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MYRISTIC ACID ISOPROPYL ESTER= ISOPROPYL MYRISTATE
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
DESCRIPTION:
Isopropyl myristate is odorless when pure.
Isopropyl myristate may be synthesized by conventional esterification of isopropanol with myristic acid.
Isopropyl myristate is an ester of isopropyl alcohol myristic acid.
Isopropyl myristate is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines.
Isopropyl myristate also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Isopropyl myristate is an ester of isopropanol and myristic acid.
Isopropyl myristate is also referred to as tetradecanoic acid.
A colorless liquid with a faint odor, it is used in many applications, including pharma, food and personal care product manufacturing.
Isopropyl myristate is manufactured from vegetable oil sources to a minimum 98-percent purity.
Isopropyl myristate can be used in some of the most demanding industrial applications and has been manufactured to the highest standards of eco-friendly management.
Isopropyl myristate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption.
Isopropyl myristate has been largely studied and impulsed as a skin penetration enhancer.
At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse.
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
Chemical Properties:
Isopropyl myristate is a colorless and odorless liquid with a faint odor, and miscible with vegetable oil.
Isopropyl myristate is not easy to be either hydrolyzed or become rancid.
The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.
Isopropyl myristate is used in many applications, including pharma, food and personal care product manufacturing.
Content Analysis:
Weight 1.5 g sample.
Then it is determined by the method ester assay (OT-18).
The equivalent factor (e) in the calculation is 135.2.
Or it is determined by a non-polar column method of gas chromatography (GT-10-4).
Uses of MYRISTIC ACID ISOPROPYL ESTER:
Isopropyl myristate (IPM) is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments.
The use of IPM is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia (EP, 2.6.13, JP, 4.06 and USP, 71) as diluent for oils and oily solutions, as well as for ointments and creams.
Indeed, its solvent properties improve the filterability of these samples.
Isopropyl myristate is known as a penetration enhancer for topical preparations.
Isopropyl myristate is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin.
Isopropyl Myristate is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances.
Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired.
A jellied isopropyl myristate was marketed as Estergel.
Isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration.
An ester of myristic acid, Isopropyl myristate is naturally occurring in coconut oil and nutmeg.
Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.
Isopropyl myristate is a polar emollient and is used in cosmetic and topical pharmaceutical preparations where skin absorption is desired.
Isopropyl myristate is also used as a treatment for head lice.
Isopropyl myristate is also in flea and tick killing products for pets.
Isopropyl myristate is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".
Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol.
The acid is theorized to be responsible for decreasing of the pH value of formulations
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
Pharmaceuticals: Thickening Agent, Emollient, Moisturizer in Topical Medicinal Preparations
Personal Care & Cosmetics: Emollient, Moisturizer, Thickening Agent in Creams and Lotions
Flavor and Fragrance: Solvent, Binder, Diluent
Isopropyl myristate is notable for promoting the absorption of medicine and other products through the skin.
Isopropyl myristate is commonly found in creams, lotions and topical medicines.
Isopropyl myristate is also used as a thickening agent, emollient and moisturizer, as well as a solvent, binder and diluent in perfumes and food flavorings.
Isopropyl myristate offers in drums, and we ship it in a liquid form that is soluble in many organic solvents.
Isopropyl myristate is wholly derived from vegetable oils and not tested on animals.
Additionally, Isopropyl myristate is GMO-, peanut-, tree nut-, wheat-, grain-, dairy-, egg-, fish- and gluten-free, and Isopropyl myristate contains no residual solvents.
Isopropylmyristate is a fatty acid found in cosmetics.
Pharmaceutical Applications of MYRISTIC ACID ISOPROPYL ESTER:
Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin.
Isopropyl myristate is used as a component of semisolid bases and as a solvent for many substances applied topically.
Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams.
For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; Isopropyl myristate is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.
Isopropyl myristate has been used in a water-oil gel prolonged-release emulsion and in various microemulsions.
Such microemulsions may increase bioavailability in topical and transdermal applications.
Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
Production Method of MYRISTIC ACID ISOPROPYL ESTER:
Isopropyl myristate is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1) 200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added.
The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%).
Under normal pressure, isopropyl alcohol and water were distilled.
While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added.
During mixing, 228 kg myristic acid was added slowly.
The mixture was heated to reflux and water was continuously separated.
Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value.
When the acid value reached 1.5 mg KOH/g, the reaction was completed.
Alkali was then added for neutralization.
After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g.
The final product is then isopropyl myristate.
Pure isopropyl myristate is virtually odorless, very slightly fatty, but not rancid
Isopropyl myristate is colourless liquid of low viscosity
Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C.
Isopropyl myristate consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.
Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent.
A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.
Occurrence of Isopropyl myristate:
Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat
Contact allergens:
Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.
Biochem/physiol Actions:
Isopropyl myristate (myristic acid isopropyl ester) is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres.
Isopropyl myristate is used as a oil phase component in the formulaton of microemulsion systems.
Pharmacology:
Isopropyl myristate is used in pharmaceutical preparations because Isopropyl myristate improves solubility and increases absorption through the skin.
External uses include a non-irritating iodine preparation for disinfecting the skin and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes.
Preparations for internal use include oral steroid formulations and anaesthetic injection solutions.
Veterinary medications containing isopropyl myristate include oral or parenteral compositions for lungworm infections and a spray formulation for bovine udders to treat mastitis, combat infection and improve the general skin condition .
Isopropyl myristate has been found to be an effective repository vehicle for im injection of penicillin in rabbits and for sc administration of oestrogens in ovariectomized rats.
In assays on human forearms, vasoconstrictor activity of ointment preparations containing 0025% betamethasone 17-benzoate in white soft paraffin was increased by the presence of isopropyl myristate.
Donovan, Ohmart & Stoklosa (1954) noted that the good solvent properties of isopropyl myristate might increase the therapeutic activity of formulations by the apparent alteration in particle size of the active ingredients, so that further evaluation and clinical study would be necessary before its use in extemporaneous compounding could be recommended.
Studies in which the antifungal activity of paraben esters solubilized by surfactants was decreased by isopropyl myristate indicate that the effectiveness of medicinal substances may be influenced by the presence of surfactants and oily ingredients such as isopropyl myristate.
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
Metabolism:
Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products.
When myristic acid (as the ethyl ester) was fed to dogs,
Storage:
Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid.
Isopropyl myristate should be stored in a well-closed container in a cool, dry place and protected from light.
Incompatibilities:
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling.
Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture.
Isopropyl myristate is also incompatible with strong oxidizing agents.
Regulatory Status:
Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations).
Used in nonparenteral medicines licensed in the UK.
Included in the Canadian List of Acceptable Non-medicinal Ingredients.
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
Chemical Properties of MYRISTIC ACID ISOPROPYL ESTER:
Melting point : ~3 °C (lit.)
Boiling point :193 °C/20 mmHg (lit.)
density :0.85 g/mL at 25 °C (lit.)
vapor pressure: <1 hPa (20 °C)
refractive index : n20/D 1.434(lit.)
Fp : >230 °F
storage temp. : 2-8°C
solubility : <0.05mg/l
form : Liquid
Specific Gravity: 0.855 (20/4℃)
Color: Clear
Water Solubility : Miscible with alcohol.
Immiscible with water and glycerol.
JECFA Number: 311
Merck : 14,5215
BRN : 1781127
Stability: Stable.
Combustible. Incompatible with strong oxidizing agents.
Appearance: colorless clear oily liquid (est)
Color/Form: Colorless oil
Odor: Practically odorless
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.84000 to 0.86000 @ 25.00 °C.
Pounds per Gallon - (est).: 6.990 to 7.156
Refractive Index: 1.42800 to 1.44300 @ 20.00 °C.
Melting Point: 2.00 to 3.00 °C. @ 760.00 mm Hg
Boiling Point: 192.00 to 193.00 °C. @ 20.00 mm Hg
Acid Value: 1.00 max. KOH/g
Saponification Value: 207.00
Vapor Pressure: 0.000329 mmHg @ 25.00 °C. (est)
Henry's Law constant : 2.34X10-2 atm-cu m/mol at 25 °C (est)
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 7.253 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Molecular Weight: 270.5
XLogP3-AA: 7.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count 2
Rotatable Bond Count: 14
Exact Mass: 270.255880323
Monoisotopic Mass: 270.255880323
Topological Polar Surface Area: 26.3 Ų
Heavy Atom Count: 19
Formal Charge: 0
Complexity: 199
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Decomposition:
When heated to decomposition it emits toxic smoke and fumes.
Stability/Shelf Life:
Withstands oxidn & does not readily become rancid.
Soluble in:
• amyris wood oil
• benzyl benzoate
• benzyl salicylate
• clove leaf oil
• deluent for candle fragrances
• ethyl acetoacetate
• ethyl lactate
• paraffin oil
• water, 0.01354 mg/L @ 25 °C (est)
Insoluble in:
• water
• isoamyl myristate
• butyl myristate
• isobutyl myristate
• ethyl myristate
• hexyl myristate
Features & Benefits of MYRISTIC ACID ISOPROPYL ESTER:
• Biodegradable
• Emollient
• 80% reduction in VOCs compared with Texanol: meets and exceeds international regulations for no VOCs
• Fragrance Extender
• Lubricant
• Nonocclusive
• Nonoily
• Plant Derived / Vegetal Based
• Spreading Agent
• USP / NF Grade
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
SAFETY INFORMATION ABOUT MYRISTIC ACID ISOPROPYL ESTER:
First aid measures:
Description of first aid measures
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Flush eyes with water as a precaution.
If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Most important symptoms and effects, both acute and delayed
Indication of any immediate medical attention and special treatment needed
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Environmental precautions:
Do not let product enter drains.
Methods and materials for containment and cleaning up:
Keep in suitable, closed containers for disposal.
Handling and storage:
Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Exposure controls/personal protectioncontrol parameter:
Hazard composition and occupational exposure limits
Does not contain substances with occupational exposure limits.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm Break through time: 480 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M) Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm Break through time: 480 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves.
This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers.
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure:
Do not let product enter drains.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Incompatibilities:
When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture.
MYRISTIC ACID ISOPROPYL ESTER is also incompatible with strong oxidizing agents.
Contaminated packaging:
Dispose of as unused product.
CAS No.: 110-27-0
EC Number: 203-751-4
Molecular Formula: C17H34O2
Formula Weight: 270.45
IUPAC Name: propan-2-yl tetradecanoate
SYNONYMS of MYRISTIC ACID ISOPROPYL ESTER:
Isopropyl Myristate, 96% 25GR
IPM 100
IPM-EX
IPM-R
Radia 7730 (IPM)
Isopropyl myristate Vetec(TM) reagent grade, 98%
MYRISTIC ACID ISOPROPYL ESTER MINIMU
ISO-PROPYL N-TETRADECANOATE
ISOPROPYL TETRADECANOATE
BISOMEL
ISOPROPYL MYRISTATE
ESTERGEL
FEMA 3556
MYRISTIC ACID ISOPROPYL ESTER
TETRADECANOIC ACID 1-METHYLETHYL ESTER
TETRADECANOIC ACID ISOPROPYL ESTER
kesscoipm
kesscoisopropylmyristate
Kesscomir
Lexol IPM-NF
Liponate IPM
Plymoutm IPM
plymoutmipm
Promyr
Propyl myristate
Radia 7190
Revenge
Sinnoester MIP
sinnoestermip
Starfol IPM
starfolipm
Stepan D-50
1-Methylethyl tetradecanoate
1-Methylethyltetradecanoate
1-Tridecanecarboxylic acid, isopropyl ester
ISOPROPYLMYRISTATE,NF
Isopropylmyristat
Myristic acid, isopropyl ester: (Tetradecanoic acid, isopropyl: Isopropyl myristate),
ISOPROPYL MYRISTATE pure
tetraclecyl isopropyl ester
Isoprooyl myristate
Isopropyl tetradecanoate, Myristic acid isopropyl ester
Propan-2-yl tetradecanoat
Isopropyl myristate,96%
Isopropyl Myristate (500 mg)
Isopropy1 myristate
Isopropyl Myristate 98% (IPM)
1-tridecanecarboxylicacid,isopropylester
component of Sardo Bath Oil
crodacolipm
Crodamol 1PM
Crodamol I.P.M.
Crodamol IPM
crodamolipm
D 50
Deltyl Extra
deltylextra
Emcol-IM
0RE8K4LNJS
110-27-0 [RN]
13VOY1&1 [WLN]
1-Methylethyl tetradecanoate
203-751-4 [EINECS]
3556
IPM
IPM 100
IPM-EX
IPM-R
Isopropyl myristate [ACD/IUPAC Name] [USAN]
isopropyl tetradecanoate
Isopropylmyristat [German] [ACD/IUPAC Name]
MFCD00008982 [MDL number]
Myristate d'isopropyle [French] [ACD/IUPAC Name]
myristic acid isopropyl ester
Myristic acid, isopropyl ester
Propan-2-yl tetradecanoate
Tetradecanoic acid 1-methylethyl ester
Tetradecanoic acid isopropyl ester
Tetradecanoic acid, 1-methylethyl ester [ACD/Index Name]
Tetradecanoic acid, isopropyl ester
XB8600000
1-Tridecanecarboxylic acid, isopropyl ester
4-02-00-01132 (Beilstein Handbook Reference) [Beilstein]
Bisomel
Crodamol 1PM
Crodamol IPM
DELTYL EXTRA
Deltylextra
EINECS 203-751-4
Emcol-IM
Emerest 2314
Estergel [Trade name]
Estergel (TN)
FEMA 3556
IPM 90
Isomyst
Isopropyl myristate (NF)
isopropyl myristate 96%
isopropyl myristate 98%
isopropyl myristate, ??? 95.0%
isopropyl myristate, 96%
iso-Propyl N-tetradecanoate
isopropyl tetradecanoate, 98%
isopropyl tetradecanoate,98%
Isopropyl tetradecanoic acid
Isopropylmyristate
Isopropylmyristate, Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester, Sterile IPM
Ja-fa IPM
Jsp000796
Kessco IPM
Kessco isopropyl myristate
Kesscomir
Lexol IPM
Liponate IPM
Methylethyl tetradecanoate
Myristic acid-isopropyl ester
NCGC00164071-01
Promyr
Radia 7190
Sinnoester MIP
Starfol IPM
Stepan D-50
Sterile Isopropyl Myristate (IPM)
Tegester
Tegosoft M
Tetradecanoic acid isopropyl ester, Myristic acid isopropyl ester
Tetradecanoic acid methyethyl ester
Tetradecanoic acid, isopropyl
UNII:0RE8K4LNJS
UNII-0RE8K4LNJS
Unimate IPM
Wickenol 101
WLN: 13VOY1&1
lsopropyl myristate
Isopropyl tetradecanoate
Isopropyl myristate
ISOPROPYL ESTER OF MYRISTIC ACID; MYRISTIC ACID ISOPROPYL ESTER
Tetradecanoic acid, isopropyl ester
CYCLOCHEM IPM
TETRADECENOIC ACID, 1-METHYLETHYL ESTER
LEXOL IPM
TETRADECANOIC ACID, 1-METHYLETHYL ESTER
Tetradecanoate <isopropyl->
tetradecanoic acid, 2-propyl ester
IPM-EX
IPM-R
IPM 100
IPM
