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MYRISTYL ALCOHOL

MYRISTYL ALCOHOL

CAS No. : 112-72-1
EC No. : 204-000-3

Synonyms:
Tetradecanol; Tetradecan-1-ol; Myristyl alcohol; Tetradecyl alcohol; 1-TETRADECANOL; Tetradecan-1-ol; Myristyl alcohol; 112-72-1; Tetradecanol; Tetradecyl alcohol; n-Tetradecanol; Myristic alcohol; n-Tetradecyl alcohol; Lanette K; Loxanol V; Lanette Wax KS; n-Tetradecanol-1; 1-Hydroxytetradecane; Alfol 14; n-Tetradecan-1-ol; Dytol R-52; Alcohols, C10-16; Alcohols, C12-16; Alcohols, C14-15; C14 alcohol; Lanette 14; 1-Tetradecyl alcohol; Alcohol(C14); Fatty alcohol(C14); tetradecan1-ol; NSC 8549; MFCD00004757; HSDB 5168; Myristyl alcohol [NF]; EINECS 204-000-3; EPA Pesticide Chemical Code 001510; BRN 1742652; AI3-00943; 67762-41-8; 68855-56-1; CHEBI:77417; V42034O9PU; kalcohl 40; 75782-87-5; Myristyl alcohol (NF); Myristyl Alcohol; 1-Tetradecanol, 99%; Alcohols, C>14; Alcohols, C12-15; CAS-112-72-1; Tetradecanol (7CI); C12-16 Alcohols; Kalcohl 4098; C14-15 alcohol; Lorol C 14; Adol 18; MYRISTYL ALCOHOL; Kalcol 4098; Conol 1495; Nacol 14-95; (C10-C16) Alkyl alcohol; (C12-C16) Alkyl alcohol; tetradecylalcohol; Alcohols, C14-22 and C16-22-unsatd.; Tetradecanol-1; MYRISTYL ALCOHOL; n-tetradecylalcohol; Dehydag wax 14; 1-tetradecanol group; Philcohol 1400; Lorol C14; 63393-82-8; Myristyl cetyl alcohol; Epal 14; Fatty alcohol (C14); 1-Tetradecanol, 97%; SDA 15-060-00; ACMC-1BY8P; EC 204-000-3; EC 616-261-4; (C14-C18)Alkyl alcohol; SCHEMBL20286; 4-01-00-01864 (Beilstein Handbook Reference); 68002-95-9; 71750-71-5; KSC177C3R; (C14-C18) Alkyl alcohol; (C14-C18)-Alkyl alcohol; CHEMBL24022; (C14-C22) and (C16-C22)Unsaturated alkylalcohol; WLN: Q14; Mixed fatty alcohols (C10-C16); NSC-8549; ZINC1644076; 1-Tetradecanol, purum, >=95.0% (GC); FT-0608311; ST51046400; 1-Tetradecanol, Selectophore(TM), >=99.0%; D05097; 1-Tetradecanol, Vetec(TM) reagent grade, 97%; n-Tetradecan-1-ol; n-Tetradecanol; n-Tetradecyl alcohol; Alfol 14; Lanette K; Lanette Wax KS; Loxanol V; Myristic alcohol; Myristyl alcohol; Tetradecyl alcohol; n-Tetradecanol-1; 1-Hydroxytetradecane; Dytol R-52; Tetradecanol; Dehydag wax 14; Epal 14; Lanette 14; Lorol C14; Philcohol 1400; Tetradecanol-1; Tetradecan-1-ol; NSC 8549; Fatty alcohol (C14); UNII-S4827SZE3L component HLZKNKRTKFSKGZ-UHFFFAOYSA-N; Myristyl alcohol, United States Pharmacopeia (USP) Reference Standard; Myristyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material


Myristyl Alcohol

1-Tetradecanol, or commonly myristyl alcohol (from Myristica fragrans – the nutmeg plant), is a straight-chain saturated fatty alcohol, with the molecular formula C14H30O. It is a white crystalline solid that is practically insoluble in water, soluble in diethyl ether, and slightly soluble in ethanol.

Myristyl alcohol may be prepared by the hydrogenation of myristic acid (or its esters); myristic acid itself can be found in nutmeg (from where it gains its name) but is also present in palm kernel oil and coconut oil and it is from these that the majority of Myristyl alcohol is produced.[2] It may also be produced from petrochemical feedstocks via either the Ziegler process or hydroformylation.

As with other fatty alcohols, Myristyl alcohol is used as an ingredient in cosmetics such as cold creams for its emollient properties. Myristyl alcohol is also used as an intermediate in the chemical synthesis of other products such as surfactants.


MYRISTYL ALCOHOL is classified as :
Emollient
Emulsion stabilising
Foam boosting
Skin conditioning
Viscosity controlling

CAS Number 112-72-1
EINECS/ELINCS No: 204-000-3
COSING REF No: 77246
Chem/IUPAC Name: Tetradecanol


Application
Myristyl alcohol was used for filling the hollow interiors of gold nanocages in the fabrication of new theranostic system having unique feature of photoacoustic imaging[1]. It was used in fabrication of temperature-regulated drug release system based on phase-change materials[2].

What Is It?
Cetearyl Alcohol, Cetyl Alcohol, Myristyl Alcohol and Behenyl Alcohol are white, waxy solids. Isostearyl Alcohol is a clear liquid. Cetyl Alcohol and Stearyl Alcohol are the two major components of Cetearyl Alcohol. These ingredients are all fatty alcohols and that are widely used in cosmetics and personal care products, especially in skin lotions and creams.

Why is it used in cosmetics and personal care products?
Cetearyl Alcohol and the other fatty alcohols keep an emulsion from separating into its oil and liquid components. These ingredients are also used to alter the thickness of liquid products and to increase foaming capacity or to stabilize foams.

Scientific Facts: 
Cetearyl, Cetyl, Myristyl and Behenyl Alcohols are straight-chain alcohols. Isostearyl Alcohol is a branched chain alcohol. Cetearyl Alcohol is a mixture of mostly of Cetyl and Stearyl Alcohols, which are fatty alcohols that occur naturally in small quantities in plants and animals.

Myristyl Alcohol is a 14 carbon chain. Cetyl Alcohol has 16 carbons, while Stearyl and Isostearyl Alcohols have 18 carbons. Behenyl Alcohol is the largest fatty alcohol in this group with 22 carbons.

Properties
Chemical formula C14H30O
Molar mass 214.393 g·mol−1
Density 0.824 g/cm³
Melting point 38 °C (100 °F; 311 K)
Boiling point >260 °C


Myristyl Alcohol
A lighter-weight fatty alcohol that functions as a thickener, emulsion stabilizer, and emollient. It is also sometimes used as a surfactant, often with other surfactants. It is considered safe as used in cosmetics.

Myristyl Alcohol is a fatty-alcohol used as an emollient in cosmetics and skin care products (Source). According to research, it is primarily used to inhibit a formula from separating into its oil and liquid components. However, Myristyl Alcohol can be drying, as can most fatty-alcohols.

* A fatty-alcohol emollient

* Also known as 1-Tetradecanol

Functions:

Myristyl Alcohol is a fatty-alcohol used as an emollient in cosmetics and skin care products (Source). According to research, it is primarily used to inhibit a formula from separating into its oil and liquid components. However, Myristyl Alcohol can be drying, as can most fatty-alcohols.

Myristyl Alcohol is also used for other properties, including as an: Emulsion Stabilizer; Skin-Conditioning Agent; Surfactant; Viscosity Increasing Agent; Foaming Agent; and Fragrance Ingredient. According to The Good Scents Company, Myristyl Alcohol provides a fruity, coconut scent.

In the Human Toxome Project, a mapping of pollution levels in people throughout the world, Myristyl Alcohol was found in 1 out of 9 people. Read more about the Human Toxome Project being done by the Environmental Working Group.

Safety Measures/Side Effects:

A study published by Toxicology and Applied Pharmacology in 1966 showed Myristyl Alcohol to be a carcinogen and cause skin tumors in multiple tests, but only in high doses given to animals, primarily mice. It’s also been shown to be an irritant in animals. Studies published in Contact Dermatitis in April and November of 2006, both done in Europe and both concerning patch testing and cosmetic allergies directly resulting from Myristyl Alcohol found that it was an irritant, but only in patients with highly sensitive skin. It is approved by the FDA as a food additive, and by the CIR for use in cosmetics (Cosmetics Database).

What: Myristyl Alcohol is a saturated fatty alcohol found in natural oils often used in cosmetics as an emollient and a stabilizer, preventing separation. Myristyl Alcohol smooths the skin and prevents moisture loss (Wiki).

Myristyl Alcohol may also be used as a foaming agent and fragrance ingredient.

Origin: Myristyl Alcohol is derived from natural fats and oils found in palm kernel oil, coconut oil, and nutmeg.

Products Found In: Hair care, skincare, body care, sunless tanners, perfumes.

Alternate Names: 1-Hydroxytetradecane; Tetradecanol; 1-Tetradecanol; Tetradecyl Alcohol; Dytol R-52; Lanette Wax Ks; Loxanol V; Myristic Alcohol; Myristyl Alcohol (Mixed Isomers) ; N-Tetradecanol-1; N-Tetradecyl Alcohol.

Toxicity: Myristyl Alcohol is generally classified as having low toxicity.(EWG).


Myristyl alcohol (myristyl alcohol) is a white solid. It is not soluble in water. USE: Myristyl alcohol is used as a perfume fixative for soaps and cosmetics. It is found in many personal care items such as; shampoo, toothpaste, cold creams, ointments and suppositories. Myristyl alcohol is used in specialty cleaning products, as an anti-foam agent and in some plastics. It is also used as a food additive. EXPOSURE: Workers that use or produce Myristyl alcohol may breathe in mists or have direct skin contact. The general population may be exposed by eating food or drinking beverages that contain Myristyl alcohol. Skin exposure will result from using some personal care items. If Myristyl alcohol is released to the environment it is expected to bind tightly to particles in soil and water. It is not expected to move through soil. It is expected to move into air from wet soil and water surfaces. It will be broken down in soil and water by microorganisms. 

It is expected to build up moderately in aquatic organisms. If Myristyl alcohol is released to air, it will be broken down by reactions with other chemicals. RISK: Allergic skin reactions have occurred in some individuals exposed to Myristyl alcohol in personal care products. No other health effects data were located for humans exposed to Myristyl alcohol. Mild-to-moderate eye irritation was observed in laboratory animals with direct eye exposure to Myristyl alcohol. Skin irritation was not observed in laboratory animals following direct skin contact. Skin tumors following skin exposure to a known cancer-causing agent (7,12-dimethylbenz(a)anthracene) were slightly increased by skin exposure to Myristyl alcohol. The potential for Myristyl alcohol to cause cancer without exposure to another known cancer-causing agent has not been examined in laboratory animals. The potential for Myristyl alcohol to cause infertility, abortion, or birth defects has not been examined in laboratory animals. The potential for Myristyl alcohol to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 13th Report on Carcinogens. 

1-dodecanol and Myristyl alcohol are used in combination with the (E, E) -8, 10-dodecadiene-1-ol, (Z)-11-tetradecene-1-yl acetate, and (Z)-9-tetradecene-1-yl acetate as pheromone confusion mixture for controlling pests on plants, e.g., codling moths and leaf wrappers. In Denmark, the product is used for insect control in apples and pears. Mode of action is to prevent mating of codling moths and several species of leaf wrappers, whereby propagation is prevented. That results in a reduced moth (leaf rollers) population and therefore less damage to the ... /crops/. The product has not previously been selected by the Danish EPA for control of content of active substances.

For Myristyl alcohol (USEPA/OPP Pesticide Code: 001510) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses.


Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Myristyl alcohol. Aggregated National Production Volume: 50 to < 100 million pounds.

USE: 
Myristyl alcohol is a white solid or crystal used in organic synthesis, plasticizers, antifoaming agent, intermediate, perfume fixative for soaps and cosmetics, wetting agents and detergents, ointments and suppositories, shampoos, toothpaste, cold creams, and specialty cleaning preparations. Myristyl alcohol and 1-dodecanol are also used in combination with the (E, E) -8, 10-dodecadiene-1-ol, (Z)-11-tetradecene-1-yl acetate, and (Z)-9-tetradecene-1-yl acetate as a pheromone confusion mixture for controlling pests on plants, e.g., codling moths and leaf wrappers. In Denmark, the product is used for insect control in apples and pears. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Myristyl alcohol has been tested as experimental medication in controlling the progression of chronic periodontal disease. 

HUMAN EXPOSURE AND TOXICITY: Thirty-one patients allergic to Hirudoid cream were patch tested with the ingredients. 29 were allergic to the cream base and 16 to one or more components. The most common allergens were for Myristyl alcohol, cetostearyl alcohol, and parabens. It has been stated that Myristyl alcohol should not be patch tested at 10% in petrolatum, but at a lesser concentration, due to irritant properties. ANIMAL STUDIES: It has been reported that Myristyl alcohol causes no skin irritation and slight eye irritation.

Myristyl alcohol's production and use in organic synthesis, in plasticizers, as an anti-foam agent, perfume fixative for soaps and cosmetics, wetting agents and detergents, ointments and suppositories, shampoos, toothpaste, cold creams, and specialty cleaning preparations may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 1.1X10-4 mm Hg at 25 °C indicates Myristyl alcohol will exist solely as a vapor in the atmosphere. Vapor-phase Myristyl alcohol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 hours. Myristyl alcohol does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, Myristyl alcohol is expected to have no mobility based upon Koc values of 18,197-34,674 in humic acid. Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 1.04X10-4 atm-cu m/mole. However, adsorption to soil is expected to attenuate volatilization. Myristyl alcohol is not expected to volatilize from dry soil surfaces based upon its vapor pressure. A biodegradation half-life of 5.5 days was calculated for Myristyl alcohol, based on a rate constant of 52.5 1/hr measured in sludge indicating that biodegradation may be an important environmental fate process in soil and water. If released into water, Myristyl alcohol is expected to adsorb to suspended solids and sediment based upon Koc values of 23,320-64,060 in suspended solids. Volatilization from water surfaces is expected based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 17 hours and 10 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 20-55 months if adsorption is considered. An estimated BCF of 190 suggests the potential for bioconcentration in aquatic organisms is high. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions (pH 5 to 9). Occupational exposure to Myristyl alcohol may occur through dermal contact with this compound at workplaces where Myristyl alcohol is produced or used. Monitoring data indicate that the general population may be exposed to Myristyl alcohol via inhalation of ambient air, ingestion of food and beverages, and dermal contact with consumer products containing Myristyl alcohol.


Myristyl alcohol emission rates from green leaf composite samples and dead leaves were 51 ug/g and 25 ug/g, respectively(1). Essential oil from the herbal part of Cymocarpum erythracum was 73.1% Myristyl alcohol; plants were collected in Erzincan, Turkey(2).

Myristyl alcohol's production and use in organic synthesis, in plasticizers, as an anti-foam agent, perfume fixative for soaps and cosmetics, wetting agents and detergents, ointments and suppositories, shampoos, toothpaste, cold creams, and specialty cleaning preparations(1) may result in its release to the environment through various waste streams(SRC).

Based on a classification scheme(1), Koc values of 18,197-26,303 in humic acid(2), indicate that Myristyl alcohol is expected to be immobile in soil(SRC). Volatilization of Myristyl alcohol from moist soil surfaces is expected given a Henry's Law constant of 1.04X10-4 atm-cu m/mole(3). However, adsorption to soil is expected to attenuate volatilization(SRC). Myristyl alcohol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.1X10-4 mm Hg at 25 °C(4). A biodegradation rate constant of 52.5 1/hr in sludge was reported for Myristyl alcohol(5), indicating that biodegradation may be an important environmental fate process in soil(SRC).

Based on a classification scheme(1), reported Koc values of 23,320-64,060 in suspended solids(2), indicate that Myristyl alcohol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.04X10-4 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 17 hours and 10 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 20-55 months if adsorption is considered(5). Myristyl alcohol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 190(SRC), from its log Kow of 6.03(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is high(SRC). A biodegradation rate constant of 52.5 1/hr was reported in sludge(9), indicating that biodegradation may be an important environmental fate process in water(SRC).


According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), Myristyl alcohol, which has a vapor pressure of 1.1X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase Myristyl alcohol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hours(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Myristyl alcohol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The first order rate constant for the biodegradation of Myristyl alcohol using an activated sludge inoculum was measured as 52.5 1/hour(1). Myristyl alcohol was found to be readily biodegradable(2); test conditions not specified.

The rate constant for the vapor-phase reaction of Myristyl alcohol with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Myristyl alcohol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). Myristyl alcohol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 190 was calculated in fish for Myristyl alcohol(SRC), using a log Kow of 6.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

The Henry's Law constant for Myristyl alcohol is reported as 1.04X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that Myristyl alcohol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 17 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 10 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 20-55 months if adsorption is considered(3). Myristyl alcohol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Myristyl alcohol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.1X10-4 mm Hg(4).


 Six snow surface sites from three different sampling events from 1985-1991 in the Antarctic were analyzed for the content of Myristyl alcohol; Mt. Crummer, Campbell Glacier, Vegetation Island, Tourmaline Plateau, Mt. Melbourne were all below detection limit and it was detected at 387 ng/L at Carezza Lake(1). Snow surface analysis were done for Myristyl alcohol at seven sites in the Antarctic in 1993/1994 season; Wood Bay at sea level (15 ng/L), Mt Melbourne at 200 meters above sea level (2 ng/L, detection limit), Vegetation Island at 220 meters above sea level (27 ng/L), Mt Melbourne at 600 meters above sea level (4 ng/L), McCarthy Ridge at 790 meters above sea level (3 ng/L), Mt Melbourne at 1130 meters above sea level (5 ng/L) and Hercules Neve at 2960 meters above sea level (23 ng/L)(2). Myristyl alcohol was detected at 5, 7 and 9 ng/L in subsurface samples from respective depths of 1, 2 and 3 meters at McCarthy Ridge(2). Myristyl alcohol was detected at 2, 6 and 5 ng/L in subsurface samples taken at Hercules Neve at 1, 2 and 3 meters deep, respectively(2). Myristyl alcohol was identified in two of eight snow samples taken from Mt Sonnblick in the Austrian Alps at concentrations of 10-11 ug/L(3).

Myristyl alcohol was detected in an advanced waste treatment concentrate from a plant in Dallas, TX, in 1974(1). Myristyl alcohol was detected in wastewater effluent at unreported concentrations from printing and publishing industries, textile mills, and publically-owned treatment works(one occurrence reported for each industry type)(2). Myristyl alcohol emission from road dust samples was 3.6 ug/g(3). Myristyl alcohol was emitted to the air at a rate of 6 ug/sq m hour from one of 10 cushion poly vinyl floorings installed for 3 days, the emission rate increased to 7 ug/sq m hour 28 days after installation(3).

Myristyl alcohol was detected, not quantified, in air samples collected along the Niagara River from Buffalo, NY to Niagara-on-the-Lake, Ontario in 1982-1983(1). Myristyl alcohol was detected in atmospheric samples at 1.4 ng/cu m and 1.1 ng/cu m in Bakersfield and Fresno, CA, respectively(2).

Myristyl alcohol was identified as a volatile component of aroma of cooked (1) and raw beef(2). Myristyl alcohol has been detected in wine and spirits(3).


Myristyl alcohol emission rates from green leaf composite samples and dead leaves were 51 ug/g and 25 ug/g, respectively(1). Essential oil from the herbal part of Cymocarpum erythracum was 73.1% Myristyl alcohol; plants were collected in Erzincan, Turkey(2). Myristyl alcohol was detected at a range of 0-432 ppm in the shoots of Mitracarpus scaber (Rubiaceae)(3).

Myristyl alcohol was detected in lake trout (Salvelinus namaycush) and walleye (Stizostedion v. vitreum) sampled in the fall of 1977 from Lake Michigan at Saugatuck and Charlevoix, Lake Huron at Rockport, Lake St. Clair, and Lake Erie at Port Clinton and Dunkirk at unreported concentrations(1).

According to the 2012 TSCA Inventory Update Reporting data, 6 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of Myristyl alcohol in the United States may be as low as <10 workers up to the range of 500-999 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 4525 workers (1820 of these are female) were potentially exposed to Myristyl alcohol in the US(1). Occupational exposure to Myristyl alcohol may occur through dermal contact with this compound at workplaces where Myristyl alcohol is produced or used. Monitoring and use data indicate that the general population may be exposed to Myristyl alcohol via inhalation of ambient air, ingestion of food and beverages, and dermal contact with consumer products containing Myristyl alcohol(SRC).


About Myristyl alcohol
Helpful information
Myristyl alcohol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 to < 1 000 000 tonnes per annum.

Myristyl alcohol is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses
Myristyl alcohol is used in the following products: biocides (e.g. disinfectants, pest control products), coating products, anti-freeze products, lubricants and greases, polishes and waxes, finger paints and washing & cleaning products.
Other release to the environment of Myristyl alcohol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Article service life
Release to the environment of Myristyl alcohol can occur from industrial use: in processing aids at industrial sites, in the production of articles and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of Myristyl alcohol is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). Myristyl alcohol can be found in products with material based on: stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material), plastic (e.g. food packaging and storage, toys, mobile phones), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), wood (e.g. floors, furniture, toys) and metal (e.g. cutlery, pots, toys, jewellery).

Widespread uses by professional workers
Myristyl alcohol is used in the following products: lubricants and greases, fillers, putties, plasters, modelling clay, coating products and biocides (e.g. disinfectants, pest control products).
Myristyl alcohol is used in the following areas: building & construction work and agriculture, forestry and fishing.
Myristyl alcohol is used for the manufacture of: machinery and vehicles, fabricated metal products, rubber products, plastic products, mineral products (e.g. plasters, cement) and furniture.
Other release to the environment of Myristyl alcohol is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Formulation or re-packing
Myristyl alcohol is used in the following products: pH regulators and water treatment products, laboratory chemicals, inks and toners, coating products, fillers, putties, plasters, modelling clay and finger paints.
Myristyl alcohol has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Myristyl alcohol can occur from industrial use: formulation of mixtures, formulation in materials and as an intermediate step in further manufacturing of another substance (use of intermediates).

Uses at industrial sites
Myristyl alcohol is used in the following products: fillers, putties, plasters, modelling clay, lubricants and greases, coating products, pH regulators and water treatment products, adhesives and sealants and non-metal-surface treatment products.
Myristyl alcohol is used in the following areas: building & construction work and mining.
Myristyl alcohol is used for the manufacture of: chemicals, machinery and vehicles, mineral products (e.g. plasters, cement), textile, leather or fur, rubber products and plastic products.
Release to the environment of Myristyl alcohol can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and of substances in closed systems with minimal release.
Other release to the environment of Myristyl alcohol is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Manufacture
Release to the environment of Myristyl alcohol can occur from industrial use: manufacturing of the substance, formulation of mixtures, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.


Myristyl alcohol may be prepared by the hydrogenation of myristic acid (or its esters); myristic acid itself can be found in nutmeg (from where it gains its name) but is also present in palm kernel oil and coconut oil and it is from these that the majority of Myristyl alcohol is produced.[2] It may also be produced from petrochemical feedstocks via either the Ziegler process or hydroformylation.

As with other fatty alcohols, Myristyl alcohol is used as an ingredient in cosmetics such as cold creams for its emollient properties. It is also used as an intermediate in the chemical synthesis of other products such as surfactants.


Myristyl Alcohol

What Is Myristyl Alcohol?
Cetearyl Alcohol, Cetyl Alcohol, Myristyl Alcohol and Behenyl Alcohol are white, waxy solids. Isostearyl Alcohol is a clear liquid. Cetyl Alcohol and Stearyl Alcohol are the two major components of Cetearyl Alcohol. These ingredients are all fatty alcohols and that are widely used in cosmetics and personal care products, especially in skin lotions and creams.

Why is Myristyl Alcohol used in cosmetics and personal care products?
Cetearyl Alcohol and the other fatty alcohols keep an emulsion from separating into its oil and liquid components. These ingredients are also used to alter the thickness of liquid products and to increase foaming capacity or to stabilize foams.

Scientific Facts: 
Cetearyl, Cetyl, Myristyl and Behenyl Alcohols are straight-chain alcohols. Isostearyl Alcohol is a branched chain alcohol. Cetearyl Alcohol is a mixture of mostly of Cetyl and Stearyl Alcohols, which are fatty alcohols that occur naturally in small quantities in plants and animals.

Myristyl Alcohol is a 14 carbon chain. Cetyl Alcohol has 16 carbons, while Stearyl and Isostearyl Alcohols have 18 carbons. Behenyl Alcohol is the largest fatty alcohol in this group with 22 carbons.

myristyl alcohol
Rating: GOOD
Categories: Emollients, Thickeners/Emulsifiers
A lighter-weight fatty alcohol that functions as a thickener, emulsion stabilizer, and emollient. It is also sometimes used as a surfactant, often with other surfactants. It is considered safe as used in cosmetics.

Myristyl Alcohol
What: Myristyl Alcohol is a saturated fatty alcohol found in natural oils often used in cosmetics as an emollient and a stabilizer, preventing separation. Myristyl Alcohol smooths the skin and prevents moisture loss (Wiki).

Myristyl Alcohol may also be used as a foaming agent and fragrance ingredient.

Origin: Myristyl Alcohol is derived from natural fats and oils found in palm kernel oil, coconut oil, and nutmeg.

Products Found In: Hair care, skincare, body care, sunless tanners, perfumes.

Alternate Names: 1-Hydroxytetradecane; Tetradecanol; 1-Tetradecanol; Tetradecyl Alcohol; Dytol R-52; Lanette Wax Ks; Loxanol V; Myristic Alcohol; Myristyl Alcohol (Mixed Isomers) ; N-Tetradecanol-1; N-Tetradecyl Alcohol.

Toxicity: Myristyl Alcohol is generally classified as having low toxicity.(EWG)

Functions:
Myristyl Alcohol is a fatty-alcohol used as an emollient in cosmetics and skin care products (Source). According to research, it is primarily used to inhibit a formula from separating into its oil and liquid components. However, Myristyl Alcohol can be drying, as can most fatty-alcohols.

Myristyl Alcohol is also used for other properties, including as an: Emulsion Stabilizer; Skin-Conditioning Agent; Surfactant; Viscosity Increasing Agent; Foaming Agent; and Fragrance Ingredient. According to The Good Scents Company, Myristyl Alcohol provides a fruity, coconut scent.

In the Human Toxome Project, a mapping of pollution levels in people throughout the world, Myristyl Alcohol was found in 1 out of 9 people. Read more about the Human Toxome Project being done by the Environmental Working Group.

Safety Measures/Side Effects:

A study published by Toxicology and Applied Pharmacology in 1966 showed Myristyl Alcohol to be a carcinogen and cause skin tumors in multiple tests, but only in high doses given to animals, primarily mice. It’s also been shown to be an irritant in animals. Studies published in Contact Dermatitis in April and November of 2006, both done in Europe and both concerning patch testing and cosmetic allergies directly resulting from Myristyl Alcohol found that it was an irritant, but only in patients with highly sensitive skin. It is approved by the FDA as a food additive, and by the CIR for use in cosmetics

Molecular Weight of Myristyl Alcohol    214.39 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
XLogP3 of Myristyl Alcohol    6.2    Computed by XLogP3 3.0 (PubChem release 2019.06.18)
Hydrogen Bond Donor Count of Myristyl Alcohol    1    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Count of Myristyl Alcohol    1    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Count of Myristyl Alcohol    12    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Mass of Myristyl Alcohol    214.229666 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Mass of Myristyl Alcohol    214.229666 g/mol    Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Area of Myristyl Alcohol    20.2 Ų    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Count of Myristyl Alcohol    15    Computed by PubChem
Formal Charge of Myristyl Alcohol    0    Computed by PubChem
Complexity of Myristyl Alcohol    102    Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Count of Myristyl Alcohol    0    Computed by PubChem
Defined Atom Stereocenter Count of Myristyl Alcohol    0    Computed by PubChem
Undefined Atom Stereocenter Count of Myristyl Alcohol    0    Computed by PubChem
Defined Bond Stereocenter Count of Myristyl Alcohol    0    Computed by PubChem
Undefined Bond Stereocenter Count of Myristyl Alcohol    0    Computed by PubChem
Covalently-Bonded Unit Count of Myristyl Alcohol    1    Computed by PubChem
Compound  of Myristyl Alcohol Is Canonicalized    Yes

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