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Microprilled Poloxamer 188 consists of spherical particles typically ranging from 50-500 μm in diameter, produced through prilling (spray congealing) technology.
This physical form offers significant advantages over conventional powders in terms of flowability, dissolution rate, and dust reduction.
The prilling process creates particles with smooth surfaces and narrow size distribution.
Systematic Nomenclature and Commercial Synonyms:
Chemical Description: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
Common Names: Poloxamer 188, Pluronic® F-68, Lutrol® F68, Kolliphor® P188
Microprilled Form: Poloxamer 188 spherical particles, Poloxamer 188 microprills
CAS Registry Number: 9003-11-6 (for poloxamer series)
Specific CAS: 106392-12-5 (for Poloxamer 188)
EC Number: 618-402-6
UNII: LGW7FRK43H
Molecular Architecture:
General Formula: HO(C₂H₄O)ₐ(C₃H₆O)ₐ(C₂H₄O)ₐH
Typical Composition: a = ~80, b = ~27 (for Poloxamer 188)
Molecular Weight: 8400-9000 Da (nominal 8350 Da)
HLB Value: 29 (very hydrophilic)
EO Content: ~80% by weight
Systematic Nomenclature and Commercial Synonyms:
Chemical Description: Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
Common Names: Poloxamer 188, Pluronic® F-68, Lutrol® F68, Kolliphor® P188
Microprilled Form: Poloxamer 188 spherical particles, Poloxamer 188 microprills
CAS Registry Number: 9003-11-6 (for poloxamer series)
Specific CAS: 106392-12-5 (for Poloxamer 188)
EC Number: 618-402-6
UNII: LGW7FRK43H
Molecular Architecture:
General Formula: HO(C₂H₄O)ₐ(C₃H₆O)ₐ(C₂H₄O)ₐH
Typical Composition: a = ~80, b = ~27 (for Poloxamer 188)
Molecular Weight: 8400-9000 Da (nominal 8350 Da)
HLB Value: 29 (very hydrophilic)
EO Content: ~80% by weight
Appearance: White to off-white spherical particles
Particle Size Distribution: D₅₀: 150-250 μm, D₉₀: <400 μm
Bulk Density: 0.4-0.6 g/cm³
Tapped Density: 0.5-0.7 g/cm³
Flowability: Excellent (Carr Index <15, Hausner Ratio <1.2)
Melting Point: 52-57°C (solid to viscous liquid transition)
Moisture Content: ≤1.0% (Karl Fischer)
pH (1% solution): 6.0-7.5
Surface Area: 0.5-2.0 m²/g (BET)
Solubility (Poloxamer 188):
Water: >100 g/L (cold water soluble)
Ethanol: 50 g/L
Propylene glycol: 100 g/L
Insoluble in hydrocarbons, fats, oils
Chemical Behavior and Functional Properties:
Surface Activity and Micelle Formation:
Critical Micelle Concentration (CMC): 4-6% w/v in water at 25°C
Micelle Size: 10-20 nm diameter (dynamic light scattering)
Cloud Point: >100°C (1% solution in water)
Surface Tension Reduction: To ~40 mN/m at CMC
Biological and Pharmaceutical Properties:
Cryoprotectant: Protects cells during freezing (0.5-1.0% in cell culture media)
Anti-adhesive: Prevents cell attachment to surfaces
Hemocompatibility: Does not cause hemolysis at physiological concentrations
Red blood cell protection: Stabilizes RBC membranes
Emulsification: Excellent O/W emulsifier
Microprilling Advantages:
Enhanced dissolution: Increased surface area accelerates dissolution
Improved flowability: Spherical shape improves handling and processing
Dust reduction: Minimizes airborne particles in manufacturing
Uniform dispersion: Better blend uniformity in solid formulations
Reduced segregation: Minimizes demixing in powder blends
Industrial Applications:
Pharmaceutical Formulations:*
Injectable formulations: Stabilizer for protein drugs, cryoprotectant (typical: 0.01-0.1%)
Solid dispersions: Carrier for poorly soluble drugs (hot melt extrusion, spray drying)
Tablet coatings: Film former and pore former
Ophthalmic preparations: Viscosity modifier and stabilizer
Biotechnology and Cell Culture:*
Cell culture additive: Reduces shear damage in bioreactors (0.05-0.2%)
Stem cell culture: Prevents differentiation by reducing cell-surface interactions
Protein stabilization: Prevents surface-induced denaturation
Medical Device Coatings:*
Anti-fouling coatings: Prevents protein and cell adhesion
Lubricious coatings: For catheters and guidewires
Blood-contacting devices: Improves hemocompatibility
Analytical Characterization:
Physical Characterization:
Particle Size Analysis: Laser diffraction (dry or wet dispersion)
Morphology: SEM imaging for sphericity and surface characteristics
Thermal Analysis: DSC for melting behavior (Tₘ ~55°C, ΔH ~100 J/g)
X-ray Diffraction: Amorphous or semi-crystalline structure
Chemical Analysis:
Size Exclusion Chromatography: For molecular weight distribution (Mw/Mn <1.1)
NMR Spectroscopy: For EO/PO ratio determination
Titration: For hydroxyl value (theoretical ~13 mg KOH/g for Poloxamer 188)
Regulatory Status:
FDA Status: Included in FDA Inactive Ingredients Guide for various routes
USP/NF: Poloxamer 188 monograph
Ph.Eur.: Poloxamer 188 monograph (07/2017:1446)
JP: Japanese Pharmacopoeia
Biocompatibility: ISO 10993 tested, suitable for medical devices
SAFETY INFORMATION ABOUT MICROPRILLED POLOXAMER 188
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
