METHANE SULFONIC ACID (MSA 70%)

Methane Sulfonic Acid (MSA 70%) is an organic acid with the chemical formula CH3SO3H. 
Methane Sulfonic Acid (MSA 70%) is a colorless, viscous liquid that is soluble in water and polar organic solvents. 
Methane Sulfonic Acid (MSA 70%) is a strong acid, meaning that it readily donates protons (H+) to other molecules in solution. 

CAS:    75-75-2
MF:    CH4O3S
MW:    96.11
EINECS:    200-898-6

Synonyms
acidemethanesulfonique;Kyselina methansulfonova;kyselinamethansulfonova;Methylsulphonicacid;SULFOMETHANE;MSA;METHANE SULFONIC ACID 70%;METHANESULFONIC ACID 4.0 M WITH 0.2%*(W/ V) TRYPTAMI

Methane Sulfonic Acid (MSA 70%) is commonly used in organic synthesis and as a catalyst in various chemical reactions. 
Thanks to its versatility, Methane Sulfonic Acid (MSA 70%) is a viable substitute for organic and inorganic strong acids in a variety of applications. 
Methane Sulfonic Acid (MSA 70%) is a strong organic acid. 
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. 
Methane Sulfonic Acid (MSA 70%) undergoes biodegradation by forming CO2 and sulphate. 
Methane Sulfonic Acid (MSA 70%) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane Sulfonic Acid (MSA 70%)  has been considered a model electrolyte for electrochemical processes.
Methane Sulfonic Acid (MSA 70%)  is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl. 

Methane Sulfonic Acid (MSA 70%) has a role as an Escherichia coli metabolite. 
Methane Sulfonic Acid (MSA 70%) is an alkanesulfonic acid and a one-carbon compound. 
Methane Sulfonic Acid (MSA 70%) is a conjugate acid of a methanesulfonate.
Methane Sulfonic Acid (MSA 70%) is a strong organic acid. 
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. 
Methane Sulfonic Acid (MSA 70%) undergoes biodegradation by forming CO2 and sulphate. 
Methane Sulfonic Acid (MSA 70%) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methane Sulfonic Acid (MSA 70%) has been considered a model electrolyte for electrochemical processes.
An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.

Methane Sulfonic Acid (MSA 70%) Chemical Properties
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
Vapor density: 3.3 (vs air)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.429(lit.)
Fp: >230 °F
Storage temp.: 2-8°C
Solubility water: soluble1,000 g/L at 20°C
Pka: -2.6(at 25℃)
Form: Solution
Color: brown
Specific Gravity: 1.48 (18/4℃)
Biological source: synthetic
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
λmax: λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals. Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methane Sulfonic Acid (MSA 70%)(75-75-2)

Methane Sulfonic Acid (MSA 70%), the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures. 
Methane Sulfonic Acid (MSA 70%) has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa),  the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃). 
Methane Sulfonic Acid (MSA 70%) is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene. 
Methane Sulfonic Acid (MSA 70%) will not subject to decomposition in boiling water and hot alkaline solution. 
Methane Sulfonic Acid (MSA 70%) also has strong corrosion effect against the metal iron, copper and lead.
Methane Sulfonic Acid (MSA 70%) is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methane Sulfonic Acid (MSA 70%) is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations. 
Beyond that, Methane Sulfonic Acid (MSA 70%) is used as a starting material for the preparation of methanesulfonyl chloride.

Uses    
Methane Sulfonic Acid (MSA 70%) is a raw material for medicine and pesticide. 
Methane Sulfonic Acid (MSA 70%) can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methane Sulfonic Acid (MSA 70%) can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry. 
Methane Sulfonic Acid (MSA 70%) can also be applied to oxidation.
Methane Sulfonic Acid (MSA 70%) has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings. 
One of the major advantages of Methane Sulfonic Acid (MSA 70%) over sulfuric acid is that it is not an oxidizing species.
Methane Sulfonic Acid (MSA 70%) is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. 

Methane Sulfonic Acid (MSA 70%) is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. 
Methane Sulfonic Acid (MSA 70%) reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. 
Methane Sulfonic Acid (MSA 70%) finds application in batteries, because of its purity and chloride absence. 
In pharmaceutical industry, Methane Sulfonic Acid (MSA 70%) is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. 
Methane Sulfonic Acid (MSA 70%) is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methane Sulfonic Acid (MSA 70%) is involved in the deprotection of peptides.
For complete protein and peptide hydrolysis with tryptophan recovery. 
After hydrolysis the samples are diluted prior to amino acid analysis.

Strong Acidic Properties:
Methane Sulfonic Acid (MSA 70%) exhibits high acidity, allowing it to efficiently catalyze chemical reactions. 
Its potent acidic properties make Methane Sulfonic Acid (MSA 70%) a valuable catalyst in numerous industrial processes, promoting faster and more selective reactions.

Non-Volatile and Non-Oxidizing:
Unlike volatile acids, Methane Sulfonic Acid (MSA 70%) is non-volatile, ensuring safer handling and reduced risks of harmful vapors. 
Additionally, its non-oxidizing nature minimizes the risk of corrosion or degradation of materials, making it compatible with a wide range of substances.

Versatile Solvent:
Methane Sulfonic Acid (MSA 70%) possesses excellent solvency power, making it an effective solvent for both polar and non-polar compounds. 
Methane Sulfonic Acid (MSA 70%) can dissolve various organic and inorganic substances, facilitating processes such as extraction, purification, and synthesis in industries such as pharmaceuticals, electroplating, and organic chemistry.

Stability and Long Shelf Life:
Methane Sulfonic Acid (MSA 70%) is known for its exceptional stability. 
Methane Sulfonic Acid (MSA 70%) can be stored for extended periods without significant decomposition or loss of potency. 
This stability ensures a longer shelf life compared to many other corrosive acids, allowing for better inventory management and reduced wastage.

Environmentally Friendly:
In terms of environmental impact, Methane Sulfonic Acid (MSA 70%) stands out positively. 
Methane Sulfonic Acid (MSA 70%) is readily biodegradable*, meaning it can be broken down by natural processes over time. 
Methane Sulfonic Acid (MSA 70%) provides environmental advantages through easy recyclability and the generation of "green" effluent. 
Methane Sulfonic Acid (MSA 70%)'s recyclable nature allows for efficient reuse and waste reduction. 
Furthermore, Methane Sulfonic Acid (MSA 70%) is considered as a "green" effluent as it produces environmentally friendly effluent, minimizing harm to ecosystems.

Production method    
Methane Sulfonic Acid (MSA 70%) can be obtained through the nitrate oxidation of thiocyanate methyl. 
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃. 
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product. 
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered. 
The filtrate is condensed to until crystalline precipitation. 
The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate. 
Methane Sulfonic Acid (MSA 70%) is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.

Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product. 
Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction. 
The reaction solution was extracted with chloroform. 
After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure. 
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride. 
Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear. 
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain Methane Sulfonic Acid (MSA 70%).
Methane Sulfonic Acid (MSA 70%) is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.