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Jeffcat DMEA

Jeffcat DMEA is a tertiary amine that is ethanolamine having two N-methyl substituents. 
Jeffcat DMEA has a role as a curing agent and a radical scavenger. 
Jeffcat DMEA is a tertiary amine and a member of ethanolamines.

CAS:    108-01-0
MF:    C4H11NO
MW:    89.14
EINECS:    203-542-8

A clear colorless liquid with a fishlike odor. 
Flash point 105°F. 
Less dense than water. 
Vapors heavier than air. 
Toxic oxides of nitrogen produced during combustion. 
Jeffcat DMEA used to make other chemicals.

Jeffcat DMEA is an organic compound with the formula (CH3)2NCH2CH2OH. 
Jeffcat DMEA is bifunctional, containing both a tertiary amine and primary alcohol functional groups. 
Jeffcat DMEA is a colorless viscous liquid. 
Jeffcat DMEA is used in skin care products for improving skin tone and also taken orally as a nootropic. 
Jeffcat DMEA is prepared by the ethoxylation of dimethylamine.

Jeffcat DMEA is a transparent, pale yellow liquid and primary alcohol that is used as a building block for the synthesis of cationic flocculants and ion exchange resins. 
Jeffcat DMEA is also used used as a chemical intermediate for pharmaceuticals, dyes, corrosion inhibitors, and emulsifiers and as an additive to boiler water, paint removers, and amino resins.

Jeffcat DMEA has low toxicity. 
Jeffcat DMEA has a stimulating effect on the skin and the central nervous system. 
Therefore, Protection Measure should still be adopted according to the toxic chemicals regulation.
Jeffcat DMEA is packed in a white iron drum with a net weight of 180kg per barrel. 
Store in a cool and ventilated place, according to the provisions of flammable and toxic chemicals storage and transportation.

Jeffcat DMEA is abbreviated as DMEA, which is a colorless and volatile liquid with ammonia smell and boiling point of 134.6℃. 
Jeffcat DMEA used in ion exchange resin; used in the preparation of high-purity water and decolorization of sugar liquid, the treatment of three wastes of film lotion; used in polyurethane soft block foam, molded foam and rigid foam, smoldering elastic foam, etc.; Co-solvent, polyurethane paint curing agent; reaction product with acrylic microorganisms as a flocculant for urban water purification.
Jeffcat DMEA has a strong stimulating effect on the eyes, skin, mucous membranes and upper respiratory tract. May cause skin burns. 
Jeffcat DMEAn can cause inflammation, edema, and spasm of the larynx and bronchus, chemical pneumonia, and pulmonary edema. 
Jeffcat DMEA has a sensitizing effect on the skin.

Jeffcat DMEA Chemical Properties
Melting point: −70 °C(lit.)
Boiling point: 134-136 °C(lit.)
Density: 0.886 g/mL at 20 °C(lit.)
Vapor density: 3.03 (vs air)
Vapor pressure: 100 mm Hg ( 55 °C)
Refractive index: n20/D 1.4294(lit.)
Fp: 105 °F
Storage temp.: Store below +30°C.
Solubility alcohol: miscible(lit.)
Form: Liquid
pka: pK1:9.26(+1) (25°C)
Color: Clear colorless to pale yellow
Odor: Amine like
PH Range: 10.5 - 11.0 at 100 g/l at 20 °C
PH: 10.5-11 (100g/l, H2O, 20℃)
Explosive limit: 1.4-12.2%(V)
Water Solubility: miscible
Freezing Point: -59.0℃
Sensitive: Hygroscopic
Merck: 14,2843
BRN: 1209235
Stability: Stable. Flammable. 
Incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.
InChIKey: UEEJHVSXFDXPFK-UHFFFAOYSA-N
LogP: -0.55 at 23℃
CAS DataBase Reference: 108-01-0(CAS DataBase Reference)
NIST Chemistry Reference: Jeffcat DMEA (108-01-0)
EPA Substance Registry System: Jeffcat DMEA (108-01-0)

Character: colorless or yellowish liquid with ammonia odor, colorless or yellowish liquid with ammonia odor, flammable miscible with water, ethanol, benzene, ether and acetone, etc.

Uses 
Jeffcat DMEA is also known as dimethylaminoethanol. 
Studies indicate skin-firming properties, and an ability to reduce the appearance of fine lines and wrinkles as well as dark circles under the eyes. 
Jeffcat DMEA is considered anti-aging, and antiinflammatory, and has exhibited free-radical scavenging activity.

Jeffcat DMEA is used as corrosion inhibitor, anti-scaling agent, paint additive, coating additive and solids separation agent. 
Jeffcat DMEA is also used as an intermediate for active pharmaceutical ingredients and dyes. 
Jeffcat DMEA serves as a curing agent for polyurethanes and epoxy resins. 
Further, Jeffcat DMEA is used as an additive to boiler water. 
In addition to this, Jeffcat DMEA is used therapeutically as a CNS stimulant.
Jeffcat DMEA is used as a curing agent for polyurethanes and epoxy resins. 
Jeffcat DMEA is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride.
The acrylate ester is used as a flocculating agent.

Related compounds are used in gas purification, e.g. removal of hydrogen sulfide from sour gas streams.
Jeffcat DMEA is used as a curing agent for polyurethanes and epoxy resins. 
Jeffcat DMEA is used to the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, emulsifiers, and corrosion inhibitors. 
Also Jeffcat DMEA is an additive to paint removers, boiler water, and amino resins.
Jeffcat DMEA may be employed as a ligand in the copper-catalyzed amination of aryl bromides and iodides.

Jeffcat DMEA is used as a chemical intermediate for antihistamines and local anesthetics; as a catalyst for curing epoxy resins and polyurethanes; and as a pH control agent for boiler water treatment. 
However, Jeffcat DMEA in the salt form, (i.e. dimethylaminoethanol acetamidobenzoate) is primarily utilized therapeutically as an antidepressant (HSDB 1988).

Moderately toxic by ingestion, inhalation, skin contact, intraperitoneal, and subcutaneous routes. 
Jeffcat DMEA is a skin and severe eye irritant. 
Jeffcat DMEA used medically as a central nervous system stimulant. 
Flammable liquid when exposed to heat or flame; can react vigorously with oxidzing materials. Ignites spontaneously in contact with cellulose nitrate of high surface area. 
To fight fire, use alcohol foam, foam, CO2, dry chemical. 
When heated to decomposition Jeffcat DMEA emits toxic fumes of NOx

Jeffcat DMEA used as pharmaceutical raw materials, manufacturing dyes, fiber treatment agents, anti-corrosion additives and other intermediates, can be used as water-soluble coating base materials, synthetic resin solvents.

Jeffcat DMEA can be used to synthesize local anesthetics, antihistamines, antispasmodics and antihypertensive drugs. 
Jeffcat DMEA is also a raw material for the preparation of emulsifiers, Textile Auxiliaries, corrosion inhibitors, flocculants, scale inhibitors, ion exchange resins and dyes. 
Jeffcat DMEA can also be used as epoxy resin low temperature curing accelerator, polyurethane foam foaming agent and paint solvent.

Preparation    
The synthesis of Jeffcat DMEA by the ethylene oxide method is obtained by the ammonification of dimethylamine with ethylene oxide, which is distilled, refined and dehydrated.
Synthesis of Jeffcat DMEA can be accomplished from equimolar amounts of ethylene oxide and dimethylamine (HSDB 1988).

Reactivity Profile    
Jeffcat DMEA is an aminoalcohol.
Amines are chemical bases. 
They neutralize acids to form salts plus water. 
These acid-base reactions are exothermic. 
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. 
Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. 
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. 
Jeffcat DMEA may react vigorously with oxidizing materials.

Health Hazard    
Jeffcat DMEA is classified as a mild skin irritant and a severe eye irritant (HSDB 1988). 
Doses as high as 1200 mg daily produce no serious side effects and a single dose of 2500 mg taken in a suicide attempt had no adverse effects (Gosselin et al 1976). 
Inhalation of the vapor or mist can cause irritation to the upper respiratory tract. 
Asthmatic symptoms have been reported. 
Extremely irritating; may cause permanent eye injury. 
Corrosive; will cause severe skin damage with burns and blistering. 
Ingestion may cause damage to the mucous membranes and gastrointestinal tract. 
No reports were found in the literature regarding carcinogenic or mutagenic potential.

Metabolism    
When administered orally, Jeffcat DMEA has been shown to cross the blood-brain barrier (HSDB 1988). 
Two other studies have examined the pharmacokinetics of Jeffcat DMEA in rats (Dormand et al 1975) and healthy adults (Bismut et al 1986).
Jeffcat DMEA has been postulated that dimethylaminoethanol undergoes endogenous methylation (LaDu et al 1971). 
After intravenous treatment of mice with [14C]-labeled dimethylaminoethanol in the brain, dimethylaminoethanol yielded phosphoryldimethylaminoethanol and phosphatidyldimethylaminoethanol. 
Acid-soluble and lipid cholines derived from dimethylaminoethanol also were found in brain (Miyazaki et al 1976). 
While examining the pharmacokinetics of the maleate acid of [14C]-dimethylaminoethanol in rats, Dormand et al (1975) observed that Jeffcat DMEA was metabolized in the phospholipid cycle and produced metabolites such as phosphoryldimethylaminoethanolamine, and glycerophosphatidylcholine. 

In kainic-acid lesioned rats, Jeffcat DMEA was converted to a substance which cross-reacted in the radioenzymatic assay for acetylcholine (London et al 1978). 
Ansell and Spanner (1979) demonstrated that [14C]-dimethylaminoethanol rapidly disappeared from brain; after 0.5, 1, and 7 h, only 30, 27, and 16% of the administered radioactivity, respectively, remained in the brain after intracerebral injection. 
They also showed that brain levels of phosphodimethylaminoethanol increased to a maximum at 1-2 h and decreased afterwards, whereas concentrations of phosphatidylethanolamine increased continuously throughout the 7 h observation period. 
This study further found that after i.p. injections of labeled dimethylaminoethanol, the brain content of phosphatidylethanolamine increased through the 7 h period and the levels were 10-40 fold higher than those of phosphodimethylaminoethanol.

Synonyms
2-(Dimethylamino)ethanol
Deanol
N,N-Dimethylethanolamine
108-01-0
Dimethylaminoethanol
Dimethylethanolamine
2-DIMETHYLAMINOETHANOL
Norcholine
DMAE
DMEA
Bimanol
Liparon
N,N-Dimethylaminoethanol
Varesal
Propamine A
(2-Hydroxyethyl)dimethylamine
Ethanol, 2-(dimethylamino)-
Kalpur P
Dimethylmonoethanolamine
Dimethylaminoaethanol
N,N-Dimethyl-2-aminoethanol
Amietol M 21
N,N-Dimethyl-2-hydroxyethylamine
N-Dimethylaminoethanol
2-(N,N-Dimethylamino)ethanol
Dimethyl(hydroxyethyl)amine
Texacat DME
Dimethylaethanolamin
Dimethyl(2-hydroxyethyl)amine
2-(Dimethylamino)-1-ethanol
N,N-Dimethyl ethanolamine
N-(2-Hydroxyethyl)dimethylamine
N,N-Dimethyl-N-(2-hydroxyethyl)amine
2-(Dimethylamino) ethanol
(Dimethylamino)ethanol
beta-Hydroxyethyldimethylamine
2-Dimethylamino-ethanol
beta-Dimethylaminoethyl alcohol
2-(dimethylamino)ethan-1-ol
2-Dwumetyloaminoetanolu
N-(Dimethylamino)ethanol
N,N-Dimethyl-N-(beta-hydroxyethyl)amine
Tegoamin DMEA
NSC 2652
Dabco DMEA
Deanol [BAN]
2-Dimethylamino ethanol
N,N-Dimethyl(2-hydroxyethyl)amine
N,N'-Dimethylethanolamine
2-(dimethylamino)-ethanol
(CH3)2NCH2CH2O
CHEMBL1135
.beta.-(Dimethylamino)ethanol
2N6K9DRA24
.beta.-Hydroxyethyldimethylamine
.beta.-Dimethylaminoethyl alcohol
CHEBI:271436
Phosphatidyl-N-dimethylethanolamine
NSC-265
Deanol (BAN)
N,N-DIMETHYLAMINOETHANOL (DMAE)
NCGC00159413-02
N,N-Dimethyl-N-(.beta.-hydroxyethyl)amine
DSSTox_CID_505
DSSTox_RID_75628
DSSTox_GSID_20505
Deanol (N,N-Dimethylethanolamine)
Demanol
Demanyl
Tonibral
CAS-108-01-0
Dimethylaethanolamin [German]
Dimethylamino ethanol
Dimethylaminoaethanol [German]
CCRIS 4802
2-Dwumetyloaminoetanolu [Polish]
HSDB 1329
EINECS 203-542-8
UN2051
BRN 1209235
N,N-Dimethyl-N-ethanolamine
UNII-2N6K9DRA24
AI3-09209
Dimethylethanoiamine
Toyocat -DMA
dimethyl ethanolamine
dimethyl-ethanolamine
MFCD00002846
Paresan (Salt/Mix)
dimethyl ethanol amine
2-dimethyamino-ethanol
n,n-dimethylethanolamin
Biocoline (Salt/Mix)
N,N dimethylaminoethanol
DEANOL [WHO-DD]
DEANOL [MI]
N,N-dimethyl-ethanolamine
N,N-dimethylamino ethanol
N,N-dimethylethanol amine
N,N-dimethylethanol-amine
DEANOL [MART.]
2-Hydroxyethyldimethylamine
2-Dimethylaminoethanol [UN2051] [Corrosive]
EC 203-542-8
beta -(dimethylamino)ethanol
DIMETHYL MEA [INCI]
Dimethylaminoaethanol(german)
Choline chloride (Salt/Mix)
Luridin chloride (Salt/Mix)
beta -hydroxyethyldimethylamine
N,N-Dimethylethanolamine/DMEA
beta -dimethylaminoethyl alcohol
2-(N,N-dimethyl amino)ethanol
2-(N,N-dimethylamino) ethanol
DTXSID2020505
N-hydroxyethyl-N,N-dimethylamine
2-(N,N-dimethyl amino) ethanol
Ni(1/4)OEN-Dimethylethanolamine
NSC2652
beta -(dimethylamino)ethyl alcohol
2-hydroxy-N,N-dimethylethanaminium
WLN: Q2N1 & 1
2-Dimethylaminoethanol, >=99.5%
BCP22017
CS-M3462
ZINC1641058
.beta.-(Dimethylamino)ethyl alcohol
N, N-Dimethyl(2-hydroxyethyl)amine
Tox21_113163
Tox21_201821
Tox21_302844
BDBM50060526
N,N-Dimethyl-beta -hydroxyethylamine
STL282730
Dimethylaminopropylamine Reagent Grade
n-(2-hydroxyethyl)-n,n-dimethylamine
AKOS000118738
N,N-Dimethyl-.beta.-hydroxyethylamine
DB13352
N,N-DIMETHYLETHANOLAMINE [HSDB]
UN 2051
N, N-Dimethyl-N-(2-hydroxyethyl)amine
NCGC00159413-03
NCGC00256454-01
NCGC00259370-01
BP-13447
N,N-Dimethyl-N-(beta -hydroxyethyl)amine
DB-002821
N, N-Dimethyl-N-(beta -hydroxyethyl)amine
D0649
D07777
2-Dimethylaminoethanol [UN2051] [Corrosive]
2-Dimethylaminoethanol, purum, >=98.0% (GC)
Q241049
2-Dimethylaminoethanol, analytical reference material
2-Dimethylaminoethanol, SAJ first grade, >=99.0%
W-108727
Z104473552
2-Dimethylaminoethanol, purified by redistillation, >=99.5%
N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethylethanolamine, DMEA

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