ISOPROPYL MYRISTATE

ISOPROPYL MYRISTATE

CAS No.: 110-27-0
EC No.: 203-751-4

Synonyms:
ISOPROPYL MYRISTATE; İZOPROPİL MİRİSTAT; isopropyl myristate; isopropylmyristate; ISOPROPYL MYRISTATE; Isopropyl tetradecanoate; 110-27-0; Estergel; Promyr; Tetradecanoic acid, 1 methylethylester; Bisomel; Isomyst; Kesscomir; Tegester; Deltyl Extra; Sinnoester MIP; Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Wickenol 101;Stepan D-50; Emerest 2314; JA-FA IPM; Kessco isopropyl myristate; Crodamol I.P.M.; Deltylextra; Myristic acid isopropyl ester; Tetradecanoic acid, isopropyl; Tetradecanoic acid, isopropyl ester; isopropylmyristate; Myristic acid, isopropyl ester; 1-Methylethyl tetradecanoate; Caswell No. 511E;UNII- 0RE8K4LNJS; 1-Tridecanecarboxylic acid, isopropyl ester; NSC 406280; FEMA No. 3556; HSDB 626; IPM-EX; IPM-R;EINECS 203-751-4; propan-2-yl tetradecanoate; EPA Pesticide Chemical Code 000207; Isopropyl tetradecanoic acid; BRN 1781127; CHEBI: 90027; IPM 100; AXISYYRBXTVTFY-UHFFFAOYSA-N; MFCD00008982; NCGC00164071-01; WE(2:0 (1Me)/14:0); DSSTox_CID_6838; Isopropyl myristate, 98%; DSSTox_RID_78224; DSSTox_GSID_26838; Q-201418; CAS-110-27-0; Isopropyl myristate [USAN]; Tegosoft M; Isopropyl myristate [USAN:NF]; Liponate IPM; Lexol IPM; Crodamol I.P.M; Estergel (TN); myristic acid isopropyl; PubChem19813; ACMC-1BVUK; methylethyl tetradecanoate; Radia 7190; E(R)EAEaOi+/-uo yen; Isopropyl myristate (NF); 0RE8K4LNJS; iso-Propyl N-tetradecanoate; AC1L1Q4R; SCHEMBL2442; component of Sardo Bath Oil; Myristic acid- isopropyl ester; KSC174S6R; Isopropyl myristate, >=98%; CHEMBL207602; IPM 90; Jsp000796; DTXSID0026838;WLN: 13VOY1&1; CTK0H4968; MolPort-003-927-101; Tetradecanoic acid methyethyl ester; E(R)EAI(1/4)EaOi+/-uo yen; ZINC8214588; Isopropyl myristate, >=90% (GC); Tox21_112080,Tox21_202065; Tox21_303171; ANW- 16142; LMFA07010677; NSC406280; AKOS015902296; Myristic acid, isopropyl ester (8CI); Tox21_112080_1; LS-2869; NSC-406280; RL00430; RTR-002139; Isopropyl tetradecanoate, 98% 100ml; component of Sardo Bath Oil (Salt/Mix); NCGC00164071-02; NCGC00164071-03; NCGC00256937-01; NCGC00259614-01; AN-22595; CC-29682; KB- 77952; LP003008; R524; SC-19093; DB-040910; TR-002139,FT-0629053; M0481; D02296; C-28193; SR-01000944751; Isopropyl myristate, Vetec(TM) reagent grade, 98%;SR- 01000944751-1; I14-13725; Isopropyl myristate, United States Pharmacopeia (USP) Reference Standard; TETRADECANOIC ACID,ISOPROPYL ESTER (MYRISTATE,ISOPROPYLESTER); Isopropyl myristate, pharmaceutical secondary standard; traceable to USP and PhEur; 1405-98-7; 852553-53-8; 1-METHYLETHYL ESTER TETRADECANOIC ACID; 1-METHYLETHYL TETRADECANOATE; IPM; ISOPROPYL ESTER MYRISTIC ACID; ISOPROPYLTETRADECONOATE; MYRISTIC ACID, ISOPROPYL ESTER; TETRADECANOIC ACID, 1-METHYLETHYL ESTER; TETRADECANOIC ACID, 1METHYLETHYL ESTER; 1-TRIDECANECARBOXYLIC ACID,ISOPROPYL ESTER; BISOMEL; CRODACOL IPM; propan-2-yl tetradecanoate; C17H34O2; isopropyl myristate; isopropylmyristate; ISOPROPYL MYRISTATE; Isopropyltetradecanoate; 110-27-0; Estergel; Promyr; Tetradecanoic acid, 1-methylethyl ester; Bisomel; Isomyst; Kesscomir; Tegester; Deltyl Extra; Sinnoester MIP; Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Wickenol 101; Stepan D-50; Emerest 2314; JA-FA IPM; Kessco isopropyl myristate;Crodamol I.P.M.; Deltylextra; Myristic acid isopropyl ester; Tetradecanoic acid, isopropyl; Tetradecanoic acid, isopropyl ester; isopropylmyristate; Myristicacid, isopropyl ester; 1-Methylethyl tetradecanoate; Caswell No. 511E; UNII-0RE8K4LNJS, 1-Tridecanecarboxylic acid, isopropyl ester; NSC 406280; FEMA No.3556; EINECS 203-751-4; EPA Pesticide Chemical Code 000207; Isopropyl tetradecanoic acid; BRN 1781127; CHEBI:90027; IPM 100; AXISYYRBXTVTFY-; Isopropyl myristate, 98%; CAS-110-27-0; Isopropyl myristate [USAN]; Tegosoft M; Isopropyl myristate [USAN:NF]; Liponate IPM; Lexol IPM; Crodamol I.P.M; Estergel (TN);myristic acid isopropyl; PubChem19813; methylethyl tetradecanoate; Radia 7190; E(R)EAEaOi+/-uo yen; Isopropyl myristate (NF); 0RE8K4LNJS; propan-2-yltetradecanoate; iso-Propyl N-tetradecanoate; AC1L1Q4R; SCHEMBL2442; component of Sardo Bath Oil; KSC174S6R; Isopropyl myristate, >=98%; CHEMBL207602;Tetradecanoic acid methyethyl ester; E(R)EAI(1/4)EaOi+/-uo yen; ZINC8214588; Isopropyl myristate, >=90% (GC); Myristic acid, isopropyl ester (8CI); İZOPROPİLMİRİSTAT; izo propil miristat; isopropil miristat; izopropil miristat; ispropyl miristat; isopropyl miristat; izopropil myristate; bisomel; crodamol IPM; deltylextra; dermol IPM;edenor IEM 17;emcol-IM;emerest 2314; estergel; exceparl IPM; hallstar IPM; hallstar IPM-NF;IPM;kessco IPM; kesscomir;liponate IPM; 1-methyl ethyltetradecanoate;1-methylethyl tetradecanoate;myristic acid isopropyl ester; myristic acid, isopropyl ester; iso myst;nikkol IPM-100;nikkol IPM-EX; promyr;propan-2-yl tetradecanoate; iso propyl myristate USP/NF; iso propyl tetradecanoate;iso propylmyristate; sinnoester MIP;starfolIPM; tegester; tetradecanoic acid 1-methyl ethyl ester; tetradecanoic acid 1-methylethyl ester; tetradecanoic acid isopropyl ester; tetradecanoic acid, 1-methylethyl ester; tetradecanoic acid, isopropyl ester; 1-tridecane carboxylic acid isopropyl ester; 1-tridecanecarboxylic acid, isopropyl ester; unimateIPM; wickenol 101; 110-27-0 [RN]; 13VOY1&1 [WLN]; 1-Methylethyl tetradecanoate; 203-751-4 [EINECS]; Isopropyl myristate [ACD/IUPAC Name] [USAN]; isopropyltetradecanoate; Isopropylmyristat [German] [ACD/IUPAC Name]; Myristate d'isopropyle [French] [ACD/IUPAC Name]; myristic acid isopropyl ester; Myristic acid,Tetradecanoic acid 1-methylethyl ester; Tetradecanoic acid isopropyl ester; Tetradecanoic acid, 1-methylethyl ester[ACD/Index Name]; Tetradecanoic acid, isopropyl ester; 1-Tridecanecarboxylic acid, isopropyl ester; 4-02-00-01132 (Beilstein Handbook Reference)[Beilstein]; Bisomel; Crodamol 1PM; Crodamol IPM;DELTYL EXTRA; Deltylextra; EINECS 203-751-4; Emcol-IM;Emerest 2314;Estergel [Trade name]; Estergel (TN); FEMA3556;IPM; IPM 100; IPM 90; IPM-EX; IPM-R; Isomyst; Isopropyl myristate (NF); iso-Propyl N-tetradecanoate;Isopropyl tetradecanoic acid; Isopropylmyristate; Ja-faIPM;Jsp000796;Kessco IPM; Kessco isopropyl myristate; Kesscomir; Lexol IPM; Liponate IPM;Methylethyl tetradecanoate; MFCD00008982 [MDL number]; Myristic acid-isopropyl ester; NCGC00164071-01; Promyr; Radia 7190; Sinnoester MIP;Starfol IPM;Stepan D-50; Tegester;Tegosoft M; Tetradecanoic acid methyethylester; Tetradecanoic acid, isopropyl; UNII:0RE8K4LNJS; UNII-0RE8K4LNJS; Unimate IPM; Wickenol 101; WLN: 13VOY1&1; XB8600000;ISOPROPYL TETRADECANOATE, TETRADECANOICACID ISOPROPYL ESTE; ISO-PROPYL N-TETRADECANOATE; ISOPROPYL TETRADECANOATE; BISOMEL;ISOPROPYL MYRISTATE; ESTERGEL; FEMA 3556; MYRISTIC ACID ISOPROPYLESTER;TETRADECANOIC ACID 1-METHYLETHYL ESTER; Cholesteryl myristate 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE Glycerol tristearate Nystatin Cholesterylpalmitate 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE ISOPROPYL CINNAMATE Myristic acid Dimethyl succinate Methyl acrylate Isopropanol Allylisothiocyanate Isopropyl myristate ISOPROPYL LAURATE Titanium tetraisopropanolate Isopropyl salicylate Diisopropyl azodicarboxylate Isopropylpalmitate;Myristic Acid Isopropyl Ester; 1-Methylethyl tetradecanoate; Bisomel; Crodacol IPM; Crodamol IPM; D 50; D 50 (emollient); Deltyl Extra; Emcol IM;Emerest 2314; Estol 1512; Estol 1514; Estol IPM 1512; Exceparl IPM; IPM; IPM 100; IPM-EX; IPM-R; Isomyst; Isopropyl myristate; Isopropyl myristate-PM;Isopropyl tetradecanoate; Kessco IPM; Kesscomir; Kollicream IPM; Lexol IPM; Liponate IPM; Matlube IPM-S; NSC 406280; Nikkol IPM; Nikkol IPM 100; Nikkol IPM-EX; Pastell IP 14; Pelemol IPM; Promyr; Radia 7190; Rilanit IPM; Sinnoester MIP; Stepan D 50; Stepan IPM; Tegosoft M; Wickenol 101;4-Acetoxy-ß-damascone 3-Acetoxy-2,2-dimethylbutyryl Chloride 2-Acetoxy-2-methyl-1-propanol Acrylic Acid (stabilized with MEHQ) 1-Adamantanecarboxylic Acid Methyl Ester;IPM 90;propan-2-yl tetradecanoate; myristic acid isopropyl ester; Tetradecanoic acid, 1-methylethyl ester; Tetradecanoic acid, isopropyl ester;ISO PROPILENMYRISTATE; ISOPROPILENMYRISTATE; iso propilen myristate; isopropilenmyristate; IZOPROPİL MİRİSTAT; İZOPROPİLMİRİSTAT; izo propil miristat; izopropilmiristat; İsopropyl Myristate; Isopropyl tetradecanoate; 110-27-0; Tetradecanoic acid, 1-methylethyl ester; Estergel; Bisomel; Isomyst; Promyr; Deltyl Extra; Kesscomir; Tegester; Sinnoester MIP; Crodamol IPM; Plymoutm IPM; Starfol IPM; Unimate IPM; Kessco IPM; Emcol-IM; Wickenol 101; Stepan D-50; Emerest 2314; 1-Methylethyl tetradecanoate; İsopropyl Myristate; isopropyl ester; Kessco İsopropyl Myristate; Crodamol I.P.M.; Deltylextra; Tetradecanoic acid, isopropyl; İsopropyl Myristate, isopropyl ester; Tetradecanoic acid, isopropyl ester; 1; Tridecanecarboxylic acid, isopropyl ester; İsopropyl Myristate [USAN]; methylethyl tetradecanoate; EINECS 203-751-4; EPA Pesticide; Chemical Code 000207; iso-Propyl N-tetradecanoate; BRN 1781127; CHEBI:90027; Tetradecanoic acid; methyethyl ester; İsopropyl Myristate, 96%; İsopropyl Myristate, 98%; Isopropyl tetradecanoic acid; isopropylmyristate; propan-2-yl tetradecanoate; CAS-110-27-0; İsopropyl Myristate (NF); Myristic acid-isopropyl ester; İsopropyl Myristate, >=98%; İsopropyl Myristate ; İZOPROPİL MİRİSTAT; Isopropyl Myristate ; IZOPROPİL MİRİSTAT; izopropyl Myristate ; İSOPROPİL MİRİSTAT; izopropil miristat; izopropilmiristat; isopropil miristat; isopropyl myristat; isopropylmyristat; isopropyl myristad; isopropyl myristade; izopropyl myristad; izopropyl myristad; izopropyl myristade; ısopropil miristat; ısopropyl myristat; ısopropylmyristat; ısopropyl myristad; ısopropyl myristade; ızopropyl myristad; ızopropyl myristad; ızopropyl myristade; İzopropil miristat; izopropil miristat 

ISOPROPYL MYRISTATE

İsopropyl Myristate
İsopropyl myristate
Names
IUPAC name
Propan-2-yl tetradecanoate
Other names
Tetradecanoic acid, 1-methylethyl ester
Myristic acid isopropyl ester
Identifiers
CAS Number
110-27-0 ☑
3D model (JSmol)
Interactive image
ChemSpider 
7751 ☒
ECHA InfoCard    100.003.412
EC Number 
203-751-4
KEGG 
D02296 ☒
MeSH    C008205
PubChem CID
8042
RTECS number 
XB8600000
CompTox Dashboard (EPA)
DTXSID0026838 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula
C17H34O2
Molar mass    270.457 g·mol-1
Density    0.85 g/cm³
Boiling point    167 °C (333 °F; 440 K) at 9 mmHg
Hazards
R-phrases (outdated)    R38
S-phrases (outdated)    S24/25
NFPA 704 (fire diamond) 
NFPA 704 four-colored diamond
100
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ verify (what is ☑☒ ?)
Infobox references
İsopropyl Myristate (IPM) is the ester of isopropyl alcohol and myristic acid.
 
Uses
İsopropyl Myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. İsopropyl Myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.[2] It is used in the same way in flea and tick killing products for pets.

İsopropyl Myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".
İsopropyl Myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from İsopropyl Myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of formulations.[3][4]

Product Name: İsopropyl Myristate
Structure
CAS110-27-0
SynonymsBISOMEL; Myristic acid isopropyl ester; ESTERGEL; Isopropyl Tetradecanoate; Isopropyl-myristate; 1-methylethyl ester of tetradecanoic acid; i-propyl myristate; ja-faipm; Emcol-IM; myristic acid isopropyl ester; IPM 100,IPM-EX,IPM-R; Isomyst; IPM; D 50; isopropyl myristinate; Promyr; Revenge; Tegester;
EC Number203-751-4
IUPAC Namepropan-2-yltetradecanoate
Molecular FormulaC17H34O2
Molecular Weight270
Exact Mass270.25600
Boiling Point167ºC (9 mmHg)
Melting Point-5°C
Flash Point308°F
Density0.856 (25°C)
AppearanceColorless or slightly yellow oily liquid
SMILESCCCCCCCCCCCCCC(=O)OC(C)C
InChI KeyAXISYYRBXTVTFY-UHFFFAOYSA-N
Safty DescriptionS26-S36
Hazard StatementsXi:Irritant
WGK Germany-
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
Packing GroupI; II; III
Viscosity4.8cp (25°C)
Alpha Sortİsopropyl Myristate
 
İsopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. İsopropyl Myristate has been largely studied and impulsed as a skin penetration enhancer. At the moment the primary usage for which İsopropyl Myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
DrugBank
Isopropyl tetradecanoate is a fatty acid ester.
ChEBI
Therapeutic Uses    HelpNew Window
... İsopropyl Myristate 50% in cyclomethicone solution (Full Marks Solution - SSL International) is a new fluid treatment with a physical mode of action that uses a 10-minute contact time /for treatment of head lice.
 
PMID:19423676
Drug Ther Bull 47 (5): 50-2 (2009) (No authors given)
HSDB
/Experimental Therapy/ ... A pediculicide rinse, 50% İsopropyl Myristate (IPM), was assessed in two phase 2 trials conducted in North America. The first trial was a nonrandomized (proof of concept) trial without a comparator conducted in Winnipeg, Canada. The second trial, conducted in the United States, was an evaluator-blinded, randomized superiority trial comparing 50% IPM rinse with a positive control (RID; pyrethrin 0.33%, piperonyl butoxide 4%). The primary end points were to determine the safety and efficacy of 50% IPM as a pediculicide rinse. METHODS: Subjects meeting inclusion criteria were enrolled in the above-mentioned trials with efficacy end points 7 and 14 days post-treatment. Subjects were also evaluated on days 0, 7, 14, and 21 for the presence of erythema and edema using the Modified Draize Scale. Other comments associated with the safety evaluation (ie, pruritus) were collected. RESULTS: IPM was found to be effective in the proof of concept study and comparator trial using a positive control. IPM was also well tolerated, with minimal adverse events. All adverse events were mild, resolving by completion of the study. CONCLUSION: Data suggest that IPM is a safe and effective therapy for the treatment of head lice in children and adults. IPM's mechanical mechanism of action makes development of lice resistance unlikely.

PMID:17942025
Kaul N et al; J Cutan Med Surg 11 (5): 161-7 (2007)
HSDB
... Due to their distinct advantages such as enhanced drug solubility, thermodynamic stability, facile preparation, and low cost, uses and applications of microemulsions have been numerous. Recently, there is a surge in the exploration of microemulsion for transdermal drug delivery for their ability to incorporate both hydrophilic (5-fluorouracil, apomorphine hydrochloride, diphenhydramine hydrochloride, tetracaine hydrochloride, and methotrexate) and lipophilic drugs (estradiol, finasteride, ketoprofen, meloxicam, felodipine, and triptolide) and enhance their permeation.... Besides surfactants, oils can also act as penetration enhancers (oleic acid, linoleic acid, İsopropyl Myristate, isopropyl palmitate, etc.). ...
 
PMID:19016057
Azeem A et al; Drug Dev Ind Pharm 35 (5): 525-47(2009)
HSDB
/Experimental Therapy/ Alpha-tocopherol (AT) is the vitamin E homologue with the highest in vivo biological activity. AT protects against the carcinogenic and mutagenic activity of ionizing radiation and chemical agents, and possibly against UV-induced cutaneous damage. For stability consideration, alpha-tocopherol is usually used as its prodrug ester, alpha-tocopherol acetate (ATA), which once absorbed into the skin is hydrolyzed to alpha-tocopherol, the active form. ... Permeation studies were conducted using modified Franz diffusion cells and human cadaver skin as the membrane. Specifically, 5% (w/w) alpha-tocopherol acetate was formulated in the following vehicles: ethanol, İsopropyl Myristate, light mineral oil, 1% Klucel gel in ethanol, and 3% Klucel gel in ethanol (w/w). ... The permeabilities of ATA through human cadaver skin were 1.0x10-4, 1.1x10-2, 1.4x10-4, 2.1x10-4, and 4.7x10-4 cm/hr for the ethanol solution, İsopropyl Myristate solution, light mineral oil solution, 1% Klucel gel, and 3% Klucel gel, respectively. The results show that the formulation had relatively minor effects on the permeability coefficients of ATA through cadaver skin in all cases except for the İsopropyl Myristate solution.
 
PMID:15868062
Mahamongkol H et al; J Cosmet Sci 56 (2): 91-103 (2005)
HSDB
/Experimental Therapy/ The purpose of this research was to prepare a pseudolatex transdermal delivery system for terbutaline sulfate and to evaluate the effect of pH and organic ester penetration enhancers on permeation kinetics of terbutaline sulfate through mice abdominal skin and human cadaver skin. ... The permeation profile and related kinetic parameters of terbutaline sulfate was determined in presence of 3 ester-type permeation enhancers incorporated in the films, viz methyl laureate, isopropyl lanolate, and İsopropyl Myristate. Among the 3, the more pronounced enhancing effect was obtained with İsopropyl Myristate, regarding the permeation flux, permeability coefficient, and diffusion coefficient. This was attributed to solubility parameter of İsopropyl Myristate being closer to the solubility parameter of human skin, and such a pronounced enhancing effect was probably caused by its passage across the skin barrier through the lipid pathway.
 
PMID:16353974
Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750528
Panigrahi L et al; AAPA PharmSciTech 6(2): E167-73 (2005)
HSDB
/Experimental Therapy/ A transdermal dosage form of trazodone hydrochloride (TZN) may be useful in the treatment of moderate to severe depression in schizophrenic patients by providing prolonged duration of action. ... The aim of /this/ investigation was to evaluate its flux and the effects of various penetration enhancers, viz., İsopropyl Myristate (IPM), isopropyl palmitate (IPP), butanol and octanol on transdermal permeation from matrix-based formulations through the skin. The enhancing effect on the permeation of TZN was determined using the mouse and human cadaver epidermis. ... The highest enhancing effect was obtained with IPM followed by butanol, octanol and IPP. In general, higher fluxes were observed through mouse epidermis as compared with the human cadaver epidermis...

PMID:17438871
Das MK et al; Acta Pol Pharm 63 (6): 535-41 (2006)
HSDB
/Experimental Therapy/ The purpose of this study was to mechanistically investigate effects of isopropanol (IPA)-İsopropyl Myristate (IPM) binary enhancers on transport of a model drug, estradiol (E2) in human epidermis (stratum corneum + viable epidermis) in vitro. The study was focused on use of the same IPA-IPM compositions on both sides of the skin ("symmetric" configuration) with saturated E2 (maximum thermodynamic activity). For E2 transport in all IPA-İsopropyl Myristate compositions tested, stratum corneum still was the rate-limiting layer of human epidermis. The relative contributions to E2 flux enhancement were separated into the changes in solubility and diffusivity of E2 in stratum corneum. As a major factor, E2 solubility in stratum corneum was enhanced by 35 times with increasing IPA from neat İsopropyl Myristate to neat IPA. E2 diffusivity in stratum corneum also played a significant role, which increased by 8 times from neat IPM to 50% IPA. Stratum corneum swelled more in IPM-rich region, decreased with increasing IPA, and even deswelled in neat IPA. IPA uptake correlated well to E2 solubility in stratum corneum; both linearly increased with increasing IPA. İsopropyl Myristateuptake appeared to correlate to E2 diffusivity in stratum corneum; both maximized around 50% IPA.
 
Description: Ester of isopropyl alcohol and myristic acid (vegetable-derived). Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants. Thanks to its low viscosity and density, it has a high spreadability. Colorless oil-like liquid. No or little odor. Water-insoluble, but soluble with silicones, and hydrocarbons. Specific gravity 0.85 (at 20°C).
CAS: 110-27-0
INCI Name: İsopropyl Myristate
Benefits:
Superior emollient for non-greasy bath, body and baby oils
Lubricant and compression aid for pressed powders
Light & non-tacky emollient for creams and lotions. Readily adsorbed by the skin
When used at high concentrations it gently lifts makeup and surface dirt
Gives gloss and shine to hair
Resistant to oxidation (does not become rancid)
Widely used as diluent for fragrance oils.
Use: Can be added to formulas as is, add to oil phase. Typical use level 1-20%. Required HLB: 11.5. Storage: Stable when kept in a closed container at a cool & dry place. For external use only.
Applications: Creams, lotions, hand creams, shampoo, shower gels, makeup removers, powders and foundations.
Country of Origin: USA
Raw material source: Vegetable oils (myristic acid) and isopropanol
Manufacture: İsopropyl Myristate is produced by distillation, which is preceded by the esterification of myristic acid and isopropanol, alkali refined to neutralize the catalyst.
Animal Testing: Not animal tested
GMO: GMO free (does not contain plant-derived components)
Vegan: Does not contain animal-derived components
Documents: SDS, Fact Sheet, Sample Recipe, Certificate of Analysis
 
İsopropyl Myristate
Messages
Overview(active tab)
Safety
Resources
 
What Is İsopropyl Myristate?
İsopropyl Myristate is a fatty acid that occurs naturally in some foods. Purified İsopropyl Myristate occurs as a hard, white or faintly yellow, glossy crystalline solid, or as a white or yellow-white powder. Salts of İsopropyl Myristate (Aluminum Dimyristate, Aluminum Isostearates/Myristate, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Potassium Myristate, Sodium Myristate, Zinc Myristate) and esters of İsopropyl Myristate (Butyl Myristate, Cetyl Myristate, Decyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isocetyl Myristate, Isodecyl Myristate, İsopropyl Myristate, Isostearyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Methyl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Propylene Glycol Myristate, Tetradecyloctadecyl Myristate, Tridecyl Myristate) may also be used in cosmetics and personal care products. İsopropyl Myristate and its salts and esters may be used in eye makeup, soaps and detergents, hair care products, nail care products, shaving products and other skin care products.
 
Why is it used in cosmetics and personal care products?
The following functions have been reported for İsopropyl Myristate and its salts and esters.
Anticaking agent - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate
Binder - İsopropyl Myristate, Isostearyl Myristate, Tetradecyloctyldecyl Myristate
Emulsion stabilizer - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Tetradecyloctyldecyl Myristate
Film former - Tetradecyloctyldecyl Myristate
Hair conditioning agent - Ethyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Oleyl Myristate
Opacifying agent - İsopropyl Myristate, Tetradecyloctyldecyl Myristate
Slip modifier - Magnesium Myristate, Zinc Myristate
Skin-Conditioning Agent - Emollient - Butyl Myristate, Ethylhexyl Myristate, Ethyl Myristate, Glyceryl Dimyristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Isobutyl Myristate, Isodecyl Myristate, İsopropyl Myristate, Isostearyl Myristate, Methyl Myristate, Propylene Glycol Myristate
Skin-conditioning agent - occlusive - Cetyl Myristate, Decyl Myristate, Isocetyl Myristate, Isotridecyl Myristate, Lauryl Myristate, Myristyl Myristate, Octyldodecyl Myristate, Oleyl Myristate, Tetradecyloctyldecyl Myristate, Tridecyl Myristate
Surfactant - cleansing agent - İsopropyl Myristate, Potassium Myristate, Sodium Myristate
Surfactant - emulsifying agent - Potassium Myristate, Sodium Myristate, Glyceryl Isostearate/Myristate, Glyceryl Myristate, Propylene Glycol Myristate
Viscosity increasing agent - nonaqueous - Aluminum Dimyristate, Aluminum Isostearates/Myristates, Aluminum Myristate, Aluminum Myristates/Palmitates, Calcium Myristate, Magnesium Myristate, Zinc Myristate
Scientific Facts: 
İsopropyl Myristate, also called tetradecanoic acid, occurs naturally in vegetable or animal fats and oils with relatively high levels found in nutmeg, palm oil, coconut oil and butter fat. The salts of İsopropyl Myristate are formed by reaction with base materials such as sodium or potassium hydroxide. The esters of İsopropyl Myristate are derived from İsopropyl Myristate and an alcohol. For example, İsopropyl Myristate is derived from İsopropyl Myristate and isopropyl alcohol, and Butyl Myristate is derived from İsopropyl Myristate and butyl alcohol.
 
İsopropyl Myristate
İsopropyl Myristateis classified as :
Binding
Emollient
Skin conditioning
Solvent
Perfuming
CAS Number    110-27-0
EINECS/ELINCS No:    203-751-4
COSING REF No:    34699
INN Name:    İsopropyl Myristate
PHARMACEUTICAL EUROPEAN NAME:    isopropylis myristas
Chem/IUPAC Name:    Tetradecanoic acid, isopropyl ester
 
You've most likely heard of moisture-enabling ingredients glycerin and hyaluronic acid, but we're willing to bet you've never heard of İsopropyl Myristate. Though, if you were to do a quick scan of the skincare and personal care products currently in your bathroom, we're also willing to bet that it's in a large percentage of them. An emollient ingredient, İsopropyl Myristate helps to strengthen the skin barrier, ensuring that moisture stays locked in. But, unlike other emollients, the benefits don't stop there.

İsopropyl Myristate is unique in that it's able to enhance the penetration of other ingredients, not to mention it's essential when it comes to formulating and creating products that are cosmetically elegant. Ahead, dermatologist Sapna Palep, MD, of Spring Street Dermatology in New York City, dermatologist Dan Belkin, MD, of Laser & Skin Surgery Center of New York, and Sheel Desai Solomon, MD, a dermatologist in Raleigh/Durham, North Carolina explain what sets this ingredient apart from its moisturizing counterparts.
İsopropyl Myristate

TYPE OF INGREDIENT: Emollient, though it also acts as a thickening agent and lubricant in beauty products.
MAIN BENEFITS: Strengthens the skin's natural moisture barrier to lock in hydration, enhances the penetration of other ingredients, thickens formulas, and makes those with a high oil content feel silky rather than greasy.
WHO SHOULD USE IT: İsopropyl Myristate is ideal for anyone with normal to dry skin looking for moisturization benefits, according to Palep.
HOW OFTEN CAN YOU USE IT: For the best results, follow the directions on the product it's found in, though daily or twice daily use is generally fine.
WORKS WELL WITH: İsopropyl Myristate works well with an assortment of active ingredients, says Solomon, which is why it's found in so many different types of products and formulas.
DON'T USE WITH: Because it does enhance penetration, it's important to assess the other ingredients in the formula and whether this increased penetration can cause unexpected side effects such as irritation, cautions Palep.

What Is İsopropyl Myristate?
A synthetic oil, İsopropyl Myristate is made up of isopropyl alcohol-a propane derivative-and myristic acid, a naturally-occurring fatty acid, explains Palep. While it's not necessarily a solo skincare star that you'll find touted as a hero ingredient, it's a popular cosmetic ingredient in a wide array of beauty products, found in everything from aftershave to anti-perspirants to anti-aging creams. Why so popular? First, there are the formulation benefits. "By thickening formulas, it gives products a denser texture and also improves the overall texture of those with a high oil content to be silky rather than greasy," says Palep. And while that's a major win for the labs and scientists making your beauty products, it does have skincare benefits for you, too. While there are plenty of emollients on the market, İsopropyl Myristate has the added benefit of enhancing the penetration of other ingredients (more on that below).

Benefits of İsopropyl Myristate For Skin
Strengthen's the skin barrier: İsopropyl Myristate keeps the outermost layer of the skin strong and intact. Think of the skin barrier as being made up of bricks and mortar: the cells are the bricks and all of the lipids (fats) are the mortar. İsopropyl Myristate is that mortar, filling in cracks in between the skin cells so that moisture can't escape.
 
İsopropyl Myristate Softens the skin: As an emollient, İsopropyl Myristate also helps soften and smooth dry skin, which is why this is a choice ingredient for those with dry or flaky skin.
 
Enhances the penetration of other ingredients: The exact mechanism by which this works isn't fully clear, but it's thought that İsopropyl Myristate changes the structure of the stratum corneum, the most external layer of the skin, making it easier for active ingredients to absorb, explains Belkin. In turn, this can make the skincare you're using more effective.

Side Effects of İsopropyl Myristate
There's one big caveat with this ingredient: "The one documented drawback to İsopropyl Myristate is that it can clog pores," notes Solomon. Translation: Those with acne or who are prone to breakouts should steer clear. And while it's generally a good thing that it enhances penetration of other ingredients, this can also prove to be a double-edged sword. "Because it is a penetration enhancer, it may make irritation from other active ingredients more common," cautions Belkin. He also points out that those with rosacea or particularly sensitive skin should be extra cautious about formulas that contain İsopropyl Myristate along with powerful actives that can be irritating to begin with, such as retinoids and acids.
And, as with any other ingredients, there's also a risk of allergic reaction.

How to Use İsopropyl Myristate
Because İsopropyl Myristate is found in so many different products and formulations, your best bet is to follow the instructions on any particular product.
Properties of isopropyl myristate
Molecular Formula:C17H34O2
Molecular Weight:270.457 g/mol
IUPAC Name:propan-2-yl tetradecanoate
Physical Description:Liquid
Color:Liquid of low viscosity of ISOPROPYL MYRISTATE
Boiling Point:588 K (315 deg C) at 760 mm Hg
Melting Point:Approximately 3 deg C
Density:0.8532 g/cu cm at 20 deg C
 
Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Composed of of Isopropyl Alcohol (a propanederivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. It is most oftenused an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Isopropyl myristate is the ester of isopropanol and myristic acid.Isopropyl Myristate is a synthetic oil used as an emollient, thickening agent, or lubricant in beauty products. Composed of of Isopropyl Alcohol (a propanederivative) and Myristic Acid (a naturally-occurring fatty acid), Isopropyl Myristate is a popular cosmetic and pharmaceutical ingredient. It is most oftenused an an additive in aftershaves, shampoos, bath oils, antiperspirants, deodorants, oral hygiene products, and various creams and lotions.

Uses of ISOPROPYL MYRISTATE

İsopropyl myristate is a polar emollient and is used in cosmetic and topical medicinal preparations where good absorption into the skin is desired. Isopropyl myristate is being studied as a skin enhancer. It is also used as a pesticide against head lice which works by dissolving the wax that covers the exoskeleton of head lice, killing them by dehydration.
İsopropyl myristate is used as a solvent in perfume materials.
İsopropyl myristate is the non-aqueous component of the two-phase mouthwash, Dentyl pH, where it removes bacteria from the oral cavity.
İsopropyl myristate is also used in the removal process of prosthetic make-up.
İsopropyl myristate is also used in flea and tick products for pets.
The hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid could be responsible for decreasing of the pH value of
formalations.

How is Isopropyl Myristate Used?

There are many reasons why skin care companies often include isopropyl myristate in their products. Perhaps one of the more common reasons is this chemical's ability to moisturize the skin. As an emollient, isopropyl myristate helps strengthen the skin's natural moisture barrier, which helps it stay hydrated by reducing moisture loss.

Another benefit of isopropyl myristate is its ability to thicken formulations, and give creams and deodorants a denser texture. Though this property may not directly improve the condition of the user's skin, a thicker cream can feel more luxurious and thus improve the consumer's enjoyment. Further, this allows some products, like deodorants, to be applied to the skin more smoothly.

Further, isopropyl myristate is valued for its ability to improve the overall texture of products with high oil content. Products with lots of oil can be amazingly beneficial for the skin, but the greasy feel can be a turn-off for many consumers. Additionally, greasiness caused by excess oil can make it impractical to use such creams in a professional setting. Including isopropyl myristate can be a useful addition to such products, as it will change the texture to be more silky, rather than greasy.

Lastly, isopropyl myristate is also believed to have strong skin penetrating properties. This is a valuable attribute, as isopropyl myristate can help other skin healing chemicals to penetrate more deeply; thus making personal care products more effective.