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N,N-Diethylethanamine is the most simple tri-substituted uniformly tertiary amine, having typical properties of tertiary amines, including salifying, oxidation, Hing Myers test (Hisberg reaction) for triethylamine does not respond.
N,N-Diethylethanamine is colorless to pale yellow transparent liquid, with a strong smell of ammonia, slightly fuming in the air.
N,N-Diethylethanamine is toxic, with a strong irritant.
CAS Number: 121-44-8
Molecular Formula: C6H15N
Molecular Weight: 101.19
EINECS Number: 204-469-4
Synonyms:TRIETHYLAMINE, N,N-Diethylethanamine, (Diethylamino)ethane, Ethanamine N,N-diethyl, Triaethylamin, Trietilamina, triethyl amine, Triethylamin, N,N,N-Triethylamine, NEt3, MFCD00009051, trietylamine, tri-ethyl amine, (C2H5)3N, N,N-diethyl-ethanamine, ethane diethylamino, Diethylaminoethane, triethyl-amine, CCRIS 4881, HSDB 896, Et3N, EINECS 204-469-4, UN1296, UNII-VOU728O6AY, triehtylamine, triehylamine, trieihylamine, triethlyamine, triethyamine, triethylamme, triethylarnine, Thethylamine, Triethlamine, triethyIamine, Triethylannine, tri-ethylamine, triehyl amine, triethyl amin, triethylam ine, triethylami-ne, triethylamine-, trietyl amine, tri ethyl amine, triethyl- amine, AI3-15425, Triethylamine anhydrous, N N-diethylethanamine, N,N,N-Triethylamine, SCHEMBL30, N(Et)3, TRIETHYLAMINE, EC 204-469-4, CHEMBL284057, N(CH2CH3)3, N(C2H5)3, (CH3CH2)3N, (C2H5)3N;(Diethylamino)ethane;ai3-15425;Ethanamine, N,N-diethyl-;ethanamine,n,n-diethyl-;N,N,N-Triethylamine;N,N-Diethylethanamin;AKOS BBS-00004381
N,N-Diethylethanamine is a tertiary aliphatic amine, widely used as a base, catalyst, and intermediate in chemical synthesis and industrial processes.
N,N-Diethylethanamines chemical formula is C₆H₁₅N.
N,N-Diethylethanamine belongs to the class of trialkylamines.
N,N-Diethylethanamine consists of a nitrogen atom bonded to three ethyl groups (–CH₂CH₃).
This structure makes it a tertiary amine with no N–H bonds.
It exhibits basic and nucleophilic properties.
Physically, N,N-Diethylethanamine appears as a colorless liquid with a strong, ammonia-like odor.
It is volatile and partially soluble in water.
N,N-Diethylethanamine is miscible with many organic solvents.
N,N-Diethylethanamine exhibits basicity due to the lone pair on the nitrogen atom.
It can accept protons and form ammonium salts.
This makes it useful in neutralization reactions.
N,N-Diethylethanamine is widely used as a proton scavenger and catalyst in organic synthesis.
N,N-Diethylethanamine helps drive reactions by neutralizing acids formed during reactions.
This improves reaction efficiency.
N,N-Diethylethanamine is chemically reactive, especially with acids, acyl chlorides, and electrophiles.
N,N-Diethylethanamine participates in various organic transformations.
This supports its role in synthesis.
N,N-Diethylethanamine is volatile and flammable, requiring careful handling.
It should be stored in tightly closed containers.
N,N-Diethylethanamine is best described as a volatile, basic tertiary amine used as a catalyst, base, and intermediate, widely applied in organic chemistry and industrial processes.
N,N-Diethylethanamine, sometimes referred to as dimethylethylamine, is an organic compound with formula (CH3)2NC2H5.
N,N-Diethylethanamine is an industrial chemical that is mainly used in foundries as a catalyst for epoxy resins and polyurethane as well as sand core production.
N,N-Diethylethanamine is a malodorous, volatile liquid at room temperature that is excreted at greater concentrations with larger dietary intake of trimethylamine.
N,N-Diethylethanamine is a tertiary amine with the formula C5H13N.
N,N-Diethylethanamine is a clear, colorless to pale yellow liquid at room temperature, and is used in various industrial and scientific applications including water desalination as well as analytical and organic chemistry.
N,N-Diethylethanamine is an acute oral and inhalation toxin although limits determining acute and chronic toxicity have not been determined, nor have the acute or chronic effects on various organ systems.
Additionally, the effects of environmental exposure or accumulation are not currently known.
N,N-Diethylethanamine can be nitrosated to its corresponding nitrosamine which may present health considerations if DEMA is used in an industrial process that involves nitrating agents at low pH or high temperatures.
The nitrosamine N-nitrosodiethylamine has been found in cosmetics and is a possible product of DEMA nitrosation.
However, this toxic nitrosamine has only rarely been identified in cosmetic products.
There are no specific storage requirements for DEMA, other than the usual precautions for storing a flammable liquid.
Melting point: -115 °C
Boiling point: 90 °C
Density: 0.728
vapor density: 3.5 (vs air)
vapor pressure: 51.75 mm Hg (20 °C)
refractive index: n20/D 1.401 (lit.)
FEMA: 4246 | TRIETHYLAMINE
Flash point: 20 °F
storage temp.: Store below +30°C
solubility: water: soluble 112 g/L at 20°C
pKa: 10.75 (at 25℃)
form: Liquid
Specific Gravity: 0.725 (20/4℃)
color: Clear
pH: 12.7 (100 g/L, H2O, 15℃) (IUCLID)
Relative polarity: 1.8
Odor: Strong ammonia-like odor
Odor Threshold: 0.0054 ppm
Odor Type: fishy
explosive limit: 1.2–9.3% (V)
Evaporation Rate: 5.6
Water Solubility: 133 g/L (20 ºC)
Merck: 14,9666
JECFA Number: 1611
BRN: 1843166
Henry's Law Constant: 1.79 at 25 °C (Christie and Crisp, 1967)
Exposure limits: NIOSH REL: IDLH 200 ppm; OSHA PEL: TWA 25 ppm (100 mg/m³); ACGIH TLV: TWA 1 ppm, STEL 3 ppm (adopted)
Dielectric constant: 5.0 (Ambient)
Stability: Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons
Cosmetics Ingredients Functions: EMULSION STABILISING
InChI: 1S/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H3
InChIKey: ZMANZCXQSJIPKH-UHFFFAOYSA-N
SMILES: CCN(CC)CC
LogP: 1.65
N,N-Diethylethanamine is a tertiary amine with no hydrogen atoms attached to the nitrogen, which prevents hydrogen bonding between molecules.
This contributes to its relatively low boiling point and high volatility.
N,N-Diethylethanamine evaporates readily at room temperature.
The molecule exhibits moderate basic strength (pKa of conjugate acid ≈ 10.7).
N,N-Diethylethanamine is weaker than inorganic bases but strong enough for many organic reactions.
This makes it a versatile organic base.
N,N-Diethylethanamine acts as a nucleophilic base, meaning it can both donate its lone pair and participate in reactions.
N,N-Diethylethanamine is commonly used to trap acidic byproducts such as HCl.
This drives reactions toward completion.
N,N-Diethylethanamine forms triethylammonium salts upon protonation.
These salts are often soluble and easily removed.
This simplifies purification processes.
N,N-Diethylethanamine shows good solubility in organic solvents and limited solubility in water.
This makes it suitable for organic-phase reactions.
N,N-Diethylethanamine is widely used in non-aqueous systems.
N,N-Diethylethanamine can participate in catalytic and acid-neutralizing roles in esterification, acylation, and condensation reactions.
N,N-Diethylethanamine improves reaction rates and yields.
This enhances synthetic efficiency.
The compound has a strong, characteristic odor detectable at low concentrations.
This is typical of low-molecular-weight amines.
N,N-Diethylethanamine is an important handling consideration.
N,N-Diethylethanamine is often used in combination with other reagents, such as acid chlorides or coupling agents.
It stabilizes reaction conditions.
N,N-Diethylethanamine is a volatile, moderately strong organic base with nucleophilic character and high utility in acid scavenging and catalysis, making it essential in organic synthesis and industrial chemistry.
N,N-Diethylethanamine exhibits low intermolecular forces due to its branched structure and lack of hydrogen bonding, resulting in high volatility.
It readily transitions to the vapor phase.
This influences handling and storage.
N,N-Diethylethanamine shows good miscibility with a wide range of organic compounds, including hydrocarbons, alcohols, and ethers.
This makes it a versatile solvent component.
N,N-Diethylethanamine supports diverse reaction systems.
N,N-Diethylethanamine can act as a phase-transfer facilitator in some reactions, helping transfer reactive species between phases.
This improves reaction efficiency.
N,N-Diethylethanamine is useful in heterogeneous systems.
N,N-Diethylethanamine plays a key role in acid scavenging during reactions involving acid chlorides or sulfonyl chlorides.
It neutralizes released acids and prevents side reactions.
This ensures cleaner product formation.
The molecule can influence reaction selectivity and kinetics by stabilizing intermediates or controlling pH.
N,N-Diethylethanamine helps maintain optimal reaction conditions.
This improves yields.
N,N-Diethylethanamine forms volatile ammonium salts that can often be removed by washing or evaporation.
This simplifies post-reaction purification.
N,N-Diethylethanamine is advantageous in synthesis workflows.
N,N-Diethylethanamine may interact with carbon dioxide from air, forming carbamate-like species over time.
This can slightly affect purity.
Proper storage minimizes this effect.
Because of its strong basicity and volatility, it is often used in controlled addition processes to manage reaction heat and rate.
N,N-Diethylethanamine is important in scale-up operations.
N,N-Diethylethanamine is a highly versatile, volatile organic base with strong acid-scavenging ability, good solvent compatibility, and influence on reaction control, making it indispensable in organic and industrial chemistry.
Uses:
N,N-Diethylethanamine is a clear, colorless liquid with an Ammonia or fish-like odor.
N,N-Diethylethanamine is used in making waterproofing agents, and as a catalyst, corrosion inhibitor and propellant.
It is mainly used as base, catalyst, solvent and raw material in organic synthesis and is generally abbreviated as Et3N, NEt3 or TEA.
N,N-Diethylethanamine can be used to prepare phosgene polycarbonate catalyst, polymerization inhibitor of tetrafluoroethylene, rubber vulcanization accelerator, special solvent in paint remover, enamel anti-hardener, surfactant, antiseptic, wetting agent, bactericides, ion exchange resins, dyes, fragrances, pharmaceuticals, high-energy fuels, and liquid rocket propellants, as a curing and hardening agent for polymers and for the desalination of seawater.
N,N-Diethylethanamine is a base used to prepare esters and amides from acyl chlorides as well as in the synthesis of quaternary ammonium compounds.
N,N-Diethylethanamine acts as a catalyst in the formation of urethane foams and epoxy resins, dehydrohalogeantion reactions, acid neutralizers for condensation reactions and Swern oxidations.
It finds application in reverse phase high-performance liquid chromatography (HPLC) as a mobile-phase modifier.
N,N-Diethylethanamine is also used as an accelerator activator for rubber, as a propellant, as a corrosion inhibitor, as a curing and hardening agent for polymers and for the desalination of seawater.
Furthermore, it is used in the automotive casting industry and the textile industry.
N,N-Diethylethanamine has found use in multiple fields of study including nuclear magnetic resonance spectroscopy (NMR), industrial extraction techniques, and water desalination.
N,N-Diethylethanamine is widely used as a base in organic synthesis.
N,N-Diethylethanamine neutralizes acids formed during reactions.
This drives reactions toward completion.
In acylation and esterification reactions, it acts as an acid scavenger.
N,N-Diethylethanamine captures byproducts such as HCl.
This improves yield and purity.
N,N-Diethylethanamine is used in pharmaceutical synthesis as a reagent and intermediate.
It helps produce active pharmaceutical ingredients.
This supports drug manufacturing.
In polymer and resin production, it functions as a catalyst or neutralizing agent.
N,N-Diethylethanamine controls reaction conditions.
This improves polymer formation.
N,N-Diethylethanamine is applied in coatings, paints, and inks as a pH regulator and catalyst.
It helps stabilize formulations.
This enhances product performance.
N,N-Diethylethanamine is used in ion-pair chromatography and analytical chemistry.
It modifies mobile phase properties.
This improves separation efficiency.
In textile and dye processing, it acts as a neutralizing and processing agent.
N,N-Diethylethanamine helps control reaction environments.
This improves treatment quality.
N,N-Diethylethanamine is used in adhesives and sealants as a catalyst and stabilizer.
It enhances curing and performance.
This supports industrial applications.
N,N-Diethylethanamine is also applied in agrochemical synthesis for producing pesticides and herbicides.
It participates in intermediate reactions.
N,N-Diethylethanamine is used wherever basicity, acid neutralization, catalytic activity, and reaction control are required across pharmaceuticals, polymers, coatings, and chemical synthesis.
Safety Profile:
Moderately toxic by ingestion and skin contact.
Human systemic effects: visual field changes.
Experimental reproductive effects mutation data reported a skin and severe eye irritant.
Can cause kidney and liver damage a very dangerous fire hazard when exposed to heat, flame, or oxidizers.
Explosive in the form of vapor when exposed to heat or flame.
Complex with dinitrogen tetraoxide explodes below 0°C when undduted with solvent.
Exothermic reaction with maleic anhydride above 150°C.
Can react with oxidzing materials. Incompatible with N2O4.
To fight fire, use CO2, dry chemical, alcohol foam when heated to decomposition it emits toxic fumes of NOx.
N,N-Diethylethanamine presents significant hazards, mainly due to its flammability, volatility, strong odor, and irritant effects.
N,N-Diethylethanamine is a hazardous organic solvent and base.
Strict safety precautions are required.
Skin contact may cause irritation and defatting of the skin.
Prolonged exposure can lead to redness and dryness.
Protective gloves and clothing are recommended.
Eye contact can cause severe irritation or damage.
Symptoms include redness, pain, and possible injury.
Immediate rinsing with water is necessary.
Inhalation of vapors may cause respiratory irritation and central nervous system effects.
Symptoms can include headache, dizziness, nausea, and drowsiness.
High exposure may lead to more serious effects.
Ingestion is harmful and may cause gastrointestinal irritation and systemic toxicity.
Symptoms can include nausea, vomiting, and discomfort.
