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MSA 70% (Methane Sulfonic Acid) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Msa 70% (Methane Sulfonic Acid) in large quantities.
MSA 70% (Methane Sulfonic Acid) undergoes biodegradation by forming CO2 and sulphate.
CAS: 75-75-2
MF: CH4O3S
MW: 96.11
EINECS: 200-898-6
Synonyms
acidemethanesulfonique;Kyselina methansulfonova;kyselinamethansulfonova;Methylsulphonicacid;SULFOMETHANE;MSA;METHANE SULFONIC ACID 70%;METHANESULFONIC ACID 4.0 M WITH 0.2%*(W/ V) TRYPTAMI
MSA 70% (Methane Sulfonic Acid) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Msa 70% (Methane Sulfonic Acid) solution has been considered a model electrolyte for electrochemical processes.
MSA 70% (Methane Sulfonic Acid) is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
MSA 70% (Methane Sulfonic Acid) has a role as an Escherichia coli metabolite.
MSA 70% (Methane Sulfonic Acid) is an alkanesulfonic acid and a one-carbon compound.
MSA 70% (Methane Sulfonic Acid) is a conjugate acid of a methanesulfonate.
An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
MSA 70% (Methane Sulfonic Acid) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA 70% (Methane Sulfonic Acid) in large quantities.
MSA 70% (Methane Sulfonic Acid) undergoes biodegradation by forming CO2 and sulphate.
MSA 70% (Methane Sulfonic Acid) is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous MSA 70% (Methane Sulfonic Acid) solution has been considered a model electrolyte for electrochemical processes.
MSA 70% (Methane Sulfonic Acid) is an organic acid with the chemical formula CH3SO3H.
MSA 70% (Methane Sulfonic Acid) is a colorless, viscous liquid that is soluble in water and polar organic solvents.
MSA 70% (Methane Sulfonic Acid) is a strong acid, meaning that it readily donates protons (H+) to other molecules in solution.
MSA 70% (Methane Sulfonic Acid) is commonly used in organic synthesis and as a catalyst in various chemical reactions.
Thanks to its versatility, MSA 70% (Methane Sulfonic Acid) is a viable substitute for organic and inorganic strong acids in a variety of applications.
MSA 70% (Methane Sulfonic Acid) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH.
MSA 70% (Methane Sulfonic Acid) is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of MSA 70% (Methane Sulfonic Acid) are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).
MSA 70% (Methane Sulfonic Acid) is hygroscopic in its concentrated form. Methanesulfonic acid can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).
MSA 70% (Methane Sulfonic Acid), also known as methanesulfonic acid or mesylic acid.
MSA 70% (Methane Sulfonic Acid) is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry.
MSA 70% (Methane Sulfonic Acid) is also a key ingredient in plating various metals to print circuit board manufacture in electric industry.
Besides, MSA 70% (Methane Sulfonic Acid) is popularly used in textile treatment, and the production of plastics and polymers.
MSA 70% (Methane Sulfonic Acid) Chemical Properties
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
Vapor density: 3.3 (vs air)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.429(lit.)
Fp: >230 °F
Storage temp.: 2-8°C
Solubility water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
Form: Solution
Color: brown
Specific Gravity: 1.48 (18/4℃)
Biological source: synthetic
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals.
Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methanesulfonic acid (75-75-2)
MSA 70% (Methane Sulfonic Acid), the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
MSA 70% (Methane Sulfonic Acid) has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
MSA 70% (Methane Sulfonic Acid) is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.
MSA 70% (Methane Sulfonic Acid) will not subject to decomposition in boiling water and hot alkaline solution.
MSA 70% (Methane Sulfonic Acid) also has strong corrosion effect against the metal iron, copper and lead.
MSA 70% (Methane Sulfonic Acid) is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methanesulfonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, MSA 70% (Methane Sulfonic Acid) is used as a starting material for the preparation of methanesulfonyl chloride.
History and synthesis
Early history
German chemist Hermann Kolbe discovered MSA 70% (Methane Sulfonic Acid) between 1842 and 1845 and originally termed it methyl hyposulphuric acid.
The discovery stemmed from earlier work by Berzelius and Marcet in 1813, who treated carbon disulfide with moist chlorine and produced a compound they named "sulphite of chloride of carbon".
By reacting it with barium hydroxide Kolbe demonstrated it to actually be trichloromethylsulfonyl chloride (CCl₃SO₂Cl in modern notation).
2 CCl3SO2Cl + 3 Ba(OH)2 → Ba(CCl3SO3)2 + 3 BaCl2 + 2 H2O
From resulting barium trichloromethylsulfonate Kolbe isolated the free acid, which he was then able to sequentially dechlorinate by electrolytically generated atomic hydrogen to ultimately yield MSA 70% (Methane Sulfonic Acid).
CCl3SO3H + 3 H → CHCl2SO3H + 2 H + HCl → … → CH3SO3H + 3 HCl
Kolbe's research on methanesulfonic and chloroacetic acids was hailed by Berzelius as strong evidence for his theory of copulated compounds, a modification of radical theory to accommodate substitution reactions which posited the combination of organic and inorganic moieties without significantly altering the properties of the latter.
Later in the 19th century, the name transitioned to methyl sulphonic acid.
Other historical laboratory synthesis routes included oxidizing methanethiol, dimethyl disulfide or methyl thiocyanate with nitric acid.
Uses
MSA 70% (Methane Sulfonic Acid) is a raw material for medicine and pesticide.
MSA 70% (Methane Sulfonic Acid) can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
MSA 70% (Methane Sulfonic Acid) can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.
MSA 70% (Methane Sulfonic Acid) can also be applied to oxidation.
Solutions of MSA 70% (Methane Sulfonic Acid) are used for the electroplating of tin and tin-lead solders.
MSA 70% (Methane Sulfonic Acid) is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.
MSA 70% (Methane Sulfonic Acid) is also a primary ingredient in rust and scale removers.
MSA 70% (Methane Sulfonic Acid) is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.
Polymerization catalyst.
MSA 70% (Methane Sulfonic Acid) has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings.
One of the major advantages of MSA 70% (Methane Sulfonic Acid) over sulfuric acid is that it is not an oxidizing species.
MSA 70% (Methane Sulfonic Acid) is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.
MSA 70% (Methane Sulfonic Acid) is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.
MSA 70% (Methane Sulfonic Acid) reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.
MSA 70% (Methane Sulfonic Acid) finds application in batteries, because of its purity and chloride absence.
In pharmaceutical industry, MSA 70% (Methane Sulfonic Acid) is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
MSA 70% (Methane Sulfonic Acid) is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
MSA 70% (Methane Sulfonic Acid) is involved in the deprotection of peptides.
For complete protein and peptide hydrolysis with tryptophan recovery.
After hydrolysis the samples are diluted prior to amino acid analysis.
Production Method
MSA 70% (Methane Sulfonic Acid) can be obtained through the nitrate oxidation of thiocyanate methyl.
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃.
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product.
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered.
The filtrate is condensed to until crystalline precipitation.
The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate.
MSA 70% (Methane Sulfonic Acid) is then added to the exchanged water to boiling, add sulfuric acid for decomposition while MSA 70% (Methane Sulfonic Acid) is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product.
Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction.
The reaction solution was extracted with chloroform.
After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure.
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride.
Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear.
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.
MSA 70% (Methane Sulfonic Acid) is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.
Purification Methods
Dry the acid, either by azeotropic removal of water with benzene or toluene, or by stirring 20g of P2O5 with 500mL of the acid at 100o for 0.5hours.
Then distil MSA 70% (Methane Sulfonic Acid) under vacuum and fractionally crystallise it by partial freezing.
Sulfuric acid, if present, can be removed by prior addition of Ba(OH)2 to a dilute solution, filtering off the BaSO4 and concentrating under reduced pressure; and is sufficiently pure for most applications.
