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CAS NO:860-22-0
EC NO:212-728-8
Indigo carmine, or 5,5′-indigodisulfonic acid sodium salt, is an organic salt derived from indigo by aromatic sulfonation, which renders the compound soluble in water.
Indigo carmine is approved for use as a food colorant in the U.S and E.U.
Indigo carmine has the E number E132.
Indigo carmine is also a pH indicator.
Properties
Chemical formula C16H8N2Na2O8S2
Molar mass 466.36 g/mol
Appearance purple solid
Melting point >300 °C (572 °F)
Solubility in water 10 g/L (25 °C (77 °F))
USES
Indigo carmine in a 0.2% aqueous solution is blue at pH 11.4 and yellow at 13.0.
Indigo carmine is also a redox indicator, turning yellow upon reduction. Another use is as a dissolved ozone indicator through the conversion to isatin-5-sulfonic acid. This reaction has been shown not to be specific to ozone, however:
Indigo carmine also detects superoxide, an important distinction in cell physiology.
Indigo carmine is also used as a dye in the manufacturing of capsules.
In obstetric surgery, indigo carmine solutions are sometimes employed to detect amniotic fluid leaks. In urologic surgery, intravenous injection of indigo carmine is often used to highlight portions of the urinary tract. The dye is filtered rapidly by the kidneys from the blood, and colors the urine blue. This enables structures of the urinary tract to be seen in the surgical field, and demonstrate if there is a leak. However, the dye can cause a potentially dangerous increase in blood pressure in some cases.
Although not absorbed by the cells, indigo carmine stain, sprayed onto regions of interest, highlights the topography of the mucosal surface with its blue coloring.
Generally used at a concentration around 0.2%, indigo carmine stain is useful as a screening method for diagnosing minute lesions, to differentiate between benign and malignant lesions, as well as to facilitate application of ME to observe and analyze the surface structure of a lesion, delineate boundaries of early stage malignant lesions and estimate the invasion depth of cancer.
Indigo carmine has been used to diagnose Barrett’s esophagus, evaluate villous atrophy, diagnose and discriminate polypoid and non-polypoid lesions in the colon, and diagnose gastric adenoma and cancer.
Physicochemical Information
Density 0.71 g/cm3 (29 °C)
Melting Point >340 °C
pH value 7 (10 g/l, H₂O, 20 °C)
Bulk density 700 - 900 kg/m3
Solubility 1 g/l
Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide.
Indigo carmine is an indicator at pH 11.5-14, changing from blue to yellow.
Indigo carmine has a role as a food colouring, a histological dye and a two-colour indicator.
Indigo carmine contains an indigo carmine(2-).
Indigo carmine is the sodium salt form of indigotindisulfonate, a synthetic blue dye and food colorant derived from indigo, that can be used as a stain in medical imaging and as a redox and pH indicator. Upon intravenous administration, indigotindisulfonate is filtered rapidly by the kidneys from the blood and colors the urinary tract which enables the urinary tract to be seen during surgery.
Indigo carmine can also be used ex vivo to stain certain specimens, differentiate between benign and malignant lesions, and help stage and diagnose certain types of cancers.
An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide.
Indigo carmine is an indicator at pH 11.5-14, changing from blue to yellow.
Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body.
Elimination of the dye begins soon after injection, appearing in the urine within 10 minutes in average cases. The biological half-life is 4 to 5 minutes following intravenous injection. Larger quantities are necessary when intramuscular injection is employed. Appearance time and elimination are delayed following intramuscular injection.
Indigo Carmine is contraindicated in patients who have previously experienced an adverse reaction following its use
Origin:
Indigo Carmine is a food colorant with the code E 132.
Indigo Carmine is in a structural structure in water. The powder is in a structure and potentially evaluable in the field.
Functions and Properties: Synthetic food coloring is contained in the codex. Permitted products are also evaluated in production in some way. This is a structure that complies with health standards and there is no visible side effect. When considering this, Indigo Carmine is a really detailed and attractive colorant.
Usage Areas:
Indigo Carmine is tried in ice creams, frosted university, candies, jellies, cleaning products, cosmetics, colored stones and games. The production area of the color it has is affected and it is shaped at a level that can be taken.
Indigo carmine is a dye consisting of an indigo dimer with sodium salts of sulfonic acids at positions 5 and 5'.
Indigo carmine has been used as a tissue stain, pH indicator, and tool for the determination of hypochlorite in solutions.
Description
Indigo carmine is indigotindisulfonate sodium, a marker dye used during cystoscopy and ureteral catheterization.
Indigo carmine is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. Indigo carmine is an unapproved drug without FDA approved labeling.
There is no single dye that can replace indigo carmine. Choice of alternative agent will depend on type of procedure and physician discretion, as well as product availability.
Indigo Carmine (IC) is the most common chemical dye for clothes dyeing, which is considered as a refractory molecule since it is required a rather strong chemical treatment for its elimination from the water waste. The presence of this dye in residuals causes notorious change of water color and smell even in very low concentration. Moreover, if some of this water reaches natural streams it can be toxic for aquatic living entities due to the formation of toxic compounds such as aromatic amines.
Uses
Colorant for nylon, surgical sutures, foods and ingested drugs. As a reagent for functional kidney tests, for detection of nitrates, chlorates and in testing milk.
Uses
Indigo Carmine is a colorant.
Indigo carmine has poor ph stability in that after 1 week at ph 3 and 5 it will appreciably fade, at ph 7 considerably fade, and at ph 8 fade completely.
Indigo carmine is the least soluble of all food colors, with a solubility of 1.6 g in 100 ml of water at 25°c. Complete fading occurs in alkalis such as 10% sodium carbonate and 10% sodium hydroxide, with fading also occurring in 10% sugar systems.
Indigo carmine has very poor light stability and oxidation stability, and moderate stability to heat; it has a deep blue hue with poor tinctorial strength.
Indigo carmine is the only food color that has good resistance to reducing agents, but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods. The common name is indigotine.
Uses
Indigo carmine is a food additive that is widely used in the market.
Indigo carmine was also used as a dye for cationic cotton fabrics.
Definition
ChEBI: An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide.
Indigo carmine is an indicator at pH 11.5-14, changing from blue to yellow.
Indigo Carmine highlights mucosal anomalies and marks the tumour margins when the limits are clearly not visible.
Indigo Carmine is classified as a non-sterile solution and suitable for single use only.
Indigo Carmine is suitable for EMR procedures.
Indigo Carmine is a dark blue food dye that gives a violet to blue hue to the products it is used in.
Indigo Carmine is known with the code E132 among food dyes.
water soluble
Indigo Carmine is suitable for use in bakery products, confectionery, desserts and cakes, sorbets, dairy products, sausages, ice creams, snack foods.
Specifications
Appearance (Colour) Deep blue
Appearance (Form) Powder/granules
Loss on drying max. 5%
Sulphated Ash 30 - 35%
Acidity max. 1.0 ml N%
Absorbance (A) of 1% solution in 0.1N HCl in a 1cm cell
@610nm min. 410
Indigo Carmine is useful in the staining of Negri bodies.
Indigo Carmine can be used as a contrast stain for plasma when red nuclear stains are used.
Indigo carmine (Indigotine, 5,5′-indigodisulfonic acid sodium salt, Brilliant Indigo) is an indicator at pH 11.5-14, changing from blue to yellow.
Indigo carmine has a role as a food colouring and a histological dye.
Indigo Carmine unlike the vital stains (which are taken up by tissues), is not absorbed by gastrointestinal epithelium.
Indigo Carmine pools in crevices between epithelial cells, highlighting small or flat lesions and defining irregularities in mucosal architecture, particularly when used with high-magnification or high-resolution endoscopy.
Indigo Carmine is used primarily in the colon for the detection and evaluation of colorectal neoplasia and is the most common form of chromoendoscopy applied in the colon.
Indigo Carmine is used to evaluate pit patterns . These patterns can help discriminate between hyperplastic polyps (which have a typical “pit” pattern) and adenomatous polyps (which have a “groove” or “sulci” pattern) . Pit patterns can also aid in the diagnosis of minute, flat, or depressed colorectal tumors and increase the detection of flat adenomas .
Indigo carmine can assist in the detection of dysplastic changes in patients with ulcerative colitis undergoing surveillance colonoscopy, as well as aid in the detection of adenomas in patients with hereditary nonpolyposis colorectal cancer.
Used as a tissue stain, pH indicator and viability stain. As a pH indicator, it is blue at pH 11.4 and yellow at 13.0.
As a viability stain, it will stain dead cells blue while living cells remain unstained.
Indigo Carmine Injection is used to localise uretheral orifices during cytoscopy and ureteral catheterisation, and as a marker to identify severed ureters and fistulous communications.
Useful in the staining of Negri bodiesIndigo carmine is used as a food colorant, pH indicator and dissolved ozone indicator.
Indigo Carmine is used to detect amino fluid leaks, highlight portions of the urinary tract, tissue stains and tool for the determination of hypochlorite. As a dye in renal function, it is used in testing and detection of nitrates and chlorates, and in the testing of milk.
A dark bluish purple, synthetic, water soluble version of Indigo. Indigo carmine, or Saxon blue, is composed of the sodium sulfonate salt of Indigotin. First prepared in 1740 by Barth, it was the earliest synthetic Acid dye.
Indigo carmine was used to color Wool and Silk.
Indigo Carmine is not lightfast and has poor washfastness.
Indigo carmine is still used for coloring nylon sutures, food, and drugs.
Indigo Carmine is also used as a biological stain and as a detection reagent for nitrates and chlorates.
Properties:
Dark-blue powder with coppery luster. Sensitive to light.
Indigo Carmine is solns have a blue or bluish-purple color. One gram dissolves in about 100 ml water at 25°. Slightly sol in alcohol. Practically insol in most other organic solvents.
Indigo Carmine is also marketed as a paste with water, the dye contents varying according to specification or requirements of the user.
Indigo Carmine almost always contains sodium chloride or sulfate used for "salting" it out.
Indigo carmine is very sensitive to oxidizing agents. The color is readily discharged by nitric acid, chlorates, etc. The color of the aq soln fades on standing.
Use: Colorant for nylon, surgical sutures, foods and ingested drugs. As a reagent for functional kidney tests, for detection of nitrates, chlorates and in testing milk.
Indigo carmine, or 5,5'-indigodisulfonic acid sodium salt, also known as indigotine or FD&C Blue #2 is a pH indicator with the chemical formula C16H8N2Na2O8S2.
Indigo carmine is approved for use as a food colorant in the United States and in Europe and has the E number E132.
Indigo carmine is commonly used as a pH indicator, often in a 0.2% aqueous solution.
Indigo carmine is blue at pH 11.4 and yellow at 13.0.
Indigo carmine is also a redox indicator, turning yellow upon reduction. Another use is as a dissolved ozone indicator through the conversion to isatin-5-sulfonic acid.
Indigo carmine has been shown not to be specific to ozone, however:
Indigo carmine also detects superoxide, an important distinction in cell physiology.
Indigo carmine is also used as a dye in the manufacturing of capsules.
Indigo Carmine, also known as indigotine or 5,5'-indigodisulfonic acid sodium salt, can be used as a pH indicator. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.
About this substance
Helpful information
Indigo carmine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 tonnes per annum.
Indigo carmine is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
Indigo carmine is used in the following products: biocides (e.g. disinfectants, pest control products), fertilisers, plant protection products, cosmetics and personal care products, air care products, coating products, fillers, putties, plasters, modelling clay, inks and toners, laboratory chemicals, perfumes and fragrances and polishes and waxes.
Other release to the environment of Indigo carmine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Article service life
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
Indigo carmine is used in the following products: biocides (e.g. disinfectants, pest control products), fertilisers, plant protection products, air care products, coating products, fillers, putties, plasters, modelling clay, inks and toners, laboratory chemicals, perfumes and fragrances, polishes and waxes, washing & cleaning products and cosmetics and personal care products.
Indigo carmine is used in the following areas: agriculture, forestry and fishing.
Other release to the environment of Indigo carmine is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).
Formulation or re-packing
Indigo carmine is used in the following products: biocides (e.g. disinfectants, pest control products), fertilisers, plant protection products, cosmetics and personal care products, air care products, coating products, fillers, putties, plasters, modelling clay, finger paints, inks and toners, laboratory chemicals, perfumes and fragrances, polishes and waxes and washing & cleaning products.
Release to the environment of Indigo carmine can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
Indigo carmine is used in the following products: laboratory chemicals.
Indigo carmine has an industrial use resulting in manufacture of another substance (use of intermediates).
Indigo carmine is used in the following areas: formulation of mixtures and/or re-packaging.
Indigo carmine is used for the manufacture of: chemicals.
Release to the environment of Indigo carmine can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, as processing aid and in the production of articles.
Manufacture
Release to the environment of Indigo carmine can occur from industrial use: manufacturing of the substance.
Specifications
Appearance (Colour) Deep blue
Appearance (Form) Powder/granules
Loss on drying max. 5%
Sulphated Ash 30 - 35%
Acidity max. 1.0 ml N%
Absorbance (A) of 1% solution in 0.1N HCl in a 1cm cell
@610nm min. 410
Indigo carmine is a dye consisting of an indigo dimer with sodium salts of sulfonic acids at positions 5 and 5'. This compound has been used as a tissue stain, pH indicator, and tool for the determination of hypochlorite in solutions.
Indigo carmine is used as a food colorant (E number 132) and a pH indicator, which turns blue at pH 11.4 and yellow at pH 13.0.
Indigo carmine can be found in many food products, such as ice-cream, sweets, baked goods, confectionery, and biscuits.
Indigo carmine is approved for use as food coloring in EU. In US,
Indigo carmine is subject to certification and permanently listed for use in food and exempt from certification and permanently listed for use in medical devices.
Indigo carmine is also known as indigotine, FD&C Blue 2 and E132.
Indigo carmine is a blue artificial coal tar dye produced by the synthesis of indoxyl by the fusion of sodium phenylglycinate in a mixture of caustic soda and sodamide.
Indigo carmine is a dark blue paint that gives a violet to blue hue in applications.
Indigo carmine was introduced by the Prussian research chemist JFW Adolf von Baeyer in 1883 following the discovery of the chemical structure of indigo and was used in the early 1900s.
Indigo carmine is one of the oldest certified food color additives used in the United States.
Indigo carmine is approved for use in various countries such as the USA, Canada, India, and the EU. On the other hand, it is banned in Norway.
Indigo carmine is used as a food coloring in bakery products, ice cream, confectionery, fruit-based products, sausages, sherbets, dairy products, sweet powders, cereals, snack foods and medicines.
Indigo carmine also has non-food uses.
Indigo carmine is used as a pH indicator, where it is blue at pH 11.4 and yellow at 13.0.
Indigo carmine is used in the medical field to help detect amniotic fluid leaks in obstetrics. Finally, it is used during surgery to highlight the urinary tract and help detect leaks.
Indigo carmine is prepared for experimental use in secondary school science or high school physics, chemistry or biology laboratories with packaging suitable for use by schools. Our school laboratory chemicals are of technical quality and are produced under the Rokim brand and assurance.
Indigo carmine is a synthetic coal tar derivative of indigo carmine FD&C Blue No:2.
Indigo carmine is commonly added to tablets and capsules.
Indigo carmine is also used in ice cream, desserts, baked goods, confectionery and biscuits. The additive to be added to the food should be safe for human health, but it should be added to the allowed foods and in the allowed amount.
The additive should not reduce the effect of a component of the food, should not react with a component to form new products, should not make a product look fresher and superior than it is.
Indigo carmine is allowed to be used in the production of many products such as ice cream, fruit yoghurt, pudding, cooked-uncooked meat products, sausage, salami, sausage at the rates specified in the Turkish Food Codex.
Indigo carmine (acid form) is a member of the class of indolones obtained by formal 2,2'-oxidative coupling of two molecules of 3-oxo-2,3-dihydroindole-5-sulfonic acids.
Indigo carmine has a role as a food colouring and a histological dye.
Indigo carmine is a member of indolones, an olefinic compound, an enone, an arenesulfonic acid and a ring assembly.
Indigo carmine is a conjugate acid of an indigo carmine(2-).
Indigo carmine is a blue-colored dye used a marker in urological procedures, also known as indigo carmine. Indigo carmine, or 5, 5'-indigodisulfonic acid sodium salt, also known as indigotine or FD& C Blue #2 is a pH indicator with the chemical formula C16H8N2Na2O8S2.
Indigo carmine is approved for use as a food dye in the United States and the EU and has the E number E132
Uses
The primary use of Indigo carmine is as a pH indicator.
Indigo carmine is blue at pH 11.4 and yellow at 13.0. .
Indigo carmine is also used in the manufacturing of capusles as a soluble pigment.
Indolesulfonic acid is a blue-colored dye used a marker in urological procedures, also known as indigo carmine.
IUPAC NAMES:
1H-Indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt
2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-1H-Indole-5-sulfonic acid, disodium salt
3,3'-dioxo-2,2'-bis-indolyden-5,5'-disulfonic acid disodium salt
disodium (2E)-3-oxo-2-(3-oxo-5-sulfonato-1H-indol-2-ylidene)-1H-indole-5-sulfonate
disodium 3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate
disodium 3-oxo-2-(3-oxo-5-sulfonato-2,3-dihydro-1H-indol-2-ylidene)-2,3-dihydro-1H-indole-5-sulfonate
Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate
disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate
disodium;(2E)-3-oxo-2-(3-oxo-5-sulfonato-1H-indol-2-ylidene)-1H-indole-5-sulfonate
FD&C Blue No. 2 powder
Indigo Carmine
Indigo carmine
SYNONYMS:
C.I. 75781
C.I. Acid Blue 74
C.I. Food Blue 1
C.I. Food Blue 1, disodium salt
C.I. Natural Blue 2
Indigotindisulfonate Sodium [USAN]
5,5-Indigodisulfonic acid, disodium salt
Acid Blue 74
disodium 5,5-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate
disodium 5,5-indigodisulphonate
E 132
Indigo-5,5-disulphonic acid disodium salt
1H-indole-5-sulfonic acid, 2-(1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro-3-oxo-, disodium salt, (2E)-
disodium (2E)-3,3'-dioxo-1,1',3,3'-tetrahydro-2,2'-biindole-5,5'-disulfonate
