diazole, 1H-Imidazol, Glyoxaline

Imidazolidine is a heterocyclic compound (CH2)2(NH)2CH2. 
The parent Imidazolidine is lightly studied, but related compounds substituted on one or both nitrogen centers are more common. 
Generally, they are colorless, polar, basic compounds. 

Imidazolidine is cyclic 5-membered examples of the general class of animals.
Imidazolidine is a saturated organic heteromonocyclic parent, a member of imidazolidines and an azacycloalkane.
Imidazolidine  is compound based on reduced Imidazolidine which contain no double bonds in the ring.

Imidazolidine is a type of inhibitor that is derived from a chemical compound with the same name.
Imidazolidine belongs to the class of organic compounds known as imidazolidines. 
These are organic compounds containing an imidazolidine ring, which is a saturated ring (derived from imidazole) with two nitrogen atoms at positions 1 and 3 respectively, and containing only single bonds. 

Based on a literature review a significant number of articles have been published on imidazolidine. 
Imidazolidine has been identified in human blood as reported by. 
Imidazolidine is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. 

Technically Imidazolidine is part of the human exposome. 
The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. 
An individual's exposure begins before birth and includes insults from environmental and occupational sources.

USES and APPLICATIONS of IMIDAZOLIDINE:
Imidazolidine can be used in imidzaole antifungal, econazole, clotrimazole. 
Imidazolidine is also the intermediate of ardiovascular ,ingredient of perservative and curing agent of epoxy resin.

ALTERNATIVE PARENTS OF IMIDAZOLIDINE:
*Dialkylamines 
*Azacyclic compounds 
*Aminals 
*Organopnictogen compounds 
*Hydrocarbon derivatives 

SUBSTITUENTS OF IMIDAZOLIDINE:
*Imidazolidine
*Azacycle
*Secondary amine
*Secondary aliphatic amine
*Aminal
*Organic nitrogen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organonitrogen compound
*Amine
*Aliphatic heteromonocyclic compound

PREPARATION OF IMIDAZOLIDINE:
Imidazolidine is traditionally prepared by condensation reaction of 1,2-diamines and aldehydes. 
Most commonly, one or both nitrogen center is substituted with an alkyl or benzyl (Bn) group:
(CH2NBn)2+PhCHO⟶(CH2NBn)2C(H)Ph+H2O
The first unsubstituted imidazolidine synthesis was reported in 1952.

REACTIONS OF IMIDAZOLIDINE:
Unsubstituted imidazolidines are often labile.
The rings are susceptible to hydrolysis back to the diamine and the aldehyde.

Formally, removal of the two hydrogens at carbon 2 (between the two nitrogens) would yield the carbene dihydroimidazol-2-ylidene. 
Derivatives of the latter comprise an important class of persistent carbenes.

Related imidazole-derived heterocycles
Classified as a diamine, Imidazolidine is formally derived by the addition of four hydrogen atoms to imidazole. 
The intermediate, resulting from the addition of only two hydrogen atoms is called imidazoline (dihydroimidazole). 

PHYSICAL and CHEMICAL PROPERTIES of IMIDAZOLIDINE:
CAS Number: 504-74-5,
Chemical formula: C3H8N2,
Molar mass: 72.109,
Molecular Weight: 72.11 g/mol,
XLogP3-AA: -0.8,
Hydrogen Bond Donor Count: 2,
Hydrogen Bond Acceptor Count: 2,
Rotatable Bond Count: 0,
Exact Mass: 72.068748264 g/mol,
Monoisotopic Mass: 72.068748264 g/mol,
Topological Polar Surface Area: 24.1Ų,

Heavy Atom Count: 5,
Formal Charge: 0,
Complexity: 24.1,
Isotope Atom Count: 0,
Defined Atom Stereocenter Count: 0,
Undefined Atom Stereocenter Count: 0,
Defined Bond Stereocenter Count: 0,
Undefined Bond Stereocenter Count: 0,
Covalently-Bonded Unit Count: 1,
Compound Is Canonicalized: Yes,
Chemical formula: C3H8N2,

Average Molecular Weight: 72.111,
Monoisotopic Molecular Weight: 72.068748266,
IUPAC Name: imidazolidine,
Traditional Name: imidazolidine,
CAS Registry Number: Not Available,
SMILES: C1CNCN1,
InChI Identifier: InChI=1/C3H8N2/c1-2-5-3-4-1/h4-5H,1-3H2,
InChI Key: WRYCSMQKUKOKBP-UHFFFAOYSA-N,
Appearance: White crystal,
Melting point: 87.0 ºC ~ 91.0 ºC,
Water content: 0.5% max,
Assay (GC): 99.0% min.

FIRST AID MEASURES of IMIDAZOLIDINE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of IMIDAZOLIDINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of IMIDAZOLIDINE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of IMIDAZOLIDINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of IMIDAZOLIDINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of IMIDAZOLIDINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available