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N,N-DIETHYLETHANAMINE

CAS NUMBER: 17440-81-2

EC NUMBER: -

MOLECULAR FORMULA: C6H16N

MOLECULAR WEIGHT: 102.20

IUPAC NAME: N,N-diethylethanamine;hydrogen

N,N-Dimethylethylamine (DMEA), sometimes referred to as dimethylethylamine, is an organic compound with formula (CH3)2NC2H5. 
N,N-Diethylethanamine is an industrial chemical that is mainly used in foundries as a catalyst for epoxy resins and polyurethane as well as sand core production.

N,N-Diethylethanamine is a malodorous, volatile liquid at room temperature that is excreted at greater concentrations with larger dietary intake of trimethylamine
N,N-Diethylethanamine is a benzimidazole derivative that inhibits phosphodiesterases. 

N,N-Diethylethanamine has been shown to be effective in the treatment of cardiac disorders and allergic reactions. 
N,N-Diethylethanamine may also be used cosmetically to improve skin elasticity. 

N,N-Diethylethanamine has an inhibitory effect on cyclic nucleotide phosphodiesterase and is metabolized by hydrolysis to form diethylamine. 
The pharmacological effects of N,N-Diethylethanamine are related to its inhibitory effect on phosphodiesterase enzymes and its ability to act as a cation at physiological pH levels.

N,N-Diethylethanamine is used in: 
-the manufacture of pharmaceuticals

-pesticides

-polymerization inhibitors

-high-energy fuels

-rubber curing agents, etc


N,N-Diethylethanamine is an organic base used in organic synthesis. 
N,N-Diethylethanamine is largely used in esters and amides synthesis from acyl chlorides.

N,N-Diethylethanamine is the chemical compound with the formula N(CH2CH3)3, commonly abbreviated Et3N. 
N,N-Diethylethanamine is also abbreviated TEA, yet this abbreviation must be used carefully to avoid confusion with triethanolamine or tetraethylammonium, for which TEA is also a common abbreviation.

N,N-Diethylethanamine is a colourless volatile liquid with a strong fishy odor reminiscent of ammonia. 
Like diisopropylethylamine (Hünig's base), N,N-Diethylethanamine is commonly employed in organic synthesis, usually as a base.

N,N-Diethylethanamine is a tertiary amine that is ammonia in which each hydrogen atom is substituted by an ethyl group.
N,N-Diethylethanamine is an organic compound having the chemical formula N(CH2CH2OH)3. 

N,N-Diethylethanamine contains three alcohol groups attached to a central nitrogen atom. 
This compound occurs as a colourless and viscous liquid at room temperature. 
However, if N,N-Diethylethanamine contains impurities, this liquid appears in yellow colour.

Synthesis and Properties:
N,N-Diethylethanamine is prepared by the alkylation of ammonia with ethanol:

NH3 + 3 C2H5OH → N(C2H5)3 + 3 H2O
The pKa of protonated triethylamine is 10.75, and it can be used to prepare buffer solutions at that pH. 
N,N-Diethylethanamine is a colorless, odorless, and hygroscopic powder, which decomposes when heated to 261 °C.

N,N-Diethylethanamine is soluble in water to the extent of 112.4 g/L at 20 °C.[10] It is also miscible in common organic solvents, such as acetone, ethanol, and diethyl ether.
Laboratory samples of N,N-Diethylethanamine can be purified by distilling from calcium hydride.

In alkane solvents N,N-Diethylethanamine is a Lewis base that forms adducts with a variety of Lewis acids, such as I2 and phenols. 
Owing to its steric bulk, N,N-Diethylethanamine forms complexes with transition metals reluctantly.

APPLIATIONS: 
N,N-Diethylethanamine is commonly employed in organic synthesis as a base. 
For example, N,N-Diethylethanamine is commonly used as a base during the preparation of esters and amides from acyl chlorides.
Such reactions lead to the production of hydrogen chloride which combines with N,N-Diethylethanamine to form the salt triethylamine hydrochloride, commonly called triethylammonium chloride. 
Hydrogen chloride may then evaporate from the reaction mixture, which drives the reaction. (R, R' = alkyl, aryl):

R2NH + R'C(O)Cl + Et3N → R'C(O)NR2 + Et3NH+Cl−
Like other tertiary amines, it catalyzes the formation of urethane foams and epoxy resins. 
N,N-Diethylethanamine is also useful in dehydrohalogenation reactions and Swern oxidations.

N,N-Diethylethanamine is readily alkylated to give the corresponding quaternary ammonium salt:

RI + Et3N → Et3NR+I−
N,N-Diethylethanamine is mainly used in the production of quaternary ammonium compounds for textile auxiliaries and quaternary ammonium salts of dyes. 
N,N-Diethylethanamine is also a catalyst and acid neutralizer for condensation reactions and is useful as an intermediate for manufacturing medicines, pesticides and other chemicals.

N,N-Diethylethanamine salts, like any other tertiary ammonium salts, are used as an ion-interaction reagent in ion interaction chromatography, due to their amphiphilic properties. 
Unlike quaternary ammonium salts, tertiary ammonium salts are much more volatile, therefore mass spectrometry can be used while performing analysis.

Uses:
N,N-Diethylethanamine is used to give salts of various carboxylic acid-containing pesticides, e.g. Triclopyr and 2,4-dichlorophenoxyacetic acid

N,N-Diethylethanamine is the active ingredient in FlyNap, a product for anesthetizing Drosophila melanogaster
N,N-Diethylethanamine is used in mosquito and vector control labs to anesthetize mosquitoes. 
This is done to preserve any viral material that might be present during species identification.

N,N-Diethylethanamine is useful in reverse phase chromatography, often in a gradient to purify nucleotides and other biomolecules.
N,N-Diethylethanamine was found during the early 1940s to be hypergolic in combination with nitric acid, and was considered a possible propellant for early hypergolic rocket engines.

Natural occurrence:
Hawthorn flowers have a heavy, complicated scent, the distinctive part of which is triethylamine, which is also one of the first chemicals produced by a dead human body when it begins to decay. 
Due to the scent , N,N-Diethylethanamine is considered unlucky to bring hawthorn into a house. 
Gangrene and semen are also said to possess a similar odour.

N,N-Diethylethanamine is in the liquid state at room temperature, and it appears as a volatile, colourless liquid. 
N,N-Diethylethanamine has a strong fishy odour that resembles the odour of ammonia.

N,N-Diethylethanamine can be produced by the alkylation of ammonia with ethanol. 
The pKa of this liquid is about 10.75 so, N,N-Diethylethanamine can be used for the preparation of buffer solutions around pH 10.75. 

N,N-Diethylethanamine is slightly water-soluble. 
However, N,N-Diethylethanamine is miscible with some organic solvents as well. e.g. acetone, ethanol, etc. 

N,N-Diethylethanamine is a colourless, odourless, and hygroscopic powder.
There are many important applications of N,N-Diethylethanamine. 

Commonly, N,N-Diethylethanamine is used in the synthesis reactions in organic chemistry as a base. 
E.g. preparation of esters, amides from acyl chlorides. 

Furthermore, N,N-Diethylethanamine is useful in the production of quaternary ammonium compounds for the textile industry. 
N,N-Diethylethanamine is also useful as a catalyst and an acid neutralizer for condensation reactions. 
Moreover, N,N-Diethylethanamine is useful as an intermediate for manufacturing medicines, pesticides, etc.


PHYSICAL PROPERTIES: 

-Molecular Weight: 102.20    

-Exact Mass: 102.128274515    

-Monoisotopic Mass: 102.128274515    

-Topological Polar Surface Area: 3.2 Ų

-Density: 0.728

-Melting point: -115°C

-Boiling point: 90°C

-Tefractive index: 1.399-1.401

-Flash point: -11°C

-Solubility in Water: 133g/L (20°C)


N,N-Dimethylethylamine is an organic compound with formula (CH3)2NC2H5. 
N,N-Diethylethanamine is a benzimidazole derivative that inhibits phosphodiesterases. 

N,N-Diethylethanamine has been shown to be effective in the treatment of cardiac disorders and allergic reactions. 
N,N-Diethylethanamine is used cosmetically to improve skin elasticity. 

N,N-Diethylethanamine is used in polymerization inhibitors
N,N-Diethylethanamine is an organic base used in organic synthesis. 


CHEMICAL PROPERTIES: 
    
-Hydrogen Bond Donor Count: 0    

-Hydrogen Bond Acceptor Count: 1    

-Rotatable Bond Count: 3    

-Heavy Atom Count: 7    

-Formal Charge: 0    

-Complexity: 25.7    

-Isotope Atom Count: 0    

-Defined Atom Stereocenter Count: 0    

-Undefined Atom Stereocenter Count: 0    

-Defined Bond Stereocenter Count: 0    

-Undefined Bond Stereocenter Count: 0    

-Covalently-Bonded Unit Count: 2    

-Compound Is Canonicalized: Yes


N,N-Diethylethanamine is largely used in esters and amides synthesis from acyl chlorides.
N,N-Diethylethanamine is the chemical compound with the formula N(CH2CH3)3, commonly abbreviated Et3N. 
N,N-Diethylethanamine is a colourless volatile liquid with a strong fishy odor reminiscent of ammonia. 

N,N-Diethylethanamine is a tertiary amine that is ammonia in which each hydrogen atom is substituted by an ethyl group.
N,N-Diethylethanamine is an organic compound having the chemical formula N(CH2CH2OH)3. 

N,N-Diethylethanamine is commonly employed in organic synthesis as a base. 
N,N-Diethylethanamine is used as a base during the preparation of esters and amides from acyl chlorides.

N,N-Diethylethanamine is also useful in dehydrohalogenation reactions and Swern oxidations.
N,N-Diethylethanamine is used to give salts of various carboxylic acid-containing pesticides, e.g. Triclopyr and 2,4-dichlorophenoxyacetic acid

N,N-Diethylethanamine is the active ingredient in FlyNap, a product for anesthetizing Drosophila melanogaster
N,N-Diethylethanamine is used in mosquito and vector control labs to anesthetize mosquitoes. 

N,N-Diethylethanamine is useful in reverse phase chromatography, often in a gradient to purify nucleotides and other biomolecules.
N,N-Diethylethanamine is in the liquid state at room temperature, and it appears as a volatile, colourless liquid. 

N,N-Diethylethanamine is slightly water-soluble. 
N,N-Diethylethanamine is a colourless, odourless, and hygroscopic powder.

N,N-Diethylethanamine is used in the synthesis reactions in organic chemistry as a base. 
N,N-Diethylethanamine is useful in the production of quaternary ammonium compounds for the textile industry. 
N,N-Diethylethanamine is useful as an intermediate for manufacturing medicines, pesticides, etc.


SYNONYMS: 

N,N-diethylethanamine;hydron
17440-81-2
SCHEMBL1334882
Ethanamine, N,N-diethyl-, conjugate acid
Ethanamine, N,N-diethyl-, compd. with borin (1:1) 
N,N-Diethylethanamin -borinin (1:1)
N,N-Diethylethanamine - borinine (1:1) 
N,N-Diéthyléthanamine - borinine (1:1)
TETN
Triethyl Amine
ethanamine
N,N-diethylethanaminium bromide
N,N-diethylethanamine sulfate
N,N-diethylethanamine acetate (1:1)
N,N-diethylethanaminium
N,N-diethylethanamine sulfate (1:1)
(C2H5)3N    
Ethanamine, N,N-diethyl-, conjugate acid
Ethanamine, N,N-diethyl-, compd. with borin
N,N-Diethylethanamin -borinin (1:1)
N,N-Diethylethanamine - borinine
(diethylamino)ethane    
N,N,N-triethylamine    
N,N-Diethylethanamine    
NEt3    
TEA
Ethanamine, N,N-diethyl-, conjugate acid
Ethanamine, N,N-diethyl-, compd. with borin
N,N-Diethylethanamine - borinine

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