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MSA Methanesulfonic Acid is used to prepare polyaniline (PANI)/graphene composites with enhanced thermal and electrical properties.
MSA Methanesulfonic Acid is used as a catalyst for the transformation of glucose/xylose mixtures to levulinic acid and furfural.
MSA Methanesulfonic Acid is used Agricultural Chemicals, Crop Protection, Curing Agent, Electronic Chemicals, Flavor & Fragrance, Household.
CAS Number: 75-75-2
EC Number: 200-898-6
MDL Number: MFCD00007518
Molecular Formula: CH₃SO₃H
Molecular Weight :96.11 g/mol
SYNONYMS:
methanesulfonic acid mesylates kyselina methansulfonova iron (3+)salt methanesulfonic acid methanesulfonic acid, silver (1+) salt, methanesulfonic acid, iron (3+)salt nickel (2+) salt methanesulfonic acid silver (1+) salt methanesulfonic acid MSA sodium salt methanesulfonic acid, methylsulfonic acid, methanesulphonic acid, methanesulfonicacid, kyselina methansulfonova, methansulfonsaeure, ccris 2783, kyselina methansulfonova czech, ch3so3h, methane sulfonic acid, sulfomethane, Methanesulfonic Acid, Lutropur MSA, Lutropure MAS, MCAT 1201, Mesylic acid, Methylsulfonic acid, NSC 3718, Scaleva, methanesulfonic acid, Methylsulfonic acid, MSA, Sulfomethane, Methanesulfonic Acid, Methanesulphonic Acid, Methylsulfonic Acid, Mesylic Acid, Sulfomethane, MsOH, MeSO₃H, Methansulfonsäure, Kyselina methansulfonova, Methylsulphonic Acid, Methane Sulfonic Acid 70%, Mesic Acid, methanesulfonic acid, Methylsulfonic acid, MSA, Sulfomethane, Mesic acid, Methylsulfonic acid, Methylsulfonic acid, Mesylic acid, MSA, Methanesulfonic acid, Methylsulfonic acid, MSA, Mesylic acid, METHANESULFONIC ACID, 75-75-2, Methylsulfonic acid, Methanesulphonic acid, Kyselina methansulfonova, DTXSID4026422, CHEBI:27376, NSC-3718, 12EH9M7279, DTXCID806422, NSC3718, J1.465F, RefChem:6013, 200-898-6, Mesylate, Mesylic acid, MFCD00007518, Sulfomethane, Methansulfonsaeure, CH4O3S, NSC 3718, METHANE SULFONIC ACID, MsOH, 22515-76-0, MSA, Methanesulfonicacid, ammoniummethanesulfonate, CCRIS 2783, Kyselina methansulfonova [Czech], HSDB 5004, EINECS 200-898-6, BRN 1446024, Alkanesulfonate, AI3-28532, UNII-12EH9M7279, metanesulfonic acid, methansulfonic acid, Aliphatic sulfonate, methansulphonic acid, methylsulphonic acid, 03S, methyl sulfonic acid, methyl-sulfonic acid, methane-sulfonic acid, MeSO3H, methane sulphonic acid, methanesulphonic-acid-, Methanesulfonic acidMSA, Nilotinib Impurity 30, LACTIC ACID(DL), CH3SO2OH, H3CSO3H, SCHEMBL105, WLN: WSQ1, EC 200-898-6, SCHEMBL1022, Methanesulfonic acid solution, 4-04-00-00010 (Beilstein Handbook Reference), SCHEMBL124735, SCHEMBL128169, SCHEMBL148135, Methanesulfonic acid, 99.5%, Methanesulfonic acid, anhydrous, SCHEMBL4432863, SCHEMBL8802624, CHEMBL3039600, SCHEMBL30161224, Methanesulfonic Acid (CH3SO3H), METHANESULFONIC ACID [II], METHANESULFONIC ACID [MI], Methanesulfonic acid, HPLC grade, Methanesulfonic acid, >=99.0%, METHANESULFONIC ACID [HSDB], Tox21_201073, STL264182, AKOS009146947, AT25153, CAS-75-75-2, NCGC00248914-01, NCGC00258626-01, BP-12823, FA164682, FM158427, DB-075013, M0093, M2059, Methanesulfonic acid - 70% aqueous solution, NS00004472, EN300-29198, Methanesulfonic acid, >=99.0%, ReagentPlus(R), Methanesulfonic acid, for HPLC, >=99.5% (T), A934985, F152800, Q414168, Methanesulfonic Acid(Discontinued,See C4X-125630), Methanesulfonic acid, Vetec(TM) reagent grade, 98%, F1908-0093, Z281776238, InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4, Methanesulfonic acid, Methanesulphonic acid, Mesylate, Methylsulfonate, Methane sulfonic acid, MSA
MSA Methanesulfonic Acid is a colorless liquid with the chemical formula CH3SO3H.
MSA Methanesulfonic Acid is the simplest of the alkylsulfonic acids.
Salts and esters of methanesulfonic acid are known as mesylates.
MSA Methanesulfonic Acid is hygroscopic in its concentrated form.
MSA Methanesulfonic Acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA Methanesulfonic Acid in large quantities.
MSA Methanesulfonic Acid undergoes biodegradation by forming CO2 and sulphate.
MSA Methanesulfonic Acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous MSA Methanesulfonic Acid solution has been considered a model electrolyte for electrochemical processes.
MSA Methanesulfonic Acid, also known as methanesulfonic acid or mesylic acid.
MSA Methanesulfonic Acid, the simplest alkanesulfonic acid, is a hygroscopic colorless liquid that freezes around 19 °C.
MSA Methanesulfonic Acid has similar proprieties respect sulfuric acid, but it does not show its oxidant character.
MSA Methanesulfonic Acid’s non-volatility and solubility properties make it industrially valuable as a catalyst in organic reactions, mainly for polymerizations, esterifications and transesterificatios, for electroplating bath and as reagent to form amine salts for pharmaceutical drug delivery purposes.
Another feature that makes MSA Methanesulfonic Acid convenient for industrial applications is its liquid state at room temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid.
MSA Methanesulfonic Acid, also known as methylsulfonic acid, is a strong organic acid with the chemical formula CH3SO3H.
MSA Methanesulfonic Acid is a colorless liquid with a mild sulfurous odor.
MSA Methanesulfonic Acid is a strong organic acid which is highly suitable for manufacturing active pharmaceutical ingredients such as Telmisartan and Eprosartan, Angiotensin II receptor antagonists.
MSA Methanesulfonic Acid is a strong caustic acid and the simplest form of the alkylsulfonic acids.
MSA Methanesulfonic Acid is a hygroscopic colourless liquid with the chemical formula CH3SO3H.
MSA Methanesulfonic Acid is highly soluble in water and oxygenated solvents, but mildly soluble in most hydrocarbons and insoluble in alkanes, benzene, and toluene.
In aqueous solution, MSA Methanesulfonic Acid is a strong acid (completely ionized).
MSA Methanesulfonic Acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
MSA Methanesulfonic Acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA Methanesulfonic Acid in large quantities.
MSA Methanesulfonic Acid undergoes biodegradation by forming CO2 and sulphate.
It is considered a green acid as MSA Methanesulfonic Acid is less toxic and corrosive in comparison to mineral acids.
The aqueous MSA Methanesulfonic Acid solution has been considered a model electrolyte for electrochemical processes.
MSA Methanesulfonic Acid’s acidity and solubility properties make it industrially valuable as a catalyst in organic reactions, particularly polymerization.
In many applications, its advantage over concentrated sulfuric acid is that MSA Methanesulfonic Acid has similar acid strength but is not an oxidant.
The first report of MSA Methanesulfonic Acid synthesis was in a 1950 patent awarded to John C. Snyder and Aristid V. Grosse of Houdry Process Corp. (subsequently acquired by Air Products).
They heated methane and sulfur trioxide to 200–325 ºC under pressure in the presence of a mercury catalyst.
BASF currently produces the acid via a two-step process in which methanol and elemental sulfur react to give dimethyl disulfide, which is then oxidized to the final product.
For decades, chemists tried to find a way to prepare MSA Methanesulfonic Acid from methane and sulfur trioxide under much milder conditions than were used in the original method.
MSA Methanesulfonic Acid (CH3SO3H, MSA) is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA Methanesulfonic Acid in large quantities.
MSA Methanesulfonic Acid undergoes biodegradation by forming CO2 and sulphate.
MSA Methanesulfonic Acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous MSA Methanesulfonic Acid solution has been considered a model electrolyte for electrochemical processes.
MSA Methanesulfonic Acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
MSA Methanesulfonic Acid has a role as an Escherichia coli metabolite.
MSA Methanesulfonic Acid is an alkanesulfonic acid and a one-carbon compound.
MSA Methanesulfonic Acid is a conjugate acid of a methanesulfonate.
MSA Methanesulfonic Acid is the simplest alkyl sulfonic acid: an organosulfur compound where a methyl group is directly bonded to the sulfonic acid functionality.
MSA Methanesulfonic Acid is a strong organic acid that has been increasingly used as a “greener” alternative to some mineral acids in certain applications thanks to its favorable properties (e.g., low volatility, non-oxidizing).
MSA Methanesulfonic Acid appears as a colourless (or slightly yellow) liquid under normal conditions and is miscible with water.
MSA Methanesulfonic Acid (MsOH, MSA) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH.
MSA Methanesulfonic Acid is the simplest of the alkylsulfonic acids (R−S(=O)2−OH).
Salts and esters of MSA Methanesulfonic Acid are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate).
MSA Methanesulfonic Acid is hygroscopic in its concentrated form.
MSA Methanesulfonic Acid can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).
USES and APPLICATIONS of MSA METHANESULFONIC ACID:
Methanesulfonic acid may be used as a catalyst to produce linear alkylbenzenes by the addition reaction between long-chain olefins and benzene.
MSA Methanesulfonic Acid is used to prepare polyaniline (PANI)/graphene composites with enhanced thermal and electrical properties.
MSA Methanesulfonic Acid is used as a catalyst for the transformation of glucose/xylose mixtures to levulinic acid and furfural.
MSA Methanesulfonic Acid is used Agricultural Chemicals, Crop Protection, Curing Agent, Electronic Chemicals, Flavor & Fragrance, Household, Industrial & Institutional Chemicals, Industrial Chemicals, Inks & Digital Inks, Lithium Battery & Electrolyte Chemicals, Lubricant & Grease, Metal Plating, Metal Working, Finishing & Flux, Personal Care & Cosmetics, Pharmaceutical & Fine Chemicals, Plastic, Resin & Rubber, Textile Auxiliaries, Catalysts, Coatings, Pesticides, Solvents.
Organic Synthesis: MSA Methanesulfonic Acid is widely used as a catalyst and solvent in various organic synthesis reactions, including esterification, acylation, and alkylation.
Electroplating: MSA Methanesulfonic Acid is utilized as an electrolyte additive in electroplating baths for metal deposition.
Chemical Reagent: MSA Methanesulfonic Acid serves as a versatile chemical reagent in the pharmaceutical, agrochemical, and polymer industries.
Cleaning Agent: MSA Methanesulfonic Acid is employed as a cleaning and descaling agent in industrial processes and for equipment maintenance.
MSA Methanesulfonic Acid is widely used as an acid catalyst and solvent in organic reactions in biological and agricultural industry.
MSA Methanesulfonic Acid is also a key ingredient in plating various metals to print circuit board manufacture in electric industry.
Besides, MSA Methanesulfonic Acid is popularly used in textile treatment, and the production of plastics and polymers.
Key applications of MSA Methanesulfonic Acid: Plastics and polymers, Fabric, textile and leather products, Corrosion inhibitor and anti-scaling agent, Metal finishing, Agricultural, Catalysts, Solvents, Pharmaceuticals, Batteries, Building & Construction products, Electronics,
Industries, Polymers, Energy Services, Cleaning, CASE & Construction, Beauty & Personal Care.
Catalysis use of MSA Methanesulfonic Acid: Acid catalyst in esterification, alkylation, and dehydration reactions
Electroplating: MSA Methanesulfonic Acid is used as a conductive, stable acid in metal finishing baths
Chemical Synthesis: MSA Methanesulfonic Acid is employed as a reagent or acid medium in specialty chemical production
Cleaning Formulations: MSA Methanesulfonic Acid is found in descaling and metal surface treatment chemicals (industrial-grade)
MSA Methanesulfonic Acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents.
MSA Methanesulfonic Acid is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters.
MSA Methanesulfonic Acid reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex.
MSA Methanesulfonic Acid finds application in batteries, because of its purity and chloride absence.
In pharmaceutical industry, MSA Methanesulfonic Acid is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan.
MSA Methanesulfonic Acid is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
MSA Methanesulfonic Acid is involved in the deprotection of peptides.
MSA Methanesulfonic Acid is used for complete protein and peptide hydrolysis with tryptophan recovery.
MSA Methanesulfonic Acid is used after hydrolysis, and the samples are diluted prior to amino acid analysis.
MSA Methanesulfonic Acid has a wide range of industrial applications due to its strong acid properties, high solubility in water, and chemical stability.
MSA Methanesulfonic Acid is used a raw material for medicine and pesticide.
MSA Methanesulfonic Acid can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
MSA Methanesulfonic Acid can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.
MSA Methanesulfonic Acid can also be applied to oxidation.
Since ca. 2000, MSA Methanesulfonic Acid has become a popular replacement for other acids in numerous industrial and laboratory applications, because it is a strong acid.
MSA Methanesulfonic Acid has a low vapor pressure (see boiling points in the "Properties" inset).
MSA Methanesulfonic Acid is not an oxidant or explosive, like nitric, sulfuric or perchloric acids.
MSA Methanesulfonic Acid is a liquid at room temperature.
MSA Methanesulfonic Acid is soluble in many organic solvents.
MSA Methanesulfonic Acid forms water-soluble salts with all inorganic cations and with most organic cations.
MSA Methanesulfonic Acid does not form complexes with metal ions in water.
It's anion, mesylate, MSA Methanesulfonic Acid is non-toxic and suitable for pharmaceutical preparations.
The closely related p-toluenesulfonic acid (PTSA) is solid.
MSA Methanesulfonic Acid can be used in the generation of borane (BH3) by reacting MSA Methanesulfonic Acid with NaBH4 in an aprotic solvent such as THF or DMSO, the complex of BH3 and the solvent is formed.
Solutions of MSA Methanesulfonic Acid are used for the electroplating of tin and tin-lead solders.
MSA Methanesulfonic Acid is displacing the use of fluoroboric acid, which releases corrosive and volatile hydrogen fluoride.
MSA Methanesulfonic Acid is also a primary ingredient in rust and scale removers.
MSA Methanesulfonic Acid is used to clean off surface rust from ceramic, tiles and porcelain which are usually susceptible to acid attack.
MSA Methanesulfonic Acid is used catalyst for esterification, alkylation, polymerisation reactions.
MSA Methanesulfonic Acid is used electroplating industry (e.g., tin, nickel plating) as part of electrolyte formulations because of its solvency and stability.
MSA Methanesulfonic Acid is used production of salts/mesylates (e.g., pharmaceuticals) since the mesylate anion is widely used in drug formulations.
MSA Methanesulfonic Acid is used surface cleaning, rust/scale removal (industrial cleaning) because of its strong acidity and favorable properties.
In coatings/resins: MSA Methanesulfonic Acid is used as a curing/accelerating agent or catalyst (due to acidity, non-oxidising nature) in place of sulfuric acid.
MSA Methanesulfonic Acid is used as an acid electrolyte in some newer battery / electrochemical processes because of its solubility, strength and stability.
-Electroplating uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid is used as an electrolyte in electroplating processes, such as nickel plating, copper plating, and tin plating.
MSA Methanesulfonic Acid acts as a buffer to maintain the pH of the electrolyte solution and helps to ensure a uniform coating on the metal substrate.
-Industrial Cleaning (Equipment & Hard Surface Cleaning) uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid is widely employed in industrial cleaning applications due to its effective and versatile properties.
MSA Methanesulfonic Acid acts as a strong acid cleaner, capable of removing various types of contaminants and residues from surfaces and equipment, maintaining the formed salts in solution throughout the cleaning process thanks to their high solubility.
MSA Methanesulfonic Acid's reactivity and properties make it suitable, efficient, and more sustainable agent for removing mineral deposits, rust, scale, and organic substances.
-Oilfield (Well stimulation) uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid is utilized in the oilfield industry for acidizing treatments, enhancing production by dissolving mineral deposits and improving reservoir permeability.
MSA Methanesulfonic Acid acts as a catalyst, aiding in the breakdown of complex hydrocarbons and increasing oil recovery efficiency.
MSA Methanesulfonic Acid offers benefits of reduced corrosion and biodegradability, minimizing equipment corrosion and extending lifespan on one side and reducing maintenance costs on the other.
Additionally, MSA Methanesulfonic Acid's biodegradable properties contribute to environmentally friendly oilfield practices.
-Chemical Industry (Esterification) uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid is a vital catalyst in the chemical industry, particularly for esterification processes.
MSA Methanesulfonic Acid's strong acidic properties enable efficient and selective ester formation from carboxylic acids and alcohols.
MSA Methanesulfonic Acid's versatility and compatibility with different substrates make it an essential component in the synthesis of pharmaceuticals, fragrances, flavors, and specialty chemicals.
Higher selectivity is obtained with MSA Methanesulfonic Acid than with other strong acids such as nitric or sulfuric acids thanks to its non-oxidizing property, preventing by product formation and product coloration.
-Biodiesel (Esterification Catalyst) uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid's application in biodiesel value chain involves key stages from esterification catalyst to lower free fatty acid content before transesterification to neutralization to improve quality of glycerol and ester.
MSA Methanesulfonic Acid-LC in biodiesell production offers dual benefits of reducing corrosion and utilizing cost-effective feedstocks.
As a catalyst, MSA Methanesulfonic Acid-LC minimizes stainless steel equipment corrosion while enabling efficient conversion processes.
MSA Methanesulfonic Acid also allows for the use of cheaper feedstocks like agricultural residues, used cooking oil, wastes cooking oils, enhancing the economic viability of biodiesel production.
MSA Methanesulfonic Acid plays a vital role in making biofuels more sustainable and economically feasible.
-Pharmaceuticals (API synthesis, drug formulation, etc.) use of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid plays a significant role in various pharmaceutical applications, ranging from active pharmaceutical ingredient (API) synthesis to drug formulation.
As a catalyst, MSA Methanesulfonic Acid facilitates key reactions in API synthesis, such as esterification, acylation, and sulfonation.
MSA Methanesulfonic Acid's effectiveness in promoting these reactions allows for the efficient production of pharmaceutical intermediates and final APIs.
MSA Methanesulfonic Acid is also utilized in drug formulation processes, where it aids in solubilizing and stabilizing active compounds.
MSA Methanesulfonic Acid's compatibility with a wide range of solvents and its mild nature contribute to the development of safe and effective pharmaceutical formulations.
-Polymerization catalyst uses of MSA Methanesulfonic Acid:
MSA Methanesulfonic Acid has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings.
One of the major advantages of MSA Methanesulfonic Acid over sulfuric acid is that it is not an oxidizing species.
WHAT ARE THE POTENTIAL FOR FUTURE RESEARCH AND DEVELOPMENT IN MSA METHANESULFONIC ACID APPLICATIONS?
There is potential for future research and development in the applications of MSA Methanesulfonic Acid due to its unique properties and versatility in various industries.
In the pharmaceutical industry, MSA Methanesulfonic Acid has shown promise as a catalyst for organic reactions and as a solvent for drug formulation.
Further research could explore the potential of MSA Methanesulfonic Acid in the development of new drugs and therapeutic agents.
In the field of catalysis, MSA Methanesulfonic Acid has been shown to be an effective acid catalyst in a range of organic reactions.
Future research could focus on optimizing the use of MSA Methanesulfonic Acid in various catalytic reactions and developing new methods potential recycling.
Its environmentally friendly profile makes it MSA Methanesulfonic Acid of choice for the development of new processes in a variety of domains ranging from oil& gas to mining and metal treatment / recycling.
Additionally, MSA Methanesulfonic Acid has potential in the development of new materials such as polymers and composites due to its ability to modify the properties of organic compounds.
Research in this area could lead to the development of new materials with unique properties and applications.
Finally, there is potential for research in the environmental impact of MSA Methanesulfonic Acid and the development of more sustainable methods for its production and use.
This could include exploring alternatives to traditional methods of MSA Methanesulfonic Acid production, such as biocatalytic processes or green chemistry approaches.
BENEFITS / CHARACTERISTICS (WHY CHOOSE MSA) of MSA METHANESULFONIC ACID:
Strong acid with manageable handling properties (liquid at ambient, low volatility) which may reduce fume hazards relative to, say, concentrated mineral acids.
*Non-oxidising:
unlike nitric acid, perchloric acid, or sometimes sulfuric under certain conditions — this means fewer side reactions/oxidative hazards in some processes.
Good solubility in water and many polar organic solvents, making it versatile in chemical synthesis.
Forms stable salts (“mesylates”) that are widely used and known in pharmaceutical/chemical contexts.
The environmental/biodegradation profile is favourable: e.g., MSA undergoes biodegradation to CO₂ + sulfate in some contexts.
WHAT ARE THE ADVANTAGES OF MSA METHANESULFONIC ACID?
*Strong, odor-free organic acid
*Non-oxidizing
*Virtually free of metal ions and sulfate
*Easy to handle in liquid form
*Strong acid prevents the formation of oxidation products.
*MSA Methanesulfonic Acid reactions at higher temperatures possible
*The excellent solubility in water enables easy phase separations.
*MSA Methanesulfonic Acid decomposes to form sulfate, carbon dioxide, water and biomass
CHEMICAL STRUCTURE OF MSA METHANESULFONIC ACID:
The chemical structure of MSA Methanesulfonic Acid consists of a central carbon atom (C) bonded to three hydrogen atoms (H).
One of the hydrogen atoms is also bonded to a sulfur atom (S), and the sulfur atom is further bonded to three oxygen atoms (O).
These oxygen atoms are also bonded to a hydrogen atom each.
This arrangement gives MSA Methanesulfonic Acid its distinct properties as a strong organic acid.
PHYSICAL PROPERTIES of MSA METHANESULFONIC ACID:
MSA Methanesulfonic Acid is a colorless or light yellow liquid
MSA Methanesulfonic Acid is odorless or with a slight sulfuric odor
MSA Methanesulfonic Acid is highly soluble in water forming a homogeneous solution and is miscible with most polar organic solvents.
Relatively high density (~1.48 g/mL at room temperature)
High boiling point (~167°C or 332°F)
WHAT ARE THE BENEFITS of MSA METHANESULFONIC ACID?
MSA Methanesulfonic Acid is a versatile and valuable chemical compound that offers a range of benefits across various industries.
Its unique properties make MSA Methanesulfonic Acid a preferred choice for numerous applications.
*Strong Acidic Properties:
MSA Methanesulfonic Acid exhibits high acidity, allowing it to efficiently catalyze chemical reactions.
Its potent acidic properties make MSA Methanesulfonic Acid a valuable catalyst in numerous industrial processes, promoting faster and more selective reactions.
*Non-Volatile and Non-Oxidizing:
Unlike volatile acids, MSA Methanesulfonic Acid is non-volatile, ensuring safer handling and reduced risks of harmful vapors.
Additionally, its non-oxidizing nature minimizes the risk of corrosion or degradation of materials, making MSA Methanesulfonic Acid compatible with a wide range of substances.
*Versatile Solvent:
MSA Methanesulfonic Acid possesses excellent solvency power, making it an effective solvent for both polar and non-polar compounds.
MSA Methanesulfonic Acid can dissolve various organic and inorganic substances, facilitating processes such as extraction, purification, and synthesis in industries such as pharmaceuticals, electroplating, and organic chemistry.
*Stability and Long Shelf Life:
MSA Methanesulfonic Acid is known for its exceptional stability.
MSA Methanesulfonic Acid can be stored for extended periods without significant decomposition or loss of potency.
This stability ensures a longer shelf life compared to many other corrosive acids, allowing for better inventory management and reduced wastage.
*Environmentally Friendly:
In terms of environmental impact, MSA Methanesulfonic Acid stands out positively.
MSA Methanesulfonic Acid is readily biodegradable*, meaning it can be broken down by natural processes over time.
MSA Methanesulfonic Acid provides environmental advantages through easy recyclability and the generation of "green" effluent.
MSA Methanesulfonic Acid's recyclable nature allows for efficient reuse and waste reduction.
Furthermore, MSA Methanesulfonic Acid is considered as a "green" effluent as it produces environmentally friendly effluent, minimizing harm to ecosystems.
MSA Methanesulfonic Acid, the simplest alkanesulfonic acid, is a hygroscopic colorless liquid or white solid, depending on whether the ambient temperature is greater or less than 20 ºC.
MSA Methanesulfonic Acid is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.
In aqueous solution, MSA Methanesulfonic Acid is a strong acid (completely ionized).
CHEMICAL PROPERTIES of MSA METHANESULFONIC ACID:
MSA Methanesulfonic Acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
MSA Methanesulfonic Acid has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
MSA Methanesulfonic Acid is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.
MSA Methanesulfonic Acid will not subject to decomposition in boiling water and hot alkaline solution.
MSA Methanesulfonic Acid also has strong corrosion effect against the metal iron, copper and lead.
HOW MSA METHANESULFONIC ACID IS CONTRIBUTING TO BRING MORE SUSTAINABLE SOLUTIONS?
MSA Methanesulfonic Acid offers notable environmental benefits across various applications.
Here are some key environmental advantages of MSA Methanesulfonic Acid:
*Biodegradability:
MSA Methanesulfonic Acid is readily biodegradable* and can be broken down by microorganisms in the environment.
This means that MSA Methanesulfonic Acid is unlikely to persist in the environment or accumulate in living organisms.
*Persistence:
MSA Methanesulfonic Acid has a low persistence in the environment and does not accumulate in living organisms.
MSA Methanesulfonic Acid is rapidly degraded in water, soil, and sediment, which reduces its potential impact on the environment.
*Toxicity:
MSA Methanesulfonic Acid is not considered to be toxic to aquatic or terrestrial organisms at environmentally relevant concentrations.
This means that MSA Methanesulfonic Acid is unlikely to cause harm to wildlife or ecosystems.
*Air Quality Benefits:
In certain applications, MSA Methanesulfonic Acid can offer advantages over other acids in term of volatile organic compounds (VOCs) and hazardous air pollutants (HAPs).
By using MSA Methanesulfonic Acid as a cleaner or catalyst, the production of undesirable products VOCs and HAPs can be minimized (strong but non-oxidizing acid), leading to improved air quality.
*Sustainable Synthesis:
MSA Methanesulfonic Acid's catalytic properties enable more sustainable synthesis processes in various industries.
MSA Methanesulfonic Acid's use as a catalyst can reduce the need for harsher reagents, minimize waste generation, and improve overall process efficiency.
*Lower Environmental Impact:
When compared to certain alternatives, such as mineral acids or strong organic acids, MSA Methanesulfonic Acid can have a lower environmental impact.
MSA Methanesulfonic Acid's production typically involves less energy-intensive processes and generates fewer harmful byproducts.
MARKETS of MSA METHANESULFONIC ACID:
Agriculture & Animal Care, CASE - Coatings, Adhesives, Sealants & Elastomers, Chemical & Materials Manufacturing, Electronics, Food & Beverage, HI&I - Household, Industrial & Institutional, Personal Care & Pharmaceutical, Surface Treatment - Fluids, Lubricants & Metalworking, Textiles
INDUSTRIAL PRODUCTION of MSA METHANESULFONIC ACID:
The first commercial production of MSA Methanesulfonic Acid, developed in the 1940s by Standard Oil of Indiana, was based on oxidation of dimethylsulfide by O2 from air.
Although inexpensive, this process suffered from a poor product quality and explosion hazards.
Starting from the 1960s, it received a shortened name of mesylic acid after the term for the "mesyl" group coined by Helferich et al. in 1938.
In 1967, the Pennwalt Corporation (USA) developed a different process for dimethylsulfide (as a water-based emulsion) oxidation using chlorine, followed by extraction-purification.
In 2022 this chlorine-oxidation process was used only by Arkema (France) for making high-purity MSA Methanesulfonic Acid.
This process is not popular on a large scale, because it co-produces large quantities of hydrochloric acid.
Between years 1970 and 2000 MSA Methanesulfonic Acid was used only on a relatively small-scale in niche markets (for example, in the microelectronic and electroplating industries since the 1980s), which was mainly due to its rather high price and limited availability.
However, this situation changed around 2003, when BASF launched commercial production of MSA Methanesulfonic Acid in Ludwigshafen based on a modified version of the aforementioned air oxidation process, oxidising dimethyldisulfide with nitric acid which is then restored using atmospheric oxygen.
The former is produced in one step from methanol from syngas, hydrogen and sulfur.
An even better (lower-cost and environmentally friendlier) process of making MSA Methanesulfonic Acid was developed in 2016 by Grillo-Werke AG (Germany).
MSA Methanesulfonic Acid is based on a direct reaction between methane and oleum at around 50 °C and 100 bar in the presence of a potassium persulfate initiator.
Further addition of sulfur trioxide gives MSA Methanesulfonic Acid instead.
This technology was acquired and commercialized by BASF in 2019.
PRODUCTION METHOD of MSA METHANESULFONIC ACID:
MSA Methanesulfonic Acid can be obtained through the nitrate oxidation of thiocyanate methyl.
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃.
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product.
The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered.
The filtrate is condensed to until crystalline precipitation.
The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate.
It is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product.
Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction.
The reaction solution was extracted with chloroform.
After drying, the extract was distilled at 60-62 °C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure.
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride.
Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear.
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain MSA Methanesulfonic Acid.
CHEMICAL PROPERTIES of MSA METHANESULFONIC ACID:
MSA Methanesulfonic Acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
MSA Methanesulfonic Acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, MSA Methanesulfonic Acid is used as a starting material for the preparation of methanesulfonyl chloride.
PURIFICATION METHODS of MSA METHANESULFONIC ACID:
Dry the acid, either by azeotropic removal of water with *benzene or toluene, or by stirring 20g of P2O5 with 500mL of the acid at 100o for 0.5hours.
Then distil it under vacuum and fractionally crystallise it by partial freezing.
Sulfuric acid, if present, can be removed by prior addition of Ba(OH)2 to a dilute solution, filtering off the BaSO4 and concentrating under reduced pressure; and is sufficiently pure for most applications.
PREPARATION of MSA METHANESULFONIC ACID:
MSA Methanesulfonic Acid is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.
MSA Methanesulfonic Acid is a strong, non-oxidizing organic acid commonly supplied as a 70% aqueous solution.
MSA Methanesulfonic Acid is highly soluble in water and organic solvents and is widely used in electroplating, chemical synthesis, and acid-catalyzed reactions.
MSA Methanesulfonic Acid is known for its high thermal and chemical stability and minimal environmental impact compared to mineral acids.
HISTORY AND SYNTHESIS of MSA METHANESULFONIC ACID:
Early history
German chemist Hermann Kolbe discovered MSA Methanesulfonic Acid between 1842 and 1845 and originally termed it methyl hyposulphuric acid.
The discovery stemmed from earlier work by Berzelius and Marcet in 1813, who treated carbon disulfide with moist chlorine and produced a compound they named "sulphite of chloride of carbon".
By reacting MSA Methanesulfonic Acid with barium hydroxide Kolbe demonstrated it to actually be trichloromethylsulfonyl chloride (CCl₃SO₂Cl in modern notation).
2 CCl3SO2Cl + 3 Ba(OH)2 → Ba(CCl3SO3)2 + 3 BaCl2 + 2 H2O
From resulting barium trichloromethylsulfonate Kolbe isolated the free acid, which he was then able to sequentially dechlorinate by electrolytically generated atomic hydrogen to ultimately yield MSA Methanesulfonic Acid.
CCl3SO3H + 3 H → CHCl2SO3H + 2 H + HCl → … → CH3SO3H + 3 HCl
Kolbe's research on methanesulfonic and chloroacetic acids was hailed by Berzelius as strong evidence for his theory of copulated compounds, a modification of radical theory to accommodate substitution reactions which posited the combination of organic and inorganic moieties without significantly altering the properties of the latter.
Later in the 19th century, the name transitioned to methyl sulphonic acid.
Other historical laboratory synthesis routes included oxidizing methanethiol, dimethyl disulfide or methyl thiocyanate with nitric acid.
MSA Methanesulfonic Acid is a strong organic acid which is highly suitable for manufacturing active pharmaceutical ingredients such as Telmisartan and Eprosartan, Angiotensin II receptor antagonists.
PHYSICAL and CHEMICAL PROPERTIES of MSA METHANESULFONIC ACID:
CAS: 75-75-2
IUPAC Name: methanesulfonic acid
Molecular Formula: CH4O3S
InChI Key: AFVFQIVMOAPDHO-UHFFFAOYSA-N
SMILES: CS(O)(=O)=O
Molecular Weight (g/mol): 96.10
Form: Liquid
Appearance (Color): Clear colorless
Assay (Aqueous acid-base Titration): ≥68.5 to ≤71.5%
Linear Formula: CH3SO3H
CAS Number: 75-75-2
Molecular Weight: 96.11
Beilstein: 1446024
MDL number: MFCD00007518
UNSPSC Code: 12352100
PubChem Substance ID: 24870724
NACRES: NA.21
CAS Number: 75-75-2
Formula: CH4O3S
Formula Weight: 96.11
Linear Formula: CH3SO3H
MDL No.: MFCD00007518
Density: 1.319 g/mL at 25 C
Refractive Index: n20/D 1.416
Beilstein Registry Number: 1446024
UNSPSC Code: 12352100
CAS No: [75-75-2]
Product Code: FM158427
MDL No: MFCD00007518
MOL file: Download
Chemical Formula: CH4O3S
Molecular Weight: 96.11 g/mol
Smiles: CS(=O)(=O)O
Melting Point: 18 °C
Boiling Point: 167 °C
Density: 1.481 g/cm3
Flash Point: 189 °C
Density: 1.483 (204 c)
Direct Evaporative Cooling: 200 c
Vapor Pressure: 1 mm hg (20 c)
Melting Point: 20 c
Refractive Index: 1.4300
Molecular weight: 96.10
Color: colorless to yellowish liquid
Flash Point: 110 c
Solubility: water, alcohol, ether, oxygenated solvs.
Boiling Point: 167 c (10 mm)
Molecular Formula / Molecular Weight: CH4O3S = 96.10
Physical State (20 deg.C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Hygroscopic
CAS RN: 75-75-2
Reaxys Registry Number: 1446024
PubChem Substance ID: 87572203
SDBS (AIST Spectral DB): 4261
Merck Index (14): 5954
MDL Number: MFCD00007518
Appearance: Colorless to pale yellow liquid
Odor: Characteristic
Melting Point: 17–19 °C
Boiling Point: 167 °C at 10 mmHg
Density: 1.481 g/cm³ at 25 °C
Solubility: Miscible with water, ethanol,
tetrahydrofuran, and dimethyl sulfoxide;
limited solubility in toluene and n-hexane
pKa: −1.9 (strong acid)
LogP: −2.424
Flash Point: 230 °F
Refractive Index: n 20/D 1.429
Vapor Pressure: 1 mm Hg at 20 °C
Hygroscopicity: Hygroscopic in concentrated form
Chemical Name: Methanesulfonic Acid
CAS Number: 75-75-2
EC Number: 200-898-6
Molecular Formula: CH₄O₃S
Molecular Weight: 96.11 g/mol
Structure: CH₃SO₃H
Density: 1.483 (204 c)
Direct Evaporative Cooling: 200 c
Melting Point: 20 c
Vapor Pressure: 1 mm hg (20 c)
Refractive Index: 1.4300
Molecular weight: 96.10
Color: colorless to yellowish liquid
Flash Point: 110 c
Solubility: water, alcohol, ether, oxygenated solvs.
Boiling Point: 167 c (10 mm)
CAS Number: 75-75-2
Molecular Weight: 96.11
Beilstein/REAXYS Number: 1446024
EC Number: 200-898-6
MDL number: MFCD00007518
PubChem Substance ID: 24870726
NACRES: NA.21
CAS Number: 75-75-2
Purity: ≥ 99% (Assay by titration)
Molecular Formula: CH4O3S
Molecular Weight: 96.11
MDL Number: MFCD00007518
PubChem ID: 6395
Melting Point: 17 - 20 °C
Density: 1.48
Appearance: Clear colorless to light yellow liquid
Boiling Point: 121 - 123 °C/1 mmHg
Refractive Index: n20/D 1.430
Conditions: Store at RT
Appearance: Colourless to light yellow liquid (solid at low temperatures/melting ~17-20 °C)
Melting point (freezing point): ~17-20 °C (some sources list ~18 °C)
Boiling point: ~167 °C (at reduced pressure ~10 mmHg / 13.3 kPa)
Density: ~1.48 g/cm³ at ~20 °C
Refractive index: ~ nᵈ₁₆/₂₀ ≈ 1.43
Solubility: Highly soluble in water (e.g., 1000 g/L at 20 °C) and miscible with many polar solvents; insoluble or very slightly soluble in alkanes, benzene, toluene.
pKₐ: The acid is very strong; pKₐ values reported around –1.9 in water.
Partition coefficient (log Kₒw): ~ –2.38
Vapour pressure: Very low at ambient temperature (virtually negligible vapour pressure)
Auto-ignition temperature: ~535 °C (ECHA data)
Oxidising properties: None (i.e., it does not act as an oxidising acid)
Characteristics / special remarks:
Because of the sulfonic acid group, MSA is a strong acid but unlike many mineral acids it is non-oxidising, and it forms stable salts (methanesulfonates or mesylates) that are often used in synthesis or in pharmaceuticals.
It is considered “green” relative to some alternatives because of lower volatility, compatibility with many substrates, and favorable environmental/toxicity profile in comparison to strong mineral acids (though it is still hazardous).
Linear Formula: CH3SO3H
CAS Number: 75-75-2
Molecular Weight: 96.11
Beilstein: 1446024
EC Number: 200-898-6
MDL number: MFCD00007518
UNSPSC Code: 12352100
PubChem Substance ID: 24870726
NACRES: NA.21
Chemical formula: CH4O3S
Molar mass: 96.10 g·mol−1
Appearance: Clear, colourless liquid
Density: 1.48 g/cm3
Melting point: 17 to 19 °C (63 to 66 °F; 290 to 292 K)
Boiling point: 167 °C (333 °F; 440 K) at 10 mmHg, 122 °C/1 mmHg
Solubility in water: miscible
Solubility: Miscible with methanol, diethyl ether. Immiscible with hexane
log P: −2.424[1]
Acidity (pKa): −1.9[2]
Molecular Weight: 96.11 g/mol
XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 0
Exact Mass: 95.98811516 Da
Monoisotopic Mass: 95.98811516 Da
Topological Polar Surface Area: 62.8 Ų
Heavy Atom Count: 5
Formal Charge: 0
Complexity: 92.6
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Physical state: liquid
Color: light yellow
Odor: characteristic
Melting point/freezing point: Melting point/range: 17 - 19 °C - lit.
Initial boiling point and boiling range: 167 °C at 13 hPa - lit.
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: Upper explosion limit: 24,3 %(V) Lower explosion limit: 11,4 %(V)
Flash point: 189 °C - closed cup - DIN 51755 Part 1
Autoignition temperature: 535 °C at 1.010 hPa - DIN 51794
Decomposition temperature: No data available
pH: < 1 at 20 °C
Viscosity:
Viscosity, kinematic: 7,86 mm2/s at 25 °C
Viscosity, dynamic: 11,6 mPa.s at 25 °C
Water solubility: ca.1.000 g/l at 20 °C - completely miscible
Partition coefficient: n-octanol/water: log Pow: -2,38 at 20 °C - - Bioaccumulation is not expected.
Vapor pressure: 0,112 hPa at 80 °C - OECD Test Guideline 104
Density: 1,481 g/cm3 at 25 °C - lit.
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Dissociation constant: -1,54 at 25 °C
Relative vapor density: 3,32 - (Air = 1.0)
Density: ~1.35 g/cm³ (70% solution at 20°C)
Melting Point (pure): 20°C
Boiling Point: ~167°C (pure compound)
pKa: ~–1.9 (strong acid)
Solubility in Water: Fully miscible
Solubility in Other Solvents: Miscible with alcohols, ethers, and polar organics
Odor: Mild or faintly sour
FIRST AID MEASURES of MSA METHANESULFONIC ACID:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of MSA METHANESULFONIC ACID:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of MSA METHANESULFONIC ACID:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of MSA METHANESULFONIC ACID:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of MSA METHANESULFONIC ACID:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of MSA METHANESULFONIC ACID:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
