KATHON 886

5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one

Cas Number: 55965-84-9

Soluble, synthetic, and semi-synthetic metalworking fluids or coolants provide an excellent environment for the growth of various microorganisms, including bacteria, mold, and yeast. If allowed to grow, these organisms can have detrimental effects on the fluids. For example, bacteria, which can grow very quickly, can destroy the integrity of the fluid by discoloration destroying lubricity characteristics, and causing emulsions to split.

Synonyms:
Kathon 886; 55965-84-9; Kathon biocide; Kathon CG; Kathon LX; Zonen F; ProClin 300; 2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one(14%in H2O); UNII-15O9QS218W; 15O9QS218W; 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one; Bio-Perge; Kathon WT; 3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone; Microcide III; Somacide RS; 5-Chloro-2-methyl-3(2H)-isothiazolone mixt. with 2-methyl-3(2H)-isothiazolone; Legend MK; Kathon 886MW; Kathon CG/ICP II; Slaoff 360; Kathon 886 W; Kathon RH 886; MBC 215; Tret-O-Lite XC 215; 3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with2-methyl-3(2H)-isothiazoloneOTHER CA INDEX NAMES:3(2H)-Isothiazolone, 2-methyl; CCRIS 4652; KKM 43; EPA Pesticide Chemical Code 107103; 2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1); C8H9ClN2O2S2; KS-00000R9C; 8175AB; MFCD01716911; AKOS016842708; CS-W018768; 2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (1:1); AK128362; CS-17384; 965K849; Q26841195; 2-Methylisothiazol-3(2H)-one 5-chloro-2-Methylisothiazol-3(2H)-one; 2-Methylisothiazol-3(2H)-one 5-chloro-2-methylisothiazol-3(2H)-one (1:1) 14% in water; 2-Methylisothiazol-3(2H)-one compound with 5; chloro-2-methylisothiazol-3(2H)-one (14% in H2O)

Bacteria can also reduce the pH of the fluid, which can promote corrosion. Some forms of bacteria have objectionable odors. Fungi typically grow more slowly than bacteria, but can form large masses which clog filters and lines and in some cases lead to system shutdown; fungi also generate foul odors and can cause corrosion. KATHON 886 MW microbicide is very effective against bacteria and fungi. It is recommended for use in soluble, semi-synthetic, and synthetic metalworking fluids. Due to the wide variations in coolant formulations, laboratory or pilot tests are recommended to evaluate KATHON 886 MW microbicide in specific metalworking fluids prior to commercial use. KATHON 886 MW microbicide is supplied as a 14% active liquid in water. It is registered with the U.S. EPA (Environmental Protection Agency), number 707-129.
KATHON biocides have been used safely and effectively in a variety of industries around the world for more than 20 years. In 1977 Rohm and Haas Company was granted EPA registration for KATHON 886 MW microbicide for use in metalworking fluids, in 2 piece can manufacture, hot aluminum rolling, and general machinery of ferrous and aluminum materials. In 1986, this registration was expanded to include the use of KATHON 886 MW microbicide in metal cleaners and water-based hydraulic fluids.
KATHON 886 MW microbicide is soluble in water, methanol, ethanol, isopropyl alcohol, acetic acid, and 3.5 parts nbutanol. KATHON 886 MW microbicide is insoluble in acetone.
pH - KATHON 886 MW microbicide is stable over a wide pH range (3.0-9.2) in water and metalworking fluid systems. Its stability and performance are improved at lower pH. Whenever possible the pH of a system should be maintained below pH 9.2. 
KATHON 886 MW biocide utilizes a two-step mechanism involving rapid growth inhibition leading to a loss of cell viability. Growth inhibition is the result of rapid disruption of the central metabolic pathways of the cell by inhibition of several specific enzymes, including dehydrogenases. The critical enzymes which are affected are associated with the Krebs cycle (alpha- ketoglutarate, pyruvate, and succinate dehydrogenase), nutrient metabolism (lactate dehydrogenase) and energy generation (NADH dehydrogenase). The key physiological activities that are rapidly inhibited in microbial cells are respiration (oxygen consumption), energy generation (ATP synthesis), and growth (assimilation). Many of these key enzymes are present in both aerobic and anaerobic microorganisms, which explains why KATHON 886 MW is such a broad spectrum biocide. Inhibition of cellular activity and growth is rapid (within minutes), whereas cell death (cidal activity) is observed after several hours contact. In general, the higher the concentration of biocide, the shorter the contact time required for more complete kill. Cell death results from the progressive loss of protein thiols in the cell from one of multiple pathways. As cell metabolism is disrupted, free radicals are produced which also results in cell death. This unique mechanism results in the broad spectrum of activity of KATHON 886 MW biocide, low use levels for microbial control, and difficulty in attaining resistance by mutation.
Method of Addition KATHON™ 886 MW Biocide should be directly dispensed into metalworking fluid concentrates or use-dilution metalworking fluids using a metering pump or other point-of-use device where possible and uniformLy dispersed throughout the fluid. Fluid Concentrate KATHON™ 886 MW Biocide should be added to metalworking fluid concentrates at a level that ensures the final use-dilution fluid will contain 55 to 167 ppm of product (25 to 75 ppm active ingredient). KATHON 886 MW stability in a given concentrate should be determined prior to commercialization. Contact your local Dow representative for assistance in selecting one of several recommended stabilizers to enhance the performance and compatibility of KATHON 886 MW in your metalworking fluid concentrate. Use-Dilution Fluid We highly recommend grossly contaminated systems be cleaned before treatment is begun. Initial Dose: For a noticeably fouled system, add 0.47 to 1.44 lbs (7 to 21 fl oz) of KATHON™ 886 MW Biocide per 1,000 gallons of fluid. This will provide 25 to 75 ppm active ingredient. Repeat until control is achieved. Subsequent Dose: For maintenance of a non-fouled system, add 0.09 to 0.58 lbs (1.3 to 8.6 fl oz) of KATHON™ 886 MW Biocide per 1,000 gallons of fluid every four weeks. This will provide 5 to 30 ppm active ingredient. A higher dose range and/or increased frequency of treatment may be required, depending upon the rate of dilution of the preservative with the makeup fluid, the nature and severity of contamination, level of control required, filtration effectiveness, system design, etc.
General Practices When Using KATHON Biocides  Know the size of your system and dose at the recommended use levels.  To improve performance and longevity add KATHON 886 MW microbicide on the clean side of the filters. It may be necessary to occasionally add KATHON 886 MW microbicide to the dirty side of the filters if large populations of microorganisms are detected there.  Minimize contamination: - Eliminate or minimize dead spots - Disconnect unused portions of the system - Do not throw trash in sumps  Always remember to triple rinse (or equivalent) empty KATHON 886 MW containers to avoid incidental contact.  Post placard with safety information and deactivation protocol near biocide handling area. Table 3 Chemical Composition Ingredients KATHON 886 MW Active Ingredients 5-chloro-2-methyl-4-isothiazolin-3-one 10.4% 2-methyl-4-isothiazolin-3-one 3.7% Total Active Ingredients (typical) 14.1% Inert Ingredients Magnesium ion 4.2 to 5.5 % (Approximate Values) Water to 100% Table 4 Typical Physical Properties These properties are typical but do not constitute specifications. Appearance Amber to gold, slightly viscous liquid Odor Mild, aromatic Specific Gravity, @ 25°C 1.29 Density, lb./gal. 10.8 pH 1 to 3 Viscosity, cps, @ 25°C 16 Melting Point, °C –33 Boiling Point, °C 100 Vapor Pressure, (mm Hg), @ 23°C 0.1 The typical physical properties of KATHON 886 MW microbicide are presented in Table 2. Maximizing the Performance of KATHON 886 MW Fungicide Additional guidelines for maximizing the performance of KATHON 886 MW microbicide are as follows:  KATHON 886 MW microbicide stability and performance is improved with lower pH. 
Whenever possible maintain the pH of system below pH 9.2. Lower pH also makes amines and amine-containing compounds less aggressive.  For systems with pH greater than 9.5, we strongly recommend determination of biological efficacy and chemical stability prior to use.  Avoid adding highly basic additives (alkaline materials with pH of 10-12) immediately prior to or after adding KATHON 886 MW microbicide to your system. If a highly basic additive must be added, allow sufficient time (at least 30 minutes) between additions.  Minimize levels of diethanolamine (DEA) in your system. If possible use 99% triethanolamine (TEA) or monoethanolamine (MEA) instead of DEA, and use these at as low a level as possible.  Avoid use of mercaptans such as mercaptobenzothiazole.  Some biocides are incompatible with KATHON 886 MW and can degrade it. To maintain performance avoid using Sodium Omadine and Triadine 10 with KATHON 886 MW microbicide. If a fungicide is needed, use KATHON 886 MW fungicide; it is completely compatible with KATHON 886 MW microbicide.  Always add KATHON 886 MW microbicide directly to the metalworking fluid sump. Never use KATHON 886 MW microbicide in a spray bottle.  Avoid charging KATHON 886 MW microbicide in high temperature zones, since increasing temperatures accelerate other degradation effects. Ideally, add KATHON 886 MW microbicide to the fluid below 60°C (140°F).  Avoid adding KATHON 886 MW microbicide and incompatible corrosion inhibitors directly to the tank at the same time.
Within minutes after addition of KATHON 886 MW microbicide to a metalworking fluid sump, the metabolic activity of the microorganisms in the system shuts down. This includes cellular respiration (oxygen uptake), growth, energy generation, and nutrient uptake. The microorganisms, although still alive, are no longer able to reproduce or metabolize metalworking fluid components. After 24 to 48 hours of contact with a lethal dose of the microbicide, most of the microorganisms have been killed.
KATHON 886 MW microbicide generally retains its antimicrobial efficacy in metalworking fluid systems for 1 to 4 weeks. Variables such as degree of fluid contamination, effectiveness of the filtration system, system turnover time, compatibility between the microbicide and the metalworking fluid components, and other system additives involved, can affect the life of the microbicide in a system.
The active ingredients in KATHON 886 MW microbicide have been shown to reduce microbial fouling and prevent biofilm development. A number of application studies have been conducted demonstrating reduction of both viable microorganisms (bacteria and fungi) as well as total biomass (total protein and dry solids) on industrial surfaces. The benefits of reduced microbial fouling include improved system performance, reduced filter plugging, reduced biocorrosion, and improved microbial control. Additional information on biofouling studies is presented in technical bulletin CS-673R. 
The performance of KATHON 886 MW microbicide was tested in controlled laboratory studies versus a pure culture of Mycobacterium chelonae (ATCC 14472). Results showed 7-20 ppm active ingredient prevented the growth of the Mycobacterium isolate (106 cfu/ml) in dilute and full strength nutrient broth. An eradication study in a soluble oil fluid showed KATHON 886 MW microbicide at 9 ppm active ingredient was sufficient to provide complete kill of 103 bacteria/ml.
The term "bacterial endotoxin" is synonymous with the lipopolysaccharide (LPS) component of the outer membrane of Gram negative bacteria. It is generally regarded that the Lipid A component of the LPS is directly responsible for the endotoxic activity of certain Gram negative bacteria. The "endotoxin" terminology refers to the fact that the "toxin" is located on the exterior of the bacterial cell and is "released" from the cell into the surrounding liquid after cell death and lysis. It is important to note that not all LPS from Gram negative bacteria are endotoxins. The most heavily studied LPS are from Escherichia, Shigella and Salmonella, all of which are enteric or intestinal bacteria. KATHON 886 MW microbicide has been shown to be efficacious versus many Gram negative bacteria, known to produce endotoxins, under controlled laboratory studies.
Minimum Inhibitory Concentrations for KATHON 886 MW microbicide are within the recommended use range for general bacterial control. In addition, KATHON 886 MW microbicide does not function by cell lysis or membrane disruption, so killed cells would be less likely to release endotoxins.
KATHON 886 MW microbicide may encounter conditions in certain metalworking fluids where stability is reduced. Several options exist to improve it’s performance and stability. Addition of inorganic or organic forms of copper to the fluid may improve the stability of the active ingredients and reduce degradation. Alternatively, KATHON MWC microbicide contains copper salts and is designed for aggressive conditions. Addition of biosurfactants or biodispersants may improve it’s efficacy, especially against biofilms or heavily contaminated systems. Addition of a chelant, such as EDTA, may also boost efficacy in challenging systems.
KATHON 886 MW microbicide was evaluated for efficacy against thermophilic bacteria in 4 hot aluminum rolling oils. KATHON 886 MW microbicide at 20 ppm a.i. (143 ppm as supplied) controlled microbial growth at 54°C in all 4 of the fluids (at recommended dilutions) at least 4 weeks and in 1 fluid for 3 weeks. 
A study to determine if repeated doses of KATHON 886 MW microbicide or magnesium chloride in use-dilution metalworking fluids cause corrosion was conducted. This study showed no detrimental effects from either the KATHON biocide or the magnesium chloride. In this study, mild steel coupons were placed in glass bottles containing a 4% solution of a commercial metalworking fluid in demineralized water. Levels of KATHON 886 MW ranging from 200-1600 ppm, product as supplied, (2-16 times the recommended use rate) or levels of magnesium chloride ranging from 110-550 ppm were added to the bottles and stored at 35°C for 6 months. The pH of all samples was @ 9.4. All tests were performed in triplicate; no observable corrosion occurred on any of the metal coupons.
More than 200 metalworking fluid additives, including emulsifiers, corrosion inhibitors, EP additives, etc., have been tested for their effect on the stability of KATHON 886 MW microbicide. Table 14 lists these compounds and their primary function by degree of compatibility with KATHON 886 MW microbicide ranging from EXCELLENT COMPATIBILITY to NOT COMPATIBLE. Table 15 cross-references Table 14 and lists these additives by type. The data in Tables 14 and 15 should be used in conjunction with the guidelines below: 1. Assume KATHON 886 MW microbicide will work. It can be used with all metalworking fluid additives except those listed as NOT COMPATIBLE. 2. Use the data in Tables 14 and 15 to assess the relative effect of your formulation additives. 3. If possible, select alternative additives in higher compatibility categories to improve the stability of KATHON 886 MW microbicide. 4. Lower the pH or the levels of aggressive additives to improve compatibility. 5. Contact Rohm and Haas Company for information on KATHON MWC microbicide which has enhanced stability and efficacy in certain metalworking fluids which are antagonistic toward KATHON 886 MW microbicide
Component 5-Chloro-2-methyl-4-isothiazolin-3-one -2-Methyl-4-isothiazolin-3-one -% Magnesium nitrate - Magnesium Chloride -Water 
All metalworking fluid formulations share the common problem of susceptibility to microbial attack by various bacteria, mold and yeast. This may result in degradation of fluid components, loss of emulsion stability, pH drop, odor, slime, filter clogging and heightened corrosion.
Especially when using water based metalworking fluids, the challenge for both formulators and metalworking facility operators is to minimize the adverse economic impact of uncontrolled microbial contamination.

A comprehensive approach to microbial control in metalworking systems must account for all facets of the biocide program – from design, to implementation and trouble shooting. Best practices for selecting a biocide treatment program must consider cost, efficacy, compatibility, stability, waste discharge, etc.
Biocides may be added to MWF concentrates, which provides a convenient method for treatment of the in-use recirculating system. As makeup fluid is added, more biocide is also added via the concentrate. However, the biocide level in the concentrate is fixed, so the amount added to the fluid cannot be significantly modified during use.
Thus, the only way to shock a metalworking system for microbial control is by tankside addition. Biocides may be dosed tankside for individual treatment of a system within the manufacturers recommended use range to control the microbial problems. The flexibility of adjusting the dose as needed is one advantage of tankside treatment.
Stability and compatibility of biocides in concentrates is critical to their effective use. Based on past studies, isothiazolone biocides generally have insufficient stability if added indiscriminately to concentrates. However, novel stabilization technology, along with definition of a preferred set of amines, has been developed by Rohm and Haas to enable these effective biocides to be used in various concentrate formulations. Benefits to formulators and end-users include enhanced stability and efficacy during extended storage and elevated temperature conditions.
Figure 1 compares the efficacy of seven types of biocides when dosed in MWFconcentrates and heat-aged. Samples of the treated concentrates were diluted over time and inoculated with microorganisms. As shown, a stabilized isothiazolone (Rohm and Haas trademarked Kordek LX 5000 biocide) provided excellent long-term efficacy versus bacteria, even when aged for six months at two temperatures. Others, including oxazolidine, triazine, dimorpholine and benzisothiazolone (BIT), lost efficacy over time, especially with heat aging, and one product (polyquaternium) was ineffective.
In addition to being free of VOCs and formaldehyde, Kordek LX 5000 has broadspectrum efficacy. It is based on the 2- methylisothiazolone (MIT) chemistry and is efficacious against bacteria, mold and yeast. MIT functions by rapidly inhibiting critical enzymes of microorganisms. This causes a massive disruption of key metabolic processes, including growth, respiration, and energy generation.
Another non-formaldehyde biocide choice for MWF concentrates is Rocima BT 2S, a trademarked Rohm and Haas product. This is based on the BIT active and is especially good for bacterial control. BIT has excellent stability at high pH with amines and is thus very stable in MWF concentrates.
Efficacy versus key problem-causing microorganisms in MWF is also a critical feature for selecting a biocide. Studies using field samples, conducted at Biosan Laboratories Inc., ranked Kordek LX 5000 as most effective against mycobacteria (followed by Kathon 886 MW, another trademarked Rohm and Haas product) in the highest percentage of fluids tested (see Figure 2). Both provided at least a 90 to 99 percent kill in the majority of fluids tested. Triazine and oxazolidine biocides were significantly less effective in the range of fluids tested, and BIT showed no kill against mycobacteria in any fluid.
MWF concentrates also require addition of high-performing fungicides, to provide rapid kill of yeasts and mold and to prevent fungal slimes on surfaces, which otherwise may block filters and cause musty odors. One example is Kathon 886 MW, a broadspectrum fungicide based on octylisothiazolone, in a propylene glycol base. When stabilized in concentrates, it provides extremely long-lasting fungal control at very low dosage in the use-diluted fluids.
Like the other isothiazolones, Kathon 886 MW also inhibits key enzymes involved in microbial metabolism, resulting in rapid inhibition of growth followed by cell death. Additionally, due to its stability in diluted fluids, it provides weeks of fungal control from a single addition.
It is most effective in synthetic and semi-synthetic fluids. Efficacy studies in six MWF dilutions showed this formulation to have equal or better control of fungi – at lower product use rates – versus commercial fungicides in most of the fluid types 
Keeping the metalworking fluid in the best possible condition will ensure that the fluid does its job well and will help keep the workplace operating smoothly. A fluid in good condition can also reduce potential worker health risks.
One preventive measure is to establish a fluid management program to continuously maintain high fluid quality. The program should continuously remove metal chips and tramp oil, use good quality water, and – very importantly – keep microbial growth under control by making timely concentrate or biocide additions before problems develop. Periodic tankside treatment with biocides is typically required to provide an additional level of control over microbial growth in the end-use fluid.
Among the questions to ask when selecting a tankside additive is whether the biocide is fast acting against a broad spectrum of microorganisms. Does it contain or release formaldehyde? Is it capable of controlling mycobacteria? Is it effective for control of biofilm (slime) formation on metal surfaces within industrial processes? And if a system develops serious microbiological problems, what can be done to bring it back under control?
All of the biocide products mentioned previously for use in concentrates may also be added tankside, as a part of a total systems management for bacterial and fungal control. Some other biocides are used exclusively as tankside additives, due to their poor compatibility in concentrates.
The most widely used tankside biocide is Kathon 886 MW, due to its high efficacy – remember Figure 2 – and lowcost performance. This water-based formulation of chloro-methylisothiazolone (CMIT) and methylisothiazolone (MIT) is used across all fluid types for broadspectrum microbial control. It is compatible with most MWF additives, with the exception of sodium pyrithione and thiocyano-methyl-thiobenzothiazole biocides, mercaptobenzothiazole, and zinc dialkyldithiophosphate (ZDDP). It is most effective in end-use fluids with pH below 9.5.
Other tankside biocide products, such as Kathon 886 and Kathon CC, are used mostly for troubleshooting purposes when serious microbiological problems arise in the system. These are based on CMIT/MIT biocide, but also contain copper salts to provide added stability to the active ingredients and odor control in more aggressive fluids and adverse conditions.
KATHON 886 microbicides are high performance, broad spectrum, antimicrobial agents based on the proven isothiazolone chemistry of Dow. They are effective at very low concentrations in controlling both the planktonic and surface growth of bacteria, fungi and algae and have been produced specifically for water treatment and paper mill applications. Dow has developed an unrivalled package of regulatory approvals and environmental fate, toxicology, and performance data to support the use of KATHON 886 in water treatment applications. For some years, Dow has manufactured KATHON 886 at facilities approved according to the internationally recognised Quality Standard ISO 9002. This reflects the commitment of Dow to supply high quality products for its customers. This technical bulletin provides efficacy, toxicology and environmental fate data to allow the safe and effective use of KATHON 886.
Rapid inhibition of growth and macromolecular synthesis: KATHON 886 causes immediate inhibition of growth on coming in contact with a microorganism. The growth inhibition rapidly becomes irreversible and results in cell death. Even before death occurs, the KATHON 886 treated organism is unable to synthesize degradative enzymes or the exopolymers which facilitate adhesion and biofilm formation. • Broad spectrum activity: KATHON 886 controls the wide variety of algae, bacteria and fungi found in industrial water systems. 
Such a broad spectrum product reduces inventory and handling costs, lowers operator training expenses and lessens the risk of dosing error. • Effective at low concentrations: Effective control of such a wide variety of microorganisms at levels as low as 1 ppm active ingredient by KATHON 886, provides an unrivalled and cost-effective treatment. • Effective against biofilm: KATHON 886 readily penetrates the surface of adhering biofilm to give effective control of sessile microorganisms. • Biodegradable/non-persistent in the environment: When diluted below use concentrations, KATHON 886 are readily biodegradable. Their decomposition does not lead to the presence of chlorinated organics in the environment. • Effective over a wide pH range: KATHON 886 microbicide exhibits excellent performance over a broad pH range, even in alkaline water systems. • Water soluble: KATHON 886 is easily incorporated into formulations. • Compatibility: KATHON 886 is compatible with chlorine, corrosion and scale inhibitors and most anionic, cationic and non-ionic formulations at normal use levels. • Non-surface active: KATHON 886 is non-foaming. • Infrequent dosing: KATHON 886 remains active for long periods of time in the water system, resulting in low service costs. • Easily deactivated: Spills of the concentrated active components of KATHON 886 are readily deactivated to non-toxic substances by the addition of a slightly acidic solution of sodium metabisulphite or sodium bisulphite. • Low toxicity: Extensive toxicological testing has shown KATHON 886 microbicides to be of low toxicity at recommended use levels. Continued testing ensures that potential risks are well defined.
KATHON 886 is stable over the wide range of conditions found in cooling water and paper mill applications. Product as supplied: KATHON 886 microbicides are stable as supplied for at least a year at ambient temperatures and for 6 months at 50°C. We recommend, however, that KATHON 886 is stored at 25°C or below for a maximum period of 6 months. Generally, storage conditions appropriate for industrial chemicals should be employed, avoiding exposure to extremes of temperature. At use levels: The performance of biocides in industrial water systems is dependent on their stability. Several factors can influence the rate of degradation including water hardness, pH and temperature. The stability of KATHON 886 is actually enhanced in hard water conditions. At normal use levels in water treatment systems, KATHON 886 biocides are biologically and physically compatible with: • anionic, cationic and non-ionic surfactants • corrosion and scale inhibitors • chlorine (Table 1) • majority of standard paper mill additives. Figure 1 shows the excellent stability of KATHON 886 compared with competitive biocides at different levels of pH, temperature and total water hardness. This is dealt with in greater detail in the section on stability/ compatibility.
Biofilm. A considerable difference exists between the efficacy of a biocide against free-living or planktonic microorganisms and surface-attached or sessile microorganisms. Sessile microorganisms build up on process surfaces that are in continual contact with water, to form biofilms, which may vary from the more obvious slimy or filamentous layers, to discrete deposits barely visible to the naked eye. Biofilms consist of complex populations of sessile microorganisms (including bacteria, fungi, protozoa and algae) inorganic and organic debris bound together by an extracellular microbial adhesive1,2 (Fig. 2). The polysaccharide matrix protects microorganisms against rapid environmental changes, including the addition of many biocides and other water treatment chemicals, making them more difficult to kill than their freeliving counter-parts. Some biocides may also be deactivated by adsorption to organic and/or inorganic debris within the biofilm itself. Not only do surface-attached microorganisms outnumber planktonic populations by several orders of magnitude, but they are also the direct cause of most problems in industrial cooling water systems, air washers and paper mills. These include: Energy loss due to fouling • increased heat transfer resistance • filter blocking • decreasing fluid flow/increasing pressure drop in pipes Microbial-induced corrosion • of unprotected metal surfaces beneath the biofilm Decreased manufacturing efficiency • breakaway biofilm interferes in paper manufacture • increased stoppages for cleaning and maintenance of equipment Failure of other water treatment chemicals • biodegradation of additives such as corrosion inhibitors Potential health effects • biofilm may harbour pathogenic or potentially pathogenic organisms e.g. Legionella and Pseudomonas spp.
KATHON 886 is ideally suited to meet the requirements of an industrial water treatment biocide. KATHON 886 microbicide is not deactivated by suspended organic matter, and is compatible with other water treatment additives, including chlorine. With the recent change of many cooling towers and paper mills to alkaline operating conditions, it is important to use a biocide such as KATHON 886, which remains stable at higher pH values. KATHON 886 is of low toxicity at use levels, easily deactivated and biodegradable. In addition to all these essential properties, KATHON 886 is cost-effective.
IUPAC
-Methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one

5-Chloro-2-methyl-4-isothiazolin-3-one [EC no.247- 500-7] / 2-Methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one (3:1)

Mixture of 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE and 2-METHYL-4-ISOTHIAZOLIN-3-ONE

Reaction mass of 2-methyl-2H-isothiazol-3-one and 5-chloro-2-methyl-2H-isothiazol-3-one

reaction mass of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-2H -isothiazol-3-one

Reaction mass of 5-chloro-2-methylisothiazol-3(2H)-one and 2-methylisothiazol-3(2H)-one

reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H -isothiazol-3-one [EC no. 220-239-6] (3:1);

reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H -isothiazol-3-one [EC no.220-239-6] (3:1)

Reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC no. 220-239-6] (3:1)
2-Methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one

2-methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one (3:1)

2-methyl-1,2-thiazol-3(2H)-one - 5-chloro-2-methyl-1,2-thiazol-3(2H)-one (3:1)

2-methyl-2H -isothiazol-3-one
2-Methylisothiazol-3(2H)-one compound with 5-chloro-2-methylisothiazol-3(2H)-one (14% in H2O)

3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt.

3(2H)-ISOTHIAZOLONE, 5-CHLORO-2-METHYL-, MIXT. WITH 2-METHYL-3(2H)-ISOTHIAZOLONE

3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone

5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone 3(2H)-isothiazolone

5-chloro-2-methyl-1,2-thiazol-3-one

5-chloro-2-methyl-1,2-thiazol-3-one; 2-methyl-1,2-thiazol-3-one

5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one

5-Chloro-2-methyl-2,3- dihydroisothiazol-3-one and 2- Methyl-2,3-dihydroisothiazol-3- one (3:1)

5-Chloro-2-methyl-2,3-dihydroisothiazol-3-one and 2-Methyl-2,3-dihydroisothiazol-3-one

5-Chloro-2-methyl-2,3-dihydroisothiazol-3-one and 2-Methyl-2,3-dihydroisothiazol-3-one (3:1)

5-chloro-2-methyl-2H-isothiazol-3-one

5-CHLORO-2-METHYL-2H-ISOTHIAZOL-3-ONE / 2-METHYL-2H-ISOTHIAZOL-3-ONE (3:1)

5-chloro-2-methyl-2H-isothiazol-3-one, mixture with 2-methyl-2H-isothiazol-3-one (3:1)

5-Chloro-2-methyl-3(2H)-isothiazolone

5-Chloro-2-methyl-3(2H)-isothiazolone, mixt. with 2-methyl-3(2H)-isothiazolone

5-Chloro-2-methyl-3(2H)isothiazole mixt. with 2-Methyl-3(2H)isothiazolone

5-chloro-2-methyl-4-isothiazolin-3-one

5-CHLORO-2METHYL-3(2H)-ISOTHIAZOLONE

Gemisch aus 5-Chlor-2-methyl-2H-isothiazol-3-on [EG Nr. 247-500-7] und 2 -Methyl-2H-isothiazol-3-on [EG Nr. 220-239-6] (3:1)

Gemisch aus 5-Chlor-2-methyl-2H-isothiazol-3-on [EG Nr. 247-500-7] und 2 -Methyl-2H-isothiazol-3-on [EG Nr. 220-239-6] (3:1) EC 611-341-5

Gemisch aus: 5-Chlor-2-methyl-2H-isothiazol-3-one [EC: 247-500-7] und 2-Methyl-2H-isothiazol-3-on [EC: 220-239-6]

Isothiazolinongemisch

Kathon 886

La reacción en masa de 2-metil -2H- isothiazol -3-ona y el agua y el 5- cloro-2- metil- 2H- isothiazol -3-

METHYL-2H or METHYL-4 (3:1)

miscela di: 5-cloro-2-metil- 2H-isotiazol-3-one [EC no 247-500-7]; 2-metil-2Hisotiazol- 3-one [EC no 220- 239-6] (3:1)

Miscela di: 5-cloro-2-metil-2H-isotiazol-3-one [EC no. 247-500-7]; 2-metil-2H-isotiazol-3-one [EC no. 220-239-6] (3:1)

Miscela di: 5-cloro-2-metil-4-isotiazolin-3-one[EC no.247-500-7] and 2-metil-4-isotiazolin-3-one [EC no.220-239-6] (3:1)

Mixture of 2-methylisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one

Other Names:
55965-84-9
3(2H)-Isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone (3:1)

Mixture containing 5-chloro-2-methyl 2H-isothiazol -3-one and 2-methyl 2H-isothiazol 3-one

Mixture of 5-chloro-2-methyl-2H-isothiazol-3-one (EINECS 247-500-7) and 2-methyl-2H-isothiazol-3-one (EINECS 220-239-6)

mixture of: 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-2H-isothiazol-3-one