ISOBUTYL SALICYLATE

ISOBUTYL SALICYLATE

Isobutyl salicylate is a member of phenols and a benzoate ester. 
Isobutyl salicylate is functionally related to a salicylic acid.

CAS: 87-19-4
European Community (EC) Number: 201-729-9

IUPAC Name: 2-methylpropyl 2-hydroxybenzoate

Molecular Formula: C11H14O3
Molecular Weight: 194.23 g/mol

Isobutyl salicylate, 87-19-4, Isobutyl 2-hydroxybenzoate, 2-Methylpropyl 2-hydroxybenzoate, Isobutyl o-hydroxybenzoate, 2-Isobutoxycarbonylphenol, Benzoic acid, 2-hydroxy-, 2-methylpropyl ester, 2-Methylpropyl o-hydroxybenzoate, SALICYLIC ACID, ISOBUTYL ESTER, 2-Methyl-1-propyl salicylate, Salicylic Acid Isobutyl Ester, FEMA No. 2213, Orchindone, 2-Methylpropyl salicylate, DTXSID3047186, S122C080GX, NSC-62140, EINECS 201-729-9, 2-Hydroxybenzoic Acid Isobutyl Ester, NSC 62140, BRN 2615955, UNII-S122C080GX, AI3-24370, iso-butyl salicylate, Salicylicacidisobutylester, SCHEMBL39110, 3-10-00-00121 (Beilstein Handbook Reference), WLN: QR BVO1Y1&1, CHEMBL2260712, DTXCID1027186, FEMA 2213, ISOBUTYL SALICYLATE [FCC], CHEBI:173947, ISOBUTYL SALICYLATE [FHFI], NSC62140, Isobutyl salicylate, >=98%, FCC, Tox21_302515, MFCD00020035, AKOS015837517, MCULE-1258001308, CAS-87-19-4, NCGC00256854-01, BS-42299, NS00012691, S0013, A862734, Q2214311, F0001-2160, Isobutyl salicylate;2-Methylpropyl o-hydroxybenzoate;Salicylic acid iobutylester, InChI=1/C11H14O3/c1-8(2)7-14-11(13)9-5-3-4-6-10(9)12/h3-6,8,12H,7H2,1-2H

Isobutyl salicylate acts as a perfumery component. 
Isobutyl salicylate has a wintergreen-like odor, sweet herbaceous-green, slightly floral, with orchid-like nuances.

Isobutyl salicylate has a somewhat hay-like, light fresh floral scent that is often imaginatively described as clover or orchid fragrance. 
The odour is not very strong or overpowering, so undiluted use is common. 
Isobutyl salicylatehas the signature somewhat metallic background smell that all salicylates share. 
Typical usage is in fantasy accords with names like clover and orchid. 
In such accords you use, for example, 30 to 50% of this substance or more in the fragrance composition.
Isobutyl salicylate can serve well in accords for field flowers, lavender, hay, grass or tuberose, as well as fougère types. 
The dose is often between 1 and 15%, very low doses are unusual. 
A creative perfumer will find that it can be used in many fragrances. 
The material is a classic synthetic fragrance but seems to have been undervalued in recent decades: time for a revival! 
Isobutyl salicylate is often a heart note or base note in perfumes. 
Isobutyl salicylate is stable in most products, it can also be used well in soap, provided it is not dosed too low. 

Isobutyl salicylate is used as a reactant in the new boron(III)-catalyzed esterifications and amidations of carboxylic acids and Ritter addition reaction.

Isobutyl salicylate (CAS NO.87-19-4) is used for essence for household and personal care chemicals and food flavor, GB 2760 96 provide for the use of edible spices. 
Mainly used in beer and a variety of fruit flavor (use very little).

Isobutyl salicylate is a colourless to pale yellow liquid at room temperature. 
The purity is at least 98%; Isobutyl salicylate has a fairly long shelf life. 
Isobutyl salicylate is rare in nature, such an exception, for example, is the magnolia. 
For use as a fragrance, the synthetic version is used, mainly based on petrochemicals.

Isobutyl salicylate belongs to the class of organic compounds known as o-hydroxybenzoic acid esters. 
These are benzoic acid esters where the benzene ring is ortho-substituted with a hydroxy group. 
Isobutyl salicylate is a bitter, clover, and floral tasting compound. 
Based on a literature review very few articles have been published on Isobutyl salicylate.

Experimental Properties

Physical Description: Liquid
Boiling Point: 261.00 °C. at 760.00 mm Hg
Melting Point: -6 °C
Solubility: insoluble in water, glycerol; 
soluble in organic solvents, oils
Density: 1.062-1.069
LogP: 4.000
Refractive Index: 1.506-1.570

Some studies have investigated the potential antimicrobial properties of Isobutyl Salicylate. 
A study published in "Letters in Applied Microbiology" found that Isobutyl salicylate exhibited antibacterial activity against various foodborne pathogens, including Staphylococcus aureus and Escherichia coli. 
However, further research is needed to determine the effectiveness and safety of Isobutyl salicylate as an antimicrobial agent in practical applications.

Anti-inflammatory Potential:
Limited research suggests that Isobutyl Salicylate might possess anti-inflammatory properties. 
A study published in "Bioorganic & Medicinal Chemistry" explored the anti-inflammatory effects of Isobutyl salicylate and its derivatives on lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. 
The results suggest that Isobutyl salicylate and its derivatives might have potential as anti-inflammatory agents, but further studies are needed to confirm these findings and understand the underlying mechanisms.

Properties
Isobutyl salicylate is a colourless to pale yellow liquid at room temperature. 
The purity is at least 98%; Isobutyl salicylate has a fairly long shelf life. 
Isobutyl salicylate is rare in nature, such an exception, for example, is the magnolia. 
For use as a fragrance, the synthetic version is used, mainly based on petrochemicals.

Use
Isobutyl salicylate has a somewhat hay-like, light fresh floral scent that is often imaginatively described as clover or orchid fragrance. 
The odour is not very strong or overpowering, so undiluted use is common. 
Isobutyl salicylate has the signature somewhat metallic background smell that all salicylates share. 
Typical usage is in fantasy accords with names like clover and orchid. 
In such accords you use, for example, 30 to 50% of this substance or more in the fragrance composition. 
Isobutyl salicylate can serve well in accords for field flowers, lavender, hay, grass or tuberose, as well as fougère types. 
The dose is often between 1 and 15%, very low doses are unusual. 
A creative perfumer will find that it can be used in many fragrances. 
The material is a classic synthetic fragrance but seems to have been undervalued in recent decades: time for a revival! 
Isobutyl salicylate is often a heart note or base note in perfumes. 
Isobutyl salicylate is stable in most products, it can also be used well in soap, provided it is not dosed too low. 

Index of Refraction:1.524
Surface Tension: 40.7 dyne/cm
Density: 1.105 g/cm3
Flash Point: 103.4 °C
Enthalpy of Vaporization: 52.2 kJ/mol
Boiling Point: 263.9 °C at 760 mmHg
Vapour Pressure: 0.00613 mmHg at 25°C 
Melting point: -5.9°C
Appearance:Colorless to pale yellow liquid.
Solubility:Soluble in ethanol, the majority of non-volatile oil and mineral oil, a few do not dissolve in propylene glycol, insoluble in glycerin and water.